Funda ngeziphumo ebezingalindelekanga kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

I-Finasteride lonyango olufana ne-steroid rhoqo emiselweyo ukunyanga i-benign prostatic hyperplasia (i-Prostate eyandisiweyo) kunye ne-baldness yomntu oyindoda. Uya kuyifumana kakhulu kwiikhabhathi zamayeza nakwiikhemesti njengamagama ezinto Iproscar okanye Ukuchaneka , nangona Uhlobo oluqhelekileyo ikwafumaneka.

Iyeza lisebenza ngokuthintela ukuguqulwa kwe testosterone ibe dihydrotestosterone (DHT), ebangela ukukhula kweprostate gland kunye nokunqongophala kweenwele. Iyaphumelela ekunciphiseni ubungakanani beprostate kwizigulana ezininzi kwaye Isibini kwisithathu samadoda ayithathela ingxelo yokulahleka kweenwele , ngokukaHarvard. Ngelixa izifundo ezithile zefinasteride bacebise ukubuyiselwa kweenwele zabasetyhini ngokunjalo, akuqhelwanga ngokwesiqhelo kubafazi okanye ebantwaneni, ngakumbi abasetyhini abakhulelweyo, njengoko kunokubangela iziphene zokuzalwa.

Ngaxeshanye ukunyanga ukulahleka kweenwele kwindoda kunye ne-BPH, iinkxalabo ezibini ezixhaphakileyo zamadoda, zenza ukuba i-finasteride ibonakale njengesiyobisi esigqibeleleyo kwindoda. Ngaba kunjalo? Ngelixa iluncedo ngendlela emangalisayo, i-finasteride ayifezekanga. Jonga ngaphaya kweenzuzo zenqanaba lomphezulu, kwaye uyakufumana iimpembelelo ezahlukeneyo zefinasteride, izilumkiso, kunye nokunxibelelana kweziyobisi. Funda ukujonga okunzulu kuzo zontathu ezi zinto.

ZIQHELEKILEYO: Yintoni iProscar? | Yintoni iPropecia? | Yintoni iFinasteride?

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Bhalisela izilumkiso zamaxabiso e-finasteride kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Iziphumo ebezingalindelekanga

Ipropecia kunye neProscar ngokubanzi ziyanyamezeleka, kodwa ziza noluhlu lweziphumo ebezingalindelekanga. I-Finasteride yeyeklasi yeziyobisi ebizwa ngokuba yi-5-alpha reductase inhibitors, echaphazela amanqanaba ehomoni kunye nokunciphisa umsebenzi wehomoni eyindoda, ngamanye amaxesha ibangela iziphumo ebezingalindelekanga zokuzala ezinje:

• Ukungabi namandla / ukungasebenzi kakuhle kwe-erectile (kuguqulwe ngokupheliswa kwamayeza)
• Ingxaki yokuphuma emzimbeni
• Ukunciphisa ivolumu ye-ejaculate
• Ukunciphisa inani lobudoda
• Ukuncitshiswa kwesondo

Ukongeza kwiziphumo ebezingalindelekanga ezidweliswe apha ngasentla, ezinye iziphumo ebezingalindelekanga eziqhelekileyo ezichazwe ngeziganeko ezimalunga ne-1% -10% yezigulana ezithatha amayeza zibandakanya:

• I-Orthostatic hypotension (uxinzelelo lwegazi oluphantsi xa umile)
• Ukuba nesiyezi
• Intloko ebuhlungu
• Ubuthathaka

Okokugqibela, iziphumo ebezingalindelekanga eziqhelekileyo, ezijongwa ngokubanzi ngaphantsi kwe-1% -2% yezigulana ezithatha i-finasteride, zibandakanya:

• Impumlo enemifinya
• Ukudumba kolusu
• Uxinzelelo lwegazi oluphantsi
• Intlungu engqina
• Ukuthamba kwebele

Izigulana ezithatha i-finasteride zinokufumana ukonyuka komchamo. Nangona kunjalo, kunyango lwe-BPH (oluhlala luthintela umchamo), oku kunokumela ukubuyela ekuhambeni kakuhle komchamo.

