I-Breo vs.Advair: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kweinshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
I-Breo kunye ne-Advair bobabini bangamayeza okurhola amayeza aboniswe kwi-COPD (isifo esinganyangekiyo sesifo semiphunga) kunye nonyango lwesifuba. Iyeza ngalinye liqulethe i-corticosteroid (ICS) kunye ne-beta esebenza ixesha elideMbini-adrenergic agonist (LABA).
Icandelo le-ICS, eliyi-fluticasone kunyango ngalunye, linceda ukunciphisa ukudumba emiphungeni. Icandelo le-LABA, eyi-vilanterol eBreo kunye ne-salmeterol e-Advair, inceda ukuvula i-airways kwimiphunga ngokuphumla kwezihlunu. IBreo ifumaneka ngegama lophawu kuphela; yenziwe yi-GSK, okanye iGlaxoSmithKline.
I-Advair ifumaneka kwi-brand kunye ne-generic; uphawu lwenziwa yi-GSK. U-Mylan wenza igeneric enophawu (ichiza elenziwe lafana nelo lenziwe ngegama), elibizwa ngokuba yiWixela Inhub. UBreo kunye neAdvair i-inhalers yomgubo , Ithetha ukuba imixholo yecapsule ikhutshiwe. I-Advair HFA yidosi ye-metered-inhaler. UBreo no-Advair banokufana okuninzi, kodwa ukwahluka okubonakalayo.
Nguwuphi umahluko ophambili phakathi kweBreo vs Advair?
| Umahluko ophambili phakathi kukaBreo kunye neAdvair | ||
|---|---|---|
| UBreo | Idilesi | |
| Iklasi yeziyobisi | I-ICS (inhaled corticosteroid) kunye ne-LABA (i-beta esebenza ixesha elideMbini-adrenergic agonist) | I-ICS (inhaled corticosteroid) kunye ne-LABA (i-beta esebenza ixesha elideMbini-adrenergic agonist) |
| Uhlobo lweBrith / generic | Igama lebrand | Brand kunye generic |
| Ngubani igama eliqhelekileyo? | I-Fluticasone furoate / vilanterol | IFluticasone propionate / salmeterol |
| Zeziphi iifom eza nalo iziyobisi? | UBreo Ellipta inhaler | I-Advair Diskus kunye negeneric, I-Fluticasone Advair HFA inethamo yethamo le-inhaler (ngokusebenza) |
| Ithini idosi esemgangathweni? | Ukugcinwa kweCOPD: UBreo Ellipta 100/25: 1 ukhukhumeza kube kanye yonke imihla Isifuba: UBreo Ellipta 100/25 okanye 200/25: 1 ukukhukhumala kube kanye yonke imihla • Ngalo lonke ixesha hlamba umlomo emva kokusebenzisa, ukunciphisa umngcipheko we-thrush yomlomo | I-Advair Diskus kunye negeneric, Ukugcinwa kwesifuba: 1 ukukhukhumala (100/50, 250/50, okanye 500/50) rhoqo kwiiyure ezili-12 Ukugcinwa kweCOPD: 1 ukukhupha (250/50) rhoqo kwiiyure ezili-12 Idilesi yeHFA: Ukugcinwa kwesifuba: I-2 ikhukhumeza ifunxa rhoqo iiyure ezili-12 • Ngalo lonke ixesha hlamba umlomo emva kokusebenzisa, ukunciphisa umngcipheko we-thrush yomlomo |
| Lude kangakanani unyango oluqhelekileyo? | Iyahluka | Iyahluka |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala abaneminyaka eyi-18 nangaphezulu | Abantu abadala nabantwana abaneminyaka emi-4 nangaphezulu |
Iimeko eziphathwe nguBreo vs.Advair
Izigulana ezininzi zinengxaki ye-COPD okanye i-asthma ebukhali, eneempawu ezinje ngokuphefumla kunye nokuphefumla okufutshane okwenzeka ngexesha lokuhlaselwa sisifuba. UBreo (Yintoni uBreo?) Lunyango olwenziwa kube kanye-lwemihla ngemihla olusetyenziswa kwizigulana ezineCOPD okanye isifuba. Ingasetyenziswa kwizigulana ezineminyaka eli-18 nangaphezulu. I-Advair (Yintoni i-Advair?) Lunyango oluphindwe kabini-imihla ngemihla kwizigulana ezine-COPD okanye i-asthma. Ingasetyenziswa kwizigulana ezineminyaka emine nangaphezulu. La mayeza akufuneki asetyenziswe kwizigulana ezine-bronchospasm ebukhali okanye isifuba esinokulawulwa yi-ICS kunye nokusetyenziswa kwe-inhaled ngamanye amaxesha i-beta emfutshane Mbini -abaphikisi (njenge-albuterol, ekwabizwa ngokuba ziifom zegama lophawu njengeProAir HFA, Proventil HFA, kunye neVentolin HFA).
