Iziphumo ebezingalindelekanga zeJardiance kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

Iziphumo ebezingalindelekanga zeJardiance | Ukuhla ukusinda | Ixhala | Uqhekeko | Zide kangakanani iziphumo ebezingalindelekanga? | Izilumkiso | Unxibelelwano | Ungaziphepha njani iziphumo ebezingalindelekanga

I-Jardiance (into esebenzayo: empagliflozin) ligama elingu-brand-prescription drug, kunye nokutya kunye nokuzilolonga, elinceda ukunciphisa iswekile yegazi kwizigulana ezinohlobo lwe-2 isifo seswekile kunye nokunciphisa umngcipheko wokufa kwentliziyo kwizigulana ezinoluhlobo lwesibini lweswekile kunye nesifo sentliziyo. I-Empagliflozin isebenza ngokwandisa ukususwa kwezintso kwi-glucose egazini ukuya kumchamo. I-Jardiance ineziphumo ezininzi emzimbeni kwaye isenokungalungeli wonke umntu. Ukuqonda iziphumo ebezingalindelekanga, izilumkiso, kunye nokuhlangana kweziyobisi kuya kunceda abaguli balungelelanise i-pros and cons of taking Jardiance.

Ezinxulumene: Funda ngakumbi malunga neJardiance | Fumana izaphulelo zeJardiance

Iziphumo eziqhelekileyo zeJardiance

Njengawo onke amayeza amiselweyo, iJardiance ivelisa iziphumo ebezingalindelekanga ezininzi. I-Jardiance, nangona kunjalo, iya kuhlala ichazwa njengonyango lwesibini ngokudibanisa namanye amayeza eswekile afana ne-metformin. Iziphumo ebezingalindelekanga zinokwahluka phakathi kwezigulana. Iziphumo eziqhelekileyo ezichaphazelekayo, ezinamava ngaphezulu kwe-5% yezigulana, ngaba usulelo lomchamo kunye nosulelo lokungunda lobufazi okanye lobudoda.

Iziphumo eziqhelekileyo zeJardiance zibandakanya:

• Usulelo lomjelo womchamo
• Umngundo wesini okanye usulelo lwegwele
• Usulelo oluphezulu lokuphefumla
• Ukwanda komchamo
• Amanqanaba aphakamileyo amafutha okanye i-cholesterol egazini
• Intlungu edibeneyo
• Isicaphucaphu kunye
• Iingxaki zezintso

Ngaphantsi kwesiqhelo, iJardiance inokuhlisa umthamo wegazi kwaye ibangele ukomisa kunye noxinzelelo lwegazi olusezantsi.

Iziphumo ezibi kakhulu zeJardiance

Iziphumo ezibi kakhulu zeJardiance zibandakanya:

• Uxinzelelo lwegazi oluphantsi
• Iswekile esezantsi yegazi
• Ketoacidosis
• Ukungasebenzi kakuhle kwezintso okanye ukwenzakala
• Usulelo olunamandla lomchamo (urosepsis)
• Usulelo lwezintso (pyelonephritis)
• I-Gangrene (i-necrotizing fasciitis ye-perineum)
• Iziphumo ezinobuzaza kunye nokubulala okunokubulala okunje nge-angioedema okanye ulusu olunamandla

I-Ketoacidosis, isiphumo esibi sesifo seswekile, senzeka xa iitoni zisakha egazini ngenxa yomzimba usebenzisa amafutha kwipetroli. I-Ketoacidosis yinto esongela ubomi engxamisekileyo kwaye iphawulwa ziimpawu ezinje ngokunxanwa kakhulu, ukuchama rhoqo, isicaphucaphu, iintlungu esiswini, ubuthathaka, ukudinwa kunye nokuphefumla kancinci. Ngenxa yokwanda komngcipheko we-ketoacidosis okanye iswekile esezantsi yegazi, omabini amanqanaba e-ketone kunye neswekile kufuneka ahlolwe rhoqo xa kuthathwa iJardiance.

