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Yintoni iHumira kwaye isetyenziselwa ntoni?

Yintoni iHumira kwaye isetyenziselwa ntoni?Ulwazi lweziyobisi

Yintoni uHumira? | Sebenzisa | Ingaba isebenza kanjani | Imithamo | Ulwazi ngokhuseleko | Ugcino





Uninzi lwethu lunokuthi ubomi bethu sele bunexinzelelo ngokwaneleyo. Phakathi komsebenzi wokugungxula, ubomi bosapho, kunye nemigaqo emitsha ejikeleze ubhubhane, akufuneki ukuba sikhathazeke malunga nokungaqiniseki okongeziweyo okanye ukuphazamiseka kongezwe kwimeko yethu yesiqhelo.



Kubantu abaninzi abanezifo ezinokutsha njenge-arthritis, i-plaque psoriasis, isifo sikaCrohn, kunye ne-ulcerative colitis, ejongene nokumangaliswa kokuphazamiseka ngokuqinisekileyo banokuziva ngathi kukuphazamiseka okungamkelekanga.

I-Humira inokubonelela ngokuthuthuzela kunye nokuqiniseka kwabantu abanezifo ezikhuselayo ezizenzekelayo ngala maxesha angaqinisekanga. Ngelixa i-Humira ayilulo unyango lwezifo ezitshisa ukutsha, inokusetyenziselwa ukulawula ngokukhuselekileyo le meko kunye nokunciphisa ubungqongqo bokuphakama xa zisenzeka. Apha, siza kuxoxa ngendlela uHumira asebenzela ngayo izifo ezahlukeneyo zokuzikhusela, ukuba uyisebenzisa njani ngokukhuselekileyo, kwaye zeziphi iidosi. Siza kuphinda sithethe ngokudibana kweziyobisi kunye neziphumo ebezingalindelekanga.

Yintoni iHumira, kwaye isetyenziselwa ntoni?

I-Humira ligama lophawu lweziyobisi iadalimumab. Ikwiklasi enkulu yeziyobisi ekuthiwa sisifo esiguqula ii-anti-rheumatic agents (i-DMARDs) kwaye ikwi-subclass ye-DMARD ebizwa ngokuba yi-biologics. I-Biologics sisiyobisi esenziwe kwizinto eziphilayo (okanye zebhayoloji) zeeseli. I-Humira sisiyobisi esenziwe ngu-AbbVie. Ayifumaneki ekhawuntarini.



I-Humira isebenza ngokuthintela ngokuthe ngqo i-TNF-alpha kwaye yamkelwa ukuba isetyenziswe yi I-FDA ngo-2002. Ithumba necrosis factor (TNF) blocker ngamachiza omzimba (abizwa ngokuba zii-immunosuppressants). Ngokuthintela umsebenzi we-TNF-into esemzimbeni ebangela ukuvuvukala-uHumira unokusetyenziselwa ukunyanga izifo ezomeleleyo zomzimba ezinje ngesifo samathambo, i-plaque psoriasis, i-ankylosing spondylitis, isifo sikaCrohn, kunye nesilonda esibuhlungu. I-Humira, njengoninzi lwe-DMARD, ihlala ithatha phakathi kweeveki ezininzi ukuya kwiinyanga ezininzi ukuqala ukusebenza. Ayisiyo NSAID (non-steroidal anti-inflammatory drug) okanye i-corticosteroid (steroid).

Kuba i-biologics inezinto ezintsonkothileyo, akukho lula ukuzala kwakhona okanye ukwenza ikopi yohlobo oluqhelekileyo. Ngaphandle kokhetho oluqhelekileyo olukhoyo, i-FDA iyasibona isidingo samachiza afanayo ukuba abekhona kwaye ikhuthaze abo bakhuphisana nabo ukuba benze ezinye iindlela. Iyeza elifana ne-biologic esele ivunyiwe yi-FDA ibizwa ngokuba sisiyobisi se-biosimilar. Kukho ii-biosimilars ezisixhenxe ze-Humira ezivunyiweyo yi-FDA: Hulio, Hadlima, Abrilada, Tremfya, Amjevita, Cyltezo, kunye ne Hyrimoz. Nangona ezi biosimilars zivunyiwe yi-FDA, azizukubakho e-United States kude kube ngo-2023, njengoko uHumira ekhuselwe patent kude kube lelo xesha.

