IArmodafinil vs.modafinil: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango iphathwe | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
Unokuba nobunzima bokulala kakhulu emini ukuba usebenza ebusuku. Kodwa ngonyango olufanelekileyo njengeArmodafinil (i-Nuvigil) okanye i-modafinil (i-Provigil), unokuhlala uphaphile kwaye uzive uphaphile ngakumbi. La mayeza angamiselwa ukuba uye wafumanisa ukuba une-shift work disorder (SWD), i-narcolepsy, okanye i-obstruction sleep apnea (OSA). Njengeearhente zokukhuthaza ukuvuka, i-armodafinil kunye ne-modafinil zineziphumo ezinjengezikhuthazi.
Ngelixa indlela yabo yokusebenza ingaziwa, i-armodafinil kunye ne-modafinil kukholelwa ukuba zisebenza kwinkqubo ye-nervous system (CNS) kunye nokunyusa umsebenzi we-dopamine kwingqondo. Iziphumo zazo zinokufana nezinye izinto ezikhuthazayo ezifana ne-amphetamine (Adderall) kunye ne-methylphenidate (Concerta). Nangona kunjalo, zahlukile ngokwakhiwa kwezinye izinto ezikhuthazayo.
Zombini i-armodafinil kunye ne-modafinil ngamachiza eShedyuli IV anamandla aphantsi okuphathwa gadalala kunye nokuxhomekeka. Zizinto ezilawulwayo ezifumaneka kuphela ngommiselo.
Nguwuphi umahluko ophambili phakathi kweArmodafinil kunye neModafinil?
IArmodafinil, ethengiswa phantsi kwegama lophawu iNuvigil, sisiyobisi esitsha xa kuthelekiswa nemodafinil. Yavunywa ngo-2007 njenge-R-enantiomer ye-modafinil. I-Enantiomers ziimolekyuli eziyimifanekiso yesipili yomnye nomnye-cinga iiglavu zasekhohlo nezasekunene. Ngale ndlela, i-armodafinil inesakhiwo semichiza esahlukileyo ngokuthelekiswa ne-modafinil.
IArmodafinil inokuba nesiqingatha sobomi obude xa kuthelekiswa ne-modafinil (igama lomthi-Provigil). Ngamanye amaxesha, i-armodafinil inokuthi ithathelwe ingqalelo njengesiyobisi esomeleleyo kunye nefuthe lokuvuka okungcono. Ngelixa omabini la machiza anokuba neziphumo ebezingalindelekanga ezifanayo, ezinye iziphumo ebezingalindelekanga zinokuba yinto exhaphake kwelinye ichiza xa lithelekiswa nelinye.
| Umahluko ophambili phakathi kwearmodafinil kunye ne modafinil | ||
|---|---|---|
| Armodafinil | Imodafinil | |
| Iklasi yeziyobisi | Isiyobisi esinjengokukhuthaza Ukunyusa iarhente | Isiyobisi esinjengokukhuthaza Ukunyusa iarhente |
| Uhlobo lweBrith / generic | Uhlobo lweBrand kunye negeneric ziyafumaneka | Uhlobo lweBrand kunye negeneric ziyafumaneka |
| Ngubani igama lophawu? | I-Nuvigil | Provigil |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo | Ithebhulethi yomlomo |
| Ithini idosi esemgangathweni? | I-150 mg kanye ngemini | 200 mg kanye ngemini |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide okanye njengoko kuyalelwe ngugqirha | Ixesha elide okanye njengoko kuyalelwe ngugqirha |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala kunye nabantu abadala abancinci abaneminyaka eli-17 nangaphezulu | Abantu abadala kunye nabantu abadala abancinci abaneminyaka eli-17 nangaphezulu |
Ngaba ufuna elona xabiso lilungileyo kwi-armodafinil?
Bhalisela iarmodafinil amaxabiso izilumkiso kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Imiqathango ephathwe yi-armodafinil kunye ne-modafinil
I-Armodafinil kunye ne-modafinil ngamachiza amiselweyo avunyiweyo yi-FDA ukunyanga ukulala emini okunxulumene ne-narcolepsy, utshintsho lomsebenzi wokuphazamiseka emsebenzini, kunye ne-apnea yokulala yokuthintela. Ezi meko zonyango zibonakaliswa kukungoneli kweemvakalelo ezikhokelela kubuthongo obugqithisileyo. Omabini la machiza aphucula ukuvuka kwabo banengxaki yokudinwa kakhulu kunye nokulala imini yonke.
IArmodafinil kunye nemodafinil ziye zafundelwa ngaphandle kweelebheli. Abanye izifundo bonisa ukuba i-modafinil inokuba lukhetho olusebenzayo lonyango lokudinwa okwenzeka ngenxa yomhlaza kunye nonyango lomhlaza. Kubantu abadala abafumana unyango lomhlaza, i-modafinil inokunceda ekunciphiseni ukudinwa okugqithisileyo kwi-chemotherapy.
