ILosartan vs. lisinopril: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango iphathwe | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
Ukuba ungomnye wezigidi ezili-103 zaseMelika igazi elonyukayo , ugqirha wakho usenokukhankanya ukuqala kwakho kumayeza ukunciphisa uxinzelelo lwegazi. ILosartan kunye ne-lisinopril ngamachiza amayeza enziwe afana nalawo enziwe ngumenzi asetyenziselwa ukunyanga uxinzelelo lwegazi ( uxinzelelo lwegazi ). ILosartan yi-angiotensin II receptor blocker (ARB) kunye lisinopril i-angiotensin-eguqula i-enzyme inhibitor (i-ACE inhibitor).
Omabini la machiza asebenza kwinxalenye yomzimba ebizwa ngokuba yinkqubo ye-renin-angiotensin kodwa ngeendlela ezahlukeneyo. Kwinkqubo ye-renin-angiotensin, i-ACE inhibitors ibhloka into ebizwa ngokuba yi-angiotensin II ekubeni yenziwe. I-Angiotensin II inciphisa imithambo yegazi kwaye inyuse uxinzelelo lwegazi, ke ngokuthintela ukuveliswa kwe-angiotensin II, uxinzelelo lwegazi luyathotywa. Ii-ARBs zithintela i-angiotensin II ukusuka ekubophelelweni ukuya kwii-receptors, ngaloo ndlela kuncitshiswa uxinzelelo lwegazi.
Leliphi umahluko ophambili phakathi kwelosartan kunye ne-lisinopril?
ILosartan yi-ARB, efumaneka ngegama lophawu kunye nefomathi yethebhulethi, njengeCozaar (okanye iHyzaar xa idityaniswe nehydrochlorothiazide, isisu esidla ngokufinyezwa njenge-HCTZ). Amanqanaba edosi aqhelekileyo ukusuka kwi-25 mg ukuya kwi-100 mg yonke imihla.
I-Lisinopril yi-ACE inhibitor efumaneka kwifomathi yetafile ngamagama e-Prinivil okanye iZestril (okanye iZestoretic xa idityaniswe ne-HCTZ). Ikwafumaneka njengesisombululo somlomo esibizwa ngokuba yiQbrelis. Amanqanaba edosi aqhelekileyo ukusuka kwi-5 mg ukuya kwi-40 mg yonke imihla.
ZIQHELEKILEYO: Iinkcukacha zeLosartan | Iinkcukacha zeLisinopril
| Umahluko ophambili phakathi kwelosartan kunye ne-lisinopril | ||
|---|---|---|
| ILosartan | Lisinopril | |
| Iklasi yeziyobisi | I-Angiotensin receptor blocker (i-ARB) | Isithintelo se-ACE |
| Uhlobo lweBrith / generic | Brand kunye generic | Brand kunye generic |
| Ngubani igama lophawu? | Cozaar IHyzaar (losartan / HCTZ) | Prinivil Zestril Qbrelis (isisombululo somlomo) IZestoretic (lisinopril / HCTZ) |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi (iyodwa kwaye idityaniswe ne-HCTZ) | Ithebhulethi (iyodwa kwaye idityaniswe ne-HCTZ) |
| Ithini idosi esemgangathweni? | 25 ukuya kwi-100 mg yonke imihla | 5 ukuya kuma-40 mg yonke imihla |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide | Ixesha elide |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala, abantwana (kuxhomekeke kwisalathiso) | Abantu abadala, abantwana (kuxhomekeke kwisalathiso) |
Ngaba ufuna elona xabiso lilungileyo kwi-lisinopril?
Bhalisela izilumkiso zamaxabiso e-lisinopril kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Iimeko eziphathwe yi-losartan vs. lisinopril
ILosartan ibonakalisiwe kunyango lwexinzelelo (i-HTN), okanye uxinzelelo lwegazi. Isetyenziselwa ukunciphisa umngcipheko wokubetha kwizigulana ezinexinzelelo oluphezulu lwegazi kunye ne-ventricular hypertrophy, kwaye ikwasetyenziselwa ukunyanga isifo sikashukela kwizigulana ezithile.
