I-Viibryd vs Lexapro: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
I-Viibryd (vilazodone) kunye neLexapro (escitalopram) ngamagama amiselweyo amayeza asetyenziselwa ukunyanga uxinzelelo olukhulu (MDD). Omabini la machiza anokunceda ukunyanga iimpawu zokudakumba, ezinokubandakanya ukudakumba ixesha elide, ukuphelelwa ngamandla kunye nokutshintsha kokulala. I-Viibryd okanye i-Lexapro inokumiselwa emva kovavanyo lonyango ngumboneleli wezempilo ojolise kwezonyango.
Zombini iVibryd kunye neLexapro zizidambisi zengqondo ezisebenza ikakhulu ukwandisa umsebenzi we-serotonin kwingqondo. I-Serotonin yi-neurotransmitter yemichiza ekukholelwa ukuba idlala indima ebalulekileyo kwiimvakalelo nakwiimvakalelo zokuphila kakuhle. I-Viibryd kunye neLexapro basebenza njenge-serotonin reuptake inhibitors (i-SSRIs), enceda ukwandisa amanqanaba e-serotonin kwingqondo.
Nangona omabini la machiza enokusetyenziselwa ukunyanga uxinzelelo, anokungafani kwindlela asetyenziswa ngayo kunye nendlela asebenza ngayo.
Nguwuphi umahluko ophambili phakathi kweVibryd kunye neLexapro?
Viibryd
I-Viibryd ligama lophawu lwe-vilazodone. Kwaqala kwavunywa nguLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) ngo-2011 ukunyanga isifo esikhulu soxinzelelo. Okwangoku akukho nguqulelo yenziwayo ekhoyo kwimarike. Ukongeza kudidi lwe-SSRI, iViibryd ikwayinxalenye ye-5-HT1A receptor agonist.
I-Viibryd iza njenge-10 mg, 20 mg, kunye ne-40 mg ye-tablet yomlomo ethathwa kube kanye yonke imihla kunye nokutya. I-Viibryd ayinakusebenza kakuhle ukuba ayithathwanga nokutya. Ifikelela kumanqanaba aphezulu egazini emva kweeyure ezintlanu kwaye inesiqingatha sobomi malunga neeyure ezingama-25 .
ILexapro
ILexapro ligama lophawu lwe-escitalopram. Kwakuyi-FDA evunyiweyo ngo-2002 ukuphatha i-MDD kubantu abadala nakwishumi elivisayo abaneminyaka eli-12 ukuya kweli-17 ubudala. Ukongeza kwixinzelelo, iLexapro inokunyanga ukuphazamiseka koxinzelelo ngokubanzi. Iinguqulelo zeGeneric zeLexapro ziyafumaneka kwimarike.
ILexapro inokuthathwa njengecwecwe lomlomo kumandla e-5 mg, 10 mg, okanye 20 mg. Ihlala ithathwa kanye yonke imihla kunye okanye ngaphandle kokutya. ILexapro ifikelela kwinqanaba lokuphakama kwegazi kwisithuba seeyure ezintlanu kwaye inesiqingatha sobomi ukuya kuthi ga kwiiyure ezingama-32 .
| Umahluko ophambili phakathi kweViibryd kunye neLexapro | ||
|---|---|---|
| Viibryd | ILexapro | |
| Iklasi yeziyobisi | Ukukhetha i-Serotonin Reuptake Inhibitor (SSRI) Inxalenye ye-5-HT1A agonist | Ukukhetha i-Serotonin Reuptake Inhibitor (SSRI) |
| Uhlobo lweBrith / generic | Akukho nguqulo yohlobo oluqhelekileyo ekhoyo | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo |
| Ngubani igama eliqhelekileyo? | IVilazodone | I-Escitalopram |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo | Ithebhulethi yomlomo |
| Ithini idosi esemgangathweni? | 20 mg kanye yonke imihla | 20 mg kanye yonke imihla |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide | Ixesha elide |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala | Abantu abadala kunye nolutsha |
Imiqathango ephathwe nguViibryd kunye neLexapro
I-Viibryd kunye ne-Lexapro zi-anti-depressants ezivunyiweyo ze-FDA ezisetyenziselwa ukunyanga isifo sokudakumba. Nokuba ngamachiza anokumiselwa ngokudibeneyo nonyango lwengqondo kunye notshintsho kwindlela yokuphila ukunceda ukunciphisa iimpawu zoxinzelelo.
