Amitiza vs.Linzess: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango iphathwe | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
I-Amitiza kunye neLinzess ngamayeza amabini amiselweyo asetyenziswa kunyango lokuqhinwa okungapheliyo kwe-idiopathic (CIC) kunye nesifo esichaphazela isisu ngokuqhinwa (IBS-C). Ukuqhina okungapheliyo kwe-idiopathic kubonakaliswa lixesha leenyanga ezintandathu okanye nangaphezulu ngokuhamba kwamathumbu amathathu okanye kancinci ngeveki. Irritable bowel syndrome liqela leempawu ezahlukileyo ezenzeka kunye kubandakanya iintlungu zesisu kunye notshintsho ekuhambeni kwamathumbu: urhudo, ukuqhina, okanye zombini. I-Amitiza kunye neLinzess zisetyenziswa ngokukodwa kwi-IBS ngokuqunjelwa. Siza kuthetha ngokufana nokwahluka phakathi kweAmitiza kunye neLinzess apha.
Nguwuphi umahluko ophambili phakathi kweAmitiza kunye neLinzess?
I-Amitiza (i-lubiprostone) sisiyobisi esinyangwa ngonyango esinyanga ukuqhina ngokunyusa ukuphuma kwamathumbu emathunjini. Yi-bicyclic fatty acid kunye ne-prostaglandin E1 (PGE 1) evela kumjelo wee-chloride osebenza kulusu lwamathumbu. Ukonyuka okukhoyo kwimfihlo kuguqula ukungaguquguquki kwesitulo kunye nokukhuthaza ukuhamba rhoqo kwamathumbu. I-Amitiza iyafumaneka njengephilisi yomlomo ethambileyo kumandla e-8 mcg kunye ne-24 mcg.
I-Linzess (linaclotide) sisiyobisi esikhutshiweyo esiboniswe kunyango lokuqhinwa. Yi-guanylate cyclase C (GC-C) i-agonist ebangela ukonyuka kwe-cyclic guanosine monophosphate (cGMP). Isenzo kwi-GC-C receptor siphumo sonyuso lweemfihlo zamathumbu. Oku kubangela ukonyuka kolwelo lwamathumbu kunye nokwandisa ukuhambisa kokuqulathwe ngamathumbu kwitraktara. Ukunyusa amanqanaba e-cGMP nawo kucingelwa ukuba athethelele ukunciphisa iintlungu ezibonakalayo kwisisu esiqhelekileyo kwi-IBS. I-Linzess iyafumaneka njengephilisi yomlomo kumandla angama-72 mcg, 145 mcg, kunye nama-290 mcg.
Umahluko ophambili phakathi kweAmitiza kunye neLinzess | ||
---|---|---|
Amitiza | Linzess | |
Iklasi yeziyobisi | I-Bicyclic fatty acid / PGE 1 isiphumo / isilumeki esisebenzayo | I-Guanylate cyclase C i-agonists |
Uhlobo lweBrith / generic | Ibhrendi kuphela | Ibhrendi kuphela |
Ngubani igama eliqhelekileyo? | ILubiprostone | Linaclotide |
Zeziphi iifom eza nalo iziyobisi? | Iphilisi yomlomo ethambileyo | Iifomsile zomlomo |
Ithini idosi esemgangathweni? | 24 mcg kabini yonke imihla | 145 mcg kanye yonke imihla |
Lude kangakanani unyango oluqhelekileyo? | Ingenasiphelo, ixesha elide | Ingenasiphelo, ixesha elide |
Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala | Abantu abadala |
Iimeko eziphathwe ngu-Amitiza kunye noLinzess
I-Amitiza kunye neLinzess nganye nganye ibonakalisiwe kunyango lokuqhinwa okungapheliyo kunye nesifo esibuhlungu sokuqunjelwa sisisu. I-Amitiza ikwamkelwe luLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kunyango lokuqhinwa okubangelwa kukusetyenziswa kweentlungu okunyanga iintlungu kwi-opioid ekusetyenzisweni kwentlungu enganyangekiyo. Ngamanye amaxesha kubizwa ngokuba yi-OIC, ukuqunjelwa okubangelwa yi-opioid.
I-Amitiza kunye neLinzess nganye iboniswa ukuba isetyenziselwe abantu abadala, kwaye ukusetyenziswa ebantwaneni nakwishumi elivisayo akuvunyelwanga. Ngugqirha wakho kuphela onokuthatha isigqibo sokuba la mayeza lukhetho olufanelekileyo kwimeko yakho.