UHumira usebenzisa

I-Humira isetyenziselwa ulawulo lwezifo ezahlukeneyo zomzimba. Ngokuthintela umsebenzi we-TNF-alpha, u-Humira unciphisa ukudumba kunye neempawu ezibuhlungu ezinxulumene nale miqathango ilandelayo.



I-Humira yesifo samathambo esivuthayo okanye samathambo: Isistim somzimba sokusebenza esingaphaya komzimba sinokubangela ukudumba kwamalungu, okudala iimpawu ezinjengeentlungu, ukudumba, kunye nokuqina kwelungu. I-TNF-alpha yenye yeeproteni ezichaphazelekayo ekubangeleni ukudumba okungafunekiyo ngokudibeneyo. Iithagethi zeHumira kunye neebhloko zomsebenzi we-TNF-alpha kumalungu, anciphisa iimpawu kwaye anciphise ukuqhubela phambili komonakalo odibeneyo. Elinye ichiza elisetyenziselwa ukunyanga isifo samathambo esidumbisayo imethotrexate . Kwizifundo zeklinikhi, abantu abathatha i-Humira kunye ne-methotrexate babonise ukuphucuka okukhulu kwiimpawu zesifo samathambo esisebenzayo ngaphezulu kokuthatha i-methotrexate yodwa.

Ezinxulumene: Unyango lwe-Arthritis kunye namayeza

Humira kwi-plaque psoriasis: Ngelixa oyena nobangela ungaziwa, ukuba ne-TNF-alpha eninzi kunokutshintsha ukukhula kweeseli zolusu, zikhokelele kubomvu, amabala amdaka. Ngokunciphisa inani le-TNF-alpha ejikelezayo emzimbeni, uHumira angancipha kwaye ngamanye amaxesha aphelise izilonda zeplastiki kulusu.



Ezinxulumene: Yonke into ofuna ukuyifumana malunga ne-biologics ye-psoriasis

I-Humira ye-psoriatic arthritis: I-Psoriatic arthritis luhlobo lwesifo samathambo esichaphazela abanye abantu esele benayo i-psoriasis. Ukugqithisa kwe-TNF-alpha kwabanye abantu kunokubangela iintlungu ezidibeneyo, ukuvuvukala, kunye nokuqina, kunye nobomvu, amabala anamaxolo kulusu olubizwa ngokuba ngamacwecwe. I-Humira inokukunceda ukulawula oku kuvutha ngokuthintela umsebenzi we-TNF-alpha egqithisileyo.



I-Humira ye-ankylosing spondylitis: I-Ankylosing spondylitis sisifo samathambo esivuthayo somqolo. Ukugqithisa kwe-TNF-alpha ukukhupha ukuvuvukala kuncedisa kwiintlungu zangasemva kunye nokuqina kwabantu abane-ankylosing spondylitis. I-Humira inokunciphisa iimpawu zezigulane zabantu abadala abane-ankylosing spondylitis esebenzayo.

Humira kwisifo sikaCrohn: Isifo sikaCrohn Iimpawu ezinje ngesifo sorhudo, iintlungu esiswini, kunye necramping zinokuvela ngaphandle kwesilumkiso. Xa umzimba wakho uvelisa kakhulu i-TNF-alpha, inokubangela ukudumba okungaphezulu okuya kuthi kubangele ezi kunye nezinye iimpawu zesifo sikaCrohn. U-Humira unokunceda ngokuphelisa ukudumba okungaphezulu.