ILexapro ikwayi-FDA evunyiweyo ukunyanga isifo soxinzelelo ngokubanzi (GAD). Nangona kungavunyelwanga ukuxhalaba, i-Viibryd ifundwe kuvavanyo lweklinikhi kunyango lwexhala. I-Viibryd okanye iLexapro ngamanye amaxesha inokusetyenziswa ngaphandle kwelebheli ukunyanga ukunganyanzelekanga okunyanzelekileyo (OCD).
| Imeko | Viibryd | ILexapro |
| Uxinzelelo olukhulu lokudakumba | Ewe | Ewe |
| Ukuphazamiseka koxinzelelo ngokubanzi | Ngaphandle kwelebheli | Ewe |
| Ubume obungalunganga obuphambanisayo | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
Ngaba iVibryry okanye iLexapro iyasebenza ngakumbi?
Kwilingo elinye elingenamsebenzi, i-vilazodone kunye ne-escitalopram zathelekiswa intloko-nentloko phakathi kwesampulu yezigulana ezingama-50. Isikali sexhala leHamilton (HAM-A) kunye neHamilton yoxinzelelo yoHlolo lweSikali (HAM-D) amanqaku athotywa kuwo omabini amaqela onyango. Nangona kunjalo, i-escitalopram yafunyanwa ukuba ithobe amanqaku apheleleyo e-HAM-A kunye ne-HAM-D ngaphezulu kwe-vilazodone (P<0.0001).
Kuphononongo olucwangcisiweyo, i-escitalopram yayi xa kuthelekiswa nezinye izidambisi zintandathu , kubandakanya i-fluoxetine, citalopram, kunye ne-sertraline. Olu phononongo luphonononge uhlalutyo lweemeta ezininzi kwaye lafumanisa ukuba i-escitalopram yayisebenza ngakumbi kwaye yanciphisa iimpawu zoxinzelelo ezikhawulezayo kunezinye ii-SSRI.
Xa kuthelekiswa ne-placebo, okanye akukho nyango, i-Viibryd kunye ne-Lexapro zezona ndlela zisebenzayo zokunyanga uxinzelelo. Nangona kunjalo, Umahluko kwindlela umntu aphendula ngayo inokudlala indima ebalulekileyo ekusebenzeni kwe-anti-depressant. Ke ngoko, kubalulekile ukubonisana nomboneleli wezempilo ngengcebiso yezonyango xa uqala okanye ukutshintshela kwi-antidepressant entsha .
Umyinge kunye nokuthelekiswa kwexabiso leViibryd vs. Lexapro
I-Viibryd ifumaneka kuphela njengonyango lwegama lophawu. Ngesi sizathu, kunokuba yindlela ebiza kakhulu xa kuthelekiswa nezinye izidambisi. Ezinye zezonyango kunye nezicwangciso zeinshurensi inokugubungela iViibryd. Ixabiso eliphakathi lemali laseViibryd lijikeleze i- $ 389. Sebenzisa isigqebhezana se-SingleCare Viibryd kunokunciphisa iindleko ukuya kwi- $ 278 kwii-pharmacy ezithatha inxaxheba.
ILexapro iyafumaneka njengegama lophawu kunye nonyango oluqhelekileyo. Xa kuthelekiswa neViibryd, lukhetho olunamaxabiso aphantsi. Ikwagutyungelwe luninzi lwezonyango kunye nezicwangciso zeinshurensi. Ixabiso eliphakathi lemali le-generic Lexapro ijikeleze i-177 yeedola. Ngekhuphoni yesaphulelo kwi-SingleCare, unokufumana i-generic malunga ne- $ 15.
| Viibryd | ILexapro | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Ubungakanani | I-20 mg kanye yonke imihla (ubuninzi beepilisi ezingama-30) | I-20 mg kanye yonke imihla (ubuninzi beepilisi ezingama-30) |
| I-Medicare copay eqhelekileyo | Iidola 1- $ 11 | $ 0- $ 30 |
| Ixabiso elilodwa | $ 278 + | $ 15 + |
Iziphumo eziqhelekileyo ezichaphazelekayo zeViibryd vs. Lexapro
Iziphumo ebezingalindelekanga eziqhelekileyo zeViibryd sisifo sorhudo, isicaphucaphu, umlomo owomileyo, intloko ebuhlungu, kunye nokubila. Ezinye iziphumo ebezingalindelekanga ezinokubakho zibandakanya ukuba nesiyezi, ukozela, ukulala, kunye nentlungu edibeneyo (arthralgia), phakathi kwabanye.
