I-Metoprolol vs atenolol: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango iphathwe | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
I-Metoprolol kunye ne-atenolol zisetyenziselwa unyango lweentlobo ezahlukeneyo zeemeko ezinxulumene nentliziyo kubandakanya i-angina pectoris kunye noxinzelelo lwegazi, okanye uxinzelelo lwegazi. I-Angina pectoris ibhekisa kwimeko apho uva khona iintlungu esifubeni okanye ukungonwabi ngenxa yentliziyo yakho engafumani gazi laneleyo le-oxygen. Oku kunokuba kunokwenzeka ukuba kwenzeke ngexesha loxinzelelo oluphezulu okanye umthambo. Uxinzelelo lwegazi ibhekisa ekubeni noxinzelelo lwegazi oluphezulu apho igazi elihamba kwimithambo yakho liphezulu kunoxinzelelo oluqhelekileyo.
I-Metoprolol kunye ne-atenolol bakudidi olunye lweziyobisi kwaye banyanga iimeko ezifanayo, kodwa kukho umahluko phakathi kwala machiza, kwaye siza kuxoxa ngala alapha.
Nguwuphi umahluko ophambili phakathi kwe-metoprolol kunye ne-atenolol?
I-Metoprolol sisiyobisi sonyango kuphela esichazwa njenge-cardioselective beta-1-adrenergic agonist, kungenjalo ibizwa ngokuba yi-beta blockers. I-Beta 1 receptors inoxanduva lokukhuthaza intliziyo okukhokelela ekwandeni kwenqanaba lentliziyo kunye nokuqina okuqinileyo kwentliziyo yemisipha. Ukuthintela ezi receptors, njengoko i-metoprolol isenza, kukhokelela kwisantya sentliziyo esicothayo kunye nokunciphisa amandla. I-Metoprolol yintsingiselo ye-cardioselective ithetha ukuba kunokwenzeka ukuba ichaphazele i-beta 1 receptors entliziyweni, kwaye ayinakufane ichaphazele ezinye iintlobo ze-beta receptors ezifumaneka emzimbeni wonke, njengakwindlela yakho yomoya.
I-Metoprolol ifumaneka kwiipilisi ezikhutshwa kwangoko kwi-25 mg, 37.5 mg, 50 mg, 75 mg, kunye neepilisi ze-100 mg. Ukukhutshwa kwangoko kukwabizwa ngokuba yi-metoprolol tartrate. Ifom yokukhutshwa eyandisiweyo ye-metoprolol, eyaziwa ngokuba yi-metoprolol succinate, iyafumaneka kumandla e-25 mg, 50 mg, 100 mg, kunye ne-200mg. Iifomsile zokukhululwa ezandisiweyo ziyafumaneka kumandla afanayo nala macwecwe. Kukho isisombululo esinokufakwa ngenaliti ye-1 mg / ml kunye nomgubo womlomo. Isiqingatha sobomi se-metoprolol tartrate simalunga neeyure ezintathu, kwaye isiqingatha sobomi be-metoprolol succinate simalunga neeyure ezisixhenxe. Oku kuthetha ukuba ukwenziwa kokunikezelwa okwandisiweyo akufuneki kwenziwe idosi rhoqo.
I-Atenolol ikwalichiza likagqirha elihlelwa njenge-cardioselective beta-1-adrenergic agonist. Isebenza ngendlela efanayo ne-metoprolol emzimbeni. Isiqingatha sobomi se-atenolol simalunga neeyure ezintandathu ukuya kwezisixhenxe, kwaye ke sinokuhlala ixesha elide kunezinye iidosi ze-metoprolol. I-Atenolol ifumaneka kwi-25 mg, 50 mg, kunye neepilisi ze-100 mg.