Zama ikhadi lesaphulelo esisodwa

Iziphumo ebezingalindelekanga ezimandundu ze-finasteride

Iziphumo eziqhelekileyo zefinasteride zanele ngokwaneleyo ukuba zingangqinelani, kodwa aziyonto ingaqhelekanga kunyango lwamayeza. Kwiimeko ezinqabileyo, nangona kunjalo, iziphumo ebezingalindelekanga ezibi kakhulu zinokubakho ezifuna unyango. Oku kubandakanya:

• Ukungasebenzi kakuhle kwe-erectile : Kwi Uphononongo lwamva nje , I-1.4% yamadoda aqalise unyango lwe-5-alpha reductase inhibitor yenze ukungasebenzi ngokwesondo okuqhubekeke ubuncinci kwiintsuku ezingama-90 emva kokuyeka amayeza. Ayikokungabi namandla okusisigxina njengemithombo ethile yemithombo yeendaba exeliweyo, kodwa inokuchaphazela impilo yesini yemihla ngemihla ngexesha nasemva konyango.
• Ukungachumi: Ukucaca, ayisiyiyo inzalo ebomini. Amanye amadoda anokufumana umgangatho wobudoda ohluphekileyo ngelixa ethatha i-finasteride, ethi iphuculwe emva kokuyekiswa kweyeza.
• Uxinzelelo: Ukugqitywa kwefinasteride kunokubangela utshintsho kwimvubu , esenza iinkqubo zokuphendula ngokweemvakalelo, zikhokelele kwimeko yokudakumba nakwiingcinga zokuzibulala. Uxinzelelo kunye noxinzelelo kunokubangelwa kukungabinakho ukusebenza ngokwesondo.
• Umngcipheko owandisiweyo womhlaza webele: Izifundo ezithile babuze unxibelelwano phakathi konyango lwe-finasteride kunye nomhlaza wamabele wamadoda, ngelixa abanye bengafumananga kulungelelaniswa. Okwangoku, nabani na othatha iyeza kufuneka aqonde izikhombisi zomhlaza ezinje ngokwandiswa kwebele, ukudumba, iintlungu, amaqhuma, okanye ukukhutshwa kwengono, kwaye undwendwele ugqirha ukuba ngaba ezi ziphumo bezingalindelekanga ziyaqhubeka.
• Umngcipheko ophezulu womhlaza webala lobudoda : Ngokwe- isifundo yiNew England Journal of Medicine , I-finasteride inciphisa umngcipheko womhlaza webala lobudoda, kodwa inokuwonyusa umngcipheko womhlaza webala lobudoda. Iziphumo zexesha elide ziveze ukuba akukho mahluko kwiziphumo zokusinda xa kuthelekiswa nezigulana ezifumana i-finasteride xa ithelekiswa ne-placebo, kwaye abo bacinga ukuba banegalelo koku kufunyaniswa kukuba i-finasteride inyusa ubuchule bokufumana olu hlobo lomhlaza.
• Ukunyanga komzimba: Kwiimeko ezinqabileyo, i-finasteride inokubangela ukusabela okungafunekiyo. Izikhombisi ezinje ngemingci, ubunzima bokuphefumla, kunye nolwimi okanye umqala wokudumba ugunyaziso lonyango kwangoko.

