I-Jardiance vs.I-Invokana: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
Ukuba unesifo seswekile sesi-2, ugqirha wakho unokucebisa elinye lamayeza eswekile abizwa ngokuba yiJardiance okanye i-Invokana. I-Jardiance (eyenziwe ngu-Boehringer-Ingelheim) kunye ne-Invokana (eyenziwe yiJanssen Pharmaceuticals) ngamagama amabini amachiza amayeza abonisa unyango lwe-2 yeswekile. Bakudidi lweziyobisi ekuthiwa zibizwa SGLT2 (Isodium-glucose cotransporter-2) inhibitors. Basebenza ngokunceda izintso zisuse iswekile yegazi kumchamo, ngaloo ndlela behlisa iswekile yegazi.
Nguwuphi umahluko ophambili phakathi kweJardiance vs.Invokana?
| Umahluko ophambili phakathi kweJardiance kunye ne-Invokana | ||
|---|---|---|
| Intlanganisela | Ingenokana | |
| Iklasi yeziyobisi | Isithinteli se-SGLT2 | Isithinteli se-SGLT2 |
| Uhlobo lweBrith / generic | Igama lebrand | Igama lebrand |
| Ngubani igama eliqhelekileyo? | I-Empagliflozin (ayikabikho kwifomu yohlobo oluqhelekileyo) | I-Canagliflozin (ayikabikho kwifom yesiqhelo) |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi: 10 mg, 25 mg (empagliflozin ikwafumaneka nge-metformin kwindibaniselwano yegama lechiza elibizwa ngokuba yi-Synjardy, kunye ne-linagliptin eGlyxambi) | Ithebhulethi: 100 mg, 300 mg (I-canagliflozin ikwafumaneka kunye ne-metformin kwindibaniselwano yegama lechiza elibizwa ngokuba I-Invokamet) |
| Ithini idosi esemgangathweni? | 10 mg yonke intsasa; inokunyuka iye kuma-25 mg qho kusasa | 100 mg rhoqo kusasa; inokunyuka iye kwi-300 mg qho kusasa |
| Lude kangakanani unyango oluqhelekileyo? | Iyahluka | Iyahluka |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala abanesifo seswekile seswekile 2 | Abantu abadala abanesifo seswekile seswekile 2 |
Ngaba ufuna elona xabiso lilungileyo kwiJardiance?
Bhalisela izilumkiso zexabiso leJardiance kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Iimeko eziphathwe yiJardiance vs.I-Invokana
Jardiance (Yintoni iJardiance?) Isetyenziswa, kunye nokutya kunye nokuzilolonga, ukuphucula iswekile yegazi kubantu abadala abanesifo seswekile, kunye nokunciphisa umngcipheko wokufa kwentliziyo (CV) kubantu abadala abanesifo seswekile sesi-2 kwaye bayasekwa Isifo seCV .
I-Invokana ikwasetyenziswa, ukongeza kukutya kunye nokuzilolonga, ukuphucula iswekile yegazi kubantu abadala abanesifo seswekile sesi-2. Kukwasetyenziselwa ukunciphisa umngcipheko weziganeko eziphambili ze-CV kubantu abadala abanesifo seswekile seswekile kunye nesifo sentliziyo esisekwe. Isibonakaliso sesithathu kukunciphisa umngcipheko wesifo sezintso zokugqibela, ukuphindaphinda i-serum creatinine, ukufa kweCV, kunye nokulaliswa esibhedlele ngenxa yokungaphumeleli kwentliziyo kubantu abadala abanesifo seswekile sesi-2 kunye nesifo seswekile nephropathy ene-albuminuria.
