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Iziphumo ebezingalindelekanga zeLinzess kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

I-Linzess ligama lophawu lonyango oluqhelekileyo olubizwa ngokuba yi-linaclotide. Iyeza lonyango elisetyenziselwa ukunyanga ukuqhina okungapheliyo, kwaye isebenza ngokwandisa ukufihlwa kwezinto ezimbini zeekhemikhali ezibizwa ngokuba yi-chloride kunye ne-bicarbonate emathunjini. Oku kubangela ukukhutshwa kwamanzi angaphezulu emathunjini, okunceda ukunciphisa ukuhamba kwesitulo. I-Linzess ikwasebenza ngokunciphisa ixesha elithathwayo ekutyeni okuhamba ngendlela yokugaya ukutya.

I-Linzess inokunyanga iintlobo ezimbini zokuqhinwa okungapheliyo okubizwa ngokuba kukucaphuka kwesisu kunye nokuqhinwa ( IBS-C ) kunye nokuqunjelwa okungapheliyo kwe-idiopathic (CIC). Kuzo zombini ezi meko, ukuqhina kuqhubeka iinyanga ezintathu okanye nangaphezulu. Makhe sijonge kwiziphumo ebezingalindelekanga eziqhelekileyo, izilumkiso, kunye nokunxibelelana kweziyobisi kweLinzess ukuze siliqonde ngcono ichiza kwaye lisebenza njani.

Ezinxulumene: Yintoni iLinzess?

Iziphumo eziqhelekileyo ezichaphazelekayo zeLinzess

I-Linzess inokubangela iziphumo ebezingalindelekanga njengalo naliphi na elinye iyeza, kwaye kubantu abaninzi abane-IBS-C okanye i-CIC, izibonelelo zokuyithatha ziya kuba ngaphezulu kweziphumo ebezingalindelekanga abanokuzifumana. Nazi izinto eziqhelekileyo iziphumo ebezingalindelekanga zeLinzess :

Intlungu zesisu
Urhudo
Ukuqunjelwa sisisu (ukudlula kwerhasi)
Intloko ebuhlungu
Gastroenteritis (ukudumba kwamathumbu)
Ukuhamba kwesisu (ukuqunjelwa)

Kuba iLinzess isebenza ngokunciphisa ixesha lokuhamba kwamathumbu, isifo sorhudo sesona sisiphumo siqhelekileyo. Ukufumana enye okanye ezingaphezulu kweziphumo ebezingalindelekanga ngelixa uthatha iLinzess kuyinto eqhelekileyo, kwaye nangona zinokungonwabi, abantu abaninzi baya kuqala ukuziva bekhululekile kukuqhinwa okungapheliyo kwakamsinya emva kokuqala iLinzess.

Iziphumo ebezingalindelekanga ezimandundu zeLinzess

Kwiimeko ezinqabileyo, iLinzess inokubangela iziphumo ezibi kakhulu ezinokufuna unyango:

Urhudo oluqatha

Ukuba uthatha i-Linzess kwaye uqala ukuba nesifo sorhudo esiba mandundu okanye esingayi kuhamba, ngakumbi ukuba unegazi okanye ilindle elimnyama, kuya kufuneka uyeke ukuthatha iLinzess kwaye uqhakamshelane nogqirha wakho ukuze ubone ukuba ukuqhubeka nonyango kukulungele na. Ugqirha wakho angakunika iingcebiso zonyango ukuba wenzeni. Kwiimeko ezinqabileyo, urhudo oluqatha lunokukhokelela ekubeni ube nesiyezi okanye utyhafe, kwaye ukulaliswa esibhedlele kunokuba yimfuneko ukuze ubeke endaweni ii-electrolyte ezilahlekileyo zokuphelelwa ngamanzi emzimbeni.

I-Anaphylaxis

I-Anaphylaxis sisifo esibi kakhulu kunyango, ukutya, okanye ityhefu. Kunqabile kakhulu ukuba umntu abe ne-allergen reaction kwi-Linzess, kodwa kunokwenzeka, kwaye i-anaphylaxis inokusongela ubomi ukuba ayinyangwa kwangoko. Ukuba uqala ukufumana ubunzima bokuphefumla, ukudumba komqala, isicaphucaphu, ukugabha, ukothuka, kunye / okanye imingxunya emva kokuthatha iLinzess, kuya kufuneka ufumane unyango kwangoko.