Ukulahleka kwesisindo seJardiance

Ukongeza ekulawuleni amanqanaba eswekile yegazi, iJardiance ibonakalisiwe ukunciphisa ubunzima bobabini kunye ukuhanjiswa kwamafutha omzimba . Ngokukodwa, i-Jardiance inciphisa kakhulu amanqatha asesiswini (i-visceral adiposity tissue okanye i-VAT). Amanqatha omzimba esiswini aphakamisa umngcipheko wokuhlaselwa yintliziyo, ukubetha, kunye nezinye iziganeko zentliziyo. Nakuphi na ukuncitshiswa kwamanqatha esisu kunceda ukunciphisa umngcipheko wokufa sisifo sentliziyo okanye ezinye iimeko zentliziyo.

Uxinzelelo lweJardiance

I-Jardiance ayichaphazeli inkqubo yeemvakalelo. Nangona kunjalo, xa usiwe namanye amayeza eswekile, iJardiance inokubangela ukuba iswekile yegazi iwele kumanqanaba asezantsi ayingozi. Ebizwa ngokuba yi-hypoglycemia, iswekile esezantsi yegazi ibangela ukuba umzimba ukhuphe i-epinephrine, eyaziwa ngokuba yi-adrenaline. Uninzi lweempawu zeswekile esezantsi yegazi zibangelwa kukungxamiseka kwe-adrenaline: ixhala, ukubetha kwentliziyo okukhawulezayo, ukubetha kwentliziyo, ukukhathazeka, ukubila, ukungcangcazela, kunye novalo. Ukuba ukuthatha iJardiance kubangela unxunguphalo okanye naziphi na ezinye iimpawu zeswekile esezantsi yegazi, thatha indawo esebenza ngokukhawuleza yeswekile efana nejusi yeziqhamo kwaye ufune unyango kwangoko. Umboneleli wakho wezempilo unokuyalela ikiti engxamisekileyo yeglucagon ukuba iswekile esezantsi yegazi yinto eqhelekileyo.

Isilonda esibuhlungu

Ngokubanzi, abaguli abanesifo seswekile basesichengeni sokosuleleka ziintsholongwane kunye nomngundo. Kungenxa yokuba iintsholongwane kunye nefungus zisebenzisa iswekile yamandla. Iswekile yegazi ephezulu yonyusa ubonelelo lokutya kwabo. Iswekile ephezulu yegazi ikwanciphisa amandla omzimba wokulwa izifo.

I-Jardiance inciphisa amanqanaba eglucose egazini ngokucoca i-glucose ephuma egazini iye kumchamo. Oku kwehlisa iswekile yegazi-eyinto elungileyo-kodwa yenza umchamo ube neswekile. Iibhaktiriya, igwele, kunye nokuvunda kumchamo kunye namalungu esini ayachuma kule meko iswekile. Ngenxa yoko, izintso, umchamo, kunye nosulelo lwangasese ziziphumo ebezingalindelekanga eziqhelekileyo zeJardiance.

Kwiimeko ezinqabileyo, usulelo lwebacteria olubangelwa yiJardiance lunokuphuma kulawulo kwaye lubangele izifo ezinje ngezi:

• I-Urosepsis (i-bacterial overload kwi-urinary tract)
• I-Pyelonephritis (usulelo olunzima lwezintso)
• Isifo esibuhlungu sikaFournier

Isifo esibuhlungu sikaFournier iziphumo xa usulelo lwebhaktiriya luqhuma ngaphandle kolawulo kwaye luqala ukuhlasela kunye nokubulala izicubu kulusu olujikeleze amalungu esini kunye ne-anus. Ngenxa yokuba sisisongelo sobomi ukuba ushiywe unganyangwa, kuya kufuneka ufune unyango kwangoko ukuba uthatha iJardiance kwaye uqaphele iimpawu zesifo esibuhlungu sikaFournier njenge:

• Ifiva
• Ziva gula
• Ukumodareyitha okumodareyitha okuphakathi kunye neentlungu kumalungu esini okanye kwindawo ejikeleze umngxuma
• Ivumba elibi kwindawo echaphazelekayo
• Ukuqhekeka, ukuqhekeka, okanye ukuphuma kwezandi xa uhlikihla loo ndawo

Iimpawu zesifo esibuhlungu sikaFournier singaqala kwiveki yokuqala yokuthatha iJardiance.

Zithatha ixesha elingakanani iziphumo ebezingalindelekanga zeJardiance?

