ICymbalta vs Lexapro: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
ICymbalta kunye neLexapro ngamachiza amabini amiselweyo aqhelekileyo asetyenziselwa ukunyanga zombini ingxaki yokudakumba (MDD) kunye noxinzelelo ngokubanzi (GAD). Uxinzelelo olukhulu lokudakumba kuqikelelwa ukuba kuchaphazele bamalunga nezigidi ezili-16 zabantu abadala eUnited States. Ibonakaliswa yimeko ephantsi ubuncinci iiveki ezimbini. Abaguli banokubonisa ukuphulukana nomdla kwimisebenzi abaqhele ukuyonwabela okanye amandla aphantsi. Abanye abaguli bafumana iintlungu ngaphandle kwesizathu esaziwayo.
Ukuphazamiseka koxinzelelo ngokubanzi kuqikelelwa ukuba kuchaphazele Abantu abadala abazizigidi eziyi-6.8 eMelika. Ibonakaliswa kukukhathazeka ngokweqile malunga nemicimbi eyahlukeneyo kubandakanya imali, usapho, impilo kunye nomsebenzi. Kufunyaniswa ukuba nje izigulana zibonisa oku kuxhalaba kwiintsuku ezininzi kunokuba kungapheli iinyanga ezintandathu.
Ngelixa iCymbalta kunye neLexapro zisetyenziselwa ukunyanga le meko kunye nezinye ezininzi, kukho umahluko omkhulu phakathi kwala mayeza mabini.
Nguwuphi umahluko ophambili phakathi kweCymbalta kunye neLexapro?
ICymbalta (duloxetine) lunyango lonyango oluboniswe kunyango lwe-MDD kunye ne-GAD. I-cymbalta yeqela le-anti-depressants eyaziwa ngokuba yi-serotonin-norepinephrine reuptake inhibitors (SNRIs) ekhethiweyo. Kwi-neuron synapse, iCymbalta ibhloka ukuphinda kuthathwe kwakhona zombini i-norepinephrine kunye ne-serotonin. Oku kushiya ii-neurotransmitters zifumaneke ngokulula ukuze zidlale indima elungileyo kwimood kunye nefuthe. Ezinye ii-SNRI onokuthi uqhelene nazo yi-Effexor (venlafaxine) kunye nePristiq (desvenlafaxine).
ICymbalta ifumaneka njenge-20 mg, 30 mg, kunye ne-60 mg capsule yomlomo.
I-Lexapro (i-escitalopram) ikwayiyeza elichazwe kunyango lwe-MDD kunye ne-GAD. ILexapro ikwiqela leziyobisi ezichasene ne-anti-depressants eyaziwa ngokuba yi-serotonin reuptake inhibitors (SSRIs) ekhethiweyo. ILexapro isebenza ngokuthintela ukuphinda kuthathwe i-serotonin kwimpompo yothutho lwe-membrane ye-neuronal. Eli nyathelo lishiya ngempumelelo i-serotonin yasimahla kwi-neuron synapse. Ezinye ii-SSRI onokuthi uqhelene nazo zibandakanya iProzac, iZoloft, iCelexa, okanye iPaxil.
ILexapro ifumaneka njengecwecwe lomlomo kumandla e-5 mg, 10 mg, kunye ne-20 mg. Ikwafumaneka njengesisombululo somlomo kwi-5 mg / 5 ml yoxinzelelo.