Kulawo ane isifo sokugubhuka , iidosi ezisezantsi ze-modafinil zinokusebenza ngokunyanga iimpawu zokudinwa. Nangona kunjalo, uninzi lweedatha lubonisa ukuba i-modafinil akufuneki isetyenziswe njengokhetho lomgca wokuqala wale meko.
Olunye usetyenziso lwelebheli engekhoyo lubandakanya unyango lweengxaki zengqondo ezinje ukudakumba kunye nengxaki yokusilela kwengqwalaselo-yehypactivity (ADHD). IArmodafinil okanye i-modafinil inokusebenza ekunyangeni iimpawu zezi ngxaki kodwa azikhuthazwa njengonyango lokuqala.
| Imeko | Armodafinil | Imodafinil |
| Ingqele | Ewe | Ewe |
| Ishift yokusebenza kwengxaki | Ewe | Ewe |
| Ukuphefumla kokulala okuthintelayo | Ewe | Ewe |
| Ukudinwa okunxulumene nomhlaza | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| Ukudinwa okuninzi okunxulumene ne-sclerosis | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| Ukuphazamiseka kwengqondo njengokudakumba kunye ne-ADHD | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
Ngaba ufuna elona xabiso lilungileyo kwimodafinil?
Bhalisela izilumkiso zamaxabiso e-modafinil kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Ngaba i-armodafinil okanye i-modafinil isebenza ngakumbi?
I-Armodafinil kunye ne-modafinil ziyasebenza ngokufanayo kunyango lokulala kwiingxaki zokulala ezinje nge-narcolepsy, isithintelo sokuphefumla kokulala, kunye nengxaki yomsebenzi wokutshintsha. Nangona kunjalo, i-armodafinil inokuba neziphumo ezihlala ixesha elide xa kuthelekiswa ne-modafinil.
Kwiiveki ezili-12 ezingahleliwe, uvavanyo lwezonyango, zombini i-armodafinil kunye ne-modafinil ukuphucula ukulala kwizifundo ezisebenza ngokutshintsha kobusuku. Iziphumo zafumanisa ukuba i-armodafinil kunye ne-modafinil zithelekiswa namanqaku afanayo okhuseleko.
Kwi Uhlalutyo lweemeta ngokuthelekisa i-armodafinil kunye ne-modafinil yokuthintela ukuphefumla kokulala, omabini la machiza afunyenwe esebenza ngokunyanga ukulala. Izigulana ezithatha iziyobisi ezinganyangekiyo kunye namava okuphucuka kokuvuka emini.
IArmodafinil ibonakalisiwe ukuba inyukile Uxinzelelo lweplasma emzimbeni kamva emini. Amanqanaba aphezulu e-armodafinil emzimbeni anokubangela ukuvuka okungcono xa kuthelekiswa ne-modafinil.
Ngelixa ichiza linokusetyenziswa njengonyango lokobiwa bubuthongo obuninzi, kungcono ukudibana nogqirha ukuze ufumane iingcebiso zonyango. Okwangoku, akukho zifundo zichazayo ezithi enye isebenza ngakumbi kunenye.
Ukufunyanwa kunye nokuthelekiswa kweendleko zearmodafinil vs.modafinil
IArmodafinil ihlala ichazwa njengecwecwe le-250 mg elithathwa kanye yonke imihla. Ifumaneka ngokubanzi njengonyango oluqhelekileyo olugqunywe yiMedicare kunye nezicwangciso zeinshurensi. IGeneric Nuvigil inokubiza ixabiso eliphakathi lokuthengisa ngaphezulu kweedola ezingama-500. Eli xabiso linokwehliswa ngekhadi lesaphulelo elilodwa. Endaweni yokuhlawula amaxabiso aphezulu, i-armodafinil inokuthengwa ngexabiso eliphantsi njenge- $ 277.
Kuxhomekeka kwisicwangciso sakho seinshurensi, imodafinil inokugqunywa. Ngapha koko, i-Medicare kunye nezicwangciso ezininzi ze-inshurensi zigubungela i-modafinil ngeenjongo ezivunyiweyo. Ixabiso eliphakathi lemodafinil linokubiza ngaphezulu kwe- $ 600. Kwiikhemesti ezithatha inxaxheba, ungasebenzisa ikhadi lokonga i-SingleCare ukugcina imali. Ukulondolozwa kwemodafinil kunokubangela amaxabiso asezantsi angama- $ 35- $ 280 kuxhomekeke kwikhemesti oyisebenzisayo.