Akukho siyobisi kufuneka sisetyenziselwe ukunyanga i-1 yeswekile okanye isifo se-ketoacidosis seswekile.
| Imeko | Intlanganisela | Ingenokana |
| Ukudibanisa ukutya kunye nokuzilolonga ukuphucula ulawulo lwe-glycemic kubantu abadala abanesifo seswekile seswekile | Ewe | Ewe |
| Ukunciphisa umngcipheko wokufa kwenhliziyo kubantu abadala abane-2 yesifo sikashukela kunye nesifo senhliziyo | Ewe | Hayi |
| Ukunciphisa umngcipheko weziganeko ezinkulu zentliziyo kubantu abadala abanesifo seswekile 2 kunye nokuseka isifo sentliziyo. | Hayi | Ewe |
| Ukunciphisa umngcipheko wesifo sezintso zokugqibela, ukuphindaphinda i-serum creatinine, ukufa kwentliziyo, kunye nokulaliswa esibhedlele ngenxa yokusilela kwentliziyo kubantu abadala abanesifo seswekile seswekile seswekile kunye nephropathy yeswekile ene-albinuria | Hayi | Ewe |
Ngaba iJardiance okanye i-Invokana isebenza ngakumbi?
Kwi-blind-blind, elawulwa yi-placebo, iiveki ezingama-24 ukufunda yeJardiance njenge-monotherapy (isetyenziswe yodwa) kwi-986 yohlobo lwe-2 yezigulana ezinesifo seswekile, unyango nge-Jardiance lubangele amanqanaba asezantsi e-HbA1c (umlinganiso wolawulo lwe-glucose kwezi nyanga zimbalwa zidlulileyo), ukuzila ukutya okuncinci kweplasma glucose, kunye nobunzima obuphantsi. Ngokudityaniswa nezinye iziyobisi zeswekile okanye nge-insulin, iJardiance ineziphumo ezifanayo zokuphucula amanani anje ngeHbA1c.
Kwi-blind-blind, elawulwa yi-placebo, iiveki ezingama-26 ukufunda ye-Invokana njenge-monotherapy (isetyenziswa yodwa) kwi-584 yohlobo lwe-2 yezigulana ezinesifo seswekile, unyango nge-Invokana lubangele amanqanaba asezantsi e-HbA1c, ukuzila ukutya okuphantsi kunye nokuhamba emva kokutya (emva kwesidlo) iswekile, ubunzima obuphantsi, kunye noxinzelelo lwegazi olusezantsi. NjengoJardiance, xa wafundwa ngokudibanisa namanye amachiza eswekile okanye nge-insulin, u-Invokana naye waba neziphumo ezifanayo zokuphucula amanani anjenge-HbA1c.
Olona nyango lusebenzayo kufuneka lumiselwe kuphela ngugqirha wakho, onokuthi ajonge umfanekiso opheleleyo weemeko zakho zonyango, ezembali, kunye namanye amayeza owathathayo.
Fumana ikhadi lesaphulelo kwikhemesti
Ukufunyanwa kunye nokuthelekiswa kweendleko zeJardiance vs.I-Invokana
Ngaphandle kweinshurensi, iJardiance ixabisa malunga ne-625 yeedola kwaye i-Invokana ibiza malunga ne-600 yeedola kunikezelo lweentsuku ezingama-30. I-Jardiance isenokwenzeka ukuba inokuthi ihlawulwe yi-inshurensi kune-Invokana; Nangona kunjalo, amaxabiso ayahluka kakhulu kangangokuba kungcono ukuba ujonge kwinkampani yeinshurensi yakho okanye isicwangciso seMedicare Part D solwazi oluthe kratya. Ungagcina imali ngeSingleCare kwiJardiance -ukufumana iyeza likagqirha nge-434- $ 500-kunye ne-Invokana, uhlawula umyinge weedola ezingama-450 nge-30 count, iipilisi ezingama-300mg.