Umahluko ophambili phakathi kwe-metoprolol kunye ne-atenolol | ||
---|---|---|
Imitha | Atenolol | |
Iklasi yeziyobisi | I-betaos 1 ekhethiweyo ye-adrenergic agonist (ibeta blocker) | I-betaos 1 ekhethiweyo ye-adrenergic agonist (ibeta blocker) |
Uhlobo lweBrith / generic | Brand kunye generic ziyafumaneka | Brand kunye generic ziyafumaneka |
Ngubani igama lophawu? | Lopressor, iTrolrol XL | Tenormin |
Zeziphi iifom eza nalo iziyobisi? | Amacwecwe omlomo kunye neepilisi njengepilisi, isisombululo esinokufakwa inaliti, umgubo womlomo | Ukukhutshwa kwangoko kwamacwecwe omlomo |
Ithini idosi esemgangathweni? | 50 mg kabini ngemini | 50 mg kanye ngemini |
Lude kangakanani unyango oluqhelekileyo? | Ixesha elide | Ixesha elide |
Ngubani oqhelekileyo usebenzisa amayeza? | Abantwana kunye nabantu abadala | Abantwana kunye nabantu abadala |
Iimeko eziphathwe nge-metoprolol kunye ne-atenolol
I-Metoprolol kunye ne-atenolol zombini zisetyenziselwa unyango lwe-angina pectoris kunye noxinzelelo lwegazi. Zingasetyenziselwa kwi-angina engapheliyo, ezinzile okanye engazinzanga i-angina. I-angina engapheliyo, ezinzileyo yenzeka ngokuqikelela xa uzibhokoxa emzimbeni okanye uphantsi koxinzelelo olukhulu. I-angina engazinzanga ayiqikelelwa kwaye inokwenzeka nasekuphumleni.
Xa isetyenziselwa unyango lwexinzelelo, i-metoprolol kunye ne-atenolol zingasetyenziselwa zodwa okanye ngokudibanisa nezinye iziyobisi ezichasayo. Xa la machiza esetyenziswa kwisicwangciso sonyango se-infyoction esebenzayo, ekrokrelwayo, okanye eqinisekisiweyo ye-myocardial, okanye isifo sentliziyo, ziyinxalenye yerejimeni yamachiza amaninzi anokuthi abandakanye ii-angiotensin-converting enzyme inhibitors (ACE inhibitors) kunye ne-diuretics. Kwisifo se-ischemic myocardial, ii-beta blockers zinciphisa imfuno yeoksijini yemisipha ye-myocardial kwaye zineempawu ezichaseneyo.
I-Metoprolol kunye ne-atenolol nazo zisetyenziselwa iilebula ezingekhoyo kwezinye izikhombisi. Ukusetyenziswa kwelebheli engasebenziyo kubhekisa ekusetyenzisweni komqondiso ongavunyelwanga nguLawulo lokutya kunye noLawulo lweziyobisi (FDA). Ziqhelekileyo zisetyenziselwa ukunceda ukuthintela i-migraines kunye nokulawula ukungcangcazela.
Olu alunakuba luluhlu olupheleleyo lokusetyenziswa kwezi ziyobisi. Kuphela ngugqirha wakho okanye ingcali yentliziyo unokuthatha isigqibo sokuba ngaba elinye lala machiza lilungele imeko yakho.
Imeko | Imitha | Atenolol |
I-angina pectoris (kubandakanya i-angina engapheliyo, ezinzileyo kunye ne-angina engaqinisekanga) | Ewe | Ewe |
Uxinzelelo lwegazi | Ewe | Ewe |
Ukumelwa yintliziyo | Ewe | Hayi |
Imyocardial infarction | Ewe | Ewe |
Ulawulo lwenqanaba lentliziyo kwi-fibrillation ye-atrial okanye i-atrial flutter | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
Ukungcangcazela | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
Imigraine prophylaxis | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
I-Paroxysmal supraventricular tachycardia prophylaxis | Hayi | Ngaphandle kwelebheli |
Ukurhoxiswa kotywala | Hayi | Ngaphandle kwelebheli |
Ngaba i-metoprolol okanye i-atenolol isebenza ngakumbi?
I-Metoprolol kunye ne-atenolol ziye zafundwa kwaye zathelekiswa kakhulu kwizalathiso ezahlukeneyo nakwiziphumo. A Uhlalutyo lweemeta epapashwe ngo-2017 kuvavanywa ukusebenza ngokuthelekisa kwezi blocker ze-beta zimbini kunye nepropranolol kunye ne-oxprenolol ngokujonga iziphumo zovavanyo lweklinikhi oluninzi. I-Metoprolol ibonise ukwehla okubaluleke ngakumbi kumngcipheko wokufa kwentliziyo xa kuthelekiswa ne-atenolol. I-Metoprolol ikwabonisa ukwehla kwendlela yazo zonke izizathu zokufa kunye nesifo sentliziyo. Xa kuvavanywa ukwehla komngcipheko wokubetha, i-metoprolol yangqina ukuba ingaphezulu kune-atenolol nayo. Nantsi lapho idatha Oko kuphakamisa ukuba omabini la machiza ayasebenza xa kuthelekiswa ne-placebo kwaye akukho mahluko ubalulekileyo phakathi kwe-atenolol kunye ne-metoprolol ngokwamandla abo okulawula uxinzelelo lwegazi (uxinzelelo lwegazi).