| Imeko | UBreo | Idilesi |
| Ixesha elide, kube kanye-yonke imihla, ulondolozo lonyango lokuthintela ukuhamba komoya kunye nokunciphisa ukunyuka kwezigulana ezine-COPD | Ewe | Hayi |
| Unyango lwe-asthma kanye ngemini kwizigulana ezineminyaka eyi-18 nangaphezulu | Ewe | Hayi |
| Ukunyangwa kabini kwemihla ngemihla unyango lwe-asthma kwizigulana ezineminyaka emine nangaphezulu | Hayi | Ewe |
| Unyango oluphindwe kabini ngemini lonyango lokuthintela ukuhamba komoya kunye nokunciphisa ukunyuka kwezigulana ezineCOPD | Hayi | Ewe |
Ngaba iBreo okanye iAdvair isebenza ngakumbi?
Kwiinyanga ezintandathu ezingenamsebenzi, ezilawulwa yi-placebo ukufunda ngokuthelekisa uBreo no-Advair kwizigulana ezingama-806 zesifo sombefu, omabini amaqela onyango afumana ukuphuculwa okulinganayo kwi-FEV1 (ivolumu yokuphefumla enyanzelekileyo; umlinganiso wobungakanani bomoya onokukhutshwa ngomzuzwana omnye emva kokuphefumla okunzulu), umgangatho wobomi, kunye namanqaku olawulo lwesifuba. Kwakungekho mahluko kumanqanaba okunyuka, kwaye omabini la machiza ayanyamezeleka.
Ntathu izifundo uthelekise uBreo kunye neAdvair kwizigulana ezingama-40 nangaphezulu nge-COPD ephakathi. Ekupheleni kwesifundo seeveki ezili-12, abaphandi bagqiba kwelokuba omabini la machiza akhokelela kuphuculo olufanayo lweklinikhi kwaye omabini la machiza aneeprofayili zokhuseleko ezifanayo.
Ukulinganisa kunye nokuthelekiswa kweendleko zeBreo vs.Advair
I-Breo kunye ne-Advair zihlala zigutyungelwe yi-inshurensi kunye ne-Medicare Part D. IiCopays ziyahluka kakhulu. Nangona i-generic ingabizi ngokubanzi ngokubanzi, ezinye iinkampani ze-inshurensi zikhetha i-brand Advair ngenxa yezivumelwano zesivumelwano. Ixabiso eliphakathi leBreo ngaphandle kwe-inshurensi yi- $ 450 kodwa ungayifumana malunga ne- $ 279 nge-SingleCare coupon. Ixabiso eliphakathi le-Advair Diskus yi- $ 474 ye-brand kwaye iphantsi njenge- $ 105 ye-generic.
