Eyona >> Iziyobisi Vs. Umhlobo >> I-Protonix vs. Nexium: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

I-Protonix vs. Nexium: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

Iziyobisi Vs. Umhlobo

I-Protonix (pantoprazole) kunye ne-Nexium (esomeprazole) ngamayeza amabini asetyenziselwa ukunyanga iingxaki zendlela yokwetyisa, enje ngesifo se-reflux se-gastroesophageal (GERD). I-GERD yimeko engapheliyo ekhulayo xa isisu esiswini sihamba rhoqo sibuyele kwisisu esiswini. Oku kunokukhokelela kwiimpawu ezinje ngokuqaqamba kwentliziyo kunye neengxaki ezinzima ezinjenge-esophagitis erosive.

Zombini iProtonix kunye neNexium ziyinxalenye yeklasi yeziyobisi ebizwa ngokuba yiproton pump inhibitors (PPIs). Basebenza ngokuthintela iimpompo zeproton esiswini, ezinoxanduva lokuvelisa iasidi. Ngokwenyani, iProtonix kunye neNexium zinceda ukunciphisa imveliso yeasidi esiswini.

Nguwuphi umahluko ophambili phakathi kweProtonix neNexium?

Iprotonix, eyenziwe yiPfizer, ligama lophawu lwepantoprazole. Iyeza lonyango elisetyenziselwa ukunyanga isifo se-esophagitis kubantu abadala kunye nabantwana abaneminyaka emi-5 nangaphezulu. Iyafumaneka njenge-20 mg kunye ne-40 mg yokukhutshwa kwethebhulethi yokukhululwa, kunye nokumiswa okungamanzi okungama-40 mg. Ngamanye amaxesha, iProthonix inokuthi ilawulwe ngenaliti efakwa ngaphakathi (IV).

I-Nexium yenziwa yi-AstraZeneca kwaye ligama lophawu lwe-esomeprazole. Iyafumaneka njengesiyobisi okanye i-OTC) esetyenziselwa ukunyanga i-GERD kubantu abadala, ebantwaneni, nakwiintsana ezineminyaka eyi-1 nangaphezulu. Ngokungafaniyo neProtonix, i-Nexium iza njenge-20 mg kunye ne-40 mg yokulibaziseka kokukhupha iphilisi. I-Nexium ikwafumaneka njenge-2.5 mg, 5 mg, 10 mg, 20 mg, kunye ne-40 mg yokumiswa kolwelo.

Umahluko ophambili phakathi kweProtonix kunye neNexium
	IProtonix	Nexium
Iklasi yeziyobisi	Iproton pump inhibitor (PPI)	Iproton pump inhibitor (PPI)
Uhlobo lweBrith / generic	Ibhranti kunye nohlobo oluqhelekileyo olukhoyo	Ibhranti kunye nohlobo oluqhelekileyo olukhoyo
Ngubani igama eliqhelekileyo?	IPantoprazole	Esomeprazole
Zeziphi iifom eza nalo iziyobisi?	Ithebhulethi yokukhululwa ngokukhawuleza Ipakethi yegranules yokumiswa kolwelo Umgubo efakwa yenaliti	Iphilisi ekhutshiweyo yokukhululwa Ipakethi yegranules yokumiswa kolwelo Umgubo efakwa yenaliti
Ithini idosi esemgangathweni?	40 mg kanye yonke imihla	I-20 okanye i-40 mg kanye yonke imihla
Lude kangakanani unyango oluqhelekileyo?	Ukuya kuthi ga kwiiveki ezisibhozo	Iiveki ezi-4 ukuya kwezi-8 kuxhomekeke kwimeko yokunyangwa
Ngubani oqhelekileyo usebenzisa amayeza?	Abantu abadala nabantwana abaneminyaka emi-5 nangaphezulu	Abantu abadala, abantwana, kunye neentsana abaneminyaka e-1 nangaphezulu ubudala

Iimeko eziphathwe yiProtonix kunye neNexium

I-Protonix kunye ne-Nexium zinganyanga zombini i-GERD kunye neemeko ezinxulumene ne-GERD, enjenge-acid reflux (ukubola kwentliziyo). Omabini la mayeza akwamkelwe njenge-FDA ukunyanga i-esophagitis erosive, okanye ukudumba kwebala lomphetho.