| Intlanganisela | Ingenokana | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Iyahluka ngokwecebo |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Iyahluka ngokwecebo |
| Umthamo osemgangathweni | Iipilisi ezingama-30, 25 mg | # 30, 300 amacwecwe mg |
| I-Medicare copay eqhelekileyo | $ 19-612 | $ 25- $ 568 |
| Ixabiso elilodwa | $ 434- $ 500 | $ 450 yeedola |
Iziphumo ebezingalindelekanga zeJardiance vs.I-Invokana
Zombini iJardiance kunye ne-Invokana, iziphumo ebezingalindelekanga ezixhaphakileyo usulelo lwe-mycotic yesini, olwenzeka kumadoda nakwabasetyhini, kodwa ngakumbi kubantu basetyhini. Usulelo lwe-Urinary tract lukwayimpembelelo efanayo yamachiza omabini. Ezinye iziphumo ebezingalindelekanga kuzo zombini ezi ziyobisi zibandakanya ukunxanwa, ukwanda kokuchama, kunye nesicaphucaphu.
| Intlanganisela | Ingenokana | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| I-DWS | Ewe | 7.6-9.3% * | Ewe | 4.4-5.9% * |
| Usulelo lwe-Mycotic | Ewe | Umfazi: 5.4-6.4% Indoda: 1.6-3.1% | Ewe | Umfazi: 10.6-11.6% Amadoda: 3.8-4.2% |
| Usulelo oluphezulu lokuphefumula | Ewe | 3.1-4% | Hayi | - |
| Unxaniwe | Ewe | 1.5-1.7% | Ewe | 2.4-2.8% |
| Ukwanda komchamo | Ewe | 3.2-3.4% | Ewe | 4.6-5.1% |
| Isicaphucaphu | Ewe | 1.1-2.3% | Ewe | 2.1-2.3% |
* Uluhlu ngenxa yedosi eyahlukileyo. Umthombo: Yonke imihla (Jardiance ), Mihla le (Invokana)
Ukudibana kweziyobisi kweJardiance vs.I-Invokana
I-Invokana inxibelelana nesifo sentliziyo seLanoxin (digoxin) kunye neziyobisi ezenza ukuba i-UGT inyanzelise (iziyobisi ezixutywe nee-enzymes ezithile) ezibandakanya i-rifampin, phenytoin, phenobarbital, kunye ne-ritonavir.
Zombini iJardiance kunye ne-Invokana zisebenzisana ne-diuretics enjengeLasix (furosemide) kunye nehydrochlorothiazide, kunye ne-insulin kunye namanye amayeza eswekile afana ne-metformin. Qhagamshelana nomboneleli wakho wezempilo malunga neengcebiso zonyango.
| Iziyobisi | Iklasi yeziyobisi | Intlanganisela | Ingenokana |
| Rifampin IPhenytoin IPhenobarbital Ritonavir | Ukunyusa i-UGT | Hayi | Ewe |
| ILanoxin (digoxin) | Glycosides zentliziyo | Hayi | Ewe |
| I-Lasix (furosemide) IHydrochlorothiazide | Womchamo | Ewe | Ewe |
| Iswekile yeglucophage (metformin) | Imfihlo ye-insulin | Ewe | Ewe |
Izilumkiso zeJardiance vs.I-Invokana
Kuba zombini iJardiance kunye ne-Invokana zii-inhibitors ze-SGLT2, babelana ngezilumkiso ezifanayo:
- Ngenxa yomngcipheko woxinzelelo lwegazi olusezantsi, kufuneka kubekwe iliso kwi-BP. Sebenzisa ulumkiso olongezelelekileyo kwizigulana ezithatha i-diuretics, izigulana esele zikhulile, izigulana ezinokukhubazeka kwezintso, kunye nezigulana ezinexinzelelo lwegazi. Ukuphelelwa ngamanzi emzimbeni kunokwenzeka.