| Umahluko ophambili phakathi kweCymbalta kunye neLexapro | ||
|---|---|---|
| ICymbalta | ILexapro | |
| Iklasi yeziyobisi | Ukukhetha i-serotonin-norepinephrine reuptake inhibitor | Ukukhetha kwakhona i-serotonin reuptake inhibitor |
| Uhlobo lweBrith / generic | Brand kunye generic ziyafumaneka | Brand kunye generic ziyafumaneka |
| Ngubani igama eliqhelekileyo? | Duloxetine | I-Escitalopram |
| Zeziphi iifom eza nalo iziyobisi? | Iifomsile zomlomo | Ithebhulethi yomlomo kunye nesisombululo somlomo |
| Ithini idosi esemgangathweni? | 60 mg kanye ngemini | 10 mg kanye ngemini |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide (iinyanga ukuya kwiminyaka) | Ixesha elide (iinyanga ukuya kwiminyaka) |
| Ngubani oqhelekileyo usebenzisa amayeza? | Ulutsha kunye nabantu abadala | Ulutsha kunye nabantu abadala |
Imiqathango ephathwa yiCymbalta kunye neLexapro
Njengoko bekutshiwo ngaphambili, iCymbalta kunye neLexapro zombini zibonisiwe ukunyanga zombini uxinzelelo olukhulu lokudakumba kunye noxinzelelo ngokubanzi lokuphazamiseka. ICymbalta yamkelwe kwizalathiso ezizodwa ezinxulumene nentlungu ye-neuropathic kunye ne-musculoskeletal. Ezi zibonakaliso zibeka iCymbalta ngaphandle kwamanye amayeza okulwa noxinzelelo njengoko kukuphela kwayo evunyiweyo kwizifo ezinxulumene nentlungu. I-Lexapro ngamanye amaxesha isetyenziswa ngaphandle kwelebheli yeemeko ezinje ngengxaki yokunyanzelwa kokunyanzelwa, i-bulimia nervosa, kunye nokutya kakhulu.
Le tshathi ilandelayo inika uluhlu lweemeko eziphathwe yiCymbalta kunye neLexapro. Isenokungabandakanyi konke ukusetyenziswa okunokubakho, kwaye kuya kufuneka usoloko ubonisana nengcali yezempilo ukubona ukuba elinye lala machiza lilungile na kuwe.
| Imeko | ICymbalta | ILexapro |
| Uxinzelelo olukhulu lokudakumba | Ewe | Ewe |
| Ukuphazamiseka koxinzelelo ngokubanzi | Ewe | Ewe |
| Fibromyalgia | Ewe | Hayi |
| Intlungu engapheliyo yesifo semisipha | Ewe | Hayi |
| Intlungu ye-Neuropathic ehambelana nesifo seswekile | Ewe | Hayi |
| I-Chemotherapy ye-peripheral neuropathy | Ngaphandle kwelebheli | Hayi |
| Uxinzelelo ukungahambi kakuhle komchamo (amadoda) | Ngaphandle kwelebheli | Hayi |
| Ukuzinkcinkca ngotywala | Hayi | Ngaphandle kwelebheli |
| Bulimia amanosa | Hayi | Ngaphandle kwelebheli |
| Ubume obungalunganga obuphambanisayo | Hayi | Ngaphandle kwelebheli |
| Ukuphazamiseka kovalo | Hayi | Ngaphandle kwelebheli |
| Ukuphazamiseka koxinzelelo lwasemva kwexesha | Hayi | Ngaphandle kwelebheli |
| Ukuphazamiseka kwangaphambi kokuya exesheni | Hayi | Ngaphandle kwelebheli |
| Ukunyuka kwangaphambili | Hayi | Ngaphandle kwelebheli |
Ngaba iCymbalta okanye iLexapro isebenza ngakumbi?
UKUYA Uhlalutyo lweemeta uphonononge izifundo ngokuthelekisa i-duloxetine kunye ne-escitalopram kunye nezinye ii-SSRI eziqhelekileyo. Uphononongo lufumanise ukuba kunyango loxinzelelo olukhulu, i-duloxetine iyasilela ukubonisa isibonelelo esibalulekileyo kwimpumelelo yonyango ngaphezulu kwee-SSRI. Nangona kunjalo, ngokolu phononongo, abaguli kunokwenzeka ukuba bayeke i-duloxetine ngenxa yeziganeko ezimbi. Umzuzwana Uhlalutyo lweemeta zangqinelana nezi ziphumo. Akunakwenzeka ukuba utsho ukuba iCymbalta okanye iLexapro ibhetele kunenye ngokweendlela zokunyanga ukudakumba. Izinga elonyukayo leziphumo ebezingalindelekanga ngeCymbalta iya kuba yinto ebalulekileyo ekufuneka iqwalaselwe xa ukhetha unyango.