| UBreo | Idilesi | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Umthamo osemgangathweni | Umzekelo: i-200 mcg / 25 mcg inhaler: 1 ikhukhumale yonke imihla | Umzekelo: I-Advair Diskus 250 mcg / 50 mcg: 1 ikhukhumele kabini yonke imihla |
| Uhlobo oluqhelekileyo lweMedicare Part D | $ 19- $ 400, iyahluka | $ 40- $ 400, iyahluka |
| Ixabiso elilodwa | $ 279 | $ 105 yeedola |
Fumana ikhadi lesaphulelo somntu ongatshatanga
Iziphumo eziqhelekileyo zeBreo vs.Advair
NgeBreo, iziphumo ebezingalindelekanga eziqhelekileyo zi-nasopharyngitis (usulelo oluncinci lomqala), usulelo oluphezulu lokuphefumla, isifo somlomo (ukungunda emlonyeni), kunye nentloko. Iziphumo ebezingalindelekanga ze-Advair ziyafana, kunye neziganeko eziphezulu kakhulu ze-pharyngitis, kunye nemicimbi yamathumbu enjenge-nausea, ukugabha, urhudo kunye nentloko.
Ukunceda ukunciphisa umngcipheko we-thrush yomlomo, izigulana kufuneka zihlale zihlamba kwaye zitshica ngamanzi emva kwedosi nganye yeBreo okanye yeAdvair.
Ngokwezokhuseleko, kukho umngcipheko okhulayo wokufa okunxulumene nesifuba ngokusetyenziswa kwe-LABA kuphela. Nangona kunjalo, i-FDA kwaziswa Ngo-2017 ukuba indibaniselwano ye-ICS / LABA enjengeBreo okanye iAdvair ayikhokeleli kwingozi yokufa.
Ezinye iziphumo ebezingalindelekanga zinokwenzeka. Nxibelelana neengcali zonyango lwakho uluhlu olupheleleyo lweziphumo ebezingalindelekanga.
| UBreo | Idilesi | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Nasopharyngitis | Ewe | 9% | Ewe | 5% |
| Usulelo oluphezulu lokuphefumula | Ewe | 7% | Ewe | 21-27% |
| I-thrush yomlomo | Ewe | 5% | Ewe | 1-4% |
| Intloko ebuhlungu | Ewe | 7% | Ewe | 12% |
| Pharyngitis | Ewe | Mbini% | Ewe | 10-13% |
| Isicaphucaphu, ukugabha, urhudo | Hayi | - | Ewe | 4% |
Umthombo: Yonke imihla (Breo) , Yonke imihla (Advair)
Ukudibana kweziyobisi kweBreo vs.Advair
Ngenxa yokuba uBreo noAdvair bobabini baqulathe i-fluticasone, kunye ne-LABA, banoluhlu olufanayo lokunxibelelana kweziyobisi. Amachiza athile abizwa ngokuba yi-CYP3A4 inhibitors, asebenzisana noBreo kunye neAdvair ngokwandisa amanqanaba amayeza. I-anti-depressants ethile kudidi lwe-MAO inhibitor efana ne-selegiline, i-Eldepryl, i-rasagiline, okanye i-Azilect, nakwi-tricyclic yodidi loxinzelelo- i-amitriptyline, i-Elavil, i-nortriptyline okanye i-Pamelor, ikwasebenzisana no-Breo no-Advair. I-Beta blockers, ezinje nge-metoprolol okanye i-atenolol, i-loop diuretics efana ne-furosemide, kunye ne-thiazide diuretics efana ne-hydrochlorothiazide, nayo iyadibana neBreo okanye i-Advair.
| Iziyobisi | Iklasi yeziyobisi | UBreo | Idilesi |
| Ketoconazole Ritonavir Clarithromycin Ukudibana Indinavir I-Nefazodone nabanye | CPY3A4 inhibitors | Ewe | Ewe |
| Selegiline I-Rasagiline | I-MAOI (monoamine oxidase inhibitor) | Ewe | Ewe |
| Amitriptyline Umgca weNortriptyline | I-Tricyclic yoxinzelelo | Ewe | Ewe |
| Imitha Atenolol nabanye | Ibhlokhi yeBeta | Ewe | Ewe |
| Furosemide IHydrochlorothiazide | I-Loop okanye i-thiazide diuretics | Ewe | Ewe |
Izilumkiso zeBreo vs Advair
Omabini la machiza eza kunye noluhlu olude lwezilumkiso.