I-Lisinopril ibonakalisiwe kunyango lwe-HTN, njengonyango olongezelelekileyo ekusileleni kwentliziyo, kunye nokuphucula ukusinda emva kokuhlaselwa sisifo sentliziyo.
Omabini la machiza anokusebenzisa iilebheli ezingekhoyo, ezichazwe apha ngezantsi.
| Imeko | ILosartan | Lisinopril |
| Unyango lwexinzelelo lwegazi (HTN) | Ewe | Ewe |
| Ukunciphisa umngcipheko wokubetha kwizigulana ezine-HTN kunye ne-ventricular hypertrophy (LVH) | Ewe | Ngaphandle kwelebheli |
| Unyango lwe-nephropathy yeswekile kunye ne-serum creatinine ephezulu kunye neproteinuria kwizigulana ezinesifo seswekile 2 kunye nembali ye-HTN | Ewe | Ngaphandle kwelebheli |
| Unyango olongezelelekileyo kulawulo lokusilela kwentliziyo kwizigulana ezingaphenduli ngokwaneleyo kwi-diuretics nakwi-digitalis | Ngaphandle kwelebheli | Ewe |
| Unyango lwezigulana ezizinzileyo emzimbeni ngaphakathi kweeyure ezingama-24 ze-myocardial infarction (MI) yokuphucula ukusinda | Ngaphandle kwelebheli | Ewe |
| Ukungaphumeleli kwentliziyo ngamaqhekeza ancitshisiweyo | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| IMarfan syndrome ukunciphisa izinga lokunyuka kwe-aortic | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| Ulawulo lwezigulana ezingenasifo se-ST-elevation acute coronary syndrome | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| Abamkeli bezintso zokufakelwa | Ngaphandle kwelebheli | Ngaphandle kwelebheli (kwizigulana ezine-erythrocytosis yasemva kokufakelwa) |
| Izigulana ezinesifo sezintso esinganyangekiyo | Ngaphandle kwelebheli (kwizigulana ezinesifo seswekile) | Ngaphandle kwelebheli (kwisifo seswekile okanye kwizigulana ezinesifo seswekile) |
| Isifo somthambo ozinzileyo | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
Ngaba i-losartan okanye i-lisinopril iyasebenza ngakumbi?
Kuphononongo lwezifundo ezingama-61 ngokuthelekisa ii-ARBs (kubandakanya i-losartan) ne-ACE inhibitors (kubandakanya i-lisinopril), omabini la manqanaba eziyobisi afunyenwe ene iimpembelelo ezifanayo zexesha elide uxinzelelo lwegazi. Ababhali baphinde bagqiba kwelokuba zombini iiklasi zamachiza anefuthe elilinganayo ekufeni, kwizigulo zentliziyo, kwiziganeko ezimbi, umgangatho wobomi, kunye nemingcipheko enje ngamanqanaba eepidid, isifo seswekile, kunye nobunzima kunye nomsebenzi.
Kwincinci ukufunda yezigulane ezinezifo zezintso, i-losartan kunye ne-lisinopril zineempembelelo ezifanayo ekusebenzeni kwezintso kunye noxinzelelo lwegazi.
Olona nyango lusebenzayo kuwe kufuneka luchongwe ngugqirha wakho, onokuthi ajonge umfanekiso opheleleyo weemeko zakho zonyango, ezembali, kunye namanye amayeza owathathayo.