I-Nexium ikwayi-FDA evunyiweyo ukunyanga usulelo lwe-Helicobacter pylori (H. pylori). Olu hlobo losulelo luyenzeka xa iH.pylori ibacteria ichaphazela indlela yokugaya, enokukhokelela kwizilonda. Ukongeza kwizilonda ezibangelwa nguH. Pylori, i-Nexium inokuthintela umngcipheko wezilonda ezinxulunyaniswa ne-nonsteroidal anti-inflammatory drug (NSAIDs).

Zombini i-Protonix kunye ne-Nexium zingasetyenziselwa ukunyanga iimeko ezi-hypersecretory, ezinje nge-Zollinger-Ellison syndrome. Ezi meko zibonakaliswa kukuveliswa okungaphezulu kwesisu esiswini. Iprotonix neNexium inokusetyenziselwa ukunyanga izilonda zep peptic, ezibandakanya zombini izilonda zesisu kunye nesisu.

I-Protonix kunye ne-Nexium zinconyelwa kuphela ukusetyenziswa kwexesha elifutshane, okanye ukuya kuthi ga kwiiveki ezisibhozo kwiimeko ezininzi.

Imeko	IProtonix	Nexium
Isifo se-reflux sesifo se-Gastroesophageal (GERD)	Ewe	Ewe
Ukuqhaqha kwesisu	Ewe	Ewe
Iimeko Hypersecretory	Ewe	Ewe
H. pylori usulelo	Ngaphandle kwelebheli	Ewe
Ukuncitshiswa komngcipheko wezilonda zesisu ezinxulumene ne-NSAID	Ngaphandle kwelebheli	Ewe
Izilonda zesisu	Ngaphandle kwelebheli	Ngaphandle kwelebheli
Izilonda esiswini	Ngaphandle kwelebheli	Ngaphandle kwelebheli
Isitshisa	Ngaphandle kwelebheli	Ewe

Ngaba iProtonix okanye iNexium isebenza ngakumbi?

Uvavanyo lweklinikhi lubonakalisile ukuba i-pantoprazole kunye ne-esomeprazole ziyasebenza ngokufanayo. Uvavanyo olunye lweklinikhi uthelekise ukusebenza I-40 mg ye-pantoprazole ukuya kwi-40 mg ye-esomeprazole kwizigulana ezine-GERD. Ngokumalunga nezigulana ezingama-580 zazingenamkhethe ukuba zifumane i-pantoprazole okanye i-esomeprazole ngaphezulu kweeveki ezi-4, 8, okanye ezili-12 zonyango. Ukuxolelwa ngokupheleleyo kwe-GERD kwafezekiswa ngazo zombini ii-PPI ngamaxabiso afanayo.

Kuvavanyo lweklinikhi olungenamsebenzi, oluyimfama, ukusebenza kwe-pantoprazole kunye ne-esomeprazole kwafaniswa nokunyanga i-GERD. Phantse abaguli abangama-200 babekhethiwe ukufumana i-40 mg ye-pantoprazole yonke imihla okanye i-40 mg ye-esomeprazole yonke imihla. Zombini ii-PPI zafunyanwa zinjalo ngokusebenza ngokulinganayo ngokhuseleko kunye nokunyamezeleka.

Nxibelelana nomboneleli wezempilo ukuze ufumane olona nyango lulungileyo. Umboneleli wakho wokhathalelo oluphambili unokukuthumela kugqirha ogxile kwi-gastroenterology ukuze ufumane ingcebiso yezonyango engaphezulu.