Iziphumo eziqhelekileyo zeJardiance zingasombulula ixesha elide lonyango. I-Jardiance ihlala icoca emzimbeni kwisithuba seentsuku ezimbalwa (isiqingatha sobomi ziiyure ezili-12, ngenxa yoko uninzi lweziyobisi luyacocwa ngaphakathi kweeyure ezingama-24, kodwa luthatha iintsuku ezininzi ukuwucoca ngokupheleleyo umzimba), ke nayiphi na imiphumela emibi njengokunyuka komchamo kufuneka iphele ngaphakathi kosuku okanye ezimbini emva kokuba iyeza liphelisiwe. Nangona kunjalo, usulelo, ukungaqheleki kwesibindi, kunye nokulimala kwezintso kunokuthatha iintsuku okanye iiveki ukuzisombulula.

Izimo kunye nezilumkiso kwiJardiance

I-Jardiance ayinyango ilungileyo kuye wonke umntu. Kuba isebenza ngokwandisa ukuhluza izintso zeswekile yegazi, ayifanelekanga kwizigulana ezinesifo sezintso eziqatha okanye ezinesiphelo okanye ezikudialysis. Ayifanelanga ukuba inikwe nabani na one-hypersensitivity eyaziwayo kwi-empagliflozin, isithako esisebenzayo kwiJardiance. Ukongeza, abantu abanesifo seswekile ketoacidosis abangabo abagqatswa abafanelekileyo kunyango lweJardiance. I-Jardiance ayisebenzisi kwizigulana ezinesifo seswekile sohlobo 1.

I-Jardiance iza nezilumkiso ezininzi, kubandakanya:

• Unokubangela uxinzelelo lwegazi olusezantsi kubantu abadala nakwizigulana ezinokukhubazeka kwezintso, uxinzelelo lwegazi oluphantsi, okanye ngubani othatha i-diuretics (iipilisi zamanzi)
• Isidingo sokubeka iliso kwizigulana kwiimpawu ze
  • Ketoacidosis
  • Ukuphazamiseka kwezintso okanye ukwenzakala
  • Usulelo olunamandla lomchamo
  • Isifo esibuhlungu sikaFournier
  • Usulelo lomngundo lwamalungu esini sangasese
  • Iswekile esezantsi yegazi kunye
  • Ukwanda kwinqanaba le-cholesterol embi (LDL)

Izigulana ezindala

Izigulana ezindala kunama-65 kunokwenzeka ukuba zibe neziphumo ebezingalindelekanga ezifana noxinzelelo lwegazi, ukomisa amanzi emzimbeni okanye iingxaki zezintso.

Abantwana

I-FDA ayivumanga iJardiance ukusetyenziswa kubantwana abangaphantsi kwe-18.

Ukuphazamiseka kwezintso

Izigulana ezinokuncipha kwezintso zisesichengeni sokonyuka kwezintso okanye ukonzakala kwezintso.

Ukukhulelwa kunye nokuncancisa

Ngokubanzi, iJardiance iyadimazeka ukuba isetyenziswe ngabafazi abakhulelweyo nakweyiphi na i-trimester kodwa iyaphikiswa kwiitrimester zabo zesibini nezesithathu. Nangona kunjalo, kuncinci uphando oludibanisa ukusetyenziswa kweJardiance ngexesha lokukhulelwa kwiziphene zokuzalwa okanye ukuphuma kwesisu.

Ngelixa kungekho zifundo zibonisa ukuba ingakanani iJardiance ekhoyo kubisi lwebele, iJardiance akufuneki ithathwe ngoomama abangabongikazi. Kukho amathuba okuba nokuba mancinci amanani anokuphazamisa ukukhula kweentso zeentsana ezanyisayo.

Unxibelelwano lweJardiance

I-Jardiance inonxibelelwano olubalulekileyo eklinikhi kunye neziyobisi ezininzi. Uninzi lonakalisa amandla omzimba wokuphelisa iJardiance. La machiza anyusa isibonelelo sonyango seJardiance kodwa anyuse umngcipheko kunye nobukhali beziphumo ebezingalindelekanga. Ezinye iziyobisi, ezinje nge-diuretics, i-insulin, kunye neziyobisi ezifanayo neJardiance kufuneka zithintelwe xa uthatha iJardiance.