Umgangatho kunye nokuthelekiswa kweendleko ze-losartan vs. lisinopril
Zombini i-losartan kunye ne-lisinopril zigutyungelwe yi-inshurensi kunye ne-Medicare Icandelo D kwifom yesiqhelo. Iinguqulelo zamagama ebhrendi zinokugqunywa kwikopi ephezulu. Iindleko zokuphuma epokothweni kwiipilisi ezingama-30 ze-losartan 100 mg zinokuhla ukusuka kwi- $ 28- $ 70, kwaye i-Medicare Part D copay imalunga ne- $ 0- $ 13. Ngekhuphoni ye-SingleCare, uluhlu lwamaxabiso yi- $ 9- $ 16 kuxhomekeke kwikhemesti ethatha inxaxheba. Iindleko ezingaphandle kweepokotho zeepilisi ezingama-30 ze-lisinopril ye-10 mg imalunga ne- $ 15, kwaye i-Medicare Part D copay imalunga ne- $ 0- $ 7. Ungagcina imali kwi-lisinopril ngokusebenzisa ikhadi lesaphulelo elilodwa okanye isigqebhezana.
Zama ikhadi lesaphulelo somntu ongatshatanga
| ILosartan | Lisinopril | |
| Ngokuqhelekileyo i-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo igutyungelwe yiMedicare? | Ewe | Ewe |
| Umthamo osemgangathweni | # 90, 100 iipilisi mg | # 90, 20 iipilisi mg |
| I-Medicare copay eqhelekileyo | $ 0- $ 13 | $ 0- $ 7 |
| Ixabiso elilodwa | $ 28- $ 70 | $ 9- $ 26 |
Iziphumo eziqhelekileyo ezichaphazelekayo ze-losartan vs. lisinopril
Iziphumo eziqhelekileyo ezichaphazelekayo ze-losartan zibandakanya ukukhwehlela, ukuxakeka, ukusuleleka kwintsholongwane, ukukhathala, kunye nesifo sohudo.
Iziphumo eziqhelekileyo ezichaphazelekayo ze-lisinopril zibandakanya ukukhwehlela, ukuxakeka, intloko, ukukhathala, kunye nesifo sohudo.
Ezinye iziphumo ebezingalindelekanga zinokwenzeka. Nxibelelana noochwepheshe bezonyango ukuze ufumane uluhlu olupheleleyo lweziphumo ebezingalindelekanga.
| ILosartan | Lisinopril | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Khohlela | Ewe | 17-29% | Ewe | 3.5-69% |
| Ukuba nesiyezi | Ewe | 3% | Ewe | 5.4% |
| Ukuphefumla okuphezulu usulelo | Ewe | 8% | Ewe | 2.1% |
| Ukuxinana kwempumlo | Ewe | Mbini% | Ewe | 0.4% |
| Umqolo obuhlungu | Ewe | Mbini% | Hayi | - |
| Ukudinwa | Ewe | > 4% | Ewe | 2.5% |
| Urhudo | Ewe | > 4% | Ewe | 2.7% |
| Isicaphucaphu | Ewe | Akuxelwanga | Ewe | Mbini% |
| Intloko ebuhlungu | Ewe | Akuxelwanga | Ewe | 5.7% |
Umthombo: Mihla le (losartan) , Mihla le (lisinopril)
Ukudibana kweziyobisi ne-losartan vs. lisinopril
ILosartan okanye i-lisinopril akufuneki isetyenziswe ne-potassium okanye amanye amayeza anyusa i-potassium (njenge-potassium-sparing diuretics), ngenxa yomngcipheko we-hyperkalemia. Ukongeza, buza ugqirha wakho malunga ne-potassium ekudleni kwakho kwaye ukuba kufuneka uphephe ukutya okune-potassium kunye neetyuwa ezithatha indawo ye potassium.
Ii-NSAID (iziyobisi ezichasayo ezingasebenziyo) akufuneki zisetyenziswe ngokudibeneyo ne-losartan okanye i-lisinopril, kuba indibaniselwano inokubangela ukulimala kwezintso okanye ukusilela kwezintso.
ILosartan okanye i-lisinopril akufuneki isetyenziswe ngokudibeneyo nenye i-ACE inhibitor, i-ARB, okanye iTekturna (aliskiren) kuba indibaniselwano inyusa umngcipheko wexinzelelo lwegazi, i-potassium ephezulu, ukuphelelwa ngamandla, ukonakala kwezintso, okanye ukusilela kwezintso.
