Ngaba i-metformin ibangela isifo sengqondo esixhalabisayo?

Ulwazi lweziyobisi

IMetformin liyeza elithandwayo elisetyenziselwa ukunyanga udidi lwesibini lweswekile. Iziphumo ze-metformin, ichiza le-biguanide, kukunciphisa inani leswekile egazini lomntu. Ukusukela oko i-metformin yangena kwimarike, kuye kwakho iinkolelo ezininzi malunga nokunxibelelana kwayo nesifo sengqondo esixhalabisayo, isifo esinxulunyaniswa nokudideka, ukulahleka kwememori kunye nokutshintsha kwemood. Kule nqaku, siza kujonga ngakumbi ikhonkco phakathi kwe-metformin kunye ne-dementia. Ngaba kukho unxibelelwano? Ukuba kunjalo, yintoni?

Yintoni isifo sengqondo esixhalabisayo?

Okokuqala, makhe siqwalasele ukuba yintoni isifo sengqondo esixhalabisayo. Isifo sengqondo esixhalabisayo ligama elisetyenziselwa ukuchaza izifo nezigulo ezikhokelela kwiingxaki ezinje ngokulahleka kwememori kunye nemiba yokuthetha nokucinga. Olunye uhlobo lwesifo sengqondo esixhalabisayo yi-Alzheimer's, echaphazela abantu abadala abadala. Isifo se-Alzheimer sisifo se-neurodegenerative esisesona sizathu siphambili sokudodobala kwengqondo, silandelwa kufutshane sisifo sengqondo esixhalabisayo. Isifo se-Alzheimer sisebenza ngokuwohloka kweeseli zemithambo-luvo kwingqondo. Njenge-Alzheimer's, isifo sika-Parkinson yenye imeko eyaziwayo enokubangela isifo sengqondo esixhalabisayo.

Ngaba ufuna elona xabiso libalaseleyo kwi-metformin?

Bhalisela izilumkiso zamaxabiso e-metformin kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Ngaba i-metformin inxulunyaniswa nesifo sengqondo esixhalabisayo?

Impendulo elula kukuba i-metformin ayibangeli isifo sengqondo esixhalabisayo kwaye inokunceda ukunciphisa umngcipheko wesifo sengqondo, utsho IVerna R. Porter, MD , ugqirha wemithambo-luvo kunye nomlawuli we-Dementia kunye neNkqubo yeZifo ze-Alzheimer kwiziko lezeMpilo e-Providence Saint John eSanta Monica, California. Ngapha koko, a Uphononongo lwamva nje I-17,000 yamagqala anesifo seswekile afumanisa ukuba ukuthatha i-metformin kunxulunyaniswa nomngcipheko ophantsi wesifo sengqondo esixhalabisayo kunezinye iziyobisi zeswekile ezaziwa ngokuba yi-sulfonylureas (njenge-glyburide kunye ne-glipizide), utshilo uGqirha Porter.

Olunye uphononongo ikwaqaqambise ukuba umsebenzi wokuqonda wamaqela athile obuhlanga unokuxhamla kwi-metformin. Kubonakalise ukuba ukusetyenziswa kwe-metformin kunxulunyaniswa namazinga ancitshisiweyo esifo sengqondo esixhalabisayo kunye nokusebenza okuphuculweyo kwengqondo phakathi kwezigulana zase-Afrika zaseMelika ezinesifo seswekile sesi-2 (umngcipheko wengozi [HR] = 0.73; 95% isithuba sokuzithemba [CI], 0.6-0.89) kodwa hayi abaguli abamhlophe ( I-HR = 0.96; 95% CI, 0.9-1.03).

Oko kwathiwa, enye izifundo bonisa ikhonkco elahlukileyo phakathi kwexesha elide lokusetyenziswa kwe-metformin yezigulana ezinesifo seswekile kunye nezinye izinto ezenza ukuba umzimba ube ne-insulin. Olunye iqela izifundo bonisa umngcipheko okhulayo wokuba nesifo sengqondo esixhalabisayo xa usebenzisa i-metformin.

Ngamanye amagama, uphando lwangoku kwikhonkco phakathi kokusetyenziswa kwe-metformin, ngakumbi njenge-monotherapy, kunye nokuxilongwa kwengqondo, kuxubekile kwaye akukacaci. Olunye uvavanyo lwezonyango kunye nezifundo zokujonga ziyafuneka.

Ezinxulumene: Amayeza eswekile kunye nonyango

Ngaba i-metformin inokubangela iingxaki kwimemori?

Uphando alucaci ngeli xesha ukuba i-metformin inokubangela iingxaki kwimemori, ke akukho mpendulo ichazayo. Nangona kunjalo, oogqirha abaninzi basacebisa i-metformin njengonyango lokuqala lodidi lweswekile II.

Yintoni enokubangela iingxaki zememori kwabo bathatha i-metformin ayililo iyeza uqobo, kodwa sisifo esisisiseko: isifo seswekile. Iziphumo zempilo yengqondo yesifo seswekile zinokuthamba ukusuka ekuthomalaliseni kwengqondo ukuya kubunzima. Ngapha koko, a Isifundo sezonyango sika-2011 ibonakalise umngcipheko phakathi kohlobo lwesibini lweswekile kunye nesifo sengqondo esixhalabisayo, esichaza olo hlobo lweswekile 2yonyusa umngcipheko wesifo sengqondo esixhalabisayo ngaphezulu kwesibini.

Enye ukufunda ukusuka kwi-2017 yenza unxibelelwano phakathi kokunganyangeki kwe-insulin-uphawu lwesifo seswekile- kunye nokwehla kwengqondo okude.