I-SGLT2 inhibitors

I-Jardiance yeyosapho lweziyobisi ezibizwa ngokuba yi-sodium-glucose co-transporter 2 (SGLT2) inhibitors. La machiza asebenza ngokuvala indlela kwizintso ezibuyisa iglucose ukusuka kumchamo ubuyele kwigazi. Ngenxa yoko, abaguli kwiJardiance bakhupha naphi na Ama-64 ukuya kuma-78 amagremu ngaphezulu kweswekile ngosuku kuxhomekeke kwidosi emiselweyo. Ukuthintela ukwehla okuyingozi kwiswekile yegazi, iJardiance akufuneki ithathwe kunye nezinye i-SGLT2 inhibitors:

• Farxiga (dapagliflozin)
• Invokana (canagliflozin)
• Steglatro (ertugliflozin)

Womchamo

I-diuretics (iipilisi zamanzi) yonyusa inani lamanzi kunye nee-electrolyte ezikhutshiwe kumchamo. Zixhaphake ngokuqhelekileyo kwiimeko ezahlukeneyo zonyango, ngokuqhelekileyo igazi elonyukayo kunye nokudumba ngenxa yokugcina amanzi. I-Jardiance inokusebenzisana ne-diuretics kwaye ibangele ukuchama okuphezulu kunokwesiqhelo, okukhokelela ekuphelisweni kwamanzi emzimbeni kunye nevolumu yegazi esezantsi, enokubangela uxinzelelo lwegazi oluphantsi. Umboneleli wezempilo unokukhetha ezinye iindlela zonyango, ukunciphisa idosi yokuchama, okanye ukubeka esweni isigulana kufutshane.

I-insulin kunye ne-insulin evuselela amayeza

I-insulin kunye neziyobisi ezonyusa imveliso yomzimba ye-insulin (imfihlo ye-insulin) yonyusa umngcipheko weswekile esezantsi yegazi xa zithathwa ngeJardiance. Unyango luya kufuna ukuvavanywa kweswekile yegazi rhoqo, kwaye idosi ye-insulin inokufuna ukwehla.

Ezinye ii-insulin secretagogues zihlala zichazwa njengonyango lokuqala kunye neJardiance. Oku kubandakanya i-glipizide, i-glyburide, kunye ne-glimepiride. Amanye amayeza anje nge-nateglinide kunye ne-repaglinide nawo abangela ukuba umzimba ukhuphe i-insulin engaphezulu. Iswekile yegazi iya kufuna ukujongwa rhoqo xa kudityaniswa iJardiance kunye nawaphi na ala mayeza.

Ezinye iziyobisi

Okokugqibela, ezinye iziyobisi ziyonyusa okanye zinciphise iziphumo zeJardiance kwiswekile esegazini. Iziyobisi ezonyusa okanye ezizalisayo iziphumo zonyango lweJardiance zibeka abantu emngciphekweni weswekile esezantsi yegazi. Oku kubandakanya:

• Amayeza eswekile Njenge metformin, pioglitazone, kunye neacarbose
• Ukukhetha i-serotonin reuptake inhibitors (i-SSRIs) njengeProzac (i-fluoxetine) okanye i-Paxil (i-paroxetine)
• I-Monoamine oxidase inhibitors (i-MAOIs) njengeMarplan (isocarboxazid), iNardil (phenelzine), okanye ilinezolid
• I-antibiotics yeQuinolone njenge-ciprofloxacin okanye i-levofloxacin
• IiSalicylates njenge-aspirin, ibuprofen, okanye i-diclofenac
• IiBarbiturates ezifana ne-butalbital okanye i-barbital
• Iibronchodilators njenge doxofylline

Kwelinye icala, ii-corticosteroidsezifana ne-dexamethasone, i-budesonide, kunye ne-hydrocortisone yonyusa umngcipheko phezulu iswekile yegazi xa ithathwa ngeJardiance.

Ukudibanisa iJardiance kunye nawaphi na la machiza kukhuselekile logama iswekile yegazi ijongwa rhoqo.

Ekugqibeleni, I-Jardiance ikwathoba uxinzelelo lwegazi . Ukongeza ekususeni iswekile ngomchamo, iJardiance kunye neziyobisi ezifanayo zikwacoca isodiyam, zinciphisa umxholo weesodium. Ngesi sizathu, iJardiance kufuneka ithathwe ngononophelo ngokudibeneyo namayeza oxinzelelo lwegazi. Ukudibanisa akonyusi kuphela umngcipheko wexinzelelo lwegazi, kodwa amanye amayeza oxinzelelo lwegazi anyusa umngcipheko weswekile esezantsi yegazi okanye ezinye iziphumo ebezingalindelekanga.