Ukufunda kunye nokuthelekisa iindleko kweProtonix vs. Nexium

Uninzi lwezonyango kunye nezicwangciso zeinshurensi ziya kugubungela uhlobo oluqhelekileyo lweProtonix, pantoprazole. Iikopi zokunyanga ngamayeza zingasukela kwi- $ 0 ukuya kwi-17 yeedola kwi-pantoprazole. Ngaphandle kwe-inshurensi, ixabiso lentengo eliphakathi kweProtonix li- $ 522. Nangona kunjalo, kunye neProtonix coupon evela kwi-SingleCare, iindleko zohlobo oluthile zimalunga ne- $ 11.

Ezinye ze-Medicare kunye nezicwangciso zeinshurensi zinokugubungela iNexium okanye uhlobo lwayo oluqhelekileyo, esomeprazole. Iikopi zokunyanga nge-Medicare ze-esomeprazole zingaqala kwi-1 ukuya kwi-41 yeedola. Ixabiso lentengiso le-Nexium ngama- $ 478 kuxhomekeke kubungakanani kunye namandla amiselweyo. Ngekhuphoni ye-SingleCare Nexium, amaxabiso aphakathi anokuncitshiswa aye kuthi ga kwi-27 yeedola.

	IProtonix	Nexium
Ngokuqhelekileyo ihlawulwa yi-inshurensi?	Ewe, njengohlobo oluqhelekileyo	Ewe, njengohlobo oluqhelekileyo
Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare?	Ewe, njengohlobo oluqhelekileyo	Ewe, njengohlobo oluqhelekileyo
Ubungakanani	Iipilisi ezingama-30 (40 mg)	Iipilisi ezingama-30 (40 mg)
I-Medicare copay eqhelekileyo	$ 0- $ 17	$ 1- $ 41
Ixabiso elilodwa	$ 11 +	$ 27 +

Iziphumo eziqhelekileyo ezichaphazelekayo zeProtonix vs. Nexium

Iziphumo zixhaphakileyo zeProtonix yintloko ebuhlungu, urhudo, isicaphucaphu, iintlungu zesisu, ukugabha, igesi, isiyezi kunye nentlungu edibeneyo.

Iziphumo eziqhelekileyo ezichaphazela i-Nexium zibandakanya intloko ebuhlungu, urhudo, isicaphucaphu, irhasi, iintlungu zesisu, ukuqunjelwa, kunye nomlomo owomileyo.

Iziphumo ebezingalindelekanga ezimandundu ze-PPIs zihlala zinxulunyaniswa nokusetyenziswa kwexesha elide. Iziphumo ebezingalindelekanga ezinzulu zinokubandakanya ukwaphuka kwamathambo okunxulumene ne-osteoporosis, ukusilela kwe-vitamin B12, kunye namanqanaba asezantsi e-magnesium (hypomagnesemia).

	IProtonix	Nexium
Imiphumela	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Intloko ebuhlungu	Ewe	12%	Ewe	≥1%
Urhudo	Ewe	9%	Ewe	≥1%
Ukuqunjelwa	Ewe	<2%	Ewe	≥1%
Umlomo owomileyo	Ewe	<2%	Ewe	≥1%
Isicaphucaphu	Ewe	7%	Ewe	≥1%
Intlungu yesisu	Ewe	6%	Ewe	≥1%
Ukuhlanza	Ewe	4%	Ewe	<1%
Ukuba nesiyezi	Ewe	3%	Ewe	<1%
Irhasi	Ewe	4%	Ewe	≥1%
Intlungu edibeneyo	Ewe	3%	Hayi	-

Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( IProtonix ), Yonke imihla ( Nexium )

Ukudibana kweziyobisi kweProtonix vs. Nexium

I-Protonix kunye ne-Nexium, njengezinye ii-PPI, zinxibelelana namanye amayeza afanayo. Ezi PPI kufuneka zibekwe esweni okanye zithintelwe ngamanye amachiza axhomekeke kubumuncu besisu ekufunxweni. Iziyobisi ezixhomekeke kwisisu esiswini sokufunxa zibandakanya iityiwa zentsimbi, i-erlotinib, i-ketoconazole, kunye ne-mycophenolate mofetil.