Nxibelelana nomboneleli wakho wezempilo uluhlu olupheleleyo lokudibana kwamachiza.
| Iziyobisi | Iklasi yeziyobisi | ILosartan | Lisinopril |
| Potassium | Umbane | Ewe | Ewe |
| Midamor (amiloride) IAldactone (spironolactone) IDyrenium (itramamterene) I-Inspra (eplerenone) | I-Potassium-yokuthintela i-diuretics | Ewe | Ewe |
| I-Aspirin Imotrin, Advil (ibuprofen) I-Aleve (naproxen) Imobic (meloxicam) ICelebrex (celecoxib) Ukuhlaziya (nabumetone) | Ii-NSAID | Ewe | Ewe |
| IVasotec (enalapril) ILotensin (benazepril) I-Accupril (quinapril) Indawo (ramipril) | I-ACE inhibitors | Ewe | Ewe |
| UDiovan (valsartan) Edarbi Ukuhlaselwa (candesartan) I-Avapro (irbesartan) IMicardis (itelmisartan) IBenicar (olmesartan) | IiARBs | Ewe | Ewe |
| I-Tekturna (aliskiren) | I-Renin inhibitor | Ewe | Ewe |
| ILithium | Ummeli we-Antimanic | Ewe | Ewe |
Izilumkiso zelosartan kunye ne-lisinopril
I-Losartan kunye ne-lisinopril bobabini beza nesilumkiso esinebhokisi, esisilumkiso esomeleleyo njengoko kufunwa yi-FDA. Iziyobisi (ezinje nge-losartan kunye ne-lisinopril) ezisebenza kwinkqubo ye-renin-angiotensin inokubangela ukonzakala komntwana / iziphene zokuzalwa okanye ukufa kwaye kufuneka kuyekwe ukukhulelwa.
Ezinye izilumkiso ezisebenza kwi-losartan kunye ne-lisinopril:
- Izigulana eziphelelwe ngamanzi emzimbeni okanye ezithatha i-diuretics zinokuphuhlisa uxinzelelo lwegazi (hypotension).
- Utshintsho ekusebenzeni kwezintso, kubandakanya ukusilela okukhulu kwezintso, kunokwenzeka. Umngcipheko uphezulu kwizigulana ezinengxaki yezintso okanye ukusilela kwentliziyo kakhulu. Ezi zigulana zisenokungabi ngumgqatswa we-ACE inhibitor okanye i-ARB. Ukuba elinye lala machiza liqalisiwe, umsebenzi wezintso kufuneka ubekwe esweni.
- Amanqanaba ePotassium kufuneka abekwe esweni.
ILisinopril inezilumkiso ezongezelelweyo:
- Kukho ukubakho kwempendulo ye-anaphylactic (ukusabela okungathethekiyo komzimba), kubandakanya i-angioedema (ukudumba) kobuso, imiphetho, imilebe, ulwimi, ulwimi, i-glottis, kunye / okanye ingqula. Le mpendulo inokwenzeka nanini na ngexesha lonyango. I-Angioedema enxulunyaniswa ne-edema yelaryngeal inokubulala. Apho kukho ukubandakanyeka kolwimi, i-glottis okanye i-larynx, enokubangela ukuphazamiseka kwomoya, unyango olungxamisekileyo luyimfuneko. I-Lisinopril kufuneka iyekwe ukuba ezi mpendulo zenzeka.
- Kukho umngcipheko omncinci weengxaki zesibindi; ii-enzyme zesibindi kufuneka zibekwe esweni.
- Ngenxa yokonakala kwento ebizwa ngokuba yi-bradykinin, kukho ukukhohlela okomileyo. Xa iyeza limisiwe, ukukhohlela kufuneka kumke.
Imibuzo ebuzwa rhoqo malunga nelosartan kunye ne-lisinopril
Yintoni ilosartan?