Iingxaki zombono aziyomphumo oqhelekileyo wecala le-finasteride, nangona kunjalo isifundo esinye ifumene unxibelelwano. Nangona kunjalo, yayisayizi yesampulu encinci, ke ukuvavanywa ngakumbi kunokuba yimfuneko yokuqinisekisa. Kodwa oku akuthethi ukuba ayinabungozi ngokupheleleyo kumbono wakho. NgokukaGqirha Yuna Rapaport, MD, MPH, umlawuli we Iliso leManhattan , i-finasteride ngokwayo inokubangela ukonakala kwe-retina kunye ne-optic nerve, enokuthi ingachaphazeli umbono wakho, kodwa inokufunyanwa kumfanekiso okhethekileyo. Ukongeza, amayeza e-Prostate afana neFlomax anokuchaphazela indlela i-iris ebeka ngayo kunye nokwenza utyando oluthile, ngakumbi utyando lwe-cataract, lucelomngeni ngakumbi.

Ukuwohloka kwengqondo kunokuba yinkxalabo, ikakhulu kuba i-dihydrotestosterone ichaphazela ukusebenza kwengqondo. Inkqubo ye- Ijenali yeeNzululwazi zeNeological Ufumene umngcipheko ophezulu wesifo sengqondo esixhalabisayo kwiminyaka emibini yokuqala yonyango lwe-5-alpha reductase inhibitor, kodwa akukho bungozi bonyukayo emva koko.

Emva kokudibana (okanye nokufunda malunga) nezinye zeziphumo ebezingalindelekanga, amanye amadoda aya kufuna ukuphelisa unyango lwawo lwe-finasteride. Akukho ziphumo zibi okanye ukurhoxa emva kokuyeka i-finasteride turkey ebandayo, kodwa ukulahleka kweenwele kunye nokukhula kweprotate kuya kuphinda kuqalise ngaphandle kokuba olunye unyango luthathe indawo yalo.

Izilumkiso ngefinasteride

Ngokubanzi, i-finasteride lukhetho olukhuselekileyo lonyango. Oko kwathiwa, mhlawumbi eyona nto ithathwayo inkulu kuzo zonke ezi ziphumo bezingalindelekanga kukuba ayinguye wonke umntu. Ngokwe- Ulwazi lweziyobisi zePropecia evela kumenzi wayo, uMerck, kunye ne-FDA, i-finasteride ayiboniswanga ukuba isetyenziswe kubafazi okanye kwizigulana zabantwana. Kwaye oku kuyinyani ngokukodwa kubafazi abakhulelweyo. Iziphumo zeziyobisi kubantwana abangamakhwenkwe abangamakhwenkwe zinokuba yingozi kangangokuba i-FDA ilumkise oomama abalindeleyo nokuba baphathe iipilisi zePropecia ezaphukileyo okanye ezaphukileyo.

Nabani na onesifo sesibindi esele sikhona okanye umsebenzi wesibindi ongaqhelekanga kufuneka alumke xa usebenzisa i-finasteride kuba ikakhulu ityetyisiwe esibindini. Akukho luhlengahlengiso luthile olucetyiswayo.

Zimbini iidosi ezisemgangathweni ezisemgangathweni: 1 mg kunye ne-5 mg. Xa zisetyenziselwa ukukhula kweenwele kwizigulana ezinempandla yamadoda okanye i-androgenetic alopecia, oogqirha bahlala bemisela iidosi ze-1 mg, ngelixa izigulana ze-BPH zihlala zifuna i-5 mg. Imilinganiselo emikhulu kune-5 mg ayikhuthazwa.

Nangona i-finasteride inokunyanga ukulahleka kweenwele, ukusetyenziswa okuqhubekayo kuyafuneka ukugcina iziphumo. Isigulana esiqala unyango lwe-finasteride sibona iziphumo, emva koko siyeke, siya kubona ezo ziphumo zibuyela umva. Idosi ye-1 mg yile kukhuselekile ukusetyenziswa kwexesha elide , kodwa kunokubangela iziphumo ebezingalindelekanga ezandisiweyo.

Unxibelelwano lweFinasteride

Ngaphandle kweziphumo ebezingalindelekanga kunye nezilumkiso, i-finasteride khange ibonise unxibelelwano olubalulekileyo kunye nalo naliphi na elinye ichiza kuvavanyo lweklinikhi. Okwangoku, kukho imibuzo eqhelekileyo malunga nokuthatha amayeza athile aqhelekileyo kunye nePropecia okanye iProscar.