I-Humira ye-ulcerative colitis: Ukudumba okwenziwa sisilonda sikabhobhosi (UC) luhlobo lwezifo zesisu ezivuthayo (IBD). Ingapheliyo kwaye ihlala ixesha elide, ibangela ukuvuvukala kumathumbu amakhulu (ikholoni), kunye ne-rectum. Oyena nobangela wokudumba akwaziwa. Nangona kunjalo, uncedo luyafumaneka. U-Humira uye waboniswa ukunciphisa okanye ukuphelisa iimpawu zesifo sezilonda ezinjenge-urcerative rhoqo kunye nokukhawuleza, ukulahleka kwesisindo, isicupunu kunye nokukhathala.

Humira ye-hidradenitis suppurativa: I-Hidradenitis suppurativa (HS) yimeko yesikhumba engapheliyo apho kukho amaqhuma abuhlungu phantsi kolusu. Ezi ziqhuma zibuhlungu zenzeka phantsi kolusu oluphethe amadlala emakhwapheni, emiphakathini, ezinqeni, okanye emabeleni. Ukuba ne-alfa eninzi ye-TNF kukholelwa ukuba iya kuba negalelo kubukhali be-HS. I-Humira inokunceda ngokuthintela iproteni ye-TNF-alpha, enokunciphisa ukudumba kunye nentlungu phantsi kolusu.



Humira ngenxa ye-uveitis: Uveitis kukudumba kwethishu ebuthathaka kwiliso elibizwa ngokuba yi-uvea. Usulelo lwe-uveitis olubangelwa lusulelo kwintsholongwane okanye kwintsholongwane. I-uveitis engosuleliyo kukudumba okungapheliyo kwe-uvea engabangelwa yintsholongwane okanye ibhaktiriya. I-alfa eninzi ye-TNF kunye nezinye iiproteni zinegalelo kukudumba, iintlungu, kunye nemvakalelo yokukhanya okubonwe kwi-uveitis engosuleliyo. I-Humira inokunciphisa ukuvuvukala kwiso, ukunciphisa iimpawu ezingathandekiyo.

Humira yentsha ye-idiopathic arthritis: Abantwana abangaphantsi kweminyaka eli-16 abaneempawu zentlungu eqhubekayo, ukudumba, okanye ukuqina kwamalungu, banokuba nawo i-juvenile idiopathic arthritis (JIA) . Xa oku kusenzeka kumdibaniso ongaphezu kwesinye, kubizwa ngokuba yi-polyarticular juvenile idiopathic arthritis. I-TNF-alpha lelinye lamagalelo ekudibaneni ngokudibeneyo okubangela iintlungu ezingapheliyo, ukudumba kunye nokuqina. I-Humira ibhloka umsebenzi we-TNF-alpha. Elinye ichiza elisetyenziselwa ukunyanga i-JIA imethotrexate . Kwizifundo zeklinikhi, abantwana abaphathwe ngeHumira kunye ne-methotrexate babonakalisiwe benokuphucuka okukhulu kweempawu ngaphezulu kwe-methotrexate yodwa.

Usebenza njani uHumira?

I-Humira yintsholongwane ye-monoclonal ebopha ngokukodwa kwi-TNF-alpha. I-TNF-alpha luhlobo oluncinci lweprotheni ebizwa ngokuba yi-cytokine. IiCytokines zisetyenziswa ngamajoni omzimba ukudala ukudumba. Ngokwesiqhelo, ukukhutshwa kwee-cytokines ezinjenge-TNF-alpha yindlela iiseli zomzimba zokuzikhusela ezinxibelelana ngayo. Xa iiseli zamajoni omzimba zibhaqa usulelo, zikhupha i-TNF-alpha ukwazisa ezinye iiseli emzimbeni ukuba usulelo lukhona. Le ndlela yonxibelelwano ibangela ukudumba okuyimfuneko emzimbeni wokubulala usulelo. Kwizifo ezithile ezinokutsha, i-TNF-alpha ikhutshwa ngaphandle kosulelo olukhoyo, olubangela ukudumba kwizicwili zomzimba.