Umyinge kunye nokuthelekiswa kwexabiso leCymbalta vs. Lexapro
ICymbalta lunyango lonyango olugqityiweyo kuzo zombini izicwangciso zorhwebo kunye nezonyango. Ixabiso eliphuma epokothweni leCymbalta 60 mg lingangaphezulu kwe- $ 300, kodwa ngekhuphoni evela kwi-SingleCare, unokufumana i-generic yexabiso eliphantsi njenge- $ 15 kwiikhemesti ezithatha inxaxheba.
I-Lexapro ikwayiyeza likagqirha elihlala ligutyungelwe zizicwangciso zorhwebo kunye nezonyango. Ixabiso lokuphuma epokothweni lokubonelela ngeentsuku ezingama-30 zeLexapro 10 mg kunokuba ngama- $ 400. I-SingleCare ibonelela ngekhuphoni kwi-Lexapro yohlobo oluqhelekileyo, enokuthi yehlise ixabiso ukuya kwi-10 yeedola okanye ngaphantsi.
ikhadi lesaphulelo semithi
| ICymbalta | ILexapro | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo igutyungelwe yiMedicare? | Ewe | Ewe |
| Umthamo osemgangathweni | 30, 60 mg njengezingxobo | Iipilisi ze-30, 10 mg |
| I-Medicare copay eqhelekileyo | Ngaphantsi kwe- $ 10 | Ngaphantsi kwe- $ 10 |
| Ixabiso elilodwa | $ 15 + | $ 10 + |
Iziphumo eziqhelekileyo ezichaphazelekayo zeCymbalta vs. Lexapro
ICymbalta kunye neLexapro zinokubangela iziphumo ebezingalindelekanga ezifanayo, nangona ezinye zisenokwenzeka kwelinye okanye kwelinye iarhente. Isicaphucaphu, umzekelo, kwaxelwa kuphela kwiipesenti ezi-5 zezigulana ezithatha iLexapro kuvavanyo lweklinikhi xa kuthelekiswa neepesenti ezingama-23 zezigulana ezithatha iCymbalta. Ngelixa isicaphucaphu singasoloko sisiphumo esecaleni esihlala sihleli, sinokuchaphazela umgangatho wobomi bomntu. Kunokwenzeka ukuba kwenzeke kwiiveki zokuqala zonyango, kwaye unikwe ukuba la machiza ngokubanzi athatha naphina kwiiveki ezimbini ukuya kwezintandathu ukubonisa ifuthe kuxinzelelo okanye kwiimpawu zoxinzelelo, isicaphucaphu sinokuba sisizathu sokupheliswa kwangaphambi kokufumana iyeza liyaziwa.
Ukubila, okanye ukubila, kwenzeka kwinqanaba elifanayo phakathi kwezi ziyobisi zimbini. Esi siphumo secala sinokuchaphazela ubomi bemihla ngemihla yomntu kunye nokuzithemba kwakhe, kwaye inokuba sisizathu sokuba abaguli bakhethe ukuyeka iyeza.
Olu luhlu lulandelayo alwenzelwanga ukuba lube luluhlu olupheleleyo lweziganeko ezimbi. Nceda uqhagamshelane nosokhemesti, ugqirha, okanye enye ingcali kwezonyango uluhlu olupheleleyo lweziphumo ebezingalindelekanga ezinokubakho.