Imeko | Amitiza | Linzess |
Ukuqhina okungapheliyo kwe-idiopathic | Ewe | Ewe |
Isifo esichaphazelayo samathumbu ngokuqhinwa | Ewe | Ewe |
I-Opiate agonist-induction constipation (iintlungu ezingapheliyo zomhlaza) | Ewe | Hayi |
Ngaba iAmitiza okanye iLinzess isebenza ngakumbi?
UKUYA uphononongo olucwangcisiweyo ye-21 yezilingo ezilawulwa ngokungekho mthethweni ngokuthelekisa izithako ezisebenzayo ze-Amitiza, iLinzess, kunye nolunye unyango oluqhelekileyo lokuqunjelwa. Olunye unyango olubandakanyiweyo kolu phando yayiyi-prucalopride, i-tegaserod, i-bisacodyl, kunye ne-polyethylene glycol (i-PEG). Olu hlalutyo lugqibe ekubeni zonke iziyobisi zibonakalise ukusebenza ngokulinganayo ngaphezulu kwe-placebo xa kuvavanywa isiphelo sokuba ne-3 okanye ngaphezulu kokuhamba kwamathumbu ngeveki. I-Bisacodyl, i-laxative yokuvuselela ekhawuntareni, yayiphezulu kwii-Amitiza naseLinzess ngokwenguqu kwinani lokuhamba kwamathumbu ngeveki. I-laxatives ezikhuthazayo zinokubangela ukungalingani kwe-electrolyte kwaye zithambekele kuphuhliso lokunyamezelana ngokuhamba kwexesha.
Ummiselo unokufuna ukuqaphela izinto ezinje ngeziganeko ezichaseneyo, ukuhlangana kweziyobisi, kunye nokuthobela kanye yonke imihla okanye kabini idosi yemihla ngemihla xa usenza isigqibo sokuba leliphi ichiza elilungele isigulana.
Ukufunyanwa kunye nokuthelekiswa kweendleko zeAmitiza vs.Linzess
I-Amitiza ihlala igutyungelwe zizo zombini izicwangciso zorhwebo kunye ne-Medicare Part D, nangona kwezinye iimeko inokufuna imvume kwangaphambili yokugubungela. Ixabiso elingaphandle kwepokotho leAmitiza linokuphakama njenge- $ 282, kodwa isigqebhezana esivela kwi-SingleCare sinokuhlisa ixabiso liye kuthi ga kwi-176 yeedola kunikezelo lweentsuku ezingama-30.
I-Linzess ihlala igutyungelwe zizo zombini izicwangciso zorhwebo kunye ne-Medicare Part D, nangona kwezinye iimeko inokufuna imvume kwangaphambili yokugubungela. Ngaphandle kwalo naluphi na uhlobo lokugubungela, iLinzess inokubiza phantse i $ 640. Ikhuphoni le-Linzess elivela kwi-SingleCare liya kukunceda ugcine kwi-Linzess, kwaye ungabhatala imali encinci njenge- $ 395.
Amitiza | Linzess | |
Ngokuqhelekileyo i-inshurensi? | Ewe ngamanye amaxesha kufuneka nogunyaziso lwangaphambili | Ewe ngamanye amaxesha kufuneka nogunyaziso lwangaphambili |
Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe ngamanye amaxesha kufuneka nogunyaziso lwangaphambili | Ewe ngamanye amaxesha kufuneka nogunyaziso lwangaphambili |
Ubungakanani | 30, 24 mcg njengezingxobo | 30, 145 mcg njengezingxobo |
I-Medicare copay eqhelekileyo | Iyahluka ngokuxhomekeke kwisicwangciso | Iyahluka ngokuxhomekeke kwisicwangciso |
Ixabiso elilodwa | $ 176- $ 204 | $ 395- $ 470 |
Fumana ikhadi lesaphulelo kwikhemesti
Iziphumo eziqhelekileyo ezichaphazelekayo zeAmitiza vs.Linzess
I-Amitiza kunye neLinzess banezehlo ezithile ezigwenxa phakathi kwabo, kodwa ezinye zahlukile kwichiza ngalinye. Urhudo sesona sizathu siqhelekileyo sokuphelisa unyango kuwo omabini la machiza, kwaye sisiphumo secala esiqhelekileyo kuwo omabini amachiza.
Amitiza kunokwenzeka kakhulu ukuba ibangele isicaphucaphu, esenzeka phantse kwisinye kwizigulana ezintathu ezithatha iyeza. Oku kubonakala ngathi kwenzeka rhoqo xa kuthathwa ngaphandle kwesisu. Ngamanye amaxesha esi sicaphucaphu siqatha kwaye siyadodobalisa, sigcina izigulana kwimisebenzi yesiqhelo yemihla ngemihla. Izigulana ezikwi-Amitiza zichaze iziganeko ezimbi ezinje ngesiyezi, ukudinwa, kunye nentlungu esifubeni, ngelixa abaguli baseLinzess bengakhange baxele ngeziphumo ebezingalindelekanga.
