Iziphumo ebezingalindelekanga zeRisperdal kunye nendlela yokuzikhusela

Ulwazi lweziyobisi Ukuxhalaba, ukuba nesiyezi, kunye nentloko ziziphumo ebezingalindelekanga eziqhelekileyo zeRisperdal, ezidla ngokuba zezokwexeshana. Nangona kunjalo, ezinye iziphumo ebezingalindelekanga ezinje ngemicimbi enxulumene nesihlunu zihlala zisisigxina.

Iziphumo ebezingalindelekanga zeRisperdal | Ukutyeba kwakho | Uxinzelelo | Gynecomastia | Ukurhoxa | Kude kube niniimiphumelaokokugqibela? | Unxibelelwano | Ungakuphepha njaniimiphumela

Umngciphekoyiigama lebrandamayeza amiselweyo aveliswa nguJanssen Pharmaceuticals. Ingasetyenziselwa ukunyanga ukuphazamiseka kwemood njengeschizophrenia,ukuxhuzula, okanye ukucaphuka okunxulumene neukuphazamiseka kwengqondo.Umngciphekoikwafumaneka njengohlobo oluqhelekileyo, olubizwaRisperidone. Eli nqaku ligubungelaIziphumo ebezingalindelekanga zeRisperdal, izilumkiso, kunye nonxibelelwano.

Ezinxulumene: Funda nzulu malunga Umngcipheko

Iziphumo eziqhelekileyoyeUmngcipheko

Iziphumo eziqhelekileyoyeUmngciphekozibandakanya Ukulandelaiziphumo ezibi :

• Ukozela
• Ixhala
• Ukuba nesiyezi
• Intloko ebuhlungu
• Ukwanda kwesidlo
• Ukozela
• Ukudinwa
• Ukuphuthelwa
• Ukuthimliswa
• Usulelo oluphezulu lokuphefumula
• Khohlela
• Ukungahambi kakuhle komchamo
• Ukugcwala okugqithisileyo
• Ukuqunjelwa
• Ifiva
• IDystonia
• Intlungu zesisu
• Isicaphucaphu
• Ummiselo wobushushu bomzimba ongalunganga
• Ukuhlanza
• Irhashalala
• Akathisia
• Dyspepsia
• Tachycardia
• Xerostomia
• Ukungcangcazela
• Ukutyeba kwakho
• Hyperprolactinemia
• Ukudideka
• Gynecomastia
• Ubume befoto
• Epistaxis
• Ukuphazamiseka okubonakalayo
• Idyslipidemia
• Iintlungu zesifuba

Iziphumo ebezingalindelekanga ezimandunduyeUmngcipheko

Iziphumo ebezingalindelekanga ezimandunduyeUmngciphekozibandakanya oku kulandelayo:

• Isifo seStevens-Johnson
• Hypothermia
• IHyperthermia
• Uxinzelelo lwegazi, eqatha
• Syncope
• Isifo esibuhlungu se-Neuroleptic
• Hyperglycemia
• Isifo seswekile
• Ukuxhuzula
• Uhlaselo lweIschemic lwethutyana (TIA)
• IDysphagia, eqatha
• Impendulo ye-Hypersensitivity
• I-Angioedema
• I-Anaphylaxis
• Iimpawu ze-extrapyramidal, eqatha
• Ukufika kade kwedyskinesia
• Erythema ezininzi
• I-necrolysis enetyhefu
• Leukopenia
• Neutropenia
• Ukubaluleka
• Ukubetha
• Igranulocytosis

Ukutyeba kwakho

Uphando lubonisa ukubaUmngciphekoinxulunyaniswaukutyeba kwakho. Isifundo esinye epapashwe ngumenzi xa kuthelekiswaukutyeba kwakhokwiqela lokuvavanya abadala be-schizophrenic bathathaUmngciphekoNgokuchasene neqela le-placebo labantu abadala be-schizophrenic abangathathiyoUmngcipheko.