IProtonix neNexium zinokusebenzisana namachiza ee-antiretroviral, okanye amachiza ahlala esetyenziselwa ukunyanga i-HIV. Ii-PPI zinokunyusa okanye zinciphise amanqanaba egazi amachiza e-antiretroviral, anokukhokelela kumngcipheko okhulayo wetyhefu okanye ukunciphisa ukusebenza ngamachiza e-antiretroviral.

Ukusetyenziswa kweProtonix okanye i-Nexium ene-warfarin kunokunyusa umngcipheko wokopha.

I-Nexium kufuneka ijongwe okanye ithintelwe nge-diazepam kuba inokunyusa amanqanaba egazi e-diazepam kwaye ikhokelele kumngcipheko owandileyo weziphumo ezibi. Ukusetyenziswa kwe-Nexium kunye ne-clopidogrel ngokudibeneyo kufuneka kuthintelwe. I-Nexium inokunciphisa indlela esebenza ngayo i-clopidogrel emzimbeni, enokunyusa umngcipheko wamahlwili egazi.

Iziyobisi	Uhlobo lweziyobisi	IProtonix	Nexium
Atazanavir Rilpivirine UNelfinavir Saquinavir	IiNtsholongwane	Ewe	Ewe
Ketoconazole	Ukubola	Ewe	Ewe
Isanti sulphate Yentsimbi gluconate Yentsimbi fumarate	Ityiwa yentsimbi	Ewe	Ewe
IMycophenolate mofetil Imethotrexate	Ugonyo	Ewe	Ewe
Erlotinib	Unyango ngamayeza	Ewe	Ewe
I-Digoxin	Iglycoside yentliziyo	Ewe	Ewe
IWarfarin	I-Anticoagulant	Ewe	Ewe
Diazepam	Benzodiazepine	Hayi	Ewe
Clopidogrel	Antiplatelet	Hayi	Ewe

Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi

Izilumkiso zeProtonix kunye neNexium

Ukusetyenziswa kwexesha elide kwee-PPIs kunokukhokelela kumngcipheko okhulayo wokuqhekeka kwethambo, ngakumbi kubantu esele befumanekile ukuba bane-osteoporosis. Ukuxinana kwamaminerali amathambo kungafuna ukubekwa esweni ngexesha lonyango lwexesha elide nee-PPIs.

Abanye abaguli baye bafumana i-tubulointerstitial nephritis (TIN) ebukhali ngelixa bethatha iProtonix okanye iNexium. I-Nephritis kukudumba kwezintso, ezinokukhokelela ekunciphiseni ukusebenza kwezintso.

Ukusetyenziswa kwee-PPIs kunokunxulunyaniswa nomngcipheko owandayo wohudo olunxulumene neClostridium difficile. Abo bafumana urhudo oluqhubekayo banokufuna ukubekwa esweni, ngakumbi kwisibhedlele.

Ukuthatha iProtonix okanye i-Nexium kunokunyusa umngcipheko wamanqanaba egazi asezantsi e-magnesium (hypomagnesemia) okanye i-vitamin B12 (ukusilela kwe-vitamin B12). Kukho umngcipheko okhulayo we-hypomagnesemia kunye ne-vitamin B12 yokunqongophala kwabo kunyango lwexesha elide nee-PPIs.

Qhagamshelana nomboneleli wakho wezempilo malunga nezinye izilumkiso kunye nezilumkiso ngaphambi kokuba uthathe iPPI.

Imibuzo ebuzwa rhoqo malunga neProtonix vs. Nexium

Yintoni iProtonix?

Iprotonix yipilisi ye-PPI yonyango kuphela esetyenziselwa ukunyanga i-esophagitis erosive ehambelana neGERD. Iprotonix iyafumaneka njengepilisi ekhutshwe kade kunye nokumiswa kolwelo. Igama eliqhelekileyo leProtonix yi-pantoprazole.

Yintoni iNexium?

