Eyona >> Iziyobisi Vs. Umhlobo >> I-Estriol vs. estradiol: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

I-Estriol vs. estradiol: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

Iziyobisi Vs. Umhlobo

I-Estriol (E3) kunye ne-estradiol (E2) ziindlela ezimbini ezahlukeneyo zehomoni yabasetyhini eyaziwa ngokuba yi-estrogen (ngamanye amaxesha ibizwa ngokuba yi-estrogen). Ezi ntlobo ze-estrogen zihomoni ze-steroid ezifumaneka ngokwendalo emzimbeni. I-Estriol kunye ne-estradiol inokusetyenziswa njengonyango olubuyisela i-hormone (HRT) kubafazi emva kokuyeka ukuya exesheni.

I-Estriol kunye ne-estradiol zimbini zeendidi ezintathu ezahlukeneyo zehomoni ye-estrogen. Uhlobo lwesithathu lwe-estrogen yi-estrone (E1), eveliswa kwabasetyhini ngexesha lokuyeka ukuya exesheni kunye nabasetyhini abancinci abafumana amaxesha abo okuqala. I-Estrone ayisetyenziselwa i-HRT kuba ithathwa njenge-estrogen engenamandla.

I-Estrogens isebenza ngokuzibophelela ii-estrogen receptors (ERcy okanye ERβ) emzimbeni. Ngelixa iindawo zabo zinokugqobhoza, i-estrogen receptor alpha (ERcy) ifunyenwe ikakhulu kwi-endometrium, izicubu zamabele, kunye nee-ovari. I-Estrogen receptor beta (ERβ) ifumaneka kwezinye iindawo zomzimba ezinje ngengqondo, intliziyo, izintso, amathambo nemiphunga.

Yintoni umahluko ophambili phakathi kwe-estriol kunye ne-estradiol?

I-Estriol (i-Estriol coupons | iinkcukacha ze-Estriol) ngamanye amaxesha zibizwa ngokuba yi-E3 okanye i-oestriol. Yeyona fomu ibuthathaka ye-estrogen emzimbeni. Njenge-estrone, amanqanaba e-estriol ayanda ngokwendalo ngexesha lokukhulelwa. I-Estriol yi-FDA evunyiweyo yokungabikho komchamo kwizinja zabasetyhini emva kokususwa kwama-ovari kunye nesibeleko. I-Estriol ayivunyelwanga yi-FDA njengesiyobisi esinyanzelweyo abantu. Nangona kunjalo, ezinye iikhemesti ezixubileyo zingathengisa i-estriol edityaniswe nezinye iziyobisi.

I-Estradiol (i-Estradiol coupons | Iinkcukacha ze-Estradiol), okanye i-E2, yeyona nto inamandla kwezi estrogens zintathu. Ezinye iindlela ze-estradiol zinokufumaneka kwiipilisi zedosi esezantsi yolawulo lokuzalwa kwabafazi be-premenopausal. Isetyenziselwa ithebhulethi, isiziba, okanye ukhilimu kunyango lwe-estrogen. I-Estradiol inokufumaneka kwiimveliso ezivunyiweyo ze-FDA ezinje nge-Estrace, Vivelle-Dot, Vagifem, kunye neClimara, phakathi kwabanye. I-FDA ikwamkele i-estradiol kwi ihomoni ebonakalayo Unyango ngeprogesterone.

Umahluko ophambili phakathi kwe-estriol kunye ne-estradiol
	I-Estriol	I-Estradiol
Iklasi yeziyobisi	Estrogen	Estrogen
Uhlobo lweBrith / generic	Igeneric iyafumaneka	Igeneric iyafumaneka
Ngubani igama lophawu?	Incurin (izinja)	Umgca Vivelle-Dot IVagifem Climara
Zeziphi iifom eza nalo iziyobisi?	Ithebhulethi yomlomo I-cream yezihloko Ikrimu yelungu lobufazi Ukufaka kwilungu lobufazi	Ithebhulethi yomlomo I-gel / jelly yezihloko Ikrimu yelungu lobufazi Ukufaka kwilungu lobufazi Isangqa sangasese Isikhutshana seTransdermal
Ithini idosi esemgangathweni?	Kuxhomekeke kumyalelo kagqirha wakho	Kuxhomekeke kumyalelo kagqirha wakho
Lude kangakanani unyango oluqhelekileyo?	Ubude bonyango buyahluka ngokuya kwimiyalelo kagqirha wakho	Ubude bonyango buyahluka ngokuya kwimiyalelo kagqirha wakho
Ngubani oqhelekileyo usebenzisa amayeza?	Abantu abadala	Abantu abadala

Ngaba ufuna elona xabiso lilungileyo kwi-estriol?