Ukuhla ukusinda

Abanye abantu abathatha i-Linzess yokuqhinwa okungapheliyo banokuba namava okuphulukana nobunzima. Oku kunokuba ngenxa yokuba amayeza anokubangela ukurhuda kunye nokulahleka kwamanzi kunye ne-electrolyte emzimbeni, oku kunokukhokelela ekulahlekelweni kwesisindo xa kunganyangwa ngokukhawuleza. Urhudo luhlala luqala kwiiveki ezimbini zokuqala zokuthatha i-Linzess, nakwiimvavanyo ezilawulwa yi-placebo, malunga Amashumi amabini% yabantu abane-IBS-C abanesifo sohudo xa kuthelekiswa namaqela e-placebo angakhange alifumane iyeza. Olunye urhudo olunqabileyo luxhaphakile, kodwa ukuba unesifo sorhudo oluqatha ngelixa uthatha iLinzess, kuya kufuneka uyeke ukusithatha kwaye ubize ugqirha ngoko nangoko. Oku kubaluleke ngakumbi kubantu abadala asebekhulile abanokuthi bathambekele ekuphelelweni kwamanzi.

Uxinzelelo

Kukho uphando oluncinci kakhulu ukucebisa ukuba iLinzess ibangela uxinzelelo, kodwa kunokubakho unxibelelwano phakathi koxinzelelo, unxunguphalo kunye ne-IBS-C. Kungenxa yokuba amathumbu alawulwa yinxalenye yenkqubo yemithambo-luvo, ethumela imiqondiso kwingqondo. Kuqikelelwa ukuba malunga Amashumi amahlanu% Abantu abane-IBS-C baya kuba neempawu zoxinzelelo kunye noxinzelelo. Umntu othatha i-Linzess ye-IBS-C kunye nokuziva enexhala okanye ukudakumba unokuziva enjalo kuba enexhala okanye uxinzelelo, hayi ngenxa yamayeza.

Ukuba uthatha uLinzess kwaye uqala ukuziva udandathekile, kungcono ukuba uthethe nogqirha okanye ingcali yezempilo malunga nento enokubangela ukuba uzive ngendlela oziva ngayo. Ugqirha wakho uya kuba nakho ukukunceda uqonde ukuba ngaba iLinzess iyenza mandundu iimvakalelo zakho zoxinzelelo kunye noxinzelelo.

Ukongeza, ukuba uqala ukuba neengcinga zokuzibulala okanye indlela yokuziphatha, kuya kufuneka ufumane unyango kwangoko. Ungatsalela umnxeba iNational Suicide Prevention Lifeline simahla apha 1-800-273-8255 ukuba ufuna umntu onokuthetha naye. I-Lifeline ifumaneka iiyure ezingama-24 ngosuku.

Ezinxulumene: Ngaba uxinzelelo lubangela IBS?

Ukulahleka kweenwele

Phakathi kwabantu abanengxaki yokugaya ukutya, zinokubakho izizathu ezininzi zokuphulukana neenwele ezinje ngoxinzelelo, ukudumba kwamathumbu, okanye ukungafumani izondlo ezaneleyo ekutyeni. Amayeza amaninzi ayaziwa ukuba abangela ukulahleka kweenwele, kodwa abukho ubungqina obaneleyo bokubonisa ukuba uLinzess uyakwenza oko. Ukulahleka kweenwele akudweliswanga njengempembelelo yeLinzess. Ngokuqinisekileyo kunokwenzeka ukuba umntu afumane iziphumo ebezingalindelekanga ezivela kwichiza abanye abantu abangazenziyo, kwaye ukuba oku kuyenzeka kuwe, kuya kufuneka wazise umboneleli wakho wezempilo. Unokuxela iziphumo ebezingalindelekanga kuLawulo lokutya kunye noLawulo lweziyobisi (FDA) kwi-1-800-FDA-1088.

Ezinxulumene: Kutheni iinwele zam zisiwa?

Zide kangakanani iziphumo ebezingalindelekanga zeLinzess?

Kumntu ophakathi othatha i-Linzess, isifo sorhudo sesona sisiphumo secala siqhelekileyo kwaye sihlala sivela kwiiveki ezimbini zokuqala zonyango. Kwezilingo zeklinikhi, isifo sorhudo sisonjululwe kwiveki emalunga noko 33% zabantu. Nangona uninzi lweziphumo ebezingalindelekanga ziya kusombulula kwixesha elifutshane, kunokwenzeka ukuba ube neziphumo ebezingalindelekanga ezihlala ixesha elide. Abanye abantu baya kuba nesifo sohudo esihlala ukuya kuthi ga kwinyanga, ke oko kuxhomekeke kumntu kunye nendlela umzimba wabo oqhuba ngayo iLinzess. Ukuba uthathe i-Linzess ngaphezulu kweeveki ezimbini kwaye iziphumo zakho ebezingalindelekanga aziyi kuhamba, kunokuba ngumbono olungileyo ukuqhagamshelana nogqirha wakho ukuze uqiniseke ukuba le nto uhlangabezana nayo ilungile.

