Eyona >> Iziyobisi Vs. Umhlobo >> ILovenox vs. heparin: Umahluko, ukufana, kwaye yeyiphi engcono kuwe

ILovenox vs. heparin: Umahluko, ukufana, kwaye yeyiphi engcono kuwe

Iziyobisi Vs. Umhlobo

Unokumiselwa iLovenox (enoxaparin) okanye i-heparin ukunyanga okanye ukuthintela i-clot yegazi. I-Lovenox kunye ne-heparin zozibini iziyobisi ezichaphazelekileyo eziyinxalenye yeqela elikhulu lamayeza abizwa ngokuba zii-anticoagulants. Njenge-anticoagulants, okanye i-thinner yegazi, i-Lovenox kunye ne-heparin zinceda ukunyanga nokukhusela i-vein thrombosis (DVT) kunye ne-pulmonary embolism (PE).

Zombini iLovenox kunye neherparin zinendlela efanayo yokusebenza. Basebenza ngokuzibophelela kwimolekyuli encinci yeprotein ebizwa ngokuba yi-antithrombin kunye nokuthintela isenzo se-thrombin, factor Xa, kunye nezinye ii-enzymes ezichaphazelekayo ekunqandeni igazi. Nangona uLovenox ehlelwa njenge-heparin yesisindo esisezantsi (i-LMWH), ayifani ne-heparin esemgangathweni.

Nguwuphi umahluko ophambili phakathi kweLovenox kunye neherparin?

ILovenox ligama lophawu lwe-enoxaparin. Yi-LMWH eyenziwe nguSanofi-Aventis. ILovenox itofwe ngendlela engaphantsi (phantsi kolusu), kwaye iyafumaneka kumanani amabini: 100 mg / ml kunye ne-150 mg / ml.

Iisirinji ezizalisiweyo zeLovenox ziza ngeendlela ezahlukeneyo zamandla kwaye ikwafumaneka kwi-300 mg / 3 ml ye-vial vials.

ILovenox inehafu yobomi ejikeleze 4.5 ukuya kwiiyure ezisi-7 emva kolawulo, kunye neempembelelo ze-anticoagulant zihlala ukuya kuthi ga kwiiyure ezili-12. Ngenxa yobomi bayo obude obunesiqingatha kunye neziphumo ezinokuqikelelwa, iLovenox ayifuni ukubeka esweni ngokubanzi okanye ukubekwa esweni ukuyisebenzisa.

I-Heparin, ekwabizwa ngokuba yi-heparin esemgangathweni okanye i-heparin engafakwanga (i-UFH), isitofu esiqhelekileyo. I-Heparin nayo ihamba ngamagama e-brand afana ne-Hep-Lock.

IHeparin ihlala ilawulwa ngaphakathi (ngokusebenzisa umthambo) okanye ngendlela engaphantsi (phantsi kolusu). Ifumaneka ngedosi enye kunye neefom zeedosi ezininzi ezinamandla ahlukeneyo anokubandakanya iiyunithi ezili-1 ze-USP / ml, iiyunithi ezingama-5,000 ze-USP / ml, kunye neeyunithi ezili-10 000 ze-USP / ml.

Xa kuthelekiswa neLovenox, heparin inobomi obufutshane obuyi-0.5 ukuya kwiiyure ezimbini. IHeparin ifuna ukunikwa rhoqo kuneLovenox, kwaye ihlala ilawulwa kwimeko yesibhedlele. Iziphumo ze-anticoagulant ze-heparin zifuna ukubekwa esweni kuba iimpembelelo zayo aziqikeleleki ngaphezu kwe-heparin yesisindo esisezantsi.

