Iziphumo ebezingalindelekanga zeHumira kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

Iziphumo ebezingalindelekanga zeHumira | Zide kangakanani iziphumo ebezingalindelekanga? | Izilumkiso | Unxibelelwano | Ungaziphepha njani iziphumo ebezingalindelekanga

I-Humira (i-adalimumab) -i-inaliti yomntu eyenzeka ngokwendalo-inciphisa uxolelo kwaye ilawula iimpawu zezifo ezisebenza ngokuzimela. Umboneleli wezempilo unokumisela uHumira irheumatoid Arthritis , i-ankylosing spondylitis, ulutsha lwe-idiopathic arthritis , isifo samathambo, I-plaque psoriasis , Isifo sikaCrohn , ulcerative colitis, uveitis, kunye ne-hidradenitis suppurativa. Kuzo zonke ezi meko, i-flare-ups yenzeka xa amajoni omzimba ehlasela ngempazamo izicwili ezisempilweni.

I-Humira icinezela impendulo yomzimba yokuzikhusela ngokuthintela imichiza eveliswe ngumzimba-ithumba necrosis factor okanye i-TNF- ebangela ukudumba. Njengawo onke amayeza, isigqibo sokuthatha uHumira kufuneka silinganise izibonelelo kunye nemingcipheko yonyango, ke kubalulekile ukuba uxoxe nogqirha wakho ngemiphumo emibi, ukusebenzisana kweziyobisi, kunye nezilumkiso ezinxulumene nesiyobisi.

Ezinxulumene: Funda nzulu ngeHumira | Fumana izaphulelo zeHumira

Iziphumo eziqhelekileyo zeHumira

I-Humira icinezela amajoni omzimba, ngenxa yoko usulelo kunye nokungalunganga kuqhelekile kunye neziphumo ebezingalindelekanga ezinokubakho. Kwakhona, njengeinaliti yangaphantsi, uHumira uvelisa ukusabela kwendawo yenaliti malunga 1 kwabaguli aba-5 . Iziphumo eziqhelekileyo ezichaphazelekayo zeHumira zi:

• Ukuphendulwa kwendawo yenaliti (ububomvu, ukudumba, iintlungu, ukurhawuzelela, kunye nerhashalala)
• Usulelo oluphezulu lokuphefumla
• Ukuxinana kwesinus
• Intloko ebuhlungu
• Ukuphuhliswa kwamagciwane omzimba
• Irhashalala
• Isicaphucaphu
• Intlungu zesisu
• Umsebenzi wesibindi ongaqhelekanga
• Usulelo lwe-Urinary tract
• Umkhuhlane okanye iimpawu ezibandayo
• Umqolo obuhlungu
• Ukunyuka kwamanqanaba egazi egazini
• I-cholesterol ephezulu ye-serum
• Igazi elonyukayo

Ngaba iHumira ibangela ukulahleka kweenwele okanye ukuzuza ubunzima?

Kwiimeko ezinqabileyo kakhulu, uHumira unokubangela ukulahleka kweenwele.

Ukuphulukana nobunzima obungachazwanga okanye ukuzuza ubunzima, nangona kunjalo, akubangelwa ngqo nguHumira. Nangona kunjalo, isithako sayo esisebenzayo sonyusa umngcipheko we-lymphoma, i-leukemia, kunye neminye imihlaza, uninzi lwayo olubonakaliswa kukuphulukana nomdla wokutya kunye nokwehla kobunzima obungazibandakanyi. Thetha nogqirha ngokukhawuleza ukuba ubona ukulahleka kwesisindo, ukunciphisa ukutya, okanye ukugcwala kwinani elincinci lokutya ngelixa uthatha uHumira.