Qaphela: I-Linzess ayisiyo isisu kwaye ayiqali ukusebenza kwangoko. Uninzi lwabantu luya kuqala ukuziva bekhululekile kwiimpawu zabo zokuqhinwa okungapheliyo malunga neveki emva kokuqala iLinzess, kwaye abaguli be-IBS-C babona ukuphucuka kwimeko yabo yonyango ngaphezulu kwekhosi Iiveki ezili-12 .

Ukungqinelana kweLinzess kunye nezilumkiso

Ukuphathwa gadalala kunye nokuxhomekeka

I-Linzess yeqela lamayeza abizwa ngokuba yi-guanylate cyclase-C agonists, asebenza ngokwandisa ukhuselo lwamathumbu emathunjini. Akukho bungqina bubonisa ukuba ezi ndidi zamayeza zenza umkhwa.

I-Linzess kufuneka ithathwe kuphela njengokuyalelwa ngugqirha. Ukuthatha ngaphezulu kwethamo lakho lemihla ngemihla laseLinzess ukuzama ukulenza lisebenze ngokukhawuleza alikhuselekanga kwaye aliyi kusebenza. Ukuthatha amayeza ngendlela ongayimiswanga kunokuba yingozi kwimpilo yakho.

Ukuba umntu one-IBS-C okanye i-CIC kufuneka ayeke ukuthatha i-Linzess ngaso nasiphi na isizathu, banokufumana iimpawu zokurhoxa ezinobumnene ezinje ngotshintsho kwiintshukumo zabo. Abantu abaninzi baya kubona iimpawu zabo zokuqhinwa ezingapheliyo zibuyela ngaphakathi iveki okanye ukumisa iLinzess.

Ukugqithisa

Elona liphezulu umthamo weLinzess ngosuku ngama-290 mcg ngaphandle kokuba kucetyiswa ngugqirha ngenye indlela. Ukugqithisa kwiLinzess akunakwenzeka ukuba kusongela ubomi, kodwa kunokubangela ezinye iimpawu ezifana nesifo sohudo.

Izithintelo

Nangona i-Linzess yonyango olusebenzayo lwe-IBS-C kunye ne-CIC, akufuneki ithathwe ngumntu wonke ohlangabezana nokuqunjelwa kwexesha elide.

I-Linzess akufuneki ithathwe zizigulana zabantwana ezingaphantsi kweminyaka eyi-18 ngenxa yokuba ukhuseleko kunye nokusebenza kweli qela leminyaka akuzange kusekwe ngokufanelekileyo. Kubantwana abangaphantsi kweminyaka yobudala be-6, iLinzess akufuneki isetyenziswe kwaphela kuba inokubangela ukomisa kakhulu emzimbeni.

I-Linzess nayo akufuneki ithathwe ngabantu abanesithintelo esaziwayo okanye esisolisayo sokuthintela ukwenzakala kwamathumbu (ukuvaleka kwamathumbu).

I-Linzess kufuneka ithintelwe ngexesha lokukhulelwa okanye ngelixa lokuncancisa ngaphandle kokuba ukusetyenziswa kwalo kuvunyiwe ngugqirha. I-Linzess khange ifundwe ngokwaneleyo kwabasetyhini abakhulelweyo. Akukho datha yomntu ifumanekayo yokucebisa ukuba i-Linzess ibangela ukwenzakala komntwana okanye inokuba yingozi kwiintsana ukuba zidlula kubisi lwebele, kodwa akufuneki zisetyenziswe ngaphandle kokuba izibonelelo zingaphezulu kobungozi.

Izigulana ezindala ezingaphezulu kweminyaka engama-65 kufuneka zibekwe esweni ngononophelo ngelixa zithatha iLinzess. Iziphumo zeLinzess azifundiswanga ngokukodwa kwaba bantu. Akukho lungelelwaniso lwethamo luyafuneka, kodwa abaguli abakhulileyo banokuba namazinga aphezulu esibindi kunye neengxaki zezintso ezifuna ulumkiso ngakumbi ngelixa besebenzisa eliyeza.

Unxibelelwano lweLinzess

Izidambisi Njenge-sodium phosphate, i-magnesium citrate, kunye ne-polyethylene glycol kufuneka ithintelwe xa uqala i-Linzess kuba inokunyusa amathuba okuba norhudo. Ukuba uthatha amayeza athile Ngelixa uthatha i-Linzess ungawonyusa umngcipheko wokufumana amanzi emzimbeni, ke kungcono ukuba unike umboneleli wakho wezonyango uluhlu lwawo onke amayeza (kubandakanya amayeza amiselweyo, amayeza e-counter-counter, kunye nezixhasi) ozithathayo ukuze abe nako ndikuxelele ukuba kukho nantoni na ongafanelekanga ukuyithatha.