Imitha ibonakalisiwe ukunciphisa uxinzelelo lwegazi lwe-systolic kunye ne-diastolic. Atenolol inokuchaphazela uxinzelelo lwegazi lwe-systolic ngaphezulu kwe-diastolic, ngakumbi ngamaxesha okuzama.
Ngokusekwe kolu lwazi, ugqirha wakho unokukhetha ukuqala nge-metoprolol kuqala xa ukhetha iarhente yakho. Ngugqirha wakho kuphela onokuchonga ukuba ngaba unyango lwe-beta blocker lulungile kuwe.
Umyinge kunye neendleko zokuthelekisa i-metoprolol vs atenolol
I-Metoprolol yonyango lonyango eligutyungelwe zizicwangciso zeinshurensi zorhwebo kunye nezonyango. Ukuba uhlawula imali yokufumana amayeza e-metoprolol, ungahlawula malunga ne- $ 31 ngonikezelo lwenyanga enye. I-singleCare ibonelela ngekhuphoni eya kukuvumela ukuba ubhatale malunga ne- $ 4 ye-metoprolol.
I-Atenolol lunyango lonyango eligutyungelwe zizicwangciso ze-inshurensi zorhwebo kunye nezonyango. Ngaphandle kweinshurensi, ungahlawula malunga ne- $ 30 ngeentsuku ezingama-30 zokubonelela ngeepilisi ezingama-50 mg. Ngekhadi lokugcina imali kwi-SingleCare, ungahlawula malunga ne- $ 9 ngalo myalelo.
Imitha | Atenolol | |
Ngokuqhelekileyo i-inshurensi? | Ewe | Ewe |
Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
Ubungakanani | Iipilisi ze-60, 50 mg | Iipilisi ze-30, 50 mg |
I-Medicare copay eqhelekileyo | $ 0- $ 9 | $ 0- $ 10 |
Ixabiso elilodwa | $ 4- $ 22 | $ 9- $ 25 |
Iziphumo eziqhelekileyo ezichaphazelekayo ze-metoprolol vs atenolol
Iibhloko blocker ze-beta ezinje nge-metoprolol kunye ne-atenolol ziyacotha isantya yokubetha kwentliziyo kunye nokubetha kwayo. Oku kuncipha kwenqanaba lentliziyo kungakhokelela kwi-bradycardia, okanye kwiqondo lentliziyo eliphantsi. Xa intliziyo ingabethi ngamandla, ngamanye amaxesha ukuhamba kwegazi akufikeleli emaphethelweni ngoxinzelelo esingathanda ngalo, kukhokelela kwiziphelo ezinokubanda kungabanjwa.
Ukuhamba kwegazi okunyanzelekileyo kunye nokunciphisa uxinzelelo lwe-arterial kunokukhokelela kwiziphumo ebezingalindelekanga ezinje nge-postural hypotension, imvakalelo yokukhanya kunye nedizzy xa umile emva kokuhlala okanye ukulala phantsi. Intloko zinokwenzeka kwizigulana ezithatha i-metoprolol kunye ne-atenolol.
Oku ayenzelwanga ukuba ibe luluhlu olupheleleyo lweziphumo ebezingalindelekanga. Nceda uqhagamshelane nosokhemesti okanye ugqirha wakho ukufumana uluhlu olupheleleyo.
Imitha | Atenolol | |||
Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
Ukudinwa | Ewe | Akuxelwanga | Ewe | 0.6% |
Ukuba nesiyezi | Ewe | Akuxelwanga | Ewe | 4% |
Uxinzelelo | Ewe | Akuxelwanga | Ewe | 0.6% |
Intloko ebuhlungu | Ewe | Akuxelwanga | Hayi | n / A |
Ukuqhawukelwa ngumphefumlo | Ewe | Akuxelwanga | Ewe | 0.6% |
Bradycardia | Ewe | Akuxelwanga | Ewe | 3% |
Iziphelo ezibandayo | Ewe | Akuxelwanga | Hayi | n / A |
Uxinzelelo lwegazi | Ewe | Akuxelwanga | Ewe | Mbini% |
Ukukhawuleza | Ewe | Akuxelwanga | Hayi | n / A |
Urhudo | Ewe | Akuxelwanga | Ewe | Mbini% |
Isicaphucaphu | Ewe | Akuxelwanga | Ewe | 4% |
Irhashalala | Ewe | Akuxelwanga | Hayi | n / A |
Umthombo: Metoprolol ( Yonke imihla I-Atenolol ( Yonke imihla )
Ukudibana kweziyobisi kwe-metoprolol vs. atenolol
I-Digoxin kunye ne-beta blockers ezinje nge-metoprolol kunye ne-atenolol nganye ichaphazela ukunyanzeliswa kokuchasana kunye nenqanaba lentliziyo. Xa zinikezelwa kunye, abaguli basemngciphekweni owandayo we-bradycardia kunye ne-hypotension. Inqanaba lentliziyo, uxinzelelo lwegazi, kunye neminye imiqondiso yokungasebenzi kakuhle kwentliziyo kufuneka ibekwe esweni rhoqo ukuba kufuneka inikezwe kunye.