Iziphumo zibonise ukwanda ngokwamanani kwiziganeko zeukutyeba kwakhokwiqela labantu abadala abathathaUmngcipheko, nge-18% yezigulana ezifumana ubunzima obukhulu. Xa kuthelekiswa, yi-9% kuphela yabantu abadala kwiqela le-placebo abafumene ubunzima. Kolu phando, kubalulekileukutyeba kwakhoyachazwa njengengeniso engaphezulu kwe-7% yobunzima bomzimba womntu kwisithuba seeveki ezintandathu ukuya kwezisibhozo.

Ngelixaukutyeba kwakhokukodwa akunako ukugunyazisa unyango kwangoko, ukutyeba ngokubanzi kwandisa umngcipheko wezifo ezahlukeneyo , kubandakanya isifo sentliziyo, isifo seswekile, i-apnea yokulala, i-osteoarthritis kunye nomhlaza. Abantu abachaphazelekayo kufuneka babonisane nokwezonyangongokubhekisele kukhetho lokulawulwa kobunzima obunempilo.

Uxinzelelo

Ngokwe- Umanyano lweLizwe kwiIsigulo sengqondo ,Risperidonengamanye amaxesha unokumiselwa ngaphandle kwelebheli njengonyango olongezelelekileyo lokuphazamiseka koxinzelelo (umzekelo, kumiselwe ukongeza kwiUxinzelelo). Ngaphandle kwelebheli kuthetha ukuba uLawulo lokutya kunye neziyobisi (I-FDA)akawamkelanga amayeza onyango lwale meko.

Uphononongo olupapashwe kwi Ijenali yoNyango lwezeMpilo ihlolweRisperidonekunye nokuzibulala kwabantu abanengxaki yokudakumba, MDD. Isifundo sijonge ukusebenza kweRisperidonenjengesihlomeloUxinzeleloUnyango kubantu abane-MDD ngeengcinga zokuzibulala. Iziphumo zibonisa ukubaRisperidonekunokuba luncedo ekunyuseni unyango kwizigulana ze-MDD ezinomngcipheko wokuzibulala kwaye kunokuba luncedo ngakumbi ekulawuleni iimpawu zoxinzelelo.

Uphononongo olupapashwe kwi-PLOS ONE iphande konke ukubangela umngcipheko wokufa kwe-antipsychotic augmentation yoxinzelelo kubantu abadala. Kugqitywe kwelokuba ukongezwa kwe-antipsychotic entsha kunxulunyaniswa nomngcipheko omkhulu wokufa xa kuthelekiswa nenye indlela yokongeza isibiniUxinzelelo.

Nangona isifundo sisodwa singenakho ukungqina ubunyani, izigqibo zophando zicebisa ababoneleli ngononophelo lwempilo ukuba babenokwazi oku kusenokwenzeka ngokubhubha okubalulekileyo okunxulunyaniswa nokwandiswa kwengqondo okutsha.

Iimpawu zoxinzelelo, ngakumbi umbono wokuzibulala, ngumba osemngciphekweni omkhulu wezempilo. Abantu abachaphazelekayo kufuneka banike ingxelo kwikwezonyangongokukhawuleza okukhulu.

Gynecomastia

Uphando lubonisa ukubaUmngciphekoinxulunyaniswagynecomastia, Ixesha lobugcisa lokwandisa amabele angamadoda.

Isifundo esinye epapashwe yiUkutya kunye noLawulo lweziyobisiicebisa ukubaUmngciphekoUkutya kungadityaniswa nomngcipheko ophakame kancincigynecomastia. Ulingo lweklinikhi lufunde i-1885 yolutsha kunye nabantwana.Gynecomastiakwaxelwa kwi-2.3% yezigulana ezanyangwaUmngcipheko.

Gynecomastiainokunyusa kancinci umngcipheko womntu ukukhula kwamadodaumhlaza webele (tshintsha izixhobo?). Nangona umngcipheko ophakanyisiweyo umncinci, kuyacetyiswa ukuba udibane ne-kwezonyangokwimeko yeengxaki.

Ukurhoxa

Uphando lubonisa ukubaUmngciphekokunokuba ngumkhwa wokwenza. Iimpawu ezinokubakho zokurhoxa zibandakanya ukuba nesiyezi, ukulala, isicaphucaphu, kunye nokubuyisa iimpawu zeschizophrenic.