| Armodafinil | Imodafinil | |
| Ngokuqhelekileyo i-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo igutyungelwe yiMedicare? | Ewe | Ewe |
| Umthamo osemgangathweni | Iipilisi ezingama-150 mg | Iipilisi ezingama-200 mg |
| I-Medicare copay eqhelekileyo | $ 15- $ 217 | $ 11- $ 392 |
| Ixabiso elilodwa | $ 277 | $ 35- $ 280 |
Iziphumo eziqhelekileyo ezichaphazelekayo zearmodafinil vs.modafinil
Iziphumo eziqhelekileyo ezichaphazelekayo kunye ne-armodafinil kunye ne-modafinil zintloko, isisongela, isisu, kunye nokulala. I-Modafinil inokubangela ezinye imiphumela ezinje ngokuba luvalo, ukuxinana kwempumlo (i-rhinitis), urhudo, kunye nentlungu yomqolo.
Omabini la mayeza anokubangela umlomo owomileyo, ukungacoleki (dyspepsia), kunye noxinzelelo. Iziphumo ezinxulumene nokulahleka kobunzima nazo zinokwenzeka. Abanye abantu abathatha i-armodafinil okanye i-modafinil banokufumana ukunciphisa ukutya.
Ezinye iziphumo ezinqabileyo kodwa ezinzulu zibandakanya ukusabela okungafunekiyo njengokukhawuleza kunye nokuphefumla okufutshane. Iziphumo ebezingalindelekanga ezinje ngoxinzelelo okanye isifo sengqondo zinokwenzeka. Funa unyango xa ufumana ezi ziphumo bezingalindelekanga.
| Armodafinil | Imodafinil | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Intloko ebuhlungu | Ewe | 17% | Ewe | 3. 4% |
| Isicaphucaphu | Ewe | 7% | Ewe | Shumi elinanye% |
| Uvalo | Ewe | 1% | Ewe | 7% |
| Ukuphuthelwa | Ewe | 5% | Ewe | 5% |
| Ukuba nesiyezi | Ewe | 5% | Ewe | 5% |
| Urhudo | Ewe | 4% | Ewe | 6% |
| Umqolo obuhlungu | Hayi | - | Ewe | 6% |
| Ukuxinana kwempumlo | Hayi | - | Ewe | 7% |
| Ukutya | Ewe | Mbini% | Ewe | 5% |
| Umlomo owomileyo | Ewe | 4% | Ewe | 4% |
| Ixhala | Ewe | 4% | Ewe | 5% |
| Ukunciphisa ukutya | Ewe | 1% | Ewe | 4% |
Olu alunakuba luluhlu olupheleleyo. Dibana nogqirha wakho okanye usokhemesti malunga neziphumo ebezingalindelekanga ezinokubakho.
Umthombo: DailyMed ( armodafinil ), Yonke imihla ( Imodafinil )
Ukudibana kweziyobisi kwearmodafinil vs.modafinil
IArmodafinil kunye ne-modafinil zabelana ngokusebenzisana okufanayo kwesiyobisi. La mayeza anokusebenza njenge-inducers ye-CYP3A4 enzyme kunye nee-inhibitors ze-CYP2C19 enzyme. Ngamanye amagama, banokuchaphazela indlela ezenziwa ngayo iziyobisi ezithile emzimbeni.
I-Armodafinil kunye ne-modafinil inokunciphisa ukusebenza kwe-steroidal izinto zokucwangcisa . Kunconywa ezinye iindlela zokuthintela ukukhulelwa ngexesha lonyango nge-armodafinil okanye i-modafinil kunye nenyanga enye emva kokuyekiswa kwala machiza.
I-Armodafinil kunye ne-modafinil inokunyusa ukucocwa kwe-cyclosporine emzimbeni. Ukuba kuthathwe kunye, ukusebenza kwe-cyclosporine kunokuncitshiswa. Kwelinye icala, i-armodafinil kunye ne-modafinil inokunyusa amanqanaba ezinye iziyobisi ezaziwa ngokuba zii-substrates ze-CYP2C19. Ukunyusa amanqanaba eziyobisi kunokukhokelela kwiziphumo ezibi.
| Iziyobisi | Iklasi yeziyobisi | Armodafinil | Imodafinil |
| I-Ethinyl estradiol Indawo encinci | Izinto zokucwangcisa zeSteroidal | Ewe | Ewe |
| ICclosporine | Ugonyo | Ewe | Ewe |
| Omeprazole IPhenytoin Diazepam | I-CYP2C19 substrates | Ewe | Ewe |
Olu alunakuba luluhlu olupheleleyo lwazo zonke izinto ezinokubakho xa kusenziwa iziyobisi. Dibana nogqirha nawo onke amayeza onokuthi uwathathe.