Ungaziphepha njani iziphumo ebezingalindelekanga zeJardiance

Onke amayeza aneziphumo ebezingalindelekanga. Ngelixa iziphumo ebezingalindelekanga zingenakuthintelwa ngokupheleleyo, iingcebiso ezimbalwa zinokukunceda ukulawula okanye ukunciphisa iziphumo ebezingalindelekanga zeJardiance:

1. Thatha iJardiance njengoko kuyalelwe

Thatha idosi emiselweyo. Ukuba uphosa idosi, sukuthatha amayeza ongezelelweyo ukwenza oko. Ukuba iyeza alibonakali lisebenza okanye iziphumo ebezingalindelekanga zinzima kakhulu ukusombulula, thetha nomboneleli wezempilo malunga nokutshintsha idosi okanye ukutshintshela kunyango olutsha.

2. Xelela umboneleli wakho wezempilo malunga nazo zonke iimeko zonyango kunye namayeza

Ngenxa yomngcipheko weziphumo ebezingalindelekanga, kuya kufuneka uxelele umboneleli wakho wezempilo malunga:

• Naziphi na iimeko zomzimba onokuba nazo, ngakumbi intliziyo, ukujikeleza, uxinzelelo lwegazi, iipancreas, izintso, okanye iingxaki zomchamo
• Onke amayeza owathathayo ngoku kunye
• Onke amayeza e-counter-counter, amayeza, kunye neyeza zonyango ozithathayo

Soloko uthetha nogqirha, usokhemisti, okanye enye ingcali yezempilo, ukuba ufumana naziphi na iziphumo ebezingalindelekanga xa uthatha iJardiance.

3. Ukujonga iswekile yegazi

I-Jardiance ihlala ichazwa njengonyango lwesibini kunye namanye amayeza eswekile kubandakanya i-insulin, metformin, pioglitazone, okanye sulfonylurea. I-Jardiance, ngakumbi xa idityaniswe namanye amayeza eswekile, inokubangela iswekile esezantsi yegazi ngokuyingozi. Umboneleli wakho wezempilo unokukucela ukuba ujonge eswekile yegazi rhoqo. Kuya kufuneka ulumkele iimpawu zeswekile esezantsi yegazi enje ngokubetha kwentliziyo okukhawulezileyo, ulusu olumhlophe, ukudinwa, unxunguphalo, ukubila, ukugungqa, ukucaphuka, ukudideka okanye indlala. Thatha umthombo okhawulezayo weswekile kwaye ufune neengcebiso zonyango.

4. Nika ingqalelo uxinzelelo lwegazi

I-Jardiance ineziphumo ezifanayo ne-diuretic, yiyo ke enokunciphisa umthamo wegazi kunye noxinzelelo lwegazi. Yiba ujonge iimpawu zoxinzelelo lwegazi oluphantsi ezinje ngokuba nesiyezi xa umile, isiqaqa, ukuba nentloko ebuthathaka, ukozela, ukungaboni kakuhle, isicaphucaphu, kunye nokubanda, ulusu olushushu. Ukuba unengxaki noxinzelelo lwegazi olusezantsi xa uthatha iJardiance, inokunceda ekuthengeni isixhobo esinoxinzelelo lwegazi kwaye ujonge rhoqo kwaye urekhode uxinzelelo lwegazi.

Izixhobo:

• Ingxelo yoPhononongo lweKlinikhi: Empagliflozin (Jardiance), I-Arhente yaseCanada yeziyobisi kunye neTekhnoloji yezeMpilo
• Empagliflozin , StatPearls
• Ulwazi lwe-Empagliflozin , ILayibrari yeSizwe yoNyango
• I-Fournier Gangrene , Umbutho weSizwe weziNto ezinqabileyo
• Iimpawu zehypoglycemia , EndocrineWeb
• Intlanganisela , Epocrates
• Iphepha loLwazi lweJardiance , EShire US
• Isikhokelo seMida yeJardiance , IBoehringer Ingelheim