Reclast vs Prolia: Umahluko ophambili kunye nokufana

Iziyobisi Vs. Umhlobo

I-Reclast (i-zoledronic acid) kunye ne-Prolia (denosumab) ngamayeza amabini atofelwayo asetyenziselwa ukunyanga i-osteoporosis kubafazi be-postmenopausal. Zingasetyenziselwa ukunyanga i-osteoporosis kwamanye amadoda. Nangona i-Reclast kunye neProlia isebenza ngokuthintela ukubuyiselwa kwethambo kunye nokwandisa ubukhulu bethambo, banomahluko okwahlukileyo ukuba kuqatshelwe.

Ukuhlaziywa kwakhona

I-Reclast (Yintoni i-Reclast?) Ligama lophawu lwe-zoledronic acid. Sisiyobisi se-bisphosphonate esisetyenziselwa ukunyanga nokukhusela i-osteoporosis kubafazi abasemva kwemini. Ingasetyenziselwa ukwandisa ubunzima bamathambo kwamanye amadoda ane-osteoporosis. Ukongeza, abo baphuhlise ubunzima bamathambo ekusebenziseni i-glucocorticoid okanye isifo sePaget banokuphathwa ngeReclast.

I-Reclast ilawulwa njengenaliti okanye ukumnika. Iyafumaneka njenge-5 mg / 100 ml isisombululo esinokunikwa kanye ngonyaka okanye yonke iminyaka emi-2 kuxhomekeke kwimeko yokunyangwa. Iziphumo ebezingalindelekanga eziqhelekileyo kwiReclast ngumkhuhlane kunye nentlungu yomzimba emva kolawulo.

Inkqubela

Prolia (Yintoni iProlia?) Ligama lophawu lwedenosumab. Ihlelwe njenge-arhente ye-anti-RANKL esebenza ngokuthintela ukwenziwa kwee-osteoclast ekugqibeleni zonyuse ubunzima bethambo. Iprolia inokunyanga amadoda kunye nabasetyhini abasemva kwe-postmenopausal abane-osteoporosis okanye umngcipheko omkhulu wokuqhekeka ngenxa yeemeko ezithile.

Iprolia ifumaneka njengesisombululo esingama-60 mg / 1 ml esilawulwa ngendlela engaphantsi rhoqo kwiinyanga ezi-6. Abo bafumana iProlia kufuneka bathathe ikhalsiyam kunye nevithamin D yonke imihla ngenxa yomngcipheko okhulayo wehypocalcemia, okanye ikhalsiyam esezantsi emzimbeni.

I-Reclast vs Prolia Side ngecala lokuthelekisa

I-Reclast kunye neProlia ngamachiza afanayo aneenjongo eziqhelekileyo zonyango. Nangona kunjalo, banokufana okubalulekileyo kunye nokwahluka kunokufumaneka apha ngezantsi.

Fumana ikhuphoni kagqirha

Ukuhlaziywa kwakhona	Inkqubela
Umiselwe i
I-Postmenopausal osteoporosis (unyango kunye nokuthintela) I-Osteoporosis emadodeni Isifo sePaget samathambo	I-Postmenopausal osteoporosis (unyango) I-Osteoporosis emadodeni Ukwanda komngcipheko wokwaphuka kwamadoda nabasetyhini
Ulwahlulo lweziyobisi
IBisphosphonate	Ummeli we-RANKL
Umenzi
I-Novartis	Amgen
Iziphumo eziqhelekileyo
Ifiva Intlungu yezihlunu Intloko ebuhlungu Intlungu edibeneyo Iintlungu ezingalweni nasemilenzeni Iimpawu ezinjengomkhuhlane Isicaphucaphu Ukuhlanza Urhudo Ukudumba kweliso	Umqolo obuhlungu Intlungu yezihlunu Iintlungu ezingalweni nasemilenzeni Intlungu edibeneyo Cholesterol ephezulu Unyango Ipancreatitis Nasopharyngitis
Ngaba ikhona igeneric?
Ewe, zoledronic acid.	Akukho generic ekhoyo ngoku.
Ngaba ihlawulwa yi-inshurensi?
Iyahluka ngokomboneleli wakho	Iyahluka ngokomboneleli wakho
Iifom zedosi
Isisombululo ngenaliti	Isisombululo ngenaliti
Ixabiso leMali eliPhakathi
$ 1,140 ye-100ml	$ 1,422 ye60ml
Ixabiso lesaphulelo esisodwa
Ixabiso lokugqibela	Ixabiso leProlia
Ukusebenzisana kweziyobisi
Aminoglycosides (gentamicin, tobramycin, njl.) I-Loure diuretics (i-furosemide, i-torsemide, njl. Iziyobisi zeNephrotoxic I-Digoxin	Akukho ndibano ibalulekileyo
Ngaba ndingasebenzisa ngelixa ndicwangcisa ukukhulelwa, ukukhulelwa, okanye ukuncancisa?
Ukuhlaziywa kwakhona kuDidi lokuKhulelwa D. Akufanele kuthathwe ngexesha lokukhulelwa. Qhagamshelana nogqirha malunga namanyathelo oza kuwathatha ngelixa ucwangcisa ukukhulelwa okanye ukuncancisa.	Iprolia ikudidi lokukhulelwa X kwaye inokubangela ukwenzakala komntwana xa enikwa abasetyhini abakhulelweyo. Iprolia ayikhuthazwa kwabasetyhini abakhulelweyo

Isishwankathelo

I-Reclast (i-zoledronic acid) kunye ne-Prolia (denosumab) ngamachiza amabini anokufakwa inaliti anyanga i-osteoporosis. Ngelixa omabini la mayeza anokunyanga i-postmenopausal osteoporosis, i-Reclast ikwavunyiwe ukukhusela i-postmenopausal osteoporosis. Zombini iReclast kunye neProlia nazo zinokunciphisa umngcipheko wokuqhekeka kwamanye amadoda nabasetyhini abaneemeko ezithile.

I-Reclast ilawulwa kube kanye ngonyaka okanye kube kanye kwiminyaka emi-2 ngelixa iProlia ilawulwa rhoqo kwiinyanga ezi-6. Iprolia ikwafuneka ithathwe nge-calcium eyongezelelweyo kunye nevithamin D ukukhusela i-hypocalcemia. Nangona kunjalo, zombini i-Reclast kunye neProlia azicetyiswa kwimeko ye-hypocalcemia esele imiselwe.

Kwisifundo esinye sokuthelekisa i-zoledronic acid kunye ne-denosumab, i-denosumab ibonakalise ukonyuka okukhulu kwi-spinal bone mass (BMD) xa kuthelekiswa ne-zoledronic acid. I-Zoledronic acid ikwabonisa imeko yeempawu ezinje ngomkhuhlane. Ngokusekwe kolu phando, iProlia inokusebenza ngakumbi kubantu abathile.

Kubalulekile ukudibana neengcebiso zikagqirha xa umisela olona nyango lulungileyo. Ngelixa omabini la mayeza ayasebenza, inokuba ilunge ngakumbi ngokuxhomekeke kwezinye izinto ezinje ngembali yezonyango kunye namanye amayeza athathwayo.