ILosartan yi-angiotensin receptor blocker enceda uxinzelelo lwegazi. Ingasetyenziselwa iimeko ezahlukeneyo, ezichazwe apha ngasentla.
Yintoni ilisinopril?
I-Lisinopril yi-ACE inhibitor enceda uxinzelelo lwegazi. Isetyenziselwa nezinye iimeko zonyango, ezichazwe apha ngasentla.
Ngaba i-losartan vs. lisinopril iyafana?
Nangona omabini la mayeza esebenza kwinkqubo ye-renin-angiotensin, ayasebenza kwiindawo ezahlukeneyo zenkqubo, kodwa omabini la mayeza athoba uxinzelelo lwegazi kwaye asetyenziselwa ezinye iimeko zentliziyo okanye izintso. Banokwahluka ngokwedosi, izilumkiso, kunye nexabiso.
Ezinye i-ACE inhibitors (njenge-lisinopril) usenokuva malunga neLotensin (benazepril), iVasotec (enalapril), iAccupril (quinapril), kunye neAltace (ramipril).
Ezinye ii-ARBs (ezinjenge-losartan) osenokuba ukhe weva ngazo zibandakanya i-Edarbi (azilsartan - akukho generic ekhoyo), Atacand (candesartan), Avapro (irbesartan), Micardis (telmisartan), Diovan (valsartan), kunye neBenicar (olmesartan).
Ngaba i-losartan okanye i-lisinopril ingcono?
Izifundo zibonise ii-ARBs ezifana ne-losartan kunye ne-ACE inhibitors njenge lisinopril ukuba neziphumo ezifanayo. Qhagamshelana nomboneleli wakho wezempilo ukuba ubone ukuba elinye lala mayeza likulungele.
Ndingayisebenzisa ilosartan okanye i-lisinopril ngelixa ndikhulelwe?
ILosartan okanye i-lisinopril akufuneki ithathwe ngelixa ukhulelwe. Omabini la machiza ayingozi kwimveku esakhulayo kwaye kunokubangela iziphene ezinzulu zokuzalwa okanye nokufa emntwaneni. Ukuba sele uthatha i-losartan okanye i-lisinopril kwaye ufumanisa ukuba ukhulelwe, nxibelelana nogqirha wakho ngokukhawuleza.
Ndingayisebenzisa i-losartan okanye i-lisinopril ngotywala?
Ukusela utywala ngelixa uthatha i-losartan okanye i-lisinopril kunokunyusa isiyezi, okanye kuchaphazele uxinzelelo lwegazi okanye ezinye iimeko zonyango. Qhagamshelana nogqirha wakho malunga nokusetyenziswa kotywala kunye ne-losartan okanye i-lisinopril.
Ngaba kufuneka ndithathe i-lisinopril kunye ne-losartan kunye?
Hayi. Nangona amanye amayeza oxinzelelo lwegazi esetyenziswa ngokudibeneyo (njenge-losartan okanye i-lisinopril ngokudibanisa ne-diuretic), i-lisinopril kunye ne-losartan akufuneki zithathwe kunye. Ukwenza njalo kwandisa umngcipheko wexinzelelo lwegazi, i-potassium ephezulu, kunye nokulimala kwizintso, ezinokuba zibi kakhulu okanye zibulale.
Ngaba i-losartan yi-ACE inhibitor okanye ibeta blocker?
ILosartan yi-angiotensin receptor blocker. Ayisiyo i-ACE inhibitor okanye ibeta blocker.
Ngaba i-losartan ibangela iziphumo ebezingalindelekanga ezimbalwa kune-lisinopril?
Omabini la machiza aneziphumo ebezingalindelekanga ezifanayo, nangona i-lisinopril inokubangela ukukhohlela okomileyo kwaye inobungozi be-angioedema (ukusabela okungalunganga). Nxibelelana neengcali zonyango lwakho uluhlu olupheleleyo lweziphumo ebezingalindelekanga.