Iziyobisi ezinje ngeHumira ezibopha ngokuthe ngqo kwi-TNF-alpha zibizwa ngokuba ziiarhente zokuthintela i-TNF. Ngokubopha kwi-TNF-alpha, izifundo zeklinikhi zibonise ukuba uHumira unciphisa-okanye athintela-umsebenzi wokukrala we-TNF-alpha. Eli chiza libangela ukuba iiseli emzimbeni eziveza kakhulu i-TNF-alpha ukuba ife.

Iiarhente zokuthintela i-TNF zii-immunosuppressants. Ngokuthintela i-TNF emzimbeni, u-Humira ucinezela-okanye ukunciphisa umsebenzi we-overactive okanye engafunekiyo yokuvuvukala kumajoni omzimba. Kuba uHumira anganciphisa ukuvuvukala kumajoni omzimba, uHumira unokusetyenziselwa ukunyanga izifo ezomeleleyo ezifana ne-arthritis, i-plaque psoriasis, i-ankylosing spondylitis, isifo sikaCrohn, kunye ne-ulcerative colitis. Oku kukwathetha ukuba uHumira unokucinezela amajoni omzimba ngokubanzi, esenza ukuba abanye abantu babesemngciphekweni wosulelo.

Ungamthatha njani uHumira

I-Humira inikezelwa ngenaliti yangaphantsi (phantsi kolusu). Amachiza okufaka inaliti afana neHumira kufuneka amiselwe ngugqirha onikwe ilayisensi. I-Humira dosing isekwe kwimeko apho isetyenziselwa ukunyanga. Kubalulekile ukuba ishedyuli efanelekileyo yokulandelwa ilandelwe kwimeko uHumira esetyenziselwa ukunyanga.

Ngokukhawuleza ukuba uHumira aqale ukusebenza kuxhomekeke kwizinto ezahlukeneyo, kubandakanya ubukhali bemeko yonyango ephathwayo kwaye yeyiphi imeko uHumira esetyenziselwa ukunyanga. Abanye abantu baqala ukuziva bekhululekile kunye noHumira emva kweeveki ezimbini, kodwa kwabanye, kunokuthatha ukuya kwiinyanga ezintathu.

I-Humira ithathwa njengeyeza lokugcina (ixesha elide). Iyaqhubeka nokubonelela ngesiqabu seempawu okoko nje usithathayo. Akukho xesha lokuphela lisetiweyo xa uyeka ukulithatha. Awuyi kuba nakho ukurhoxa xa uyeka ukuthatha u-Humira, kodwa iimpawu zakho zinokuvela kwakhona. Umboneleli wakho wezempilo uya kuvavanya rhoqo ukujonga impendulo yakho yokuvuvukala kunye nempendulo yakho kuHumira. Wena kunye nomboneleli wakho wezempilo unokuthatha isigqibo xa, okanye ukuba, ukuyeka uHumira kufanelekile. Akufanele uyeke ukuthatha u-Humira ngokwakho ngaphandle kokufuna iingcebiso zonyango.

I-Humira idosiwe ngeendlela ezimbini. Xa uqala uHumira, unikwa idosi yokuqala. Idosi yokuqala kufuneka itofwe okanye phantsi kweliso lomboneleli wezempilo. Kubalulekile ukuba kusetyenziswe indlela efanelekileyo yenaliti. Inkqubo efanelekileyo yenaliti inokuboniswa kuwe ngumboneleli wakho wezempilo. Iindawo ezilungileyo zokujova ziya kuba sisisu (hlala malunga ne-intshi kude nesisu) kunye namacala amathanga, utsho UVictoria Ruffing , RN, umphathi ongumongikazi eJohns Hopkins.

Emva kwethamo lokuqala, uthotho lweedosi zokugcinwa zinikezelwa. Kubalulekile ukuba ukhumbule ukuba idosi yokuqala yeHumira kunye needosi zokugcina azisoloko zifana. Iidosi zolondolozo zinokuthi zizitofele ngokwazo kwintuthuzelo yekhaya lakho. Umboneleli wakho wezempilo angabonisa ukuba ungayenza njani inaliti ekhaya. Kukwakhona nezixhobo zokufundisa umboneleli wakho wezempilo anokukunika zona ukuze ubhekise kuzo xa usekhaya. I-Humira akufuneki ijojowe ngeentsuku ezingachazwanga ngeedosi zokuqala okanye zokugcina.