Umahluko ophambili phakathi kweLovenox kunye neheparin
	Imvelaphi	IHeparin
Iklasi yeziyobisi	I-Anticoagulant	I-Anticoagulant
Uhlobo lweBrith / generic	Ibhranti kunye nohlobo oluqhelekileyo olukhoyo	Ibhranti kunye nohlobo oluqhelekileyo olukhoyo
Ngubani igama eliqhelekileyo?	Enoxaparin	IHeparin ligama eliqhelekileyo leHeparin Sodium ADD-Vantage
Zeziphi iifom eza nalo iziyobisi?	Isisombululo ngenaliti	Isisombululo ngenaliti
Ithini idosi esemgangathweni?	I-40 mg yangaphantsi kanye yonke imihla. Idosi inokwahluka ngokuxhomekeke kwimeko yokunyangwa.	Iiyunithi ezingama-5000 zangaphantsi kweeyure ezisibhozo ukuya kwezili-12. Idosi inokwahluka ngokuxhomekeke kwimeko yokunyangwa.
Lude kangakanani unyango oluqhelekileyo?	Iintsuku ezisi-7, ngaphezulu okanye ngaphantsi kuxhomekeke kwimeko yokunyangwa	Iintsuku ezisi-7, ngaphezulu okanye ngaphantsi kuxhomekeke kwimeko yokunyangwa
Ngubani oqhelekileyo usebenzisa amayeza?	Abantu abadala, abantwana kunye neentsana	Abantu abadala, abantwana kunye neentsana

Ngaba ufuna elona xabiso lilungileyo kwiLovenox?

Bhalisela izilumkiso zamaxabiso eLovenox kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Iimeko eziphathwe nguLovenox kunye neherparin

Zombini i-Lovenox kunye ne-heparin zamkelwe e-U.S. Kunyango lwe i-venous thromboembolism (VTE) , imeko ebandakanya i-vein thrombosis enzulu kunye ne-pulmonary embolism. Amagqabantshintshi egazi ahlala esenza emilenzeni okanye ezingalweni (deep vein thrombosis / DVT) kwaye anokuhamba aye emiphungeni apho angena khona kwimithambo yegazi (pulmonary embolism / PE).

I-Lovenox kunye ne-heparin zikwasetyenziselwa ukuthintela amahlwili egazi, ngakumbi emva kotyando olufana nokuhlinzwa edolweni okanye uqhaqho. Ukuphumla ebhedini emva kotyando yenye yezona zinto zibeka emngciphekweni igazi. Eminye yemingcipheko yamahlwili egazi ibandakanya imbali yosapho yokuphazamiseka kwegazi, ukukhulelwa, ukutyeba kakhulu, ukutshaya kunye nomhlaza.

IHeparin ikwavunyiwe ukukhusela nokunyanga amahlwili egazi anokuvela i-fibrillation ye-atrial . Kwelinye icala, iLovenox ivunyiwe ukuba inyange kwaye ithintele iingxaki kubantu abafumana iintlobo ezithile zentlungu yesifuba (angina engaqinisekanga) kunye nokuhlaselwa sisifo sentliziyo (non-Q-wave myocardial infarction).

Imeko	Imvelaphi	IHeparin
Unyango kunye nokuthintela i-venous thromboembolism	Ewe	Ewe
Unyango kunye nokuthintela amahlwili egazi emva kotyando	Ewe	Ewe
Uthintelo kunye nonyango lweengxaki ezivela kwi-fibrillation ye-atrial	Ngaphandle kwelebheli	Ewe
Ukuthintela iingxaki ezivela kwi-angina engazinzanga kunye nokuhlaselwa kwentliziyo	Ewe	Ngaphandle kwelebheli

Ngaba i-Lovenox okanye i-heparin isebenza ngakumbi?

I-Lovenox kunye ne-heparin zombini ziyasebenza ekunyangeni nasekuthinteleni amahlwili egazi. Basebenza ngeendlela ezifanayo ukuvumela igazi ukuba lihambe ngokukhululekileyo. Ukukhetha ichiza elinye kwelinye kuxhomekeke kwiindleko, iziphumo ebezingalindelekanga kunye nolawulo.

Xa kuthelekiswa neherparin, uLovenox unesiqingatha sobomi. Intsingiselo, ihlala ixesha elide kwaye inokulawulwa kube kanye yonke imihla. Umthamo uqikeleleka ngakumbi ngeLovenox, nangona izigulana ezinobunzima obuphezulu bomzimba zifuna i-dosing rhoqo, enje ngenaliti enye kabini ngemini.

Kuhlalutyo lweemeta ukusuka Ijenali yeThrombosis kunye neHaemostasis , i-enoxaparin kunye ne-heparin engachazwanga yathelekiswa nokuthintela amahlwili egazi kwizigulana ezibhedlele. Izilingo ezine zeklinikhi zibandakanyiwe kuhlalutyo lwe-meta kwaye kuvavanywa inani lezigulana ezingama-3,600. Iziphumo zafumanisa ukuba, xa kuthelekiswa ne-heparin, i-enoxaparin yehlise kakhulu amahlwili egazi ngaphandle kokonyusa umngcipheko wokopha kakhulu.