UKUYA ukurhoxisa isifundo epapashwe yiumenzikuvavanywe izigulana ezibonakalise impendulo ethembekileyoUmngcipheko(ichazwe njengokuphuculwa okungama-25% ngokwesikali esichaziweyo) ngaphezulu kweenyanga ezine ukuya kwezintandathu. Izigulana zabelwa ngokungakhethiyo kwi-placebo kunye neqela lokuvavanya ukuvavanya ukurhoxa. Uhlalutyo lwezigulana ezigqibe isifundo sokurhoxa lubonise inqanaba eliphantsi kakhulu lokubuyela umva kwiUmngciphekoabaguli ngokuchasene neqela le-placebo.

Uphononongo olwenziweyo olupapashwe kwi- Ingqondo yePsychopharmacology kuvavanywe imeko ye-akathisia ebangelwe ngesiqupheRisperidoneukurhoxa. Akathisia yiingxaki yokuhambaesele inxulunyaniswa nokurhoxa kunyango lwe-antipsychotic.

Kwimeko yeempawu zokurhoxa, abantu kufuneka babonisanekwezonyango. Izigulana zivuliweUmngciphekokufuneka adibane nogqirha wabo malunga nokwenza naluphi na utshintsho kumthamo okanye ekutyeni.

Kude kube niniIziphumo ebezingalindelekanga zeRisperdalokokugqibela?

NgokukaMbutho weSizwe kwiImpilo Yengqondo(njengoko kuchaziwe apha ngasentla), someIziphumo ebezingalindelekanga zeRisperdalinokuba yeyethutyana, ngelixa ezinye zisisigxina.

Iziphumo eziqhelekileyozihlala zethutyana. Okunye okunzima ngakumbiimiphumelainokuhlala ixesha elide. Oku kubandakanyaiimpawu ze-extrapyramidal,I-EPS, okanyetardive idiskkinesiaTD. Le micimbi enxulumene nemisipha enokubangela ukungcangcazela, ukuqina, kunye nokuphumla. UJanssen Pharmaceuticals, umenzi weUmngcipheko, ityhila ukuba kwezinye iimeko, eziimiphumelainokuhlala ngokusisigxina, ngakumbi kunye nokusetyenziswa kwesitofu UmngciphekoIbandakanya .

UmngciphekoIzimo kunye nezilumkiso

Umngciphekoayilungelanga wonke umntu. Iyeza liyaphikiswa kwizigulana ezine-hypersensitivity kwichiza / kwiklasi / kwicandelo kunye / okanye kwi-palersidone.

Ukongeza, Isilumkiso siyabongozwa kwizigulana ezihlangabezana nezi nqobo zilandelayo:

• Ukukhulelwa kwekota yesithathu
• I-PKU (iifom ye-phenylalanine)
• Izigulana ezalupheleyo
• Isifo sengqondo esinxulumene nesifo sengqondo esixhalabisayo
• Isifo sengqondo esiyingozi w / imizimba Lewy
• Isifo seParkinson
• Isifo esibuhlungu se-Neurolepticimbali
• Isifo seswekile
• Isifo seswekile
• Isifo seCerebrovascular
• Uxinzelelo lwegazi
• Hypovolemia
• Ubushushu obuphezulu bokusingqongileyo
• Ukuphefumla umngcipheko wenyumoniya
• Ileukopenia ebangelwa ziziyobisi okanye imbali ye-neutropenia
• Leukopenia okanye neutropenia
• Ukuphazamiseka kwezintso
• Ukukhubazeka kwe-Hepatic
• Imbali yokuhlutha
• Umngcipheko wokubanjwa
• Isifo sentliziyo

Izigulana ezigugileyo ezinesifo sengqondo esihambelana nesifo sengqondo esixhalabisayo esinyangwa nge-antipsychotic, kubandakanya iRisperdal, basemngciphekweni wokufa. Eli chiza, nangayiphi na indlela, alivunyelwanga ukuba lisetyenziswe kwizigulana ezinengqondo enxulumene nesifo sengqondo esixhalabisayo.

Ukugqithisa kweUmngciphekoinokubulala. Ityala elinye Ukugqithisa kwe-36 mg ethathwe ngomlomo kunxulunyaniswa nokubanjwa, isehlo esinokubulala impilo.