I-Humira yabantu abadala
Inkcazo Ukuqala kwedosi Ukugcinwa kwedosi
Irheumatoid Arthritis I-40 mg ngoSuku loku-1 40 mg qho ngeveki enye
I-Plaque psoriasis I-80 mg ngoSuku loku-1 40 mg ngosuku lwe-8, kunye ne-40 mg rhoqo ngeveki
Isifo samathambo 40 mg 40 mg qho ngeveki enye
I-Ankylosing spondylitis I-40 mg ngoSuku loku-1 40 mg qho ngeveki enye
Isifo sikaCrohn I-160 mg ngoSuku 1 (inikwe ngosuku olunye okanye yahlulwe phakathi kweentsuku ezimbini zilandelelana) I-80 mg ngoSuku lwe-15, kunye ne-40 mg rhoqo ngeveki ukuqala ngoMhla wama-29
Ukudumba okwenziwa sisilonda sikabhobhosi I-160 mg ngoSuku 1 (inikwe ngosuku olunye okanye yahlulwe phakathi kweentsuku ezimbini zilandelelana) I-80 mg ngoSuku lwe-15, kunye ne-40 mg rhoqo ngeveki ukuqala ngoMhla wama-29
Hidradenitis suppurativa I-160 mg ngoSuku 1 (inikwe ngosuku olunye okanye yahlulwe phakathi kweentsuku ezimbini zilandelelana) I-80 mg ngoSuku lwe-15, kunye ne-40 mg veki nganye ukuqala ngoMhla wama-29 OKANYE ngama-80 mg qho ngeveki ukuqala ngoMhla wama-29
Uveitis I-80 mg ngoSuku loku-1 40 mg ngosuku lwe-8, kunye ne-40 mg rhoqo ngeveki
Humira ithamo labantwana
Inkcazo Ukuqala kwedosi Ukugcinwa kwedosi
I-juvenile idiopathic arthritis: abantwana abaneminyaka emi-2 okanye ngaphezulu
  • Iilitha ezingama-22-33: 10 mg
  • Iilitha ezingama-33-66: 20mg
  • Iilitha ezingama-66 +: 40mg
  • 22 lbs ukuya ngaphantsi kwe-33 lbs: 10 mg qho ngeveki enye
  • I-33 lbs ukuya ngaphantsi kwe-66 lbs: 20mg rhoqo ngeveki
  • Iilbs ezingama-66 okanye ngaphezulu: 40mg qho ngeveki
Isifo sikaCrohn: abantwana abaneminyaka emi-6 okanye ngaphezulu
  • I-37-87 lbs: 80 mg ngoSuku 1
  • I-88 + lbs: 160 mg ngoSuku 1 (inikwe ngosuku olunye okanye yahlulwe phakathi kweentsuku ezimbini zilandelelana)
  • I-37 lbs ukuya kwi-87 lbs: 40 mg ngoSuku lwe-15, kunye ne-20 mg qho ngeveki nganye ukuqala ngoMhla wama-29
  • I-88 lbs okanye ngaphezulu: i-80 mg ngoSuku lwe-15, kunye ne-40 mg qho ngeveki nganye ukuqala ngoMhla wama-29
I-Ulcerative colitis: abantwana abaneminyaka emi-5 okanye ngaphezulu
  • I-44-87 lbs: 80 mg ngoSuku 1
  • I-88 + lbs: 160 mg ngoSuku 1 (inikwe ngosuku olunye okanye yahlulwe phakathi kweentsuku ezimbini zilandelelana)
  • I-44 lbs ukuya kwi-87 lbs: 40 mg ngoSuku lwe-8 kunye nosuku lwe-15, kunye ne-40 mg qho ngeveki nganye ukuqala ngomhla we-29 OKANYE 20mg veki nganye ukuqala ngoMhla wama-29
  • I-88 lbs okanye ngaphezulu: i-80 mg ngoSuku lwe-8 kunye nosuku lwe-15, kunye ne-80 mg qho ngeveki nganye ukuqala ngomhla we-29 OKANYE 40mg veki nganye ukuqala ngoMhla wama-29
I-Hidradenitis suppurativa: abantwana abaneminyaka eli-12 okanye ngaphezulu
  • I-66-132 lbs: 80mg ngoSuku 1
  • I-132 + lbs: 160 mg ngoSuku 1 (inikwe ngosuku olunye okanye yahlulwe phakathi kweentsuku ezimbini zilandelelana)
  • 40 mg ngosuku lwe-8, kunye ne-40 mg rhoqo ngeveki
  • I-80 mg ngoSuku lwe-15, kunye NOKUBA ngama-40 mg veki nganye ukuqala ngoMhla wama-29; OKANYE 80 mg qho ngeveki ukuqala ngoMhla wama-29
Uveitis: abantwana abaneminyaka emi-2 nangaphezulu
  • Iilitha ezingama-22-33: 10 mg
  • Iilitha ezingama-33-66: 20mg
  • Iilitha ezingama-66 +: 40mg
  • 22 lbs ukuya ngaphantsi kwe-33 lbs: 10 mg qho ngeveki enye
  • I-33 lbs ukuya ngaphantsi kwe-66 lbs: 20mg rhoqo ngeveki
  • Iilbs ezingama-66 okanye ngaphezulu: 40mg qho ngeveki