Isilumkiso esinye sokusebenzisa iLovenox kukuba idosi yayo kufuneka ihlengahlengiswe kwizigulana ezinokusilela kwezintso. Ngaphandle koko, kukho umngcipheko okhulayo wokopha. Kwinkqubo yeklinikhi, i-heparin engachazwanga iyakhethwa kubantu abanokukhubazeka kwezintso.

Ugqirha wakho uya kukuyalela eyona anticoagulant efanelekileyo kwimeko yakho. Eyona anticoagulant isebenzayo iya kumiselwa ngokusekwe kwimbali yakho yonyango iyonke.

Umyinge kunye neendleko zokuthelekisa iLovenox vs. heparin

Uninzi lwezonyango kunye nezicwangciso zeinshurensi ziya kugubungela uLovenox. Nangona kunjalo, i-inshurensi isenokwenzeka ukuba igubungele i-generic Lovenox, kwaye ayinakho ukuhlawula iindleko ezipheleleyo. Ixabiso eliphakathi lokuthengisa likaLovenox lijikeleze i- $ 380. Ukuba uthenga inaliti yeLovenox yokusetyenziswa ekhaya kwikhemesti, ungasebenzisa ikhadi leLovenox SingleCare ukugcina imali. Endaweni yokuhlawula ixabiso elipheleleyo leLovenox, ungabhatala imali engaphantsi kweedola ezingama-75 ngeesirinji ezili-10 ezifakiweyo.

IHeparin ihlala igutyungelwe yi-Medicare kunye nezicwangciso zeinshurensi. Ikwahlala ingabizi kakhulu kuneLovenox. Okwangoku, ixabiso lentengiso le-heparin yi- $ 120, kuxhomekeke kubungakanani kunye nomthamo. Ngeponi enye ye-SingleCare, ungayifumana ngaphantsi kwe- $ 50 kwii-pharmacy ezithatha inxaxheba.

	Imvelaphi	IHeparin
Ngokuqhelekileyo ihlawulwa yi-inshurensi?	Ewe	Ewe
Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare?	Ewe	Ewe
Umthamo osemgangathweni	I-40 mg yangaphantsi kube kanye yonke imihla (ubungakanani be-10)	Iiyunithi ezingama-5000 zangaphantsi kweeyure ezisibhozo ukuya kwezili-12 (ubuninzi be-10)
I-Medicare copay eqhelekileyo	$ 5- $ 58	$ 1- $ 3
Ixabiso elilodwa	$ 71 +	$ 45 +

Fumana ikhadi lesaphulelo kwikhemesti

Iziphumo eziqhelekileyo ezichaphazelekayo zeLovenox vs. heparin

Iziphumo ebezingalindelekanga zixhaphakileyo zeLovenox kunye neheparin kukusabela kwendawo yenaliti. Emva kolawulo lweLovenox okanye inaliti ye-heparin, unokufumana iintlungu, ukungonwabi, ukucaphuka, okanye ukudumba ujikeleze indawo yenaliti. Nangona kunjalo, ezi ziphumo bezingalindelekanga zihlala zinobulali kwaye zihambe zodwa.

Kuba iLovenox kunye neherparin zithintela amahlwili egazi, zinokubangela iziphumo ebezingalindelekanga zokopha. Ngelixa usebenzisa i-Lovenox okanye i-heparin, unokufumana ukutyumka rhoqo. I-Anticoagulants nayo inokubangela ukopha kakhulu. Iimpawu zokopha kakhulu kubandakanya ukutyumka okunzima kunye negazi kwisitulo okanye umchamo. Funa unyango xa ufumana iimpawu zokopha kakhulu.

Jonga itshathi engezantsi yezinye iziphumo ebezingalindelekanga eziqhelekileyo.