- I-Breo okanye i-Advair ayifanele iqalwe kwisiqendu esisongela ubomi seCOPD okanye i-asthma.
- Ukuthintela ukugqithisa, i-Breo okanye i-Advair kufuneka isetyenziswe njengoko kuyalelwa ngugqirha, kwidosi emiselweyo, kwaye akufuneki ithathwe nenye i-LABA.
- Hlamba kwaye uchithe ngamanzi emva kwethamo ngalinye leBreo okanye leAdvair ukunqanda i-thrush yomlomo (igwele).
- Ukubeka iliso kumngcipheko wenyumoniya.
- Izigulana ezinamajoni omzimba acinezelweyo ngenxa yeemeko ezithile zonyango okanye amayeza asemngciphekweni omkhulu wosulelo xa uthatha iBreo okanye iAdvair.
- Sebenzisa isilumkiso xa uhambisa isigulana kwi-steroids yomlomo (njenge-prednisone) ukuya eBreo okanye kwiAdvair.
- Izigulana kufuneka zijongwe ngononophelo kwiimpawu zenkqubo yokufakwa kwe-steroid, enje nge-hypercorticism kunye noxinzelelo lwe-adrenal xa uthatha iBreo okanye iAdvair.
- I-Breo okanye i-Advair inokukhokelela ekusongeleni ubomi nge-bronchospasm ephikisayo (indlela yokuphefumla yomoya). Ukuba oku kuyenzeka, isigulana kufuneka siphathwe nge-bronchodilator emfutshane.
- I-LABA inokubangela ukwanda kwenqanaba lokubetha okanye uxinzelelo lwegazi, kunye ne-arrhythmias yentliziyo. Sebenzisa ngononophelo kwizigulana ezinengxaki yentliziyo.
- Ukusetyenziswa kwexesha elide kwe-ICS kunokukhokelela kumngcipheko okhulayo wokuqhekeka, kunye ne-glaucoma kunye ne-cataract.
- Ukujonga ukwanda kweswekile yegazi kunye nokuhla kwe potassium.
- Ukujonga ukukhula kubantwana nakwishumi elivisayo.
- Ukujonga ukuphendula ngokukhawuleza kwe-hypersensitivity (ukurhawuzelela, i-angioedema, irhashalala, ukukhohlela, uxinzelelo lwegazi), kubandakanya i-anaphylaxis. Izigulana ezinobunzima obuninzi beeprotheyini zobisi akufuneki zisebenzise iBreo okanye iAdvair.
- I-Advair kufuneka isetyenziswe ngononophelo kwizigulana ezineengxaki ezithile zokuxhuzula okanye i-thyrotoxicosis.
Akukho zifundo zaneleyo, ezilawulwa kakuhle zeBreo kunye neAdvair kwabasetyhini abakhulelweyo. Iyeza kufuneka lisetyenziswe kuphela ngexesha lokukhulelwa ukuba isibonelelo sikamama sigqithile kumngcipheko wosana olungekazalwa, kwaye ngemvume kagqirha wakho kuphela. Ukuba sele uthabathe iBreo okanye iAdvair kwaye ufumanisa ukuba ukhulelwe, nxibelelana nomboneleli wakho wezempilo.
Imibuzo ebuzwa rhoqo malunga neBreo vs Advair
Yintoni uBreo?