Bhalisela izilumkiso zamaxabiso e-estriol kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Iimeko eziphathwe nge-estriol kunye ne-estradiol

I-Estrogen ixhaphake kakhulu njengonyango lokutshintsha i-hormone kwabasetyhini abafumana iimpawu zokuyeka ukuya exesheni. I-Estrogens zihlala zidityaniswa neprogesterone okanye ezinye iihomoni ze-steroid ezibizwa ngokuba ziiprogestins. I-Estradiol i-FDA yamkelwe ukunyanga iimpawu zokuyeka ukuya exesheni. Ezi mpawu zibandakanya iimpawu ze-vasomotor ezinje ngokutshisa okutshisayo, ukubila ebusuku, kunye nokugungxula ulusu. Ezinye iimpawu ze-menopausal zibandakanya i-atrophy yelungu lobufazi, okanye ukoma kwilungu lobufazi, ukudumba kunye nokuncipha.

I-Estradiol inokusetyenziswa kwinqanaba lokugqibela umhlaza webele ethe yanwenwela kwamanye amalungu omzimba. Isetyenziselwa ukunceda ukunciphisa ubukrakra bomhlaza (ukhathalelo lokunyanga). Kubafazi abanesifo somhlaza webele se-ER-positive (ER +) esine-metastasized, idosi ephezulu ye-estradiol inokusetyenziswa njengonyango. Ngokwezifundo ezivela Ukuqola , ukuba amathumba ebele abonisa uhlobo lwe-ESR1, umhlaza unokuphendula kakuhle kunyango lwe-estradiol.

Iitafile ze-Estradiol nazo ziyavunywa ukuba zinyange umhlaza we-Prostate cancer oxhomekeke kwi-androgen. Ngelixa amanqanaba e-estrogen inokuba negalelo kumhlaza wedlala lobudoda, i-estradiol inokusetyenziswa njengonyango lokunyanga kwamanye amadoda. Izifundo bonisa ukuba i-estradiol yindlela esebenzayo yonyango lweentlobo ezithile zomhlaza wedlala lobudoda.

I-Estriol ayivunyelwanga yi-FDA ebantwini. Nangona kunjalo, ngamanye amaxesha kudityaniswa namanye amayeza kunyango lokutshintsha i-hormone. Ngenxa yokuba iyi-estrogen, inokusetyenziswa njengechiza elingelilo ilebhile yeemeko ezinxulumene ne-estrogen. Eyona fomu yamkelwe yi-FDA ye-estriol yile Incurin , ephatha ukungangqubeki komchamo kwizinja zabasetyhini emva kokususwa kwama-ovari kunye nesibeleko (ovariohysterectomy).

Olunye uhlobo olusetyenzisiweyo ngaphandle kwelebheli lwe-estriol kunye ne-estradiol lubandakanya ukukhululeka kwimigraines yokuya exesheni kunye nokuthintela i-osteoporosis (ukulahleka kwethambo) emva kokuyeka ukuya exesheni. I-Estrogen idlala indima enkulu ekuxineni kwethambo. Abafazi be-Postmenopausal abanesiphene se-estrogen banokuba nobuninzi beethambo zamaminerali. Unyango lwe-Estrogen lunokusetyenziselwa ukunyanga uxinzelelo lwasemva kokubeleka. Ngokutsho kwabanye izifundo , I-transdermal estradiol ibonakalisiwe iluncedo ekunciphiseni uxinzelelo emva kokubeleka.

Imeko	I-Estriol	I-Estradiol
Unyango olubuyisela iHormone	Ngaphandle kwelebheli	Ewe
Ukuyeka ukuya exesheni	Ngaphandle kwelebheli	Ewe
I-atrophy yelungu lobufazi	Ngaphandle kwelebheli	Ewe
Iimpawu zeVasomotor	Ngaphandle kwelebheli	Ewe
Umhlaza webele (ukhathalelo lokuthomalalisa)	Ngaphandle kwelebheli	Ewe
Umhlaza wesibeletho ophambili (ukhathalelo lokuthomalalisa)	Ngaphandle kwelebheli	Ewe
Ukungahambi kakuhle kwe-Urinary (kwizinja)	Ewe	Hayi
Ukunyuka kwexesha lokuya esikhathini	Ngaphandle kwelebheli	Ngaphandle kwelebheli
I-Postmenopausal osteoporosis	Ngaphandle kwelebheli	Ngaphandle kwelebheli
Uxinzelelo lwasemva kokubeleka	Ngaphandle kwelebheli	Ngaphandle kwelebheli

Ngaba i-estriol okanye i-estradiol isebenza ngakumbi?