| ICymbalta | ILexapro | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Isicaphucaphu | Ewe | 2. 3% | Ewe | 5% |
| Umlomo owomileyo | Ewe | 13% | Ewe | 5% |
| Ukubila | Ewe | 6% | Ewe | 5% |
| Urhudo | Ewe | 9% | Ewe | 8% |
| Ukuqunjelwa | Ewe | 9% | Ewe | 3% |
| Dyspepsia | Hayi | n / A | Ewe | 3% |
| Ukuba nesiyezi | Ewe | 9% | Hayi | n / A |
| Ukozela | Ewe | 10% | Ewe | 6% |
| Intloko ebuhlungu | Ewe | 14% | Hayi | n / A |
| Ukunyusa uxinzelelo lwegazi | Ewe | Mbini% | Hayi | n / A |
| Ukunciphisa ukutya | Ewe | 7% | Ewe | 3% |
| Ukuncipha kwe-libido | Hayi | n / A | Ewe | Mbini% |
Umthombo: ICymbalta ( Yonke imihla ILexapro ( Yonke imihla )
Ukudibana kweziyobisi neCymbalta vs. Lexapro
ICymbalta kunye neLexapro nganye inezinto ezenziwa emzimbeni yinkqubo ye-cytochrome enzyme esibindini. ICymbalta sisiseko esikhulu seCYP1A2, kunye ne-inhibitor yokumodareyitha yeCYP2D6. Kubalulekile ukuba uqaphele ukuba ezinye izigulana zinokubandezeleka kukuphazamiseka kwengqwalaselo ukongeza kuxinzelelo kunye noxinzelelo loxinzelelo. Izigulana ezininzi ezinengxaki yokuqwalaselwa ziphathwa ngee-amphetamines. ICymbalta inokunyusa uxinzelelo lwe-serum yee-amphetamines ngokuthintela i-CYP2D6. Izigulana ezithatha olu dibaniso kufuneka zijongwe kufutshane.
ILexapro sisiseko esikhulu seCYP2C19 kunye neCYP3A4, kunye ne-inhibitor ebuthathaka yeCYP2D6.
Ukusetyenziswa kweLexapro nge-tricyclic antidepressants, enje nge-amitriptyline, kunokunyusa umngcipheko wokwandiswa kwe-QT kunye ne-serotonin syndrome. Ngokubanzi, olu dibaniso kufuneka luthintelwe.
Olu luhlu lulandelayo alwenzelwanga ukuba lube luluhlu olupheleleyo lokunxibelelana kweziyobisi. Kungcono uqhagamshelane nomboneleli wakho okanye usokhemesti uluhlu olupheleleyo.
| Iziyobisi | Iklasi yeziyobisi | ICymbalta | ILexapro |
| Acalabrutinib Dabrafenib Erdafitinib Gilteritinib Ibrutinib | Antineoplastics | Ewe | Ewe |
| IAlmotriptan Eletriptan I-Oxitriptan | I-5HT Agonist / Triptans (iiarhente zentsholongwane) | Ewe | Ewe |
| Iityuwa zeAmphetamine Dexmethylphenidate Imethylphenidate | IiAmphetamines | Ewe | Ewe |
| IAlosetron Ondansetron KwiRamosetron | 5HT3 Abachasi (izixhobo zokulwa isicaphucaphu) | Hayi | Ewe |
| Apixaban Edoxaban | Iiplatelets | Ewe | Ewe |
| Aripiprazole | Intshutshiso yengqondo | Ewe | Ewe |
| I-Aspirin Ibuprofen INaproxen Diclofenac | Izidakamizwa ezichasayo ezichasayo (i-NSAID) | Ewe | Ewe |
| Bemiparin Enoxaparin IHeparin | Iintsholongwane | Hayi | Ewe |
| IBupropion | Dopamine / norepinephrine reuptake inhibitor | Hayi | Ewe |
| Ibhayiprone | Ukuxhalaba | Ewe | Ewe |
| ICarbamazepine | I-Anticonvulsant | Hayi | Ewe |
| Enzalutamide | Unyango ngamayeza Ummeli | Hayi | Ewe |
| Esomeprazole Omeprazole | Impompo Proton inhibitor | Hayi | Ewe |
| IFluconazole | Ukubola | Hayi | Ewe |
| IFluoxetine Duloxetine Paroxetine Sertraline | SSRIs | Ewe | Ewe |
| IHydroxychloroquine | I-Aminoquinolone / i-Antimalarial | Hayi | Ewe |
| Umgca we-Linezolid | Zintsholongwane | Ewe | Ewe |
