Ukuthatha iTrintellix yoxinzelelo? Nantsi into ekufuneka uyazi
Ulwazi lweziyobisiI-Trintellix ngumyalelo wokudambisa uxinzelelo yi-FDA evunyiweyo ukunyanga isifo esikhulu soxinzelelo (MDD). Isebenza ngokulinganisa amanqanaba e-neurotransmitter serotonin, edlala indima ebalulekileyo kwiimvakalelo, kwiimvakalelo nakumdla wokutya. Ngenxa yokuba i-serotonin ikholelwa ukuba iyanceda ukulawula uxinzelelo, iTrintellix ngamanye amaxesha isetyenziselwa ngaphandle kwelebheli ukunyanga uxinzelelo. Makhe sijonge ngakumbi ekujongeni iTrintellix yoxinzelelo.
Ngaba iTrintellix isebenza ngoxinzelelo?
I-Trintellix lelinye lamagama e-brand generic ye-vortioxetine, ekwiqela lamayeza abizwa ngokuba yi-serotonin reuptake inhibitors ekhethiweyo (SSRIs). I-Trintellix yayiqhele ukubizwa ngokuba yiBrintellix, kodwa yaphinde yathiywa igama ngo-2016 kuba yayihlala idideka ngamayeza e-antiplatelet abizwa ngokuba ngu-Brilinta. Ukuthiya kwakhona amayeza kwiTrintellix kuye kwanceda ukunciphisa ukudideka koogqirha nakwizigulana.
I-Trintellix yi-SSRI enokunceda ukuphucula imeko yomntu, iimvakalelo kunye neendlela zokulala. Ulawulo lokutya kunye neziyobisi (i-FDA) yamkele kuphela iTrintellix yokunyanga uxinzelelo olukhulu lokudakumba, kodwa inokumiselwa off-ileyibheli ukunyanga uxinzelelo.
Ukumiselwa ngaphandle kwelebheli kuyenzeka xa ugqirha emisela isigulana iyeza elamkelwe yi-FDA ukunyanga imeko eyahlukileyo kule inesigulana. Esi sisiganeko esiqhelekileyo esisemthethweni ngokupheleleyo ukuba senziwe, kwaye kuqikelelwa ukuba malunga 1 kwimigqaliselo emi-5 ngokwenene yimigqaliselo yeelebheli engekhoyo.
Ke ugqirha angabhala umntu enexhala iyeza likaTrintellix, kodwa kutheni benokwenza oku xa kukho amayeza amaninzi okulwa uxinzelelo kwimarike? I-Trintellix ibhloka ukuphinda kuthathwe kwakhona kwe-serotonin njengezinye ii-SSRI, kodwa ngokungafaniyo nezinye i-antidepressants, ikwanazo neziphumo ze-agonist kunye ne-antagonistic kwi-5-HT1A kunye ne-5-HT3 receptors ye-serotonin kwingqondo. Abaphandi abaqinisekanga ncam ukuba isebenza njani le nto, kodwa bakholelwa ukuba inegalelo kuyo Iziphumo ezichasene noxinzelelo lweTrintellix .
Izifundo zibonise ukuba iTrintellix iphucula iimpawu zesifo esixhalabisayo ngokubanzi kunendawo ye-placebo kwaye iyasebenza kwaye iyanyamezeleka kwizigulana ezinexhala elinzima. Uphononongo lwe-meta-uhlalutyo olupapashwe kwi Iithagethi zangoku zeziyobisi Ijenali yafumanisa ukuba iTrintellix iyasebenza kubantu abanengxaki yokuxhalaba abaneziphumo ebezingalindelekanga ezinobulali. Ngokubanzi, kuye kwangqineka kunjalo olusebenzayo ekunciphiseni uxinzelelo kunye neempawu zokudakumba kubantu abanexinzelelo olukhulu lokudakumba okanye amanqanaba aphezulu oxinzelelo.
Ukuqala kweTrintellix yoxinzelelo
Ukuqala nawaphi na amayeza amatsha kunokuba noxinzelelo, kwaye ukuba sele unexhala, ukwazi ukuba ulindele ntoni xa uqala ukuthatha iTrintellix kunokunceda ekwenzeni inkqubo ibe lula. Enye yezona zinto zibaluleke kakhulu ukuba uqaphele xa uqala ukuthatha iTrintellix kukuba ayisiyonyango esebenza ngokukhawuleza. Kungathatha ixesha ngaphambi kokuba uqale ukuzibona iimpawu zakho zoxinzelelo ziphucuka. Ingathatha iiveki ezimbini ukuya kwezine (okanye ngaphezulu) ukuziva umphumo opheleleyo weTrintellix.