I-Metoprolol kunye ne-Atenolol zidityaniswe ne-calcium channel blocker ezinje nge-amlodipine inokubangela ukuncitshiswa okongeziweyo kwintsebenzo yentliziyo enokuba yingozi. Ukuba indibaniselwano iyimfuneko, kubalulekile ukufumana imilinganiselo yokusebenza yesiseko kunye nokulandela ngokulandelelana.
Izidakamizwa eziqhelekileyo ezifana ne-fluvoxamine, i-clomipramine, kunye ne-serotonin reuptake inhibitors (i-SSRIs) ekhethiweyo inhibit enzyme (CYP2D6) ejongene ne-metabolism ye-metoprolol. Xa unikwa ngokudibeneyo kunye ne-metoprolol, la machiza anokukhokelela ekwandeni kwamanqanaba egazi le-metoprolol. Oku kunokukhokelela kwiziphumo ezandayo nge-metoprolol kwinkqubo yentliziyo.
Oku ayenzelwanga ukuba ibe luluhlu olubandakanya konke ukunxibelelana kweziyobisi okunokubakho. Kuya kufuneka unxibelelane nengcali yakho yokhathalelo lwempilo uluhlu olupheleleyo.
Iziyobisi | Iklasi yeziyobisi | Imitha | Atenolol |
Hlaziya ngokutsha Clonidine IMethyldopa | I-alpha adrenergic antagonists | Ewe | Ewe |
Selegiline IPhenelzine Isocarboxazid | I-Monoamine oxidase inhibitors (MAOIs) | Ewe | Ewe |
I-Digoxin | I-Digitalis glycosides / antiarrhythmic | Ewe | Ewe |
Amlodipine Nifedipine Diltiazem I-Verapamil | Isithinteli seCalcium blocker | Ewe | Ewe |
IFluvoxamine Clomipramine Desipramine | Ukudakumba | Ewe | Hayi |
IFluoxetine Paroxetine Sertraline | Ukukhetha i-serotonin reuptake inhibitors (i-SSRIs) | Ewe | Hayi |
IHydralazine | IVasodilator | Ewe | Ewe |
I-Dipyridamole | Isithintelo seplatelet | Ewe | Ewe |
Ergotamine Dihydroergotamine | I-Erkot alkaloids | Ewe | Ewe |
Izilumkiso ze-metoprolol kunye ne-atenolol
I-Beta blockers zibangela uxinzelelo lwentliziyo yesivumelwano. Kwezinye izigulana ezinomngcipheko othile, oku kunokubangela ukusilela kwentliziyo. Ukuba oku kuyenzeka, ukusilela kwentliziyo kufuneka kunyangwe ngokwezikhokelo ezikhoyo.
Iibhloko blocker zeBeta akufuneki zinqunyanyiswe ngequbuliso, ngakumbi kwizigulana ezinesifo semithambo. Ukuhlaselwa kwentliziyo kunye ne-ventricular arrhythmias kuye kwaxelwa kwizigulana eziyekise ngesiquphe ii-beta blockers.
Xa kunokwenzeka, iiarhente zokuthintela i-beta kufuneka zithintelwe kwizigulana ezinesifo se-bronchospastic, esifana nesifuba. Ukusetyenziswa ngokudibeneyo kunokunyusa isifo se-bronchial. Ukuba kunyanzelekile ukuba kusetyenziswe iibhloko ze-beta, kukhethwa ii-cardioselective. Ukusetyenziswa kweebhloko blocker ze-non-cardioselective beta, ezifana ne-carvedilol, ayikhuthazwa.
I-Atenolol dosing kufuneka incitshiswe kwizigulana ezinesifo sezintso okanye ukuphazamiseka kwezintso njengoko ukukhutshwa kweziyobisi kucotha.
Ulawulo olungenamkhethe ulingo lwezonyango epapashwe yi-Lancet icebisa ukuba izigulana ezenziwa utyando ngelixa zikwi-beta blockers (i-metoprolol ngokukodwa) zisengozini yokunyuka kwesiphumo esibi njengokuhlaselwa kwentliziyo okanye ukubetha. Nangona kunjalo, akucebisi ukuba unqande i-beta-blocker yotyando ukuba isigulana sizinzile kuyo.