Akukho meko ikhethekileyo xa kulawulwa uHumira. Akudingi kutofwa malunga nexesha elithile losuku okanye umsebenzi (njengokutya). Uninzi lwabantu lukhetha ukujova uHumira ngexesha elingaguquguqukiyo kubo kwaye lingena kwishedyuli yabo yemihla ngemihla, njengaphambi kokulala okanye emva kwesidlo sakusasa. Ukusetyenziswa kweekhalenda okanye usetyenziso lwefowuni inokuba luncedo ngokuseta izikhumbuzo zokuba kufuneka kwenziwe inaliti yolondolozo.

Ukuba uphosa idosi yeHumira, jofa idosi elandelayo ngokukhawuleza xa ukhumbula. Ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uthathe idosi yesondlo elandelayo ngokweshedyuli yedosi.

I-Humira ine-half-life (ixesha elithathayo ichiza lokulahla isiqingatha semisebenzi yayo yebhayoloji) yeentsuku ezili-10 ukuya kwezi-20. Uninzi lwamachiza lususwe ngokupheleleyo emzimbeni kubomi obunesiqingatha ukuya kwisihlanu, ke umkhondo kaHumira unokufunyanwa emzimbeni ukuya kuthi ga kwiiveki ezili-14 emva kokuyeka ukusetyenziswa.

Kunqabile kakhulu ukugqithisa kwiHumira. Nangona kunjalo, ukuba usebenzisa ngengozi iHumira, tsalela umnxeba iZiko loLawulo lweTyhefu kwangoko ngo-1-800-222-1222 okanye ufune iinkonzo zonyango ezingxamisekileyo.

Humira ukugcinwa

Humira uza kwifayile ye- isirinji egcwalisiweyo okanye a kukhethwe i-Humira Pen kwaye kufuneka igcinwe kwisikhenkcisi kwisitya sayo santlandlolo kwaye ikhuselwe ekukhanyeni kude kube kusetyenziswa. I-Humira akufuneki ibe ngumkhenkce, ishushu, okanye isetyenziswe emva komhla wokuphelelwa. Sukusebenzisa i-Humira ukuba ikhenkcisiwe kwaye yanyibilika okanye yatshiswa nangayiphi na indlela.

