Xiidra vs.Restasis: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

Iziyobisi Vs. Umhlobo

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I-Xiidra (i-lifitegrast) kunye ne-Restasis (i-cyclosporine) ngamagama egama lonyango asetyenziselwa ukunyanga izifo zamehlo ezomileyo. Abantu abanesifo esomileyo seso banamava okuswela okungapheliyo emehlweni kwaye abanakho ukuvelisa iinyembezi ezaneleyo zokuthambisa amehlo. Le meko inokukhokelela kukungonwabi kwamehlo kunye neengxaki zokufunda okanye ukusebenza kwikhompyuter, phakathi kwezinye iingxaki. IXiidra kunye neRestasis ngamayeza awisa iliso asetyenziswa kuwo omabini amehlo mihla le.

Nguwuphi umahluko ophambili phakathi kweXiidra kunye neRestasis?

Xiidra

I-Xiidra, ekwabizwa ngegama layo eliqhelekileyo, i-lifitegrast, yenziwa ngu-Shire. Yayi-FDA evunyiweyo ngo-2016 kwiklasi entsha yamayeza ebizwa ngokuba yi-lymphocyte-ehambelana ne-antigen 1 (LFA-1) echasene ne-antigen. Indlela ngqo esebenza ngayo ayaziwa. Nangona kunjalo, kukholelwa ukuba kunciphisa ukudumba kunye nokwanda ukuveliswa kweenyembezi Ngokuthintela iprotein ebizwa ngokuba yi-LFA-1 ekusebenzeni nenye iprotein ebizwa ngokuba yi-ICAM-1 emehlweni.

I-Xiidra sisisombululo semehlo esisi-5% esilawulwa njengethontsi elinye kwiliso ngalinye kabini ngemini (malunga neeyure ezili-12 ngokwahlukana). Inokukunceda ukunciphisa ukoma kwiso ngaphakathi kweeveki ezimbini, nangona kunokuthatha ukuya kuthi ga kwiiveki ezintandathu ukuya kwezili-12 ukubonelela ngoncedo olupheleleyo kwabanye abantu.

Ukuphumla

I-Restasis yayivunyiwe yi-FDA ngo-1983 ukunyanga ukoma emehlweni. Yenziwe ngu-Allergan kwaye yaziwa ngegama layo eliqhelekileyo, i-cyclosporine. I-Restasis ikholelwa ukuba iyasebenza ngokulawula iinkqubo zokuvuvukala kwiso ezinokuchaphazela ukuveliswa kweenyembezi.

I-Restasis yi-emulsion yamehlo eyi-0.05% efakwe emehlweni omabini kabini ngemini okanye rhoqo kwiiyure ezili-12. Kungathatha ukuya kwiinyanga ezintathu ukufumana isiqabu ngeRestasis. Abanye abantu, kunokuthatha ukuya kwiinyanga ezintandathu ukufumana uncedo olwaneleyo.

Umahluko ophambili phakathi kweXiidra kunye neRestasis
	Xiidra	Ukuphumla
Iklasi yeziyobisi	Umsebenzi we-lymphocyte onxulumene nomsebenzi we-antigen 1 (LFA-1)	ICalcineurin inhibitor immunosuppressant
Uhlobo lweBrith / generic	Akukho nguqulo yohlobo oluqhelekileyo ekhoyo	Akukho nguqulo yohlobo oluqhelekileyo ekhoyo
Ngubani igama eliqhelekileyo?	Iifayile	ICclosporine
Zeziphi iifom eza nalo iziyobisi?	Isisombululo se-Ophthalmic	I-Ophthalmic emulsion
Ithini idosi esemgangathweni?	Ithontsi elinye kwiliso ngalinye kabini ngosuku okanye rhoqo kwiiyure ezili-12	Ithontsi elinye kwiliso ngalinye kabini ngosuku okanye rhoqo kwiiyure ezili-12
Lude kangakanani unyango oluqhelekileyo?	Eli yeza lisetyenziswa njengonyango lwexesha elide	Eli yeza lisetyenziswa njengonyango lwexesha elide
Ngubani oqhelekileyo usebenzisa amayeza?	Abantu abadala kunye nolutsha oluneminyaka eli-17 nangaphezulu ubudala	Abantu abadala kunye nolutsha oluneminyaka eli-16 nangaphezulu ubudala

Imiqathango ephathwa yiXiidra kunye neRestasis

IXiidra kunye neRestasis zombini zivunyiwe ukuba zinyange isifo sesiso esomileyo, kungenjalo saziwa njenge Iimpawu zamehlo ezomileyo . Isifo samehlo esomileyo sinokunxulunyaniswa nezinye iimeko zamehlo ezinjenge-blepharitis, okanye ukudumba kweenkophe, ezibangelwa kukungabikho komzimba okanye ezinye iingxaki. La mayeza anceda ukonyusa ukuveliswa kweenyembezi kunye nokunciphisa ukuvuvukala kumphezulu weoyile.