Iziphumo ezibi kakhulu zeHumira

Ngenxa yokuba uHumira ecinezela amajoni omzimba, izigulana zisengozini yokosulelwa zizifo ezinobuzaza kunye nokusongela ubomi kunye nomhlaza. Njengazo zonke iinaliti ze-antibody, iimpendulo ezichaseneyo nazo ziyingozi. Iziphumo ebezingalindelekanga ezibi kakhulu zikaHumira zezi

• Izifo ezinobungozi okanye ezisongela ubomi
• Umhlaza (lymphoma, leukemia, non-melanoma cancer cancer, and other malignancies)
• Ukugula kakhulu okanye okusongela ubomi
• Isifo sephepha okanye isifo se-hepatitis B sokuqalisa kwakhona
• Ukunyuka okanye ukuqala kweengxaki zenkqubo ye-nervous ezifana ne-multiple sclerosis okanye i-optic neuritis
• Iingxaki zentliziyo (i-fibrillation ye-atrial, i-tachycardia, i-arrhythmia yentliziyo, iintlungu zesifuba, isifo sentliziyo)
• Ukunyuka kokungaphumeleli kwentliziyo
• Isifo esifana nelupus
• Ukuthoba iiseli zegazi okanye i-anemia
• Ukonakala kwesibindi okanye ukusilela
• Amatye egall
• Iimpawu
• Isifo samathambo
• Ubuthathaka bemisipha
• Ukudideka

Kuya kufuneka uyeke ukuthatha u-Humira kwaye ufune unyango kwangoko ukuba ufumana naziphi na ezi zinto zilandelayo xa usenza u-Humira:

• Umkhuhlane, ukudinwa, ukungabinamdla wokutya, iintlungu esiswini, okanye ezinye imiqondiso yosulelo lwe-hepatitis B .
• Ukudumba kwamadlala, ukudinwa, umkhuhlane, ukugodola, ukubila ebusuku, ukuphelelwa ngumdla wokutya, ukwehla kobunzima obungafunekiyo, ukungqubeka kolusu okungachazwanga, ukugruzuka okanye ukopha, okanye ezinye iimpawu eziqhelekileyo zomhlaza .
• Imihlathi, ukudumba kobuso, ukudumba, isikhumba esimfusa, ukungaphefumli kakuhle, ukwehla koxinzelelo lwegazi, isiyezi, ukuphelelwa ngamandla, okanye enye into Iimpawu zokungabikho komzimba okanye i-anaphylaxis .
• Ukukhathala, umkhuhlane, iintlungu ezidibeneyo, ukuqubuka ebusweni, izilonda zolusu ezibangelwa lilanga, ukuphefumla kancinci kunye nokunye Iimpawu zesifo esifana nelupus .
• Umdyarho wokubetha kwentliziyo, ukubetha kwentliziyo, iintlungu zesifuba, okanye ezinye iimpawu zokungahambi kakuhle kwentliziyo .

Iinaliti ze-Humira zinokupheliswa ukuba kukho enye yezi meko ezinamava.

Kuya kufuneka uthethe kwangoko nogqirha wakho malunga nokuyeka uHumira ukuba unamava:

• Umkhuhlane, ukukhohlela, ukudumba, ukugodola, amadlala adumbileyo, ukuphelelwa ngumdla wokutya, iintlungu esiswini, okanye ezinye iimpawu zosulelo .
• Ubuthathaka, ukudinwa, ulusu olumhlophe, ukubetha kwentliziyo okukhawulezayo, ukutyumka ngokulula okanye ukopha, okanye enye into iimpawu zeengxaki zegazi .
• Isikhumba esimthubi, amehlo atyheli, kwicala lasekunene iintlungu esiswini, ukudumba kwesisu, ukudideka, kunye nokunye iimpawu zeengxaki zesibindi .
• Ubuthathaka bemisipha, utshintsho kumbono, ukuqina kwemisipha, ukuxhamla kwezihlunu, ukubetha, ukuba ndindisholo, okanye enye into imiqondiso ukuphazamiseka kwenkqubo yemithambo-luvo .

I-Humira ilawulwa kube kanye kuphela kwiiveki ezimbini, ke oogqirha kunye nezigulana banexesha lokuphinda baqwalasele uHumira xa ejongene neziphumo ezibi.