Ipeni yeHumira okanye isirinji ekhethiweyo inokukhutshwa ngaphandle kwefriji imizuzu eli-15 ukuya kwengama-30 ngaphambi kwenaliti ukuvumela ulwelo lufikelele kubushushu begumbi. Kanye kubushushu begumbi, uHumira kusafuneka akhuselwe ekukhanyeni kwaye asetyenziswe kwiintsuku ezili-14. Lahla kwaye ungasebenzisi uHumira ukuba ubushushu begumbi ixesha elide kuneentsuku ezili-14.

Akufanele uzame ukufudumeza uHumira nangayiphi na indlela (ungayigijimi phantsi kwamanzi ashushu okanye uyibeke kwi-microwave). I-Humira akufuneki isetyenziswe ukuba ulwelo lukhanye ngombala okanye kunamafu okanye kukho amasuntswana kulo. Isilumkiso kufuneka sithathwe xa uphatha ipeni yeHumira okanye isirinji ekhethiweyo. Akufanele zichithwe okanye ziwe.

Ulwazi lokhuseleko lwaseHumira

Izithintelo

  • I-Humira ikhuselekile kubantu abadala kunye nabantwana abadala kuneminyaka emi-2, kuxhomekeke kwimeko esetyenziselwa ukunyanga.
  • I-Humira ingasetyenziswa ngabafazi abakhulelweyo okanye abancancisayo emva kokuqwalaselwa komngcipheko kunye nezibonelelo ezinokubakho.
  • I-Humira akufuneki ithathwe nangubani na osulelayo, okanye nabani na ofumana usulelo oluninzi. Kuya kufuneka uvavanyelwe isifo sephepha ngaphambi kokuqala iHumira.
  • I-Humira akufuneki ithathwe nangubani na onengxaki yokungezwani komzimba nazo naziphi na izithako okanye izinto.
  • Abantu abathatha amanye amayeza acinezela amajoni omzimba (jonga ukuhlangana) kufuneka baxoxe ngomngcipheko kunye nezibonelelo kunye nomboneleli wabo wezempilo.
  • Ngaphambi kokuba uqale uHumira, umboneleli wakho wezempilo unokufuna ukuqhuba uvavanyo lwegazi ukujonga ukusebenza kwegazi kunye namanqanaba okuvutha.
  • Abantu abathatha uHumira akufuneki bafumane izitofu zokuphila. Amayeza okugonya aphilayo aquka iFlumist kunye neyeza lokuthintela irhashalala. Ukuba ufumene naluphi na ugonyo, qiniseka ukwazisa umboneleli wakho wezempilo ngaphambi kokuba uqale uHumira.

Izilumkiso

  • Emva kokuqala uHumira, umboneleli wakho wezempilo kufuneka aziswe kwangoko ukuba ufumana usulelo okanye naziphi na iimpawu zosulelo. Abantu abathatha i-Humira banomngcipheko owandayo kwiintlobo ezahlukeneyo zosulelo kubandakanya usulelo olunobuzaza okanye olubulalayo lokungunda.
  • Ukuba ubona naluphi na ukwanda kweempawu emva kokuqala uHumira, qiniseka ukuba wazise umboneleli wakho wezempilo.
  • Ezinye iingxelo Ndicebise ukuba ukusebenzisa i-Humira kunokunyusa imiba yenkqubo ye-nervous, kubandakanya ne-multiple sclerosis.
  • Kubantwana nakubantu abadala abathatha iHumira okanye ezinye iibhlokhi ze-TNF, amathuba okufumana umhlaza angonyuka. Kukho iimeko ezingaqhelekanga zomhlaza kubandakanya umhlaza wolusu kunye ne-lymphoma ebantwaneni, kulutsha, nakubantu abadala abancinci abathatha i-TNF-blockers.