Ukongeza kokoma, iXiidra kunye neRestasis inokunceda ekunyangeni ezinye iimpawu zesifo esomileyo samehlo, kubandakanya ukuba bomvu emehlweni, ukudinwa kwamehlo, ukungaboni kakuhle kunye nokuqaqamba emehlweni. Abanye oogqirha banokucebisa unyango olongezelelekileyo ngelixa besebenzisa iXiidra okanye iRestasis, enje ngokucinezelwa okufudumeleyo ukuthomalalisa iliso.

Imeko	Xiidra	Ukuphumla
Isifo samehlo esomileyo	Ewe	Ewe

Ngaba iXiidra okanye iRestasis iyasebenza ngakumbi?

Okwangoku akukho zilingo zonyango ngokuthelekisa ngokuthe ngqo ukusebenza kweXiidra kunye neRestasis yesifo esomileyo. Nangona kunjalo, omabini la mayeza abonakalisiwe ukuba ayasebenza kwiimvavanyo zeklinikhi xa kuthelekiswa ne-placebo. Olona nyango lusebenzayo luya kuba lolona lusebenzela wena.

Kuzo zonke izilingo zeklinikhi ezine, ngokungaqhelekanga Ukusebenza kunye nokukhuseleka kwe-lifitegrast yavavanywa kwizigulana ezili-1,181. Ukuphela kweeveki ezili-12, bekukho ukuphucuka okukhulu kwiimpawu kwabo basebenzisa i-lifitegrast yesifo esomileyo samehlo. Inqaku lokoma kwamehlo lalisetyenziselwa ukuvavanya ukungonwabi ngexesha lonyango.

ICyclosporine, eyona nto isebenzayo kwiRestasis, yayinjalo wafunda kwizilingo ezine ezingenamsebenzi equka malunga nezigulana ezili-1,200 ezineempawu zamehlo ezomileyo ukuya kwezomeleleyo. Emva kweenyanga ezintandathu, kuye kwakho ukwanda kakhulu kwimveliso yeenyembezi kwi-15% yezigulana ezanyangwa nge-cyclosporine xa kuthelekiswa ne-5% yezigulana ezanyangwa nge-placebo.

Nxibelelana nomboneleli wezempilo ukumisela olona nyango lulungileyo onokulufumana. Unokuthunyelwa kwingcali yokhathalelo lwamehlo okanye ugqirha ogxile kwi-ophthalmology kwimeko yakho.

Umyinge kunye nokuthelekiswa kwexabiso leXiidra vs.Restasis

I-Xiidra ayisoloko igutyungelwe zizicwangciso zeinshurensi ye-Medicare. Ayikho enye i-generic efumanekayo kwiXiidra, ngoko kunokubiza kakhulu. Ixabiso leCopay lingahluka ngokubanzi kuxhomekeke kwisicwangciso seinshurensi. Ngaphandle kwe-inshurensi, i-singleCare Xiidra ikhadi lekhuphoni linokunceda ukunciphisa ixabiso lonyango ukuya kuthi ga kwi-580 yeedola. Ngaphandle koko, ixabiso lentengiso leXiidra lijikeleze i- $ 730.

I-restasis ifumaneka kuphela njengeyeza elinophawu-lwegama. Nangona kunjalo, uninzi lwe-Medicare kunye nezicwangciso ze-inshurensi ziya kugubungela iRestasis. Iikopi zinokwahluka ngokuxhomekeke kwisicwangciso seinshurensi. Ngaphandle kweinshurensi, ixabiso eliphakathi lemali yeRestasis lijikeleze i- $ 389. Sebenzisa isigqebhezana kunokunceda ukuthoba iindleko zeRestasis. Ikhuphoni le-SingleCare Restasis liyafumaneka ukuze lisetyenziswe kwiikhemesti ezithatha inxaxheba kwaye liya kuthoba iindleko zeRestasis ukuya kwi- $ 255.