Ubungakanani
I-Trintellix ifumaneka njengepilisi ekhutshwa kwangoko kumandla amathathu eedosi: 5 mg, 10 mg, kunye ne-20 mg. Idosi yokuqala yesiqhelo yeTrintellix 10 mg ithathwa kanye ngemini kunye okanye ngaphandle kokutya. Le dosi inokunyuswa iye kwi-20 mg ngosuku okanye yehle ye-5 mg ngosuku kuxhomekeke kwindlela elisebenza ngayo ichiza okanye naziphi na iziphumo ebezingalindelekanga.
Inani elichanekileyo leTrintellix oya kuyidinga ukuba uyithathe kwaye uza kuyithatha ixesha elingakanani liya kwahluka ngokuya ngokweempawu zakho kunye nembali yezonyango. Ukuthatha iidosi eziphezulu okanye ngaphezulu kwedosi enye yeTrintellix ukuzama ukuyenza isebenze ngokukhawuleza ayikhuselekanga kwaye kunokubangela iziphumo ebezingalindelekanga. Kungenxa yoko le nto kubalulekile ukuba uthethe nomboneleli wakho wezempilo malunga nedosi efanelekileyo yokulawula uxinzelelo lwakho. Ukuba uthathe i-Trintellix kakhulu kufuneka ubize ugqirha wakho okanye iZiko loLawulo lweTyhefu kwi-1-800-222-1222. Bazokwazi ukukucebisa malunga nokuba ungaya na kwigumbi likaxakeka okanye kwiziko lokhathalelo olungxamisekileyo.
Unxibelelwano
I-Trintellix akufuneki ithathwe ngaxeshanye namayeza athile ngenxa yokuhlangana kweziyobisi. Akufanele ithathwe kwiiveki ezimbini zokuthatha:
- I-Monoamine Oxidase Inhibitors (ii-MAOIs)
- I-Methylene eluhlaza okwesibhakabhaka
- Umgca we-Linezolid
I-Trintellix akufuneki ithathwe kwiiveki ezimbini zokuthatha i-monoamine oxidase inhibitor (MAOI), kunye ne-MAOI akufuneki ithathwe zingaphelanga iintsuku ezingama-21 zokumisa iTrintellix ngenxa yomngcipheko ophakamileyo wokufumana i-serotonin syndrome. Isifo seSerotonin yimeko enokusongela ubomi eyenzekayo xa i-serotonin eninzi isakha emzimbeni. Iimpawu zeserotonin syndrome zibandakanya ukungcangcazela, ukungcangcazela, uxinzelelo lwegazi, ukubetha kwentliziyo ngokukhawuleza, ukudideka, ukuqina kwemisipha kunye nokuxhuzula.
Kuya kufuneka uxelele ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo, kuba anokuchaphazela indlela iTrintellix esebenza ngayo okanye inyuse umngcipheko weziphumo ebezingalindelekanga:
- Olunye uxinzelelo
- Amayeza antipsychotic
- Amayeza angaphezulu kwe-counter-counter-counter njenge-NSAID okanye i-aspirin
- Abacoci begazi abanjengoCoumadin (warfarin)
- Amayeza e-Triptan okanye i-tryptophan supplements
- Womchamo
- Wort eSt
- ICarbamazepine
- Fentanyl
- ILithium
- IPhenytoin
- Iquinidine
- IBupropion
- Ibhayiprone
- Rifampin
- I-Tramadol
Imiphumela
Xa uqala ukuthatha i-Trintellix, unokufumana ezinye iziphumo ezinokubakho. Abanye abantu banokuziva bengenakuphumla okanye benamandla kungekudala emva kokuthatha idosi, enokuthi ikhokelele kwingxaki yokulala. Nazi ezinye iziphumo ebezingalindelekanga eziqhelekileyo ezifunyanwa ngabantu xa beqala ukuthatha iTrintellix:
- Isicaphucaphu
- Ukuhlanza
- Ukuqunjelwa
- Urhudo
- Umlomo owomileyo
- Ukuqina kwemisipha
- Irhasi
- Ukutyeba kwakho
- Amaphupha angaqhelekanga
- Intlungu yamehlo
- Umbono utshintsha
- Ukuba nesiyezi
- Ukungasebenzi kakuhle ngokwesondo
Kubalulekile ukuba uphephe ukulahleka idosi yeTrintellix ukuqinisekisa ukuba unyango luhlala luhambelana kwaye kunciphisa umngcipheko wokuphinda ubuye kwiimpawu zokudakumba. Ukuba uyaphoswa yidosi kungcono ukuba uthathe idosi yakho ngokukhawuleza nje ukuba ukhumbule, ngaphandle kokuba ilixesha lokuthatha idosi yakho elandelayo. Ukuphindaphindeka kwiidosi kunokubangela iziphumo ebezingalindelekanga kwaye, kwiimeko ezinqabileyo, kunokubangela i-serotonin syndrome. Ababoneleli abaninzi bezempilo baya kuncoma ukuthatha iTrintellix malunga nexesha elifanayo yonke imihla.