	Imvelaphi	IHeparin
Imiphumela	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Iintlungu, ukucaphuka, ukudumba okujikeleze indawo yenaliti	Ewe	*	Ewe	*
Ukopha	Ewe	*	Ewe	*
I-enzyme zesibindi eziphakamileyo	Ewe	*	Ewe	*
Isicaphucaphu	Ewe	*	Hayi	-
Urhudo	Ewe	*	Hayi	-

* akuxelwa
Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( Imvelaphi ), Yonke imihla ( IHeparin )

Ukudibana kweziyobisi neLovenox vs. heparin

I-Lovenox kunye ne-heparin zinonxibelelwano olufanayo lweziyobisi. I-Platelet inhibitors, okanye ii-antiplatelet agents, zodidi olwahlukileyo lwamachiza anokunceda ukuthintela amahlwili egazi. Ukudibanisa ii-antiplatelets ezifana ne-clopidogrel, ticagrelor, okanye iprasugrel kunye ne-Lovenox okanye i-heparin kunokunyusa umngcipheko wokopha.

Izidakamizwa ezichasayo ezichasayo (i-NSAID) zingachaphazela Umsebenzi weeplatelets . Umngcipheko wokopha unokunyuswa xa uthatha ii-NSAID kunye neLovenox okanye i-heparin. Tshela ugqirha wakho ukuba uthatha ii-NSAID ngaphambi kokuqala unyango kwiLovenox okanye heparin.

Iziyobisi	Iklasi yeziyobisi	Imvelaphi	IHeparin
I-Aspirin Ibuprofen Indomethacin Umgqube	Izidakamizwa ezichasayo ezichasayo (i-NSAID)	Ewe	Ewe
Clopidogrel I-ticagrelor Iprasugrel I-Dipyridamole	Iiarhente zeantiplatelet	Ewe	Ewe

Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi

Izilumkiso zeLovenox kunye neheparin

I-Anticoagulants efana neLovenox kunye neheparin inokunyusa umngcipheko wokopha kakhulu, okanye ukopha. Ukopha kunokuba nzima kwaye kuhlala kuboniswa ngemiqondiso efana negazi kumchamo okanye isitulo. Umngcipheko wokuphuma kwegazi unokuphakama nakubantu abanembali yokuphazamiseka kokopha.

IHeparin inokubangela I-heparin-indened thrombocytopenia (HIT) , imeko enzulu ebonakaliswa linani eliphantsi leplatelet. Ngelixa abantu bengahlali befumana iimpawu ezicacileyo ze-HIT, sisongelo esisongela ubomi esinokubangela ukopha kakhulu okanye ukufa. Xa kuthelekiswa neLovenox, heparin inomngcipheko ophezulu weHIT. Ukusetyenziswa kweHeparin kuhlala kuhlolwe ngakumbi ngesi sizathu.

ILovenox inomngcipheko okhulayo we-spinal epidural hematoma, okanye ingqokelela yegazi elijikeleze intambo yomqolo. I-spinal epidural hematoma inokukhokelela kwiingxaki okanye ukukhubazeka. Umngcipheko uyonyuswa ukuba ukhe wadlula okanye ukuphinda ugqobhoze umqolo okanye ukuphamba; uthatha ii-NSAID, iiplatelet inhibitors, kunye ne-anticoagulants; okanye unayo i-catheter ehlala ngaphakathi.

Nxibelelana nomboneleli wakho wezempilo malunga nezinye iindlela zokukhusela ezinxulumene neLovenox kunye neheparin.

Imibuzo ebuzwa rhoqo malunga neLovenox vs. heparin

Yintoni iLovenox?

ILovenox yi-anticoagulant, okanye igazi elincinci. Ikwahlelwa njenge-heparin yesisindo esisezantsi. ILovenox iyafumaneka kwi-100 mg / ml kunye ne-150 mg / ml. Ihlala ilawulwa kube kanye okanye kabini imihla ngemihla ngenaliti yangaphantsi. Igama eliqhelekileyo likaLovenox yi-enoxaparin.

Yintoni ihipparin?

IHeparin yaziwa ngokuba ngumgangatho okanye I-heparin engabonakaliyo . Iyafumaneka kuhlobo oluqhelekileyo okanye olunegama lophawu. I-heparin ilawulwa njengenaliti efakwa ngaphakathi okanye ngaphakathi. Ihlala inikwa kwimeko yesibhedlele, nangona ezinye iintlobo zeheparin zinokuqhutywa ekhaya.

Ngaba iLovenox kunye neherparin ziyafana?

ILovenox kunye neherparin azifani. ILovenox sisisindo esisezantsi se-heparin (LMWH), eyahlukileyo kwi-heparin esemgangathweni okanye engafakwanga (UFH). Nangona i-Lovenox kunye ne-heparin zombini zizi-anticoagulants, zinomahluko kulwakhiwo kunye nokusetyenziswa okuvunyiweyo kwe-FDA.