Izigulana ezixhalabileyo malunga nokuqina kwe-finasteride yokubangela ukungasebenzi kakuhle kwe-erectile (ED) kunye nokunye ukuphazamiseka kokuzala kunokuzibuza ukuba bangayithatha ngaxeshanye neViagra, Cialis, okanye ezinye iziyobisi ze-ED. Impendulo nguewe. Ayinakusetyenziswa kunye, kodwa ukusetyenziswa ngaxeshanye kunokunceda ukunciphisa okanye ukuthintela iziphumo ezithile zesondo.

Kodwa uthini ngezinye iindlela zonyango lokukhula kweenwele ezinje Rogaine ( imicocidil ) okanye ibhayotin ? Ewe, zombini ezi zikhuselekile Ukusetyenziswa ngaxeshanye ne-finasteride . Gcina ukhumbula, nangona kunjalo, ukuba iRogaine ineziphumo zayo, ezinokuthi zibekho kwisigulana kunye neziphumo ebezingalindelekanga.

Unyango lwe-testosterone yokutshintsha luyakhuseleka ukusetyenziswa kunye ne-finasteride kwizigulana ezine-testosterone esezantsi.

Kuthekani ngotywala? Ngokubanzi, utywala kunye ne-finasteride yindibaniselwano ekhuselekileyo. Nangona kunjalo, izifundo ezithile bonisa ukuba yonke imihla, ukusela kakhulu kunokwandisa umngcipheko womhlaza webala lobudoda, njengoko kunjalo ngefinasteride. Ke, ukusebenzisa eli chiza kunye nokusela utywala mihla le ithiyori kunokubangela umngcipheko.

Ungaziphepha njani iziphumo ebezingalindelekanga

Ngelishwa, iziphumo ebezingalindelekanga azisoloko ziphetshwa. Ngamanye amaxesha, ziyenzeka nje. Okwangoku, amanye amanyathelo kunye nokuthintela kunokunciphisa umngcipheko weziphumo ebezingalindelekanga.

Olona nyango lusisiseko kukuthatha amayeza njengoko kumiselwe yingcali yezempilo. Izigulana zinokuthatha kunye okanye ngaphandle kokutya, kodwa kufuneka zithathe idosi enye ngosuku (naliphi na ixesha losuku). Ngokwesiqhelo, iziphumo zeziyobisi azibonakali kangangeenyanga ezintathu, emva koko ukusetyenziswa okungaguqukiyo kuyimfuneko kwizibonelelo ezizinzileyo.

Kwakhona, gcinani engqondweni ukuba ezinye iziphumo ebezingalindelekanga zinokuba zezokwexeshana. Iziphumo ebezingalindelekanga zinokuhla njengoko uqhubeka nokuthatha amayeza, kwaye aphela ngokupheleleyo emva kokuyeka amayeza, ngokukaGqirha Rapaport. Ke, izigulana ezihlangabezana neziganeko ezigwenxa zihlala zibamisa ngokuphelisa amayeza. Kukho iimeko ezithile zokungasebenzi kakuhle ngokwesondo ezinokuthi ziqhubeke ixesha elide ngaphambi kokuba ziphele.

Eyona nto iphambili yile: Ngaba izibonelelo zefinasteride zigqithile kwiziphumo ebezingalindelekanga ezinokubakho? Kodwa impendulo ayilula. Iyahluka kumntu ngamnye, kuxhomekeka kwimeko yabo, imbali yezonyango, izinto eziphambili ngokubaluleka kunye nokunye. Eyona ntshukumo ilungileyo kuye nabani na ocinga ngamayeza afana nePropecia okanye iProscar kukufumana ingcebiso kwezonyango kugqirha.