	Xiidra	Ukuphumla
Ngokuqhelekileyo ihlawulwa yi-inshurensi?	Hayi	Ewe
Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare?	Hayi	Ewe
Ubungakanani	Izikhongozeli ezingama-60 zokusebenzisa into enye	Iibhotile ezingama-60
I-Medicare copay eqhelekileyo	$ 3- $ 637	$ 19- $ 652
Ixabiso elilodwa	$ 578 +	$ 255 +

Iziphumo eziqhelekileyo zeXiidra vs.Restasis

Iziphumo eziqhelekileyo ezichaphazelekayo ze-Xiidra ziyakucasula kwaye zibomvu emehlweni, ukukhutshwa kwamehlo, intloko, kunye nombono ophazamisayo. I-Xiidra inokubangela incasa engaqhelekanga emlonyeni, ekwabizwa ngokuba yi-dysgeusia.

Iziphumo eziqhelekileyo ezichaphazelekayo zeRestasis zibandakanya ukutshisa, ukucaphuka, kunye nokubomvu emehlweni, kunye nombono ophazamisayo. I-restasis ayaziwa ukuba ibangele ukungcamla okugqwethekileyo; Nangona kunjalo, kunokuba kunokwenzeka ngakumbi kuneXiidra ukubangela uvakalelo oluvuthayo emehlweni emva kolawulo.

Iziphumo ebezingalindelekanga ezimandundu zeXiidra kunye neRestasis zibandakanya iimpendulo zehypersensitivity. Iimpawu kunye neempawu zempembelelo ye-hypersensitivity zibandakanya irhashalala, ukudumba, ukurhawuzelela, kunye nokuphefumla okufutshane.

	Xiidra	Ukuphumla
Imiphumela	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Ukucaphuka kwamehlo	Ewe	5% –25%	Ewe	1% –5%
Ukuvutha emehlweni	Ewe	1% –5%	Ewe	17%
Ubomvu bamehlo	Ewe	1% –5%	Ewe	1% –5%
Umbono omfiliba	Ewe	5% –25%	Ewe	1% –5%
Ukuziva okungaqhelekanga	Ewe	5% –25%	Hayi	-
Ukukhutshwa kwamehlo	Ewe	1% –5%	Ewe	1% –5%
Ukuphazamiseka kwamehlo okanye iintlungu	Ewe	1% –5%	Ewe	1% –5%
Intloko ebuhlungu	Ewe	1% –5%	Hayi	-

Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( Xiidra ), Yonke imihla ( Ukuphumla )

Ukudibana kweziyobisi kweXiidra vs.Restasis

Akukho nxibelelaniso lubalulekileyo lweziyobisi oluxeliweyo ngeXiidra okanye iRestasis. Olunye unyango lokuyeka amayeza kufuneka luthintelwe ngelixa usebenzisa iXiidra okanye iRestasis ngaphandle kokuba iyalelwe ngumboneleli wezempilo. Tshela ugqirha wakho malunga nawaphi na amayeza onokuthi uwathathe, njengamayeza kagqirha, iivithamini, kunye nezongezo zamayeza.

Izilumkiso zeXiidra kunye neRestasis

Ukuchukumisa incam yesikhongozeli, igutyana, okanye ibhotile ngokuthe ngqo kwiliso okanye kwindawo ejikelezileyo kufuneka kuthintelwe ngexesha lolawulo. Ukwenza njalo kunokunyusa umngcipheko wongcoliseko, olunokukhokelela kulo usulelo emehlweni . Ukuchukumisa incam yesikhongozeli, ibhotile, okanye ibhotile emehlweni kunokubangela ukwenzakala.

Iilensi zonxibelelwano kufuneka zisuswe ngaphambi kolawulo lweXiidra okanye iRestasis. Iilensi zonxibelelwano zinokufakwa kwakhona emva kwemizuzu eli-15 emva kokusebenzisa iXiidra okanye iRestasis.

Izikhongozeli ezizodwa zokusebenzisa iXiidra kufuneka zisetyenziswe kwangoko emva kokuvula. Kuya kufuneka emva koko balahlwe emva kolawulo lwamayeza.

Qhagamshelana nomboneleli wezempilo malunga nezinye izilumkiso kunye nezilumkiso ezinxulumene neXiidra okanye iRestasis.

Imibuzo ebuzwa rhoqo malunga neXiidra vs.Restasis

Yintoni iXiidra?

IXiidra sisisombululo se-ophthalmic esinegama lophawu esisetyenziselwa ukunyanga izifo zamehlo ezomileyo. Ihlelwe njenge-LFA-1 antagonist ethintela unxibelelwano lweeproteni ezithile ukunciphisa ukudumba. Igama eliqhelekileyo leXiidra liyimpilo enkulu; Nangona kunjalo, azikho iinguqulelo eziqhelekileyo zeXiidra ezikhoyo ngoku. IXiidra ilawulwa kabini imihla ngemihla ukunciphisa ukoma emehlweni. Yenziwe nguShire.