Ngaba i-Lovenox okanye i-heparin ingcono?

I-Lovenox kunye ne-heparin zombini ziyasebenza ekunyangeni nasekuthinteleni iimeko zokuvala igazi njenge-vein thrombosis (DVT) kunye ne-pulmonary embolism (PE). ILovenox ineedosi zokuqikelela kunye nokujonga iiparameter kwaye ke, ikhethwa ngakumbi ekusebenziseni ikhaya. Ixesha elide lobomi beLovenox lithetha ukuba linokutsalwa kube kanye yonke imihla.

Xa kuthelekiswa neLovenox, i-heparin kufuneka inyangwe rhoqo kwaye ngeedosi eziphezulu ngenxa yobomi bayo obufutshane. I-Heparin ayibizi kakhulu kuneLovenox, kwaye ihlala ilawulwa kwisibhedlele apho ukubekwa esweni kweziphumo ezibi kulula.

Ndingayisebenzisa iLovenox okanye iHeparin xa ndikhulelwe?

I-Lovenox okanye i-heparin ikhuselekile kwaye iyasebenza ekunyangeni ukuphazamiseka kwethromboembolic ngexa lokukhulelwa . Zombini ii-anticoagulants aziweli i-placenta. Nangona kunjalo, ii-heparins ezinobunzima beemolekyuli (i-LMWHs), njengeLovenox, zikhethwa kunyango lwegazi kubafazi abakhulelweyo.

Ndingayisebenzisa iLovenox okanye iHepparin ngotywala?

Ababoneleli ngezempilo bancomela ukunciphisa okanye ukunqanda utywala ngelixa usebenzisa i-Lovenox okanye i-heparin. Utywala Unokwenza njengegazi elincinci , ezinokuthi zikhokelele emngciphekweni wokopha xa utywala budityaniswa nesiyobisi se-anticoagulant.

Yintoni enokusetyenziswa endaweni yeheparin?

Ubunzima beemolekyuli ezisezantsi (ii-LMWHs) zihlala zisetyenziswa endaweni ye-heparin. ILovenox (enoxaparin), iFragmin (dalteparin), kunye ne-Innohep (tinzaparin) yimizekelo yee-LMWH ezinokusetyenziselwa ukunyanga okanye ukunqanda amahlwili egazi. I-Arixtra (fondaparinux) yenye yearhente ye-antithrombotic, eyahlukileyo kwi-LMWH kunye ne-UFH, enokuthintela i-factor Xa kunye nokunyanga amahlwili egazi.

I-anticoagulants yomlomo ngqo (ii-DOACs), eziza kwifom yeepilisi, zisetyenziswa kakhulu endaweni ye-heparin. Imizekelo ye-DOACs ibandakanya iXarelto (rivaroxaban powder), Pradaxa (dabigatran), kunye ne-Eliquis (apixaban).

Isebenziselwa ntoni iLovenox?

ILovenox (enoxaparin) isetyenziselwa i-anticoagulation kunye ne-thromboprophylaxis. Inokukunceda ukunyanga okanye ukuthintela amahlwili egazi anokuvela kwimithambo yegazi. ILovenox inokunceda ukunyanga amahlwili egazi enza emilenzeni okanye ezingalweni (deep vein thrombosis) okanye amahlwili afakwa emiphungeni (pulmonary embolism). ILovenox iluncedo ekuthinteleni iingxaki ezivela kwi-angina engazinzanga kunye neentlobo ezithile zokuhlaselwa sisifo sentliziyo.

Ngaba iLovenox lonyango olunomngcipheko ophezulu?

ILovenox ngumngcipheko ophezulu, okanye amayeza aphezulu okulumkisa. Nangona ihlala iyeza elikhuselekileyo, iLovenox inokubangela ukonzakala okukhulu kunye neengxaki ukuba zisetyenziswe ngendlela engeyiyo. Ukuba iLovenox inikwe idosi ephezulu kakhulu, kukho umngcipheko okhulayo wokopha kunye neziphumo ezibi. ILovenox kufuneka isetyenziswe kuphela ngommiselo kunye nesikhokelo esifanelekileyo esivela kumboneleli wezempilo.