Kubalulekile ukwazi ukuba kunokuba nzima ukuqaphela iimpawu zehypoglycemia kwizigulana ezinesifo seswekile, ezinje nge-tachycardia, kuba ziya kugutyungelwa ziziphumo ze-beta blocker.
Ukuba nesiyezi kunye ne-hypotension ebangelwa yi-metoprolol kunye ne-atenolol kunokunyusa umngcipheko kunye neziganeko zokuwa, ezinokuba yingozi okanye zikhokelele kukonzakala kwentloko. Isilumkiso kufuneka sithathwe kubantu abadala asebekhulile abasemngciphekweni wokuwa.
Ngugqirha wakho kuphela onokuthatha isigqibo sokuba ngaba unyango lwe-metoprolol okanye i-atenolol lukhuselekile kuwe.
Imibuzo ebuzwa rhoqo malunga ne-metoprolol vs atenolol
Yintoni metoprolol?
I-Metoprolol yinyango yonyango echazwe njenge-cardioselective beta blocker. Isebenza ukunyanga uxinzelelo lwegazi kunye ne-angina ngokunciphisa izinga lokubetha kwentliziyo kunye nokunyanzeliswa kwentliziyo yeentliziyo. Iyafumaneka kwiipilisi zomlomo ezikhutshwa kwangoko, iipilisi zokukhupha ezandisiweyo kunye neepilisi, isisombululo esitofwayo, kunye nomgubo womlomo.
Yintoni i-atenolol?
I-Atenolol yi-beta blocker ye-cardioselective efumaneka ngonyango kuphela. Isebenza ukunyanga uxinzelelo lwegazi kunye ne-angina ngokunciphisa izinga lokubetha kwentliziyo kunye nokunyanzeliswa kwentliziyo yeentliziyo. Iyafumaneka kwiipilisi zomlomo ezikhutshwa kwangoko.
Ngaba i-metoprolol kunye ne-atenolol ziyafana?
I-Metoprolol kunye ne-atenolol zizibhlokhi ze-beta zentliziyo, kunye ne-pharmacology yendlela abasebenza ngayo iyafana, kodwa ayifani ncam. I-Metoprolol ineefom ezimbini ezikhoyo, enye isebenza ngokufutshane kwaye enye isebenza ixesha elide, kwaye inokutsalwa kanye okanye kabini imihla ngemihla kuxhomekeke kubume. I-Metoprolol nayo i-lipophilic, oku kuthetha ukuba ihlala ichithwa kwiindawo ezinamafutha (lipid). Ngesi sizathu, ukuthatha iMetoprolol ngesidlo kuyacetyiswa. I-Atenolol ithathwa kanye yonke imihla kwaye i-hydrophilic. I-Atenolol inyibilika kwindawo ezinamanzi amaninzi, ke ngoko kufuneka ithathwe kuphela ngeglasi yamanzi.
Ngaba i-metoprolol okanye i-atenolol ingcono?
Idatha iphakamisa ukuba la machiza mabini aneziphumo ezifanayo kwizigulana ezixinzelelekileyo, nangona kunjalo iziphumo zesifo sentliziyo, ezinje ngokuhla kwesifo, zinokuba zilunge ngakumbi nge-metoprolol.
Ndingayisebenzisa i-metoprolol okanye i-atenolol ngelixa ndikhulelwe?
IMetoprolol ikudidi lokukhulelwa C. Akukho zifundo zilawulwa kakuhle zokumisela ukhuseleko xa ukhulelwe. Nxibelelana nodokotela malunga nokuthatha iMetoprolol ngelixa ukhulelwe okanye uncancisa. I-Atenolol ikudidi lokukhulelwa D. Kuyaphikiswa kwaye akufuneki kuthathwe ngexesha lokukhulelwa. Nxibelelana nogqirha malunga namanyathelo oza kuwathatha ngelixa ucwangcisa ukukhulelwa okanye ukuncancisa.
Ndingayisebenzisa i-metoprolol ye-atenolol ngotywala?
Ngelixa kungekho kunxibelelana ngokuthe ngqo kwemichiza phakathi kotywala kunye ne-beta blockers ezinje nge-metoprolol kunye ne-atenolol, ukusetyenziswa kotywala kubangela ukuba uxinzelelo lwegazi lwakho luwe. Iziphumo ezidibeneyo zeziyobisi notywala zinokukubeka emngciphekweni wokuwa isiqaqa okanye ukuwa nokuzenzakalisa.