Nangona kunqabile, iTrintellix inokubangela iziphumo ebezingalindelekanga ezinokufuna unyango. Ileta ye-FDA yeTrintellix iqulethe isilumkiso sebhokisi yeengcinga ezinokubulala kunye nokuziphatha, ngakumbi ebantwaneni, kulutsha nakwabantu abadala abancinci. Ukuba uthatha iTrintellix kwaye uqala ukuba nazo naziphi na iingcinga zokuzibulala okanye indlela yokuziphatha, kuya kufuneka ufune uncedo lwezonyango kwangoko.
I-Trintellix nayo inokubangela iziphumo ebezingalindelekanga ezinje:
- Ukopha okungaqhelekanga
- Ukutyumka okungaqhelekanga
- I-Mania okanye i-hypomania kubantu abane-bipolar disorder
- Ukuvalwa kweglaucoma
- Amanqanaba esodium ephantsi egazini (hyponatremia)
Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ngelixa uthatha iTrintellix kuya kufuneka uthethe nomboneleli wakho wezempilo ngokukhawuleza. Ukuba uxabisa i-vortioxetine okanye ezinye izithako kwi-Trintellix kufuneka ugweme ukuthatha amayeza kuba kunokubangela ukungabikho komzimba.
Izithintelo
Abantu abane-bipolar disorder kufuneka bathathe i-Trintellix kuphela xa kuvunywa ngugqirha wabo kuba kunokubangela iziqendu zomntu. Abantu abane-glaucoma kunye nokuphazamiseka kwegazi kufuneka bathathe kuphela i-Trintellix phantsi kolawulo lukagqirha kuba inokunyusa umngcipheko wokuphuma kweziqwengana kunye nokuqaqamba kweglaucoma evaliweyo.
Amayeza athile akakhuselekanga kwizigulana esele zikhulile, kodwa iTrintellix ibonakalisiwe ukuba iyanyamezeleka kwaye ikhuselekile kubantu abadala abangaphezulu kweminyaka engama-65 ubudala. Izifundo zonyango khange abonise mahluko kukhuseleko okanye ekusebenzeni phakathi kwabantu abadala kunye nabadala, kwaye akukho mahluko ubonakalayo ekuphenduleni kunyango phakathi kwabantu abadala kunye nabadala. I-Trintellix ayivunyelwanga kuso nasiphi na isigulana esingaphantsi kweminyaka ye-18.
I-Trintellix inokuchaphazela umntwana okhulelweyo. Ukuthatha iTrintellix kwikota yesithathu yokukhulelwa kunokukhokelela kwi ukwanda komngcipheko yemeko ekuthiwa yinto eqhubekayo yoxinzelelo lwegazi kwimiphunga kwiintsana. Akukho datha kwiTrintellix kunye nendlela oluchaphazela ngayo ubisi lwebele okanye iintsana ezincancisayo, yiyo loo nto kubalulekile ukulinganisa izibonelelo kunye nemingcipheko yokusebenzisa amayeza ngelixa uncancisa umboneleli wezempilo.
Yeyiphi eyona nto iphambili yoxinzelelo kuxinzelelo?
Akukho nelinye iyeza elisebenza ngokunyanga uxinzelelo. Into esebenzela umntu omnye ayinakusebenzela omnye, kodwa iindaba ezimnandi zezokuba zininzi iindlela ezahlukeneyo zokuthomalalisa uxinzelelo ezinokunyanga iimeko zempilo yengqondo ezinje ngexhala. Ukongeza kwii-SSRIs, nazi ezinye iindidi zezidambisi:
- I-Serotonin kunye ne-norepinephrine reuptake inhibitors (SNRIs): Yandisa ukufumaneka kwe-serotonin kunye ne-norepinephrin kwingqondo.