Ngaphandle kweendlela ezintathu ze-estrogen, i-estradiol yile eyona fomu inamandla . Iyakwamkelwa yi-US Food and Drug Administration ukuphatha iimeko ezinxulumene ne-estrogen. I-Estriol kunye ne-estrone azivunyelwanga e-US kwabasetyhini. Nangona kunjalo, ezi estrogens zisenokusetyenziswa kwamanye amayeza ahlanganisiweyo.

Akukho zilingo zentloko ziye zenziwa nge-estriol kunye ne-estradiol. Abanye izifundo zibonise ukuba i-estriol ikhuselekile kwaye iyasebenza kwiimpawu zokuyeka ukuya exesheni. Xa isetyenziswe phezulu kwi-atrophy yelungu lobufazi, i-estriol ibikhona ixelwe ukuze isebenze namanye amayeza. Ngenxa yokuba i-estriol ayinamandla kangako, inokuba neziphumo ezibi ezimbalwa. Sebenzisa i-estriol, njengolunye unyango lwe-estrogen, isenokunyusa umngcipheko womhlaza webele, i-endometrial hyperplasia, kunye nomhlaza we-endometrium.

Unyango lwe-Estradiol lunokuba luncedo njenge-HRT emva kokuyeka ukuya exesheni. Ngapha koko, yeyona estrogen ixhaphakileyo emiselweyo kwiimpawu zokuyeka ukuya exesheni. Zonke iintlobo ze-estradiol zivunyiwe kunyango lwehomoni. Ipatch transdermal patch ibikhona kubonisiwe ukukhokelela kumanqanaba e-estrogen azinzileyo kunyango olufanelekileyo.

Nxibelelana nomboneleli wakho wezempilo ukuba axoxe ngokhetho lwakho ukuba ucinga ngamayeza achaphazela amanqanaba ehomoni. Unokucetyiswa ezinye iindlela ze-estrogen ezinje ngamachiza aqukethe ii-estrogens zokudibanisa (umzekelo, i-Premarin, i-Prempro).

Ngaba ufuna elona xabiso lilungileyo kwi-estradiol?

Bhalisela izilumkiso zamaxabiso e-estradiol kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Umyinge kunye nokuthelekiswa kweendleko ze-estriol vs estradiol

Okwangoku, akukho ziyobisi zivunyiweyo ze-FDA ziqukethe i-estriol yabantu. Ke ngoko, ayiqhelekanga i-Medicare kunye nezicwangciso zeinshurensi. I-Incurin ligama lophawu lwe-estriol elivunyiweyo kwizinja ezinomchamo wokuchama. Iindleko zinokwahluka ngokuxhomekeke kwikhemesti oyithengileyo. Izaphulelo ze-singleCare ze-estriol azifumaneki okwangoku.

I-Estradiol iyafumaneka njengesiqwenga solusu oluqhelekileyo. Amagama ebhrendi e-estradiol afaka iMinivelle, iClimara, kunye neVivelle-Dot. Igama lebrand estradiol ixabiso eliphakathi lemali lingahluka kwi-Medicare kunye nezicwangciso zeinshurensi kodwa ungathenga uhlobo oluqhelekileyo lweedola ezingama-33- $ 63 ngekhadi lesaphulelo se-SingleCare.

Fumana ikhadi lesaphulelo somntu ongatshatanga

	I-Estriol	I-Estradiol
Ngokuqhelekileyo i-inshurensi?	Hayi	Ewe
Ngokuqhelekileyo igutyungelwe yiMedicare?	Hayi	Ewe
Umthamo osemgangathweni	Iipilisi ze-1 mg	1 ukuya ku-2 mg ngosuku
I-Medicare copay eqhelekileyo	Ayigutyungelwanga	$ 0- $ 171
Ixabiso elilodwa	Izaphulelo kwi-Estriol azibonelelwa ngoku nge-SingleCare	$ 33- $ 63

Iziphumo ebezingalindelekanga ze-estriol kunye ne-estradiol

Iziphumo ebezingalindelekanga eziqhelekileyo zonyango lwe-estrogen zibandakanya utshintsho lokuya exesheni (utshintsho kwiipateni zokopha), ukubonwa, iintlungu ngexesha (i-dysmenorrhea), ukuthamba kwebele, isicaphucaphu, ukugabha kunye nentloko. Ezinye iziphumo ebezingalindelekanga ze-topical kunye zomlomo ze-estrogens zibandakanya ukuqunjelwa, ukuzuza ubunzima, kunye nokulahleka kweenwele.