- Iingxelo zeketoacidosis (iswekile yegazi ephezulu kakhulu; iiconic ketones ezakhiwe kumchamo) zenzekile kwizigulana ezikwi-SGLT2 inhibitors. Oku kunokuba kubi, okanye kude kubulale. Iimpawu zinokubandakanya ukunxanwa, ukuchama rhoqo, isicaphucaphu, iintlungu esiswini, ubuthathaka, umphefumlo onuka iziqhamo kunye nokudideka. Funa unyango olungxamisekileyo, kwaye ichiza kufuneka lipheliswe. Izigulana ezisemngciphekweni omkhulu we-ketoacidosis zibandakanya ukwehla kwe-insulin yedosi, ukutya kancinci kwekhalori ngenxa yokugula okanye uqhaqho, ukusetyenziswa gwenxa kotywala, kunye nesifo sepancreatic.
- I-SGLT2 inhibitors inokubangela iingxaki zezintso . Ugqirha wakho uya kuvavanya ukusebenza kwezintso, kwaye aqwalasele izinto ezonyusa umngcipheko wokulimala kwezintso, ezinje ngamayeza ahambelana nezinye iimeko zonyango.
- Kukho umngcipheko owandileyo wosulelo olunzima lomchamo (UTI) kunye nosulelo lwe-mycotic yesini (i-vulvovaginal candidiasis kwabasetyhini; i-Candida balanitis emadodeni, ihlala ingalukanga).
- Sebenzisa i-insulin okanye amayeza athile eswekile kunokunyusa umngcipheko we-hypoglycemia (iswekile esezantsi yegazi) ngelixa uthatha i-SGLT2 inhibitor.
- Ukuba i-hypersensitivity iyenzeka (iimpawu zempendulo engalunganga efana nokudumba, ukuvala umqala, njl.), Amayeza kufuneka eyekwe kwaye kufuneka ufune unyango olungxamisekileyo.
- Ukunyuka kwamanqanaba e-cholesterol ye-LDL kunokwenzeka; I-cholesterol kufuneka ibekwe esweni.
- Inzima, isongela ubomi Isifo esibuhlungu sikaFournier (i-necrotizing fasciitis ye-perineum, isifo esibi se-bacterial) kuye kwaxelwa. Izigulana kufuneka zivavanywe kwangoko ukuba ngaba zikhona ezi mpawu: iintlungu, ukuthamba, ubomvu, okanye ukudumba kwindawo yesini okanye yendawo yeperianal, umkhuhlane, okanye ukuqaqamba.
I-Invokana inezinye izilumkiso ezongeziweyo:
- Kukho isilumkiso esibhokisiweyo esiza ne-Invokana, esisilumkiso esomeleleyo njengoko kufunwa yi-FDA (Ukutya kunye noLawulo lweeDrug), malunga nokunqunyulwa kwamalungu asezantsi.
- Kwezilingo zeklinikhi, kwabakho umngcipheko okhulayo wokunqunyulwa kwamalungu asezantsi kwizigulana ezithatha i-Invokana, kwizigulana ezinesifo seCV okanye ababesemngciphekweni wesifo seCV. Ezona ziqu zinqunyulwa rhoqo zazisezinzwaneni naphakathi kweenyawo, nangona ezinye zazibandakanya imilenze. Abanye abaguli babenqunyulwe imithambo okanye banqunyulwa amalungu amaninzi omzimba. Ngaphambi kokuba uqale u-Invokana, kuya kufuneka uthethe nogqirha wakho malunga nemingcipheko yakho yokunqunyulwa. Ukuba uthatha i-Invokana, kuya kufuneka ujongwe ngononophelo kusulelo, iintlungu, ukuthamba, izilonda, okanye izilonda kumalungu asezantsi, uyeke ukuthatha i-Invokana kwaye ufune unyango kwangoko ukuba oku kuyenzeka.
- Kukho umngcipheko owandileyo wokuqhekeka kwethambo kunye no-Invokana.