Zide kangakanani iziphumo ebezingalindelekanga zeHumira?

Iziphumo ebezingalindelekanga zeHumira ziya kwahluka ekuqaleni kunye nexesha. Indawo yenaliti okanye izinto ebezingalunganga zenzeka ngaphakathi kwemizuzu yenaliti kwaye zihlala imizuzu embalwa ukuya kwiintsuku ezimbalwa. Inaliti yokuqala iya kuhlala yenziwa yingcali yokhathalelo lwempilo kwimeko yeklinikhi yokujonga iimpendulo ezinokubakho. Ezinye iziphumo ebezingalindelekanga eziqhelekileyo njengentloko ebuhlungu, ukuxinana kwesono, isicaphucaphu, umkhuhlane okanye iimpawu ezibandayo zikwimfutshane kwaye zinokunyangwa ngamayeza eekhawuntareni kunye nokuphumla.

Nangona kunjalo, iziphumo ebezingalindelekanga ezimandundu, ezinje ngesibindi, usulelo, kunye neengxaki zegazi ziya kuthatha iiveki okanye iinyanga ukukhula kwaye zinokuqhubeka zisiba mbi logama kuthathwa uHumira. Usulelo olomeleleyo, umhlaza, ukusilela kwesibindi, iingxaki zentliziyo, kunye ne-auto-antibodies zinokuba neziphumo zexesha elide okanye zobomi nasemva kokuba uHumira eyekile. Ukutyelelwa rhoqo kweeofisi kunye neemvavanyo ziyimfuneko ukubeka esweni iziphumo zexesha elide zeHumira.

Humira Izimo kunye nezilumkiso

I-Humira ayisoloko iyeza elifanelekileyo kuwo wonke umntu. Abantu abanezifo ezosulelayo, usulelo olufihlakeleyo, ukubhencwa sisifo sephepha, imbali yomhlaza, ukungaphumeleli kwentliziyo, iingxaki zemithambo-luvo ezinje nge-multiple sclerosis, isifo sesibindi, okanye ii-aleji kwichiza okanye naziphi na izithako ezinokuthi zingabinabagqatswa abafanelekileyo bokuthatha uHumira.

Usulelo olubi

I-Humira iqulethe isilumkiso sebhokisi emnyama ngesifo esibi. I-Humira iya kupheliswa ukuba usulelo olunzulu, isifo se-sepsis, okanye usulelo lokungunda olonakalisayo luyenzeka ngelixa uthatha iyeza.

Izigulana ziya kufuna ukuvavanywa isifo sephepha ngaphambi nangexesha lonyango kunye noHumira. Nasiphi na isigulana esivavanya ukuba sinesifo sephepha esingekabikho siza kufuna unyango lwe-TB ngaphambi kokufumana iHumira. Iyeza liya kuyeka ukuba isigulana siveliswa yi-TB ngexesha lonyango.

Izigulana ezisengozini ye-hepatitis B okanye usulelo lwe-histoplasmosis ziya kuvavanywa ngaphambi kokufumana iHumira. Kwakhona, iyeza liza kuyekiswa ukuba inaliti ivuselele usulelo lwe-hepatitis B.

Iimpawu ezimbi

I-Humira kunye nezinye iibhlokhi ze-TNF zinesilumkiso sebhokisi emnyama yezilonda, ngakumbi i-lymphoma. Ezinye izigulana e-Humira nakwezinye i-TNF blockers ziye zaphuhlisa i-hepatosplenic T-cell lymphoma (HSTCL), uhlobo olunolunya, olunqabileyo, nolusoloko lubulalayo lwe-lymphoma. Izigulana eziye zanyangwa nawuphi na umhlaza ngaphandle komhlaza wolusu ongengowomhlaza wesifo se-melanoma zisenokungabi ngabagqatswa abafanelekileyo kunyango lwe-Humira okanye i-block block ye-TNF efanayo. Ukuba isifo sikhula ngexesha lonyango, uHumira unokuyekiswa.