Ungaziphepha njani iziphumo ebezingalindelekanga zeLinzess

Ngelixa ukuthintela ngokupheleleyo iziphumo ebezingalindelekanga zeLinzess akunakwenzeka, kukho izinto onokuzenza ukunciphisa ubungqongqo:

1. Thatha idosi ekucetyiswa ukuba uyisebenzise

Idosi ekhuthazwayo yemihla ngemihla yeLinzess ye-IBS-C yi-290 mcg ethathwe kwisisu esingenanto ubuncinci imizuzu engama-30 ngaphambi kwesidlo sokuqala sosuku. Umthamo ocetyiswayo wemihla ngemihla weLinzess yeCIC yi-145 mcg ethathwe ubuncinci imizuzu engama-30 ngaphambi kwesidlo sokuqala sosuku. Umthamo we-72 mcg ethathwe kube kanye ngemini inokusetyenziselwa abaguli abane-CIC abanokunyamezeleka okuphantsi kweLinzess.

Ukungaguquguquki kunye nokuba uthatha njani amayeza akho kubaluleke kakhulu kuba ukungaguquguquki kuya kunceda inkqubo yomzimba wakho uLinzess ngcono kwaye kunciphise amathuba okuba neziphumo ebezingalindelekanga. Ukuthatha idosi emiselweyo rhoqo kusasa imizuzu engama-30 ngaphambi kwesidlo sakho sokuqala sosuku kuya kwenza umahluko omkhulu ekusebenzeni kakuhle kweLinzess kuwe.

Ukuba uphosa idosi yeLinzess, tsiba idosi oyiphosileyo kwaye uthathe idosi elandelayo ngosuku olulandelayo ngaphambi kwesidlo sakho sokuqala. Jonga isikhokelo sonyango ngolwazi oluthe kratya lwamachiza.

I-Linzess akufuneki ityunyuzwe okanye ihlafunwe. Ukuba unengxaki yokuginya iipilisi, unokuvula i-Linzess capsule yakho kwaye ufefe iyeza kwi-1 ithisipuni ye-applesauce okanye i-30 ml yamanzi.

Gcina iLinzess ngokufanelekileyo

Ukwazi indlela yokugcina amayeza akho kubalulekile ukuba uqiniseke ukuba uhlala usebenza ngokusemandleni akho. Ukuthatha amayeza aphelelwe lixesha okanye agcinwe ngokungafanelekanga kunokubangela ukuba iyeza lingasebenzi kakuhle kwaye kunokubangela neziphumo ebezingalindelekanga ezingafunekiyo. I-Linzess kufuneka igcinwe kubushushu begumbi kwindawo eyomileyo kwisitya sayo sokuqala. Kubalulekile ukuba ushiye iarhente yokomisa eza kwibhotile ngaphakathi kwebhotile ukunqanda ukufuma okungaphezulu kokuchaphazela amayeza, kwaye ibhotile kufuneka ivalwe ngokuqinileyo.

3. Yabelana nembali yakho yezonyango nogqirha wakho

Ukwabelana ngembali yakho yezonyango epheleleyo kunye nogqirha wakho kubalulekile ukunceda ugqirha wakho aqonde ukuba uLinzess uza kukusebenzela njani. Ukunika uluhlu olupheleleyo lwawo onke amayeza kunye nezibonelelo ozisa kugqirha kuya kubavumela ukuba babone ukuba ngaba nantoni na osele uyithatha iza kuphazamisa iLinzess kwaye ibangele iziphumo ebezingalindelekanga. Ugqirha wakho uya kulungelelanisa idosi yakho xa kufuneka okanye akutshintshele kwelinye iyeza, njenge Amitiza , ukuba iziphumo ebezingalindelekanga ziyaqhubeka.

4. Mamela umzimba wakho

Ukumamela umzimba wakho ngelixa uthatha iLinzess kubalulekile. Ukuba uqala ukufumana naziphi na iziphumo ebezingalindelekanga zeLinzess, kungcono wazise ugqirha wakho ngokukhawuleza ukuze akuncede unciphise ubuzaza bezo ziphumo bezingalindelekanga. Abantu abaninzi baya kuba nakho ukuthatha ngokukhuselekileyo i-Linzess yexesha elide kunye neziphumo ebezingalindelekanga ezincinci ukuba bayithatha ngokufanelekileyo, kodwa abanye banokuphendula ngokwahlukileyo kuyo.

Ngokwe- I-FDA , kuvavanyo lwexesha elide apho abantu abangama-2,147 abane-IBS-C befumana i-290 mcg ye-Linzess yonke imihla ukuya kwiinyanga ezili-18, i-29% yezigulana ziye zancitshiswa okanye zanqunyanyiswa ngenxa yeziganeko zokungalunganga okunje kurhudo. Ezi ziphumo bezingalindelekanga ezinokubakho kufuneka zijongwe ngononophelo ngokumamela indlela oziva ngayo umzimba wakho ngelixa uthatha iLinzess kwaye uhlala unxibelelana kakhulu nomboneleli wakho wezempilo.