Nokuba yiJardiance okanye i-Invokana ayikhuthazwa ngexesha lesibini nakwisithathu seenyanga ezintathu zokukhulelwa. Ngenxa yomngcipheko weziphumo ezibi kwizintso zomntwana, akukhuthazwa ukuba usebenzise naliphi na ichiza ngexesha lokuncancisa.
Imibuzo ebuzwa rhoqo malunga neJardiance vs.I-Invokana
Yintoni iJardiance?
I-Jardiance, equlathe iyeza empagliflozin, lunyango kwiklasi yeziyobisi eyaziwa ngokuba yi-SGLT2 inhibitors, esebenza ngokunceda ukususa iswekile emzimbeni ngomchamo. I-Jardiance yenziwa ngu-Boehringer-Ingelheim kwaye ithengiswa ngu-Boehringer-Ingelheim kunye no-Eli Lilly kunye neNkampani.
Yintoni i-Invokana?
I-Invokana, equlathe iyeza i-canagliflozin, ikwayinyango kwiklasi yeziyobisi eyaziwa ngokuba yi-SGLT2 inhibitors, esebenza ngokunceda ukususa iswekile emzimbeni ngomchamo.
Ngaba i-Jardiance vs. i-Invokana iyafana?
Kuba bakwiklasi enye yeziyobisi, banokufana okuninzi, kodwa umahluko othile kwiziphumo ebezingalindelekanga, idosi, ukuhlangana kweziyobisi, izilumkiso, njl njl.
Ngaba i-Jardiance vs.I-Invokana ingcono?
Oko kuxhomekeke. Omabini la machiza abonakalise ukuba ayasebenza, njengoko kuchaziwe apha ngasentla. Khange kubekho zifundo ngokuthelekisa la mayeza mabini entloko. Ugqirha wakho unokukunceda uthathe isigqibo sokuba ngaba iJardiance okanye i-Invokana ikulungele na.
Ngaba ndingayisebenzisa iJardiance vs.I-Invokana ngelixa ukhulelwe?
Akukho nalinye ichiza elicetyiswayo ngexesha lesibini nakwesithathu seenyanga ezintathu zokukhulelwa. Kananjalo, akukhuthazwa ukuba usebenzise naliphi na ichiza ngexesha lokuncancisa ngenxa yomngcipheko weziphumo ezibi kwizintso zomntwana.
Ukuba sele uthatha iJardiance okanye i-Invokana kwaye ufumanisa ukuba ukhulelwe, nxibelelana nogqirha wakho ukuze akukhokele. Ukulawulwa kweglucose ngexesha lokukhulelwa kubaluleke kakhulu; Nangona kunjalo, kunokwenzeka ukuba ugqirha wakho uza kuwatshintsha amayeza akho ukuze afezekise ulawulo lwe-glucose ngokukhuselekileyo.
Ngaba ndingayisebenzisa iJardiance vs.I-Invokana notywala?
Utywala yenye yezinto ezinokukhokelela kwi-ketoacidosis. Thetha nogqirha wakho ukuba usela utywala ngaphambi kokuba uthathe iJardiance okanye i-Invokana.
Ngawaphi amayeza alingana no-Invokana?
I-Invokana ikwiklasi efanayo yeziyobisi kodwa ayilingani ncam neJardiance, Farxiga (dapagliflozin), kunye neSteglatro (ertugliflozin).
Ngaba i-Jardiance sisiyobisi esiyingozi?
Onke amayeza eza nomngcipheko weziphumo ebezingalindelekanga kunye nezilumkiso. Nxibelelana nogqirha wakho ukuze ubone ukuba iJardiance sisiyobisi esikhuselekileyo nesifanelekileyo na kuwe.
Ngaba u-Invokana uyasuswa kwintengiso?
Okwangoku, u-Invokana usesemarikeni. I-FDA yenze ngo-2017 malunga nomngcipheko owandileyo wokunqunyulwa kwamalungu asezantsi kwizigulana ezinesifo sentliziyo.