Imixholo ye-estriol okanye i-estradiol inokubangela iziphumo ngokuthe ngqo xa isetyenziswa kwilungu lobufazi. Iziphumo ezingalunganga zinokubandakanya ukurhawuzelela kunye nokunyuka kwemfihlo. Eminye imiphumo emibi kakhulu ingabandakanya ukusuleleka kwefungal (candidiasis).

I-Estrogen ibonakalisiwe ukuba iyayitshintsha okanye iyonyuse imveliso melanin , into ejongene nombala wesikhumba. I-Estrogen inokunyusa i-pigment kwaye ibenze mnyama ulusu kwezinye iimeko.

Iziphumo ebezingalindelekanga ezibi zokusetyenziswa kwe-estrogen zibandakanya uxinzelelo lwegazi (uxinzelelo lwegazi), isifo sentliziyo, amahlwili egazi (thromboembolism), ukuwohloka kwesifuba, isifo se-gallbladder, kunye namanqanaba asezantsi e-calcium. Ezinye iziphumo ezibi ezibi zinokubandakanya ukwandiswa kwe-fibroids kwisibeleko kunye nomngcipheko owandayo womhlaza webele nowesibeleko.

	I-Estriol	I-Estradiol
Imiphumela	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Utshintsho lokuya exesheni	Ewe	* akuxelwa	Ewe	*
Ukujonga	Ewe	*	Ewe	*
Idysmenorrhea	Ewe	*	Ewe	*
Ukuthamba kwebele	Ewe	*	Ewe	*
Isicaphucaphu	Ewe	*	Ewe	*
Ukuhlanza	Ewe	*	Ewe	*
Intloko ebuhlungu	Ewe	*	Ewe	*
Ukutyeba kwakho	Ewe	*	Ewe	*
Ukulahleka kweenwele	Ewe	*	Ewe	*
Ukulunywa kwilungu lobufazi	Ewe	*	Ewe	*
Ukuqhawula	Ewe	*	Ewe	*
Utshintsho kumbala wolusu	Ewe	*	Ewe	*

Olu alunakuba luluhlu olupheleleyo. Dibana nogqirha wakho okanye usokhemesti ngezinye iziphumo ebezingalindelekanga.
Umthombo: DailyMed ( I-Estriol ), Yonke imihla ( I-Estradiol )

Ukudibana kweziyobisi kwe-estriol vs. estradiol

I-Estrogen ngokuyintloko i-metabolism kwisibindi yi-CYP3A4 enzymes. I-CYP3A4 inhibitors, ezinje ngamayeza athile okubulala iintsholongwane, ii-antifungals, ii-steroids, kunye nee-anticonvulsants, zinokunyusa amanqanaba e-estrogenic iziyobisi emzimbeni. Kananjalo, oku kunokunyusa umngcipheko weziphumo ebezingalindelekanga.

I-CYP3A4 inducers efana ne-antibiotics ethile, i-antifungals, kunye ne-antivirals inokunciphisa inqanaba le-estriol okanye i-estradiol egazini. I-CYP3A4 inducers inokukhokelela ekunciphiseni ukusebenza kweziyobisi ezine-estrogen. (Jonga itshathi yemizekelo)

I-Estriol kunye ne-estradiol nazo zinokunxibelelana nejusi yeziqhamo ze grapefruit. Ukusetyenziswa kwejusi yeziqhamo zeediliya kunye neemveliso eziqukethe i-estrogen kunokunyusa umngcipheko weziphumo ebezingalindelekanga. Kubalulekile ukuba uxoxe ngembali yakho yezonyango epheleleyo nogqirha ogxile kwi-endocrinology.

Iziyobisi	Iklasi yeziyobisi	I-Estriol	I-Estradiol
Clarithromycin Erythromycin Ketoconazole Itraconazole Cimetidine Ritonavir	Isithinteli seCYP3A4	Ewe	Ewe
Wort eSt IPhenobarbital IPhenytoin ICarbamazepine Rifampin Dexamethasone	I-CYP3A4 inducer	Ewe	Ewe

Olu alunakuba luluhlu olupheleleyo lwazo zonke izinto ezinokubakho xa kusenziwa iziyobisi. Dibana nogqirha nawo onke amayeza onokuthi uwathathe.