| Imetaxalone | Izihlunu zezihluli | Ewe | Ewe |
| IPimozide | Intshutshiso yengqondo | Hayi | Ewe |
| Selegiline IPhenelzine I-Rasagiline | I-Monoamine oxidase inhibitor (MAOI) | Ewe | Ewe |
| Wort eSt | Unyango lweherbal | Ewe | Ewe |
| IHydrochlorothiazide IChlorthalidone Imetolazone | I-Thiazide yomchamo | Hayi | Ewe |
| I-Tramadol | Opiate iintlungu | Ewe | Ewe |
| Amitriptyline Clomipramine Doxepin Umgca weNortriptyline | I-Tricyclic yoxinzelelo | Ewe | Ewe |
| IVenlafaxine | Ukukhetha i-norepinephrin / serotonin reuptake inhibitor (SNRIs) | Ewe | Ewe |
Izilumkiso zeCymbalta kunye neLexapro
ICymbalta kunye neLexapro ayizukuvelisa uxolelo kwangoko lweempawu zokuphazamiseka koxinzelelo okanye ukuphazamiseka koxinzelelo. Kuya kuthatha ubuncinci beeveki ezimbini ukuqaphela naluphi na utshintsho kwizigulana ezininzi zeposi, kwaye ukuya kuthi ga kwiiveki ezine ukuya kwezintandathu ukuqonda isiphumo esipheleleyo sonyango. Kubalulekile ukuba abaguli bakuqonde oku ukuze bangayeki ngaphambi kwexesha amayeza abo benenkolo yokuba ayisebenzi.
Izigulana ezine-MDD zinokufumana ukonyuka kokudakumba okanye iingcinga zokuzibulala nokuba zithatha amayeza oxinzelelo. Ezi meko zinokuba mandundu kude kube kufezekisiwe ukuxolelwa. Unyango lweCymbalta kunye neLexapro lunokunyusa umbono wokuzibulala kunye neengcinga phakathi kolutsha nakubantu abadala abancinci, ngakumbi kumanqanaba okuqala onyango ngaphambi kokuba kufikelelwe kuxolelo. Ezi zigulana kufuneka zijongwe ngeliso elibukhali ukuba olu nyango lubonwa luyimfuneko kwezonyango. Utshintsho kunyango lunokuba yimfuneko ukuba iimpawu zivela ngesiquphe okanye ziba mandundu.
Kukho iingxelo ngokusilela kwesibindi, ngamanye amaxesha kuyabulala, kunye neCymbalta. Ezi meko zinokubonisa iintlungu zesisu kunye ne-enzyme zesibindi eziphakamileyo kunye okanye ngaphandle kwe-jaundice. Ukusetyenziswa kotywala kunokwandisa lo mngcipheko, kwaye ke olu dibaniso kufuneka luphetshwe.
Iserotonin syndrome ixeliwe ngazo zonke ii-SSRI kunye nee-SNRIs, kubandakanya iCymbalta kunye neLexapro. Le yimeko enxulumene namanqanaba aphezulu ngokungaqhelekanga e-serotonin kwaye inokubangela ukuba isigulana sizive siphazamisekile, siba nesiyezi, kwaye sibe nokunyuka kwentliziyo. Oku kunokuziswa kukusetyenziswa kwamachiza amabini e-serotonergic kunye. Kubalulekile ukubhekisa kulwazi lomenzi malunga nokusebenzisana kweziyobisi xa kumiselwa la machiza.
Imibuzo ebuzwa rhoqo malunga neCymbalta vs. Lexapro
Yintoni iCymbalta?
ICymbalta lunyango olunokusetyenziswa ukunyanga uxinzelelo olukhulu, ukuphazamiseka koxinzelelo ngokubanzi, kunye nokuphazamiseka kwentlungu kunye nemisipha. ICymbalta ifumaneka njengephilisi yomlomo kwi-20 mg, 30 mg, kunye namandla e-60 mg.
Yintoni iLexapro?
I-Lexapro lunyango lokunyanga uxinzelelo olusetyenziswa kunyango loxinzelelo olukhulu kunye noxinzelelo ngokubanzi loxinzelelo. ILexapro ifumaneka njengecwecwe lomlomo kwi-5 mg, 10 mg, kunye namandla e-20 mg. Ikwafumaneka njengesisombululo somlomo.