Ukuphazamiseka kwenkqubo

Izigulana ezinengxaki yokudambisa isifo njenge-multiple sclerosis, isifo se-Guillain-Barre, isifo esiqhekeza isifo, okanye i-optic neuritis isenokungabi ngabagqatswa abafanelekileyo kunyango lukaHumira. Izifo ezikhuphayo kukuphazamiseka kwemithambo-luvo ethi ngokuthe ngcembe isuse isikhuseli esingqonge amasebe emithambo-luvo, ukunciphisa amandla abo okudlulisa imiqondiso ye-nerve. I-Humira inokubangela ukuphazamiseka kwayo nayiphi na kwezi ngxaki, ke unyango lweHumira luya kufuna ukubeka esweni rhoqo kwezi zigulana.

Ukusilela kwentliziyo

I-Humira inokudodobalisa ukungaphumeleli kwentliziyo, ngenxa yoko izigulana ezinesiphene sentliziyo ziya kufuna ukubekwa esweni ngokusondeleyo xa zithatha uHumira.

Umzimba

Izigulana ezinobungozi kumachiza, nasiphi na isithako sazo, okanye irabha kunye nelatex zisenokungabi ngabagqatswa abafanelekileyo baseHumira. Iyeza liya kuyeka nangaluphi na uphawu lwempendulo ebukhali.

Ukukhulelwa

Idatha yeklinikhi iphakamisa ukuba umngcipheko wokuhambelana neziphene zokuzalwa ezinkulu awukho ngaphezulu kwabasetyhini abaphathwa ngeHumira ngokuchasene nabo bengekho. Njengeprotheni, u-Humira udlula kwi-placenta ukuya kumntwana. Zimbalwa izilwa-buhlungu ezidlulela kwimveku engekazalwa ngexesha lekota yokuqala, kodwa ukudlula kwama-antibodies ngokuthe chu kuyonyusa kude kube kunyuka kwitrimester yesithathu. Abafazi abakhulelweyo banokufuna ukuxoxa noogqirha babo ngomngcipheko kunye nezibonelelo zokuthatha uHumira ngexesha lokukhulelwa kwabo.

Ukuncancisa

I-Humira ithathwa njengekhuselekile ukuthatha xa uncancisa iintsana. I-Humira ayibonakali ichaphazela imveliso yobisi okanye yenzakalise iintsana zokuncancisa. I-Humira ikhona kubisi lwebele kodwa kwipesenti enye okanye ngaphantsi koxinzelelo lwayo kwigazi. Ikwayiprotheni, ke iya kwaphulwa kwinkqubo yokwetyisa yosana.

Ukuphathwa gadalala kunye nokuxhomekeka

I-Humira ayivelisi ukuxhomekeka emzimbeni okanye iimpawu zokurhoxa. Akukho matyala aziwayo eHumira okanye olunye uxhatshazo lwe-TNF blocker.

Ukudibana kukaHumira

Amanye amayeza e-immune-suppressing drug akufuneki asetyenziswe kunye noHumira kuba, ngokudibeneyo noHumira, la machiza ayingozi ekucinezeleni amajoni omzimba. I-Humira ayizukumiselwa ngokudibeneyo nala ma-immunosuppressants alandelayo:

• IOrencia (isacacept)
• Kineret (anakinra)
• I-Remicade (infliximab)
• I-Enbrel (etanercept)
• ICimzia (i-certolizumab pegol)
• ISimponi (golimumab)

U-Humira unokunyusa imiphumo yezinye iziyobisi ezichaphazela amajoni omzimba okanye ukonyusa amajoni omzimba, ukwandisa umngcipheko wosulelo kunye nomhlaza. Ugqirha uya kulumka xa emisela uHumira nge:

• Imuran (azathioprine)
• IPurinethol (6-mercaptopurine)
• Cladribine
• Rituxan (rituximab)
• Xgeva (idenosumab)
• I-Ocrevus (ocrelizumab)
• I-Actemra (tocilizumab)
• IGilenya (fingolimod)
• Mayzent (siponimod)
• I-Daliresp (roflumilast)