Izilumkiso ze-estriol kunye ne-estradiol

Ukusebenzisa i-estrogen kunokunyusa umngcipheko womhlaza we-endometrium, ngakumbi xa ingathathwanga ngeprogestin. I-Estriol kunye ne-estradiol nazo zinomngcipheko okhulayo wokuhlaselwa sisifo sentliziyo (i-myocardial infarction), ukubetha, ukubola kwemiphunga (igazi elijiya emiphungeni), kunye ne-vein thrombosis enzulu (igazi elijiyileyo emithanjeni) kubafazi abaneminyaka engama-50 ukuya kuma-79 ubudala. Kwindawo efanayo yabasetyhini, ukusetyenziswa kwe-estrogen nako kunokukhokelela kumngcipheko womhlaza wamabele owandayo, ngokwe Initiative yezeMpilo yaBasetyhini . I-Estrogen isenokwandisa umngcipheko wesifo sengqondo esixhalabisayo kwabanye abantu ababhinqileyo abaya exesheni abangaphezu kweminyaka engama-65 ubudala.

Nxibelelana nogqirha ukuba unemingcipheko kubandakanya imbali yezonyango ye:

Ukuhlaselwa yintliziyo
Ukubetha
Amahlwili egazi
Umhlaza (walo naluphi na uhlobo)
Amaxesha angaqhelekanga
Igazi elonyukayo
Isifo sentliziyo
Isifo sombefu
Isifo senyongo
Isifo sesibindi
Zesibeleko fibroids
Endometriosis
Hypocalcemia

Abasetyhini abatshayayo icuba banokuba semngciphekweni wokonyuka kwegazi. Iimveliso ezine-Estrogen akufuneki zisetyenziswe kwaba bafazi.

I-Estriol, i-estradiol, kunye nezinye iziyobisi ezinxulumene ne-estrogen zinokwenzakalisa umntwana ongekazalwa. Akufanele zisetyenziswe ngexesha lokukhulelwa okanye ukuncancisa.

Imibuzo ebuzwa rhoqo malunga ne-estriol vs estradiol

Yintoni i-estriol?

I-Estriol luhlobo lwe-estrogen oluveliswa ngokwendalo emzimbeni. I-Estriol ayivunyelwanga yi-FDA kunyango lwehomoni ebantwini. Ezinye iikhemesti ezihlanganisayo zingathengisa amayeza aqukethe i-estriol esetyenziselwa iinjongo zelebheli engekhoyo. I-Estriol yamkelwe kuphela ukunyanga ukungabikho komchamo kwizinja zabasetyhini.

Yintoni i-estradiol?

I-Estradiol yeyona ndlela inamandla ye-estrogen. Iyafumaneka kwiinguqulelo ezahlukeneyo zeempawu kunye neegeneric. Amagama eBrand aquka i-Estrace, iClimara, kunye neVivelle-Dot. Ingasetyenziselwa njengepilisi yomlomo, i-patch transdermal, okanye ukhilimu wesini kubafazi abaneempawu ze-postmenopausal. Ingasetyenziselwa ukunyanga okunyanga ixesha lesibeleko kunye nomhlaza webele.

Ngaba i-estriol kunye ne-estradiol ziyafana?

I-Estriol kunye ne-estradiol azifani. I-Estriol yindlela ebuthathaka ye-estrogen enokuthi ifumaneke kuphela kwiimveliso zonyango lwehomoni. I-Estradiol inamandla ngakumbi kune-estriol kwaye i-FDA ivunyiwe kunyango lwehomoni.

Ngaba i-estriol okanye i-estradiol ingcono?

I-Estradiol yomelele kwaye isebenza ngakumbi kune-estriol. I-Estriol yindlela ebuthathaka ye-estrogen kwaye inokuba neprofayili yokhuseleko olungcono xa kuthelekiswa ne-estradiol. Nangona kunjalo, iimvavanyo ezingaphezulu zeklinikhi zinokufuneka ekusebenzeni nakukhuseleko lwe-estriol.

Ndingayisebenzisa i-estriol okanye i-estradiol ngelixa ndikhulelwe?

Hayi ii-Estrogens ezinjenge-estriol kunye ne-estradiol kufuneka zithintelwe ngelixa ukhulelwe. Ukuthatha la mayeza ngelixa ukhulelwe kungakhokelela kumngcipheko okhulayo wokukhubazeka kokuzalwa. I-Estrogen akufuneki ithathwe ngelixa uncancisa.

Ndingayisebenzisa i-estriol okanye i-estradiol ngotywala?

Hayi. I-Estriol okanye i-estradiol akufuneki isetyenziswe ngotywala. Ukusetyenziswa kotywala kunokunyusa amanqanaba e-estrogen egazini. Ukusela utywala ngonyango lwe-estrogen kunokunyusa umngcipheko womhlaza wamabele.