Ngaba iCymbalta kunye neLexapro ziyafana?
Ngelixa zombini iCymbalta kunye neLexapro inyanga uxinzelelo kunye noxinzelelo, azifani. ICymbalta ibhloka ukuphinda kuthathwe i-serotonin kunye ne-norepinephrine kwi-neuronal synapse, ngelixa i-Lexapro ibhloka i-serotonin reuptake kuphela. ICymbalta inezinto ezongezelelweyo ezibonisa iingxaki zentlungu.
Ngaba iCymbalta okanye iLexapro ingcono?
ICymbalta kunye neLexapro zibonakala zisebenza ngokufanayo kunyango loxinzelelo. Uhlalutyo olukhulu lweemeta lwezifundo ezininzi lubonisa ukuba inqanaba eliphezulu leziganeko ezichaseneyo neCymbalta inokuba sisizathu sokuzama iLexapro kuqala kwizigulana ezininzi.
Ndingayisebenzisa iCymbalta okanye iLexapro ngelixa ndikhulelwe?
Ulawulo lwezoKutya kunye noLawulo lweziyobisi (FDA) luthathela ingqalelo iCymbalta kunye neLexapro yodidi C lokukhulelwa, okuthetha ukuba khange kubekho zifundo zoluntu zaneleyo ukumisela ukhuseleko. NgeCymbalta, iimpembelelo ezingezizo ezomhlaba ziye zabonwa kwiintsana emva kolawulo lweCymbalta ngelixa ukhulelwe. Oku kubandakanya uxinzelelo lokuphefumla, ubunzima bokondla, kunye neenyikima. Ngokusetyenziswa kweLexapro, uphononongo lwezilwanyana lubonakalise iziphumo zomntwana kumntwana, kubandakanya neziphumo zentliziyo, kwaye kuye kwagqitywa ukuba unqumla kwi-placenta yomntu. Ngenxa yezi zizathu, ukusetyenziswa kweCymbalta okanye iLexapro xa ukhulelwe kufuneka kulinganiswe nobungozi kumntwana ongekazalwa.
Ndingayisebenzisa iCymbalta okanye iLexapro ngotywala?
Utywala bunokunyusa iziphumo ezinetyhefu kuzo zombini iCymbalta kunye neLexapro. Ukusela utywala ngelixa uthatha la machiza kunokubangela ukuphazamiseka kwengqondo, kwaye ngenxa yesi sizathu, izigulana ziyacetyiswa ukuba zingabuphathi utywala ukuba zithatha iCymbalta okanye iLexapro. Njengoko bekuxoxiwe ngaphambili, ukusela utywala ngelixa useCymbalta kwandisa amathuba okusilela kwesibindi.
Ngaba iCymbalta iyanceda ngoxinzelelo?
ICymbalta yamkelwe kunyango lokuphazamiseka koxinzelelo ngokubanzi. Izigulana kufuneka zifundiswe ukuba ichiza alizukubonelela ukuxolelwa kwangoko kweempawu zoxinzelelo, kwaye ezinye izigulana zinokufuna amayeza ongezelelweyo kwiziqendu ezixhalabisayo.
Ngaba iCymbalta iyonwabisa?
ICymbalta isebenza ngokwandisa i-norepinephrine kunye ne-serotonin. Ezi neurotransmitters zidlala indima ebalulekileyo kwiimvakalelo okanye zichaphazele. Izigulana ezithatha iCymbalta zinokuthi zichaze ukonwaba okanye ukudandatheka, ngakumbi emva kweeveki ezine ukuya kwezintandathu zonyango.
Ngaba iCymbalta iyabutshintsha ubuntu bakho?
ICymbalta iyakuchaphazela imeko ngokwandisa i-norepinephrine kunye ne-serotonin. Uninzi lwezigulana, oku kubangela utshintsho olululo kwimpilo yabo yengqondo. Ukuba ubona utshintsho olubi kuwe okanye kumntu omkhathaleleyo ngelixa uthatha iCymbalta, kubandakanya neengcinga zokuzibulala okanye iinjongo, funa uncedo kwangoko.