Umngciphekoiyafumaneka kwiifom ezahlukeneyo zedosi kunye namandla. Iitafile ziyafumaneka kwi-0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, kunye ne-4 mg doses. Izisombululo zomlomo ziyafumaneka kwi-1 mg / mL yedosi. Okokugqibela, ngomlomoukudilikaAmacwecwe ayafumaneka kwi-0.5 mg, 1 mg, 2 mg, 3 mg, kunye ne-4 mg doses.

Kukwakho nezinye iindlela zokutofaUmngcipheko.UmngciphekoUConsta kunye noPerseris. Le inaliti esebenza ixesha elide inefayile ye- iyeza elifanayo njengefomathi yethebhulethi, kodwa ineendlela ezahlukileyo ezamkelweyo ze-FDA kuneefomula zomlomo.

Iingcebiso zedosi Kwi-Risperidone yomlomo zezi zilandelayo:

Imeko	Umthamo wokuqala	Umxholo	Umthamo ekujoliswe kuwo	Uluhlu lweeDosi olusebenzayo
Ischizophreniakubantu abadala	2 mg / ngosuku	1-2 mg yonke imihla	4-8 mg yonke imihla	4-16 mg / ngosuku
Ischizophreniakulutsha	0.5 mg / ngosuku	0.5- 1 mg yonke imihla	3 mg yonke imihla	1-6 mg / ngosuku
I-bipolar mania kubantu abadala	2-3 mg / ngosuku	1mg yonke imihla	1-6 mg yonke imihla	1-6 mg / ngosuku
I-bipolar mania ebantwaneni / kulutsha	0.5 mg / ngosuku	0.5-1 mg yonke imihla	2.5 mg yonke imihla	0.5-6 mg / ngosuku
Ukucaphuka okunxulunyaniswa neukuphazamiseka kwengqondo	0.25 mg / ngosuku (<20 kg) 0.5 mg /day (≥20 kg)	0.25-0.5 mg kwi ≥ 2 iiveki	I-0.5 mg yonke imihla (ukuba<20 kg) or 1 mg /day (≥20 kg)	0.5-3 mg / ngosuku

Umngciphekounxibelelwano

Inkqubo ye- Ilebheli evunyiweyo ye-FDA yeRisperdalQaphela oku kulandelayoUnxibelelwano lweziyobisi:

• Kucetyiswa ukuba usebenzise isilumkiso xa ulawulaUmngciphekonamanye amachiza asebenza kwinkqubo ye-nervous system (CNS) ngenxa yokunyuka kweziphumo ze-CNS.
• Ukusetyenziswa kotywala kufuneka kuthintelwe njengoko kukonyusa iziphumo ze-CNS ze-risperidone.
• Iziphumo ezixhomis 'amehlo zezinye iziyobisi okanye iziyobisi ezinokubakho kwi-hypotensive zinokuphuculwa ngenxaUmngcipheko'S iziphumo zexabiso.
• ILevodopa kunyedopamineIziphumo ze-agonists zinokuchasana.
• Ukufumaneka kweRisperidoneyandiswa ngeCimetidine kunye neRanitidine.
• Ukucinywa kweRisperidoneinokuhla ngeIClozapine.
• Ukujongwa kweplasmaiqeqeshweukwanda ngeFluoxetine kunyeParoxetine.
• Ukujongwa kweplasmaiqeqeshwencipha ngeICarbamazepinekunye nezinye i-enzyme inducers.

Risperidoneinokusebenzisana neziyobisi ezithile, kunye iimpawu zonxibelelwano kubandakanya :

• Ukucutha iziphumo zembali ye-histamine
• Iziphumo zehyperglycemic
• Uxinzelelo lwe-CNS
• Umgaqo weCYP2D6
• Iziphumo ze-Extrapyramidal
• Umgaqo weCYP3A4
• Iziphumo ezixhasayo
• Iziphumo zehyperprolactinemic, zomelele
• Umqobo wokubamba uthothisa

Njalo qhagamshelana nodokotelaUlwazi lweziyobisikunye nokuchasana ngaphambi kokuba uthathe naliphi na iyeza elitsha okanye uxube nawaphi na amayeza, kubandakanyangaphaya kwekhawuntaiziyobisi, izongezo, kunye namalungiselelo e-herbal.