Le nto ayenzelwanga ukuba ibe luluhlu olubanzi lweziphumo ezibi, nceda unxibelelane nogqirha okanye usokhemesti uluhlu olupheleleyo.
Amitiza | Linzess | |||
Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
Isicaphucaphu | Ewe | 29% | Ewe | <2% |
Urhudo | Ewe | 12% | Ewe | 16-20% |
Intloko ebuhlungu | Ewe | Shumi elinanye% | Ewe | 4% |
Intlungu zesisu | Ewe | 8% | Ewe | 7% |
Ukuqaqanjelwa sisisu / ukudumba | Ewe | 6% | Ewe | 2-3% |
Ukuqunjelwa sisisu | Ewe | 6% | Ewe | 4-6% |
Ukuhlanza | Ewe | 3% | Ewe | <2% |
Edema | Ewe | 3% | Hayi | n / A |
Ukungahambi kakuhle esiswini | Ewe | 3% | Hayi | n / A |
Ukuba nesiyezi | Ewe | 3% | Hayi | n / A |
Iintlungu zesifuba | Ewe | Mbini% | Hayi | n / A |
IDyspnea | Ewe | Mbini% | Hayi | n / A |
Dyspepsia | Ewe | Mbini% | Ewe | <2% |
Ukudinwa | Ewe | Mbini% | Hayi | n / A |
Umlomo owomileyo | Ewe | 1% | Hayi | n / A |
Umthombo: Amitiza ( Yonke imihla I-Linzess ( Yonke imihla )
Ukudibana kweziyobisi neAmitiza vs. Linzess
I-Amitiza kunye neLinzess kufuneka zisetyenziswe ngononophelo kwizigulana ezinamachiza ane-anticholinergic. Amachiza e-anticholinergic anokukhuthaza ukuqunjelwa kunye nokuchasana nezenzo ze-pharmacologic ze-Amitiza kunye ne-Linzess.
Izigulana ezikwi-loop diuretics, ezinje nge-furosemide (Lasix), kufuneka ziphephe i-Amitiza njengoko zinokuba semngciphekweni wokuphulukana ne-potassium eninzi (hypokalemia). Kwezi zigulana, iLinzess inokuba lukhetho olukhethiweyo.
Olu ayilo luhlu lupheleleyo lokunxibelelana kweziyobisi okunokubakho. Uluhlu olupheleleyo, nceda ufune iingcebiso zonyango kugqirha wakho wezempilo.
Iziyobisi | Iklasi yeziyobisi | Amitiza | Linzess |
Atropine UBelladonna I-Benztropine Chlordiazepoxide Dicclomine I-Flavoxate IGlycopyrrolate IHomatropine IHyoscyamine IMethscopolamine Oxybutynin I-Scopolamine | I-Anticholinergics | Ewe | Ewe |
I-Bismuth salicylate Loperamide | Iimpawu zokuthintela urhudo | Hayi | Ewe |
Bumetanide Furosemide I-Torsemide | Umchamo wethambo | Ewe | Hayi |
Lactulose | Laxative | Ewe | Hayi |
Solifenacin | I-Antimuscarinic | Ewe | Hayi |
Imethadone | I-Opioid | Ewe | Hayi |
Izilumkiso zeAmitiza kunye neLinzess
I-Amitiza inokubangela isicaphucaphu. Ukuvela kwesicaphucaphu kunokuhla ngokuthatha i-Amitiza ngokutya.
I-Amitiza neLinzess akufuneki zinikwe izigulana ezinesifo sohudo esiqatha kuba oko kunokubangela urhudo ukuba lubi. Ukuba isifo sohudo siqala emva kokuba uqale unyango, uyeke unyango, kwaye uqhagamshelane nomboneleli wakho wezempilo.
I-Syncope, okanye utywala ekumeni, kunye ne-hypotension, okanye uxinzelelo lwegazi oluphantsi, lunokwenzeka emva kokuqala kokuqala kwe-Amitiza. Izigulana kufuneka zibeke esweni uxinzelelo lwegazi kwaye ziphakame kancinci ukusuka kwindawo yokuhlala ukuphepha ukuwa. Yazisa ugqirha wakho ngazo naziphi na iimeko zonyango okanye ezinye iziyobisi onokuthi uzithathe ezinokwenza mandundu i-syncope.
I-Dyspnea, okanye imvakalelo yokuqina kwesifuba kunye nokuphefumla okufutshane, inokwenzeka kunye neAmitiza. Olu phawu luhlala lubeka ngaphakathi kwimizuzu engama-30 ukuya kwengama-60 yedosi kwaye inokuhlala iiyure ezimbalwa. Ukuba oku kuyenzeka, kufuneka unxibelelane nogqirha wakho.