I-Humira yonyusa ityhefu kwaye yandisa iziphumo ebezingalindelekanga zamayeza athile, kubandakanya oku kulandelayo:

• I-Arava (leflunomide)
• Ilaris (ikhonkco)
• ITysabri (natalizumab)
• Entyvio (vedolizumab)
• IPrograf (itacrolimus)
• Elidel (ipimecrolimus)
• IArcalyst (rilonacept)

I-Humira inciphisa unyango lwezinye iziyobisi ezifana ne-warfarin, izitofu kunye ne-echinacea. Nangona kungekho bungozi, iqela lokhathalelo lwempilo lisenokufuna ukutshintsha le migqaliselo okanye idosi yabo.

Umenzi weHumira akabonisi ukuba utywala mabuthintelwe. Kuyenzeka ke ukuba ukusela utywala ngokumodareyitha ngelixa uthatha uHumira kukhuselekile. Oku akunakuba yinyani, nangona kunjalo, kwizigulana ezinengxaki yesibindi. I-Humira inokubangela iingxaki zesibindi kwaye-kwiimeko ezinqabileyo kakhulu-ukusilela kwesibindi, ke nxibelelana nogqirha malunga nokusela utywala ngelixa uthatha uHumira.

Ungaziphepha njani iziphumo ebezingalindelekanga zeHumira

Uninzi lwamachiza lubangela iziphumo ebezingalindelekanga, ngenxa yoko akukho ndlela iqinisekileyo yokuthintela iziphumo ebezingalindelekanga xa usela amayeza. Nangona kunjalo, unokunciphisa umngcipheko kunye nobukhali beziphumo ebezingalindelekanga ngeengcebiso ezimbalwa.

1. Tshela ugqirha wakho ngazo zonke iimeko zonyango kunye namayeza akho

Ngenxa yomngcipheko weziphumo ebezingalindelekanga ezimandundu, kuya kufuneka uxelele ugqirha wakho malunga:

• Usulelo olusebenzayo okanye lwangaphambili (ngakumbi i-hepatitis B okanye isifo sephepha)
• Imbali yomhlaza, ukuphazamiseka kwenkqubo ye-nervous (njenge-multiple sclerosis okanye i-Guillain-Barre syndrome), okanye ukusilela kwentliziyo
• Ukuba ukhulelwe okanye uncelisa
• Nawaphi na amayeza okanye izongezo zokutya onokuthi uzithathe, kubandakanya amayeza e-counter
• Ugonyo lwamva nje okanye oluzayo
• Ubudenge, ukubetha, iingxaki zombono, okanye ubuthathaka bemisipha
• Irabha okanye i-latex allergies

Xa uthatha uHumira, yazisa ugqirha wakho ngokukhawuleza ukuba uyagula okanye ukhulelwe. Ungaqali ukuthatha nasiphi na isiyobisi okanye isongezelelo sokutya de ube uthethe nogqirha wakho kuqala.

2. Gcina konke ukuqeshwa kwezonyango okulandelayo

Izigulana e-Humira ziya kujongwa ukuze kuthintelwe iziphumo ebezingalindelekanga ezibi. Oku kuyakufuna uvavanyo lwegazi rhoqo kunye nokutyelelwa ziofisi ukufumana iingxaki ngaphambi kokuba zibe yingxaki enkulu yezonyango.

3. Ziphephe izifo

I-Humira yenza ukuba izigulana zisengozini yosulelo. Ukuzigcina ukhuselekile, ziqhelanise nomgama ekuhlaleni, nxiba imaski esidlangalaleni, gwema abantu abosulelekileyo, hlamba izandla rhoqo, uhlambe rhoqo, uphathe kwaye usebenzise isicoci sezandla rhoqo.