- I-Tricyclic yoxinzelelo: ukonyusa amanqanaba e-serotonin kunye ne-norepinephrine kwingqondo kunye ne-acetylcholine.
- I-Monoamine oxidase inhibitors (i-MAOIs): thintela i-enzyme monoamine oxidase ekususeni i-dopamine, i-serotonin, kunye ne-norepinephrine kwingqondo.
Nazi ezinye zezona zixhobo zokulwa noxinzelelo.
Ukudakumba koxinzelelo | ||||||
|---|---|---|---|---|---|---|
| Igama leziyobisi | Iklasi yeziyobisi | Ukusebenza koxinzelelo | Umthamo osemgangathweni | Iziphumo eziqhelekileyo | Ugcino olulodwa | Funda nzulu |
| I-Trintellix | I-SSRI | Iqinisekisiwe ukuba iyasebenza ngakumbi kune-placebo kwizifundo ezilawulwa yi-placebo | 5 ukuya kuma-20 mg ngosuku | Isicaphucaphu, ukuqhina | Fumana amatikiti eTrintellix | Iinkcukacha zeTrintellix |
| Zoloft (Sertraline) | I-SSRI | Ngokubonakalayo isebenza ngakumbi kunendawo ye-placebo ekunyangeni uxinzelelo lwentlalo kunye nokuphazamiseka kwengqondo | 25 ukuya ku-200 mg ngosuku | Isihlunu, isifo sohudo, kunye nokunciphisa ukutya | Fumana amatikiti eZoloft | Iinkcukacha zeZoloft |
| Paxil (paroxetine) | I-SSRI | Ukusebenza kunyango lokuphazamiseka koxinzelelo ngokubanzi kunye nokunye ukuphazamiseka koxinzelelo | 10 ukuya kuma-60 mg ngosuku | Ukozela, isicaphucaphu, kunye nentloko | Fumana amatikiti ePaxil | Iinkcukacha zePaxil |
| Iprozac (fluoxetine) | I-SSRI | Isetyenziswa ngokubanzi njengonyango olusebenzayo lokuphazamiseka kwengqondo | 10 ukuya kuma-60 mg ngosuku | Ukuphuthelwa, isicaphucaphu, nomlomo owomileyo | Fumana amatikiti eProzac | Iinkcukacha zeProzac |
| ILexapro (isitalitalopram) | I-SSRI | Iqinisekisiwe ukuba iyasebenza kwaye iyanyamezeleka kunyango lokuphazamiseka koxinzelelo ngokubanzi | 10 ukuya ku-20 mg ngosuku | Ukuphuthelwa, isicaphucaphu, kunye nokuhla kwe-libido | Fumana amatikiti eLexapro | Iinkcukacha zeLexapro |
| ICymbalta (duloxetine) | ISNRI | Kuvunyiwe ukunyanga isifo soxinzelelo ngokubanzi | 30 ukuya ku-60 mg ngosuku | Isihlunu, umlomo owomileyo, kunye nokozela | Fumana iikhuphoni zeCymbalta | Iinkcukacha zeCymbalta |
| UCelexa(Ikitalopram) | I-SSRI | Isetyenziselwa ukunyanga uxinzelelo kodwa inokusetyenziselwa ngaphandle kwelebheli ukunyanga uxinzelelo | 20 ukuya kuma-40 mg ngosuku | Isihlunu, umlomo owomileyo, kunye neentloko | Fumana ikhuphoni zikaCelexa | Iinkcukacha zikaCelexa |
| UmncedisiXR(Iphilisi) (venlafaxine XR) | ISNRI | Ukuvunywa kunyango lokuphazamiseka koxinzelelo ngokubanzi, ukuphazamiseka koxinzelelo kwezentlalo, kunye nokuphazamiseka kwovalo | 37.5 ukuya kuma-225 mg ngosuku | I-nausea, somnolence, kunye nomlomo owomileyo | Fumana i-Effexor XR amatikiti | Iinkcukacha ze-Effexor XR |
| Tofranil(imipramine) | I-Tricyclic yoxinzelelo | Ingasetyenziselwa ngaphandle kwelebheli ukunyanga ukuphazamiseka kwengqondo | 100 ukuya ku-200 mg ngosuku | Umlomo owomileyo, isiyezi kunye nokozela | Fumana amatikiti eTofranil | Iinkcukacha zikaTofranil |