Yintoni iRestasis?

I-restasis ligama lophawu lwe-cyclosporine ophthalmic solution, eyenziwe ngu-Allergan. Ilawulwa kabini ngemini ukunyanga iimpawu zokoma emehlweni. Isebenza njenge calcineurin inhibitor immunosuppressant ukunciphisa ukudumba kunye nokwandisa ukuveliswa kwamehlo emehlweni. Azikho iinguqulelo eziqhelekileyo zeRestasis ezikhoyo ngoku.

Ngaba iXiidra kunye neRestasis ziyafana?

Zombini iXiidra kunye neRestasis zinezinto ezichasayo, kodwa azifani. IXiidra ngumchasi we-LFA-1 ngelixa iRestasis iyi-calcineurin inhibitor. Zenziwe ziinkampani ezahlukeneyo zoxubo mayeza kwaye ziza ngeendlela ezahlukeneyo. I-Xiidra sisisombululo se-ophthalmic esiza kwizikhongozeli esinye sokusebenzisa. I-Restasis yi-emulsion ye-ophthalmic eza ngeebhotile zokusebenzisa into enye okanye ibhotile engenanto yokuthintela ukutya.

Ngaba iXiidra okanye iRestasis ingcono?

IXiidra kunye neRestasis zombini ziyasebenza ekunyangeni iimpawu ezingapheliyo zamehlo ezomileyo. Nangona kunjalo, iXiidra inokunciphisa iimpawu zamehlo ezomileyo ngokukhawuleza kuneRestasis. IXiidra ingaqala ukusebenza kwiiveki ezimbini ngelixa iRestasis ihlala ithatha ukuya kwiinyanga ezintathu ukuqala ukomisa emehlweni.

Ndingayisebenzisa iXiidra okanye iRestasis ngelixa ndikhulelwe?

Sebenzisa iXiidra okanye iRestasis ngelixa ukhulelwe ngokubanzi kukhuselekile. Kuba iXiidra kunye neRestasis zilawulwa ngamehlo, azifakwanga egazini izixa ezikhulu. Ke ngoko, umngcipheko weziphene zokuzalwa ngelixa usebenzisa iXiidra okanye iRestasis iphantsi. Qhagamshelana nomboneleli wezempilo malunga neengcebiso zonyango ukuba ukhulelwe okanye uncelisa.

Ndingayisebenzisa iXiidra okanye iRestasis ngotywala?

IXiidra kunye neRestasis azifakwanga kwigazi izixa ezikhulu. Endaweni yoko, la mayeza asebenza emehlweni. IXiidra kunye neRestasis ayaziwa ukuba inxibelelana notywala.

Ngaba iXiidra inganyanga amehlo owomileyo?

IXiidra isetyenziselwa ukunyanga amehlo owomileyo ahambelana nesifo samehlo esomileyo okanye i-blepharitis. Isetyenziswa njengonyango lwexesha elide ukukhulula amehlo owomileyo. Ukuba iXiidra iyekile, ukoma kwamehlo kungabuya.

Ngaba iXiidra isteroid?

I-Xiidra ayisiyi-steroid. Inesithako esisebenzayo se-lifitegrast, esebenza njenge-anti-1 ye-antigen 1 (LFA-1) echasene nomsebenzi. Isebenza ngokuthintela iprotein ebizwa ngokuba yi-LFA-1 ekusebenzeni neprotein ebizwa ngokuba yi-ICAM-1. Ukudibana kwezi proteni kudlala indima kwiinkqubo zokukrala kwamehlo.

Ngaba iXiidra inciphisa ukudumba?

IXiidra lunyango olusebenzayo olunceda ukunciphisa ukudumba kunye nokomisa emehlweni. Inokuqala ngokudambisa amehlo owomileyo kwiiveki ezimbini, nangona inokuthatha ukuya kuthi ga kwiiveki ezili-12 ukubonelela ngoncedo olupheleleyo. I-Xiidra ilawulwa kabini imihla ngemihla njengesisombululo se-ophthalmic.

Ngaba ikhona enye indlela engabizi kakhulu kwiRestasis?

Kunokubakho enye into ebiza ixabiso eliphantsi enokubangela ukuba iRestasis iveliswe ngoku kodwa isenokungabikho ngoku. Umboneleli wakho wokhathalelo lwempilo unokucebisa ngemveliso engaphaya kwekhawunta efana nayo iinyembezi ezingezizo ngokoma ngamanye amaxesha okanye ukucaphuka emehlweni. I-Restasis lunyango olumiselweyo olubonakaliswe ukunyanga iimpawu ezingapheliyo kwizifo zamehlo ezomileyo.