Izilumkiso ze-armodafinil kunye ne-modafinil
Zombini i-armodafinil kunye ne-modafinil zinokubangela irhashalala elibi. La machiza kufuneka ayekiswe kwangoko xa kukho irhashalala elinzima. Musa ukuwathatha la machiza ukuba unokrokrelwa ukuba kukho izinto ezingahambisani nawe.
Imilinganiselo ye-armodafinil okanye i-modafinil inokufuna ukulungiswa ukuze kuphuculwe ubuthongo emini. Ngelixa ulungiselela iidosi, ukulala okungapheliyo kusenokwenzeka. Ke ngoko, kubalulekile ukunqanda ukuqhuba okanye ukuthatha inxaxheba kwimisebenzi eyingozi xa uqala ukwenza iziyobisi njenge-armodafinil okanye i-modafinil.
I-Armodafinil kunye ne-modafinil zinokubangela iimpawu zengqondo ingakumbi kwabo banembali ye ngengqondo , ukudakumba, okanye i-mania. La mayeza kufuneka abekwe esweni okanye ayekiswe kwiimeko ezibi zempembelelo zengqondo.
Iziyobisi ezinje ngokukhuthaza zinokubangela iziphumo ezibi entliziyweni nakwinkqubo yeentliziyo. Abo banexinzelelo lwegazi banokufuna ukubekwa esweni xa kuqala i-armodafinil okanye i-modafinil. Dibana nogqirha ukuba uva iintlungu esifubeni, ukuphefumla kancinci, okanye ukubetha kwentliziyo (ukubetha kwentliziyo okukhawulezileyo).
Imibuzo ebuzwa rhoqo malunga nearmodafinil vs.modafinil
Yintoni iArmodafinil?
IArmodafinil yaziwa njengegama layo elinguNuvigil. IArmodafinil isetyenziselwa ukunyanga ubuthongo obuninzi kwi-narcolepsy kunye nezinye iingxaki zokulala. Iza kwi-50 mg, 150 mg, 200 mg, kunye neepilisi ezingama-250 mg.
Yintoni imodafinil?
I-Modafinil ligama eliqhelekileyo lika-Provigil. I-Modafinil ivunyiwe yi-FDA ukunyanga ukulala emini okubangelwa kukungalali kakuhle. Inokuphatha i-apnea yokulala yokuthintela, isiqwenga , kunye nokutshintsha kokuphazamiseka emsebenzini.
Ngaba i-armodafinil kunye ne-modafinil ziyafana?
IArmodafinil kunye ne-modafinil ziqulathe izinto ezifanayo kodwa azifani. IArmodafinil iqulethe i-R-enantiomer ye-modafinil. I-Modafinil iqulethe umxube wobuhlanga we-R- kunye ne-S-modafinil.
Ngaba i-armodafinil okanye i-modafinil ibhetele?
IArmodafinil kunye ne-modafinil ziyafana ngokusebenza kunye nokhuseleko. Nangona kunjalo, i-armodafinil inokuba nayo amanqanaba aphezulu emzimbeni ekuhambeni kwemini. Iziphumo zeArmodafinil zinokuhlala ixesha elide ngokuthelekiswa ne-modafinil.
Ngaba ndingasebenzisa i-armodafinil okanye i-modafinil ngelixa ndikhulelwe?
Hayi. IArmodafinil kunye ne-modafinil zihlala zingacetyiswa ngexesha lokukhulelwa. Xoxa ngonyango lwakho ukuba ukhulelwe okanye uncelisa.
Ngaba ndingasebenzisa i-armodafinil okanye i-modafinil ngotywala?
Akucetyiswa ukuba uthathe i-armodafinil okanye i-modafinil ngelixa usela utywala. Ukusela utywala ngelixa ukwi-armodafinil okanye i-modafinil kunokubangela iziphumo ebezingalindelekanga.
Ngaba ungathatha i-armodafinil kunye ne-modafinil kunye?
IArmodafinil kunye ne-modafinil azihlali zithathwa kunye. Zombini i-armodafinil kunye ne-modafinil ziqulathe izinto ezifanayo. Ukuthatha i-armodafinil kunye ne-modafinil kunye kunokunyusa umngcipheko weziphumo ezibi.
Ngaba i-armodafinil iya kubonisa kuvavanyo lweziyobisi?
Hayi. Uvavanyo lweziyobisi aluhlali lukhangela i-armodafinil. IArmodafinil ayiqulathanga amphetamine kunqabile ukuba neempembelelo zobuxoki ze-amphetamine.
Ngaba ungathatha i-armodafinil yonke imihla?
IArmodafinil isebenza kakuhle xa ithathwa yonke imihla. Kuyacetyiswa ukuba uthathe idosi enye yeArmodafinil ngexesha elifanayo yonke imihla, ngesiqhelo kusasa.