Iziphumo eziqhelekileyo zeHumira zibandakanya:

  • Ukuphendula kwendawo yenaliti (iintlungu, ukuba bomvu, irhashalala, ukudumba, ukurhawuzelela, ukugruzuka)
  • Usulelo oluphezulu lokuphefumla, usulelo lwe-sinus, kunye nosulelo lomchamo
  • Intloko ebuhlungu
  • Rashes
  • Isicaphucaphu
  • Intlungu edibeneyo, isisu, okanye umqolo
  • Igazi elonyukayo
  • Igazi kumchamo
  • Ukuphakama kwe-enzyme yesibindi okanye yemisipha
  • Cholesterol ephezulu

I-Humira nayo inokubangela iziphumo ebezingalindelekanga ezibi, kubandakanya:

  • Usulelo olubi njengesepsis yebacteria
  • Usulelo lwe-Hepatitis B kubathwali bentsholongwane
  • Ukuvuselelwa kwesifo sephepha
  • Ukuphendula ngokuchaseneyo (i-anaphylaxis, ingxaki yokuphefumla, imihlathi, ukudumba ebusweni, imilebe, okanye umlomo)
  • Iingxaki zenkqubo yemithambo-luvo (imiqondiso ibandakanya ukurhawuzelela okanye ukuba ndindisholo, iingxaki ngombono, ubuthathaka kwiingalo okanye emilenzeni, kunye nesiyezi)
  • Iingxaki zegazi (ukunciphisa iiseli zegazi ezilwa nosulelo)
  • Ukungaphumeleli kwentliziyo (iimpawu zibandakanya ukuphefumla okufutshane, ukudumba emaqatheni nasezinyaweni, okanye ukuzuza ubunzima ngesiquphe)
  • Ukuphendula kwamajoni omzimba kubandakanya isifo esinjenge-lupus (iimpawu zibandakanya ukungonwabi esifubeni, ukuphefumla kancinci, iintlungu ezidibeneyo, okanye irhashalala kwiingalo nasezidleleni ezibi kakhulu elangeni)
  • Iingxaki zesibindi (iimpawu zibandakanya ukuziva udiniwe kakhulu, ulusu okanye amehlo ajongeka emthubi, ukunciphisa ukutya okanye ukugabha, okanye iintlungu kwicala lasekunene lesisu), ezinokukhokelela ekusileleni kwesibindi okanye ekufeni
  • I-Psoriasis (amabala abomvu anamaxolo okanye amaqhuma aphakanyisiweyo kulusu olunokuthi luzaliswe bubofu)
  • Iingxaki zemiphunga (isifo semiphunga esiphakathi okanye i-sarcoidosis)
  • Ukudumba kwenqanawa yegazi
  • Umhlaza (kubandakanya umhlaza wolusu, i-lymphoma, kunye neleukemia)
  • Izifo ezizimeleyo

Unxibelelwano

U-Humira unokuba nokusebenzisana okungalunganga kunye nezinye iziyobisi ezenza buthathaka amajoni omzimba. Abantu kwezinye i-TNF-blocker bathanda I-Remicade (infliximab) , IOrencia (abatacept), iKineret (anakinra), I-Enbrel (etanercept) , Cimzia (certolizumab pegol), okanye iSimponi (golimumab) kufuneka iphephe ukuthatha la machiza kunye neHumira ngaxeshanye. Yazisa umboneleli wakho wezempilo ukuba ukhe wathatha iRituxan (rituximab), Imuran (azathioprine), okanye iPurinethol (mercaptopurine, 6-MP) ngaphambi kokuqala uHumira.

I-Humira inokunciphisa uxinzelelo lwe-warfarin kunye nokusebenza kwe-BCG.

Akukho kunxibelelana noHumira kunye nokusetyenziswa kotywala.

Akukho kutya kufuneka kuthintelwe xa uthatha uHumira.

Ulondolozo lweHumira

Ngaba ucinga ukuba uHumira ulungele wena okanye usapho lwakho kodwa ukhathazekile ngendleko? I-Humira ibiza kakhulu ( ngaphezulu kwe- $ 7,000 yonikezelo lwenyanga ). Ngethamsanqa, i-SingleCare inamakhuphoni asimahla eHumira onokuwasebenzisa kuyo yonke into egcwaliswayo. Fumana amatikiti I-Humira ifake iisirinji apha okanye amatikiti eepeni zeHumira apha .