Eyona nto iphambili kukuba uphando oluninzi luyafuneka ukufumana iimpendulo eziqinisekileyo malunga nendlela i-metformin enegalelo ngayo kwiingxaki zememori, nangona kunjalo, imeko esisiseko ephatha i-metformin-uhlobo lweswekile-ngokuqinisekileyo inokukhokelela ekunciphiseni ukusebenza kwengqondo kunye nemiba yememori.

Zithini iziphumo zokusetyenziswa kwe-metformin yexesha elide?

Rhoqo xa abantu bemiselwe i-metformin kukhathalelo lwesifo seswekile, bahlala kuyo ixesha elide, ke kukho iziphumo ebezingalindelekanga zexesha elide ekufuneka ziqwalaselwe.

Ezi ziziphumo ebezingalindelekanga eziqhelekileyo kwimetformin:

• Irhasi
• Intlungu yesisu
• Isihlunu / ukugabha
• Urhudo
• Isitshisa
• Ukuhla ukusinda
• Intloko ebuhlungu
• Ukungathandeki kwesinyithi emlonyeni

Rhoqo ezi ziphumo ebezingalindelekanga eziqhelekileyo ziya kuthi emva kweentsuku okanye iiveki ezimbalwa, ngakumbi ukuba zithambile. Ngamanye amaxesha kukho umngcipheko omncinci wale miphumo mibi xa uthatha i-metformin ngesidlo. Nangona kunjalo, iziphumo ebezingalindelekanga ezimandundu zingadinga ingcebiso yezonyango kwangoko kumboneleli wezempilo. Baza kukucebisa ngeyona ndlela ingcono yokwenza kwaye ulandele ngokufanelekileyo.

Apha ngezantsi kukho uluhlu lweziphumo ebezingalindelekanga ezinobuzaza ze-metformin ezifuna unyango olukhawulezileyo.

Lactic acidosis

Le meko isongela ubomi yenzeka xa kukho ulwakhiwo oluyingozi lwe-lactic acid, kunye nokwehla kwe-pH kunye nokuphazamiseka kwe-electrolyte emzimbeni. Kuyenzeka ukuba izintso azisebenzi kakuhle, kwaye ngenxa yoko azikhuphi metformin ngokufanelekileyo. Isifo seswekile sexesha elide sinokukhokelela kwiingxaki zezintso, zikhokelela ekwakhiweni kwe-metformin emzimbeni, nto leyo edala i-lactic acidosis. Amathuba okuphucula i-lactic acidosis ayonyuka kwizigulana ezinesifo sentliziyo okanye ukusilela kwentliziyo.

Iimpawu ze-lactic acidosis ekufuneka uyijongile zibandakanya:

• Ukudinwa
• Ubuthathaka
• Intlungu engaqhelekanga
• Ingxaki yokuphefumla
• Ukulala ngokungaqhelekanga
• Iintlungu zesisu, isicaphucaphu, okanye ukugabha
• Utywala okanye intloko
• Ukubetha kwentliziyo kancinci okanye okungaqhelekanga

Hypoglycemia (iswekile esezantsi yegazi)

Ngokwayo, i-metformin ayizukubangela i-hypoglycemia. Nangona kunjalo, kwiimeko ezinqabileyo kakhulu iswekile esezantsi yegazi inokwenzeka ukuba idityaniswe nokutya okungalunganga, umthambo onzima, ukusela kakhulu utywala, okanye ezinye iziyobisi ezichasene nesifo seswekile. Ukushiya kunganyangwa, i-hypoglycemia inokubangela ukuba abanye abantu baphume, babambe, kwaye kwimeko ezimbi, zikhokelele ekonakaleni okungapheliyo kwengqondo.

Ezi zilandelayo zibonakalisa amanqanaba asezantsi eswekile yegazi:

• Ubuthathaka
• Ukudinwa
• Isicaphucaphu
• Ukuhlanza
• Intlungu yesisu
• Ukuba nesiyezi
• Ubumhlophe
• Ngokukhawuleza okungaqhelekanga okanye ukubetha kwentliziyo

Ukunqongophala kwegazi

I-anemia lixabiso eliphantsi leeseli ezibomvu zegazi, ezinokubangelwa ngamanqanaba asezantsi evithamini B12. Kuba i-metformin inokubangela ukusilela kwe-vitamin B12, kubalulekile ukuba abaguli bathathe isongezo se-vitamin B12 okanye baqinisekise ukuba batya ngokwaneleyo ngokutya kwabo.

Iimpawu ze-anemia zibandakanya:

• Ubumhlophe
• Ukuba nesiyezi
• Ukudinwa
• Ulusu oluthuthu
• Izandla kunye neenyawo ezibandayo
• Iinzipho Brittle

Ezinxulumene: Ukuhlolwa rhoqo kwezempilo kuya kufuneka ukuba ufike kwi-40s yakho

Ngaphambi kokuba uyeke ukuthatha i-metformin

Xa umntu eqala ukuthatha i-metformin, kubalulekile ukuba uqwalasele umngcipheko wokumisa amayeza ngequbuliso. Izigulana kufuneka zisoloko zithetha nogqirha wazo ngaphambi kokuyeka naliphi na iyeza njengoko kunokubakho iimpawu okanye imeko enokuba mandundu. Ugqirha uya kugqiba indlela ekhuselekileyo yokutshintshela kwelinye iyeza elichasene nesifo seswekile, njenge-sulfonylurea, okanye ukucebisa ngendlela yokwenza utshintsho olufunekayo kwindlela yokuphila.

Ezinxulumene: Isikhokelo sakho sokuguqula ii-prediabetes ngokutya kunye nonyango

Ukubona ukuba ungagcina malini kwimetformin yakho okanye kugqirha weGlucophage, jonga amaxabiso akhethekileyo eSingeCare Apha .