I-Nexium lunyango lwe-PPI olusetyenziselwa ukunyanga i-acid reflux kunye nesitshisa, kunye ne-esophagitis erosive ehambelana neGERD. Iyafumaneka ngugqirha okanye ikhawuntara. I-Nexium ubukhulu becala iza njengecapsule yokukhululwa okanye yokumiswa kolwelo. Igama eliqhelekileyo le-Nexium yi-esomeprazole.

Ngaba iProtonix kunye neNexium ziyafana?

Iprotonix kunye neNexium ngamayeza amabini e-PPI anokunyanga i-GERD, iimeko ze-hypersecretory, kunye ne-peptic ulcers. Nangona kunjalo, ziqukethe izinto ezahlukeneyo ezisebenzayo kwaye ziza ngeendlela ezahlukeneyo. Iprotonix iqulethe i-pantoprazole kunye ne-Nexium ine-esomeprazole. I-Protonix inokunyanga i-GERD kubantu abadala kunye nabantwana abaneminyaka emi-5 nangaphezulu ngelixa i-Nexium inokunyanga i-GERD kubantu abadala, abantwana, nakwiintsana ezinenyanga enye nangaphezulu.

Ngaba iProtonix okanye iNexium ingcono?

Iprotonix kunye neNexium ziyafana ngokusebenza. Eyona PPI ifanelekileyo iya kumiselwa ngokusekwe kubudala, imeko yezonyango, indleko, i-inshurensi, kunye namanye amayeza athathwayo.

Ndingayisebenzisa iProtonix okanye i-Nexium ngelixa ndikhulelwe?

I-Protonix okanye i-Nexium inokukhuseleka ukuyithatha ngelixa ukhulelwe. Nangona kunjalo, kufuneka zisetyenziswe kuphela ukuba izibonelelo zingaphezulu komngcipheko. Okwangoku, akukho zifundo zaneleyo zokubonisa ukuba iProtonix okanye iNexium ikhuseleke ngokupheleleyo ukuba isetyenziswe ngexesha lokukhulelwa. Nxibelelana nomboneleli wezempilo ngengcebiso yezonyango malunga nolona nyango lulungileyo lwe-GERD ngelixa ukhulelwe.

Ndingayisebenzisa iProtonix okanye i-Nexium ngotywala?

Ngelixa utywala bungaziwa ukuba budibane neProtonix okanye i-Nexium, bunokonyusa i-acid reflux kunye neempawu zokubetha kwentliziyo kwabanye abantu. Ukusetyenziswa kotywala kunokukhuseleka ngokumodareyitha ngelixa uthatha iProtonix okanye iNexium, kodwa ayikhuthazwa ngokubanzi.

Yeyiphi eyona proton pump inhibitor isebenzayo?

Eyona PPI isebenzayo iya kuxhomekeka kwimeko yokuphathwa, idosi ye-PPI, kunye namanye amayeza umntu anokuwathatha. Iindleko zePPI kufuneka zithathelwe ingqalelo xa kuthathwa eyona ndlela isebenzayo.

Ndingathatha ntoni endaweni yeNexium?

I-Nexium (esomeprazole) yiproton pump inhibitor. Ezinye ii-proton pump inhibitors zibandakanya i-Prilosec (omeprazole), i-Prevacid (lansoprazole), i-Aciphex (rabeprazole), kunye ne-Protonix (pantoprazole). Ukuba iimpawu ze-GERD aziphucuki nge-PPI, umboneleli wezempilo unokucebisa nge-H2 blocker iyeza endaweni yoko. Imizekelo ye-H2 blocker ibandakanya iPepcid (famotidine), iZantac (ranitidine), kunye neTagamet (cimetidine).

Ngaba i-Nexium ingayenza ngakumbi i-reflux?

I-Nexium isetyenziselwa ukunyanga i-acid reflux. Ukuyeka unyango lwe-Nexium kwangaphambi kokucetyiswa ngumboneleli wezempilo kunokukhokelela ekubuyisweni kweempawu ze-reflux. I-Nexium isenokungasebenzi ngokufanayo kuye wonke umntu. Ukuba iimpawu aziphucuki nge-Nexium, ezinye iindlela zonyango zinokucetyiswa.