I-Linzess ithwala isilumkiso esikhutshiweyo kunye nokuchasana nokusetyenziswa kwezigulana zabantwana ngenxa yokuba nako ukubangela ukomisa kakhulu emzimbeni. Ulwazi oluthe kratya ngesi silumkiso sinokufumaneka kwi fda.gov .
Imibuzo ebuzwa rhoqo malunga neAmitiza vs.Linzess
Yintoni iAmitiza?
I-Amitiza sisiyobisi esisetyenziselwa ukunyanga ukuqhina okungapheliyo kunye nokunyanga isifo samathumbu ngokuqhinwa. I-Amitiza ikwavunyiwe ukunyanga ukusetyenziswa kwesisu sokuqunjelwa kwe-opioid yeentlungu ezinganyangekiyo zomhlaza. Isebenza ngokwandisa ukuphuma kwamathumbu emathunjini ukutshintsha ukungqinelana kwesitulo. Iyafumaneka njengephilisi yomlomo kwi-8 mcg kunye ne-24 mcg yamandla.
Yintoni iLinzess?
I-Linzess sisiyobisi esigqirha esibonisiweyo kunyango lokuqhinwa okungapheliyo kunye nokuqaqanjelwa kwamathumbu ngokuqhinwa. Iyonyusa umxholo wamathumbu emathunjini kunye nokuhamba. Iyafumaneka njengezingxobo zomlomo kumandla angama-72 mcg, 145 mcg, kunye nama-290 mcg.
Ngaba iAmitiza neLinzess ziyafana?
Ngelixa iAmitiza kunye neLinzess nganye inyanga ukuqhina, ayifani. I-Amitiza yi-bicyclic fatty acid kunye ne-prostaglandin E1 (PGE 1), kwaye idosiwe kabini yonke imihla. I-Linzess yeyeklasi ye-guanylate cyclase C (GC-C) i-agonists, kwaye inyanzelwa kube kanye yonke imihla.
Ngaba iAmitiza okanye iLinzess ingcono?
I-Amitiza kunye neLinzess zibonise ukusebenza ngokufanayo ekupheliseni ukuqhina. Ababhali banokujonga izinto ezinje ngeedosi zedosi kunye neziganeko ezimbi xa usenza isigqibo sokuba leliphi iyeza elilungele isigulana. I-Amitiza kunye neLinzess zikhethwa kukuqhinwa okungapheliyo kuba olunye unyango lwesiNtu olunjengezithambisi zestool (umz.I-docusate), i-osmotic laxatives (umz.I-Miralax), okanye ii-laxatives ezikhuthazayo (umz.
Ndingayisebenzisa iAmitiza okanye iLinzess ngelixa ndikhulelwe?
Imingcipheko enxulumene neziyobisi yokusetyenziswa kweAmitiza okanye iLinzess ayichongwanga kuba akukho zilingo zaneleyo, zilawulwayo zeklinikhi ukubonisa ukhuseleko lwabo. Ukusetyenziswa kwala machiza xa ukhulelwe kufuneka kuthintelwe kwiimeko apho izibonelelo ngokucacileyo zingaphezulu komngcipheko.
Ndingabusebenzisa i-Amitiza okanye iLinzess ngotywala?
Akukho zichaso zingqalileyo ngokuthatha la machiza kunye nokuselwa kotywala, nangona kunjalo, kubalulekile ukuba ukhumbule ukuba utywala bunokukhokelela ekuphelelweni ngumzimba nakwisifo sorhudo, njengoko kunokwenzeka la machiza, ukubeka izigulana emngciphekweni wokuphelelwa ngamandla.
Ngaba iAmitiza ibangela ukutyeba?
I-Amitiza ayiboniswanga ukuba ibangela ukutyeba.
Kuthatha ixesha elingakanani ukuze uLinzess asebenze?
Uncedo lokuqunjelwa ngokubanzi lwenzeka kwiveki enye ukuya kwezimbini, kunye nophuculo oluqhubekayo kwiimpawu ezenzeka ukuya kuthi ga kwiiveki ezili-12.
Ngubani ongafanele athathe iAmitiza?
Izigulana ezinezithintelo ezenziwa ngoomatshini kwiindlela zesisu (GI) zazo akufuneki zithathe i-Amitiza. Kwakhona, izigulana ezifumana urhudo olulinganiselweyo akufuneki zithathe i-Amitiza. Abasetyhini abakhulelweyo okanye abancancisayo, kunye nezigulana zabantwana, kufuneka baphephe i-Amitiza.