IBreo iqulethe i-ICS kunye ne-LABA kwaye isetyenziselwa ukunyanga abaguli abane-COPD okanye i-asthma. Isetyenziswa kanye ngemini kwaye inokusetyenziswa kwizigulana ezineminyaka eli-18 nangaphezulu.
Yintoni iAdvair?
I-Advair iqulethe i-ICS kunye ne-LABA kwaye isetyenziselwa ukunyanga abaguli abane-COPD okanye i-asthma. Isetyenziswa kabini ngemini kwaye inokusetyenziswa kwizigulana ezineminyaka emi-4 nangaphezulu.
Ngaba iBreo vs Advair iyafana?
Omabini la machiza ane-ICS efanayo (i-fluticasone) kunye ne-LABA. I-LABA eBreo ibizwa ngokuba yi-vilanterol kunye ne-LABA e-Advair ibizwa ngokuba yi-salmeterol. Omabini la machiza ayafana kodwa aneeyantlukwano ezithile. Umzekelo, iAdvair isetyenziswa kabini yonke imihla, ngelixa iBreo isetyenziswa kube kanye yonke imihla.
Ngaba iBreo vs Advair ibhetele?
Oko kuxhomekeke. Izigulana ezininzi zibona ukuphuculwa kweempawu ngamanye amayeza. Ugqirha wakho unokukunceda uthathe isigqibo sokuba ngaba iBreo okanye iAdvair sisiyobisi esifanelekileyo kuwe.
Ngaba ndingayisebenzisa iBreo vs.Advair ngelixa ndikhulelwe?
Ngenxa yokuba uBreo no-Advair bengakhange bavavanywe kwabasetyhini abakhulelweyo, sebenzisa kuphela iyeza ngokufumana imvume kugqirha wakho ukuba uthatha isigqibo sokuba isibonelelo singaphezulu komngcipheko. Ukuba sele usebenzisa uBreo okanye iAdvair kwaye ufumanisa ukuba ukhulelwe, nxibelelana nogqirha wakho ngengcebiso yezonyango.
Ngaba ndingayisebenzisa iBreo vs.Advair ngotywala?
Ulwazi lomenzi we UBreo kwaye Idilesi ayithethi ngotywala. Nxibelelana nomboneleli wakho wezempilo ukuze akukhokele.
Usebenza njani amayeza okuthintela isifuba?
I-ICS eBre naseAdvair inceda ukunciphisa ukudumba kwimiphunga yakho, ngelixa i-LABA ihlaziya izihlunu kwaye ivule iindlela zomoya. Ngokwenza njalo, isifo sakho se-asthma okanye seCOPD kufuneka siphucule.
Ngaba iBreo ibiza kakhulu kuneAdvair?
Kuxhomekeke kwisicwangciso sakho seinshurensi. Ixabiso likaBreo xa kuthelekiswa neAdvair liyafana. Ungagcina imali ngokusebenzisa amatikiti omenzi okanye ukukhangela i-SingleCare.com yamakhuphoni.
Ngaba iBreo kunye neSimboli yinto enye?
IBreo kunye neSymbicort ziyafana. IBreo iqulethe i-ICS fluticasone kunye ne-LABA vilanterol. I-Symbicort ikwanayo ne-ICS, ebizwa ngokuba yi-budesonide, kunye ne-LABA, ebizwa ngokuba yi-formoterol.
Wenza ntoni uBreo kwimiphunga yakho?
I-ICS eBreo inceda ukunciphisa ukudumba emiphungeni, ngelixa i-LABA inceda ukukhulula izihlunu kunye nokuvula iindlela zomoya. Oku kuya kunceda ukuphucula iimpawu ze-asthma okanye i-COPD.
Yiyiphi inhaler efaniswa neAdvair?
I-Dulera (mometasone / formoterol), iSymbicort (budesonide / formoterol), kunye neBre (fluticasone / vilanterol) zonke ziyafana neAdvair. Onke la mayeza ane-ICS kunye ne-LABA.