4. Ziphephe izitofu zokugonya

Unokufumana ugonyo ngelixa uthatha uHumira ukuba nje ayizizo izitofu zokuphila. Xa kunikezelwa kwizigulana ezonakaliswe ngamajoni omzimba, izitofu eziphilayo azigcini nje ngokuba semngciphekweni wokubangela usulelo, usulelo lunokusasazeka kuwo wonke umzimba. Thetha nomboneleli wezempilo ngaphambi kokuba uthathe isitofu ngelixa uthatha uHumira. Olona hlobo lusebenzayo kukufumana ulwazi olupheleleyo malunga nokugonya ngaphambi kokuba uqale uHumira okanye naliphi na iyeza elinciphisa ukhuseleko. Xa uHumira enqunyanyisiwe, linda ubuncinci iinyanga ezimbini ngaphambi kokuba ufumane iyeza lokuphila.

5. Gcina uluhlu lwawo onke amayeza akho

Ukunciphisa umngcipheko weziphumo ebezingalindelekanga kunye nokunxibelelana kweziyobisi neziyobisi okunokuba yingozi, kuhlala kungumbono olungileyo ukugcina uluhlu lwawo onke amayeza akho ehlaziywa ngalo lonke ixesha. Bandakanya nawaphi na amayeza athengiswayo, iivithamini, kunye namayeza ezinto ozithatha rhoqo. Njalo bonisa olo luhlu xa ubona ugqirha okanye xa ugcwalisa amayeza.

6. Rhoqo tshintsha indawo yenaliti

Iziphumo ebezingalindelekanga eziqhelekileyo zikaHumira kukusabela kwendawo yenaliti. Eyona ndlela ilula yokulawula ukusabela kwenaliti kukutshintsha indawo yenaliti ngenaliti nganye. I-Humira ijojowe ngokungxama emva kweeveki ezimbini esiswini okanye ethangeni, ke jonga ukujikeleza inaliti phakathi kwethanga ngalinye kunye nesisu. Kulumkele ukufaka inaliti kulusu oluthambileyo, olucaphukisayo, olubomvu, oludumbileyo, olonzakeleyo okanye olurhawuzayo.

Unokunciphisa ukusabela kwendawo yenaliti ngokususa isirinji okanye ipenal injector kwifriji ngaphambi kwenaliti. I-Humira inokuba kwindawo yeqondo lobushushu kwigumbi ukuya kuthi ga kwimizuzu engama-30 ngaphambi kwenaliti. Qiniseka, nangona kunjalo, ayivelwanga kukukhanya kwelanga. Ungazami ukufudumeza amayeza nangayiphi na indlela.

7. Buza ugqirha wakho ngeHumira engenazitrate

I-acid ye-citric yindawo yokugcina izilwanyana ezisebenzisa inaliti-ngakumbi iiprotein ezinje ngeHumira- ezinzileyo kwiinyanga ezininzi zokugcina. Iitrate zesitrate, nangona kunjalo, zihlala zibangela iintlungu ezibonakalayo kwimizuzu embalwa emva kwenaliti. Ukuba iintlungu zenaliti yeHumira zininzi kakhulu ukuba ungazithwala, buza ugqirha wakho malunga neHitrate-free Humira njengenye indlela.

Izixhobo ezinxulumene neziphumo ebezingalindelekanga zeHumira:

• UAdalimumab , StatPearls
• Izinto eziguqula iimpendulo zebhayoloji , StatPearls
• Ukophula imikhwa yakudala: Ukufuduka ushiye izixhobo ezisetyenziswa rhoqo kumayeza amayeza , Uphengululo lwaMayeza lwaseYurophu
• Humira , Abaxhasi
• Humira kubaqeqeshi bezempilo , AbbVie
• Isikhokelo samayeza kaHumira , AbbVie
• Humira ukumisela ulwazi , AbbVie
• Ithumba necrosis factor inhibitors , StatPearls
• I-tumor necrosis factor inhibitors: i-primer yeklinikhi , Ulawulo lweeNtlungu eziSebenzayo