Ungakuphepha njaniIziphumo ebezingalindelekanga zeRisperdal

Abantu kufuneka bathathe kuphelaUmngciphekongokhokelo, nangommiselo kagqirha. Amanyathelo athile anokunceda ukunciphisa ukubakho okanye ubukhali beimiphumelakubandakanya:

1. Ukuthatha idosi efanelekileyo: Umngciphekokufuneka kuthathwe njengoko kuvunyelwene ngugqirha wesigulana. Ngokubanzi, iipilisi ezigutyungelweyo kufuneka ziginywe ziphelele ngamanzi. Iipilisi ze-Orodispersible kufuneka zivunyelwe zinyibilike kulwimi kwaye emva koko zihlanjwe ngamanzi xa kufuneka njalo. Isisombululo somlomo sinokuhlanjululwa kwisiselo esingesiso esinxilisayo okanye siginywe njengoko kunjalo. Nangona kunjalo, isisombululo somlomo akufuneki sixutywe neziselo eziqukethe iitannins, kubandakanya iti okanye ikola.
2. Ukubonelela ngugqirha onika ingxelo ngembali yonyango eneenkcukacha: Izigulana kufuneka zinike zonke iinkcukacha zembali yazo yezempilo kugqirha wazo ngaphambi kokuba zithatheUmngcipheko.Umngciphekokuyaphikiswa kuso nasiphi na isigulana esaziwayo kwi-hypersensitivity toRisperidone.
3. Ukuphonononga lonke unxibelelwano olunokubakho nogqirha: Izigulana kufuneka ziqhubeke nokubonisana noogqirha babo ukuba zeziphi iziyobisi okanye ukutya okunokubachaphazela kakubi ngelixa bethathaUmngcipheko. Umzekelo,Umngciphekoakufuneki uthathwe notywala.

Ngokukodwa, isilumkiso kufuneka sithathwe xa kwenzeka ukungqinelana kunye / okanye izilumkiso.

Ii-FAQ

NgabaUmngciphekoNgaba kufuneka ithathwe yonke imihla?

Ukuze iRisperdone isebenze ngokufanelekileyo, kufuneka ithathwe njengoko iyalelwe ngumboneleli wezempilo. Kubantu abathatha ithebhulethi, oku kunokuthetha ukuthathaUmngciphekokube kanye ukuya kabini ngemini.

Zeziphi ezinye iindlelaUmngcipheko?

Ifom enesitofu yeUmngcipheko, yaziwa njengeUmngciphekoUConsta, uyafumaneka. Oku kuthetha ukuba kufuneka kulawulwe ngumboneleli wezempilo qho kwiiveki ezimbini. IPerseris lolunye uhlobo lwefom esebenza ixesha elide enokutofa kwaye kufuneka ikhutshwe rhoqo ngenyanga.

Kukhuseleke kangakanani ukuthathaUmngcipheko?

Ngokwe-Ukutya kunye noLawulo lweziyobisi , akwaziwa ukuba isigulana sinexesha elingakananischizophreniakufuneka iqhubeke nokuthathaUmngcipheko. I-Risperdal ivunyelwe ukusetyenziswa kwexesha elide xa kunyangwa i-schizophrenia okanye ukucaphuka okunxulunyaniswa nengxaki ye-autistic. Ukuvavanywa kwakhona kwexeshana kuyacetyiswa ukumisela isidingo sonyango lokugcina kunye nokulungisa idosi njengoko kufuneka.

Xa isetyenziswa kubantwana abangabantwana, iRispderal iyavunywa ukuba isetyenziswe ixesha elide xa kunyangwa i-schizophrenia kubantwana abaneminyaka eli-13 ukuya kweli-17 ubudala, okanye ukucaphuka okunxulunyaniswa nengxaki ye-autistic kubantwana abaneminyaka emi-5-16 ubudala. Ivunyiwe ukuba isetyenziswe ixesha elifutshane xa kunyangwa iziqendu zeBipolar I Disorder kubantwana abaneminyaka eli-10 ukuya kweli-17 ubudala.