Iziphumo ebezingalindelekanga eziqhelekileyo zeLexapro isicaphucaphu, intloko ebuhlungu, urhudo, ukubila, kunye nomlomo owomileyo. Ezinye iziphumo ezichaphazelekayo zeLexapro zingabandakanya ukuqunjelwa kunye neempawu ezinjengomkhuhlane.
Viibryd kunye neLexapro, njengezinye izidambisi zengqondo , kunokubangela utshintsho kumdla wokutya. Oku kunokukhokelela ekuzuzeni ubunzima okanye ukunciphisa umzimba kwabanye abantu.
Zombini iVibryd kunye neLexapro kunokubangela iziphumo ebezesondo . Ukusetyenziswa kwe-antidepressant kunokubangela ukwehla kwesondo (libido). I-Viibryd kunye neLexapro inokubangela ukungasebenzi kakuhle ngokwesondo, njengokungasebenzi kakuhle kwe-erectile, kunye neengxaki nge-ejaculation. Kungenxa yokuba iViibryd ikwasebenza njengenxalenye ye-5-HT1A receptor agonist, inokuba nayo ubungozi obuncinci beziphumo ebezesondo ngaphezu kweLexapro.
| Viibryd | ILexapro | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Urhudo | Ewe | 26% | Ewe | 8% |
| Ukuqunjelwa | Hayi | - | Ewe | 3% |
| Ukwanda kokubila | Ewe | * | Ewe | 5% |
| Isicaphucaphu | Ewe | 22% | Ewe | Shumi elinantlanu% |
| Umlomo owomileyo | Ewe | 8% | Ewe | 6% |
| Ukutya | Ewe | Mbini% | Ewe | 3% |
| Iimpawu ezinjengomkhuhlane | Hayi | - | Ewe | 5% |
| Intloko ebuhlungu | Ewe | Shumi elinantlanu% | Ewe | 24% |
| Ukuba nesiyezi | Ewe | 6% | Ewe | 5% |
| Ukozela | Ewe | 4% | Ewe | 6% |
| Ukuphuthelwa | Ewe | 7% | Ewe | 9% |
| Iipalpitations | Ewe | 1% | Ewe | * |
| Ukwanda kwesidlo | Ewe | 1% | Ewe | * |
| Ukutyeba kwakho | Ewe | 1% | Ewe | * |
| Ukunciphisa ukutya | Ewe | * | Ewe | 3% |
| Intlungu edibeneyo | Ewe | Mbini% | Ewe | * |
| Ukungasebenzi kakuhle kwe-Erectile | Ewe | 3% | Ewe | 3% |
| Ukuphazamiseka kumjelo | Ewe | 1% | Ewe | 9% |
| Ukuncipha kwe-libido | Ewe | 4% | Ewe | 3% |
* akuxelwa
Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( Viibryd ), Yonke imihla ( ILexapro )
Ukudibana kweziyobisi neViibryd vs. Lexapro
I-Viibryd kunye neLexapro kufuneka zithintelwe ngelixa zithatha i-monoamine oxidase inhibitors (MAOIs), efana ne-selegiline kunye ne-phenelzine. I-Viibryd okanye i-Lexapro akufuneki ithathwe zingaphelanga iintsuku ezili-14 zokuyeka i-MAOI okanye kunokubakho umngcipheko owandayo we-serotonin syndrome. I-Viibryd kunye neLexapro kufuneka zithintelwe okanye zibekwe esweni ngamanye amachiza e-serotonergic anje ngee-anti-depressants, ezinokunyusa umngcipheko we-serotonin syndrome.
Ukusetyenziswa kweViibryd okanye iLexapro kufuneka kubekwe esweni ngelixa kuthathwa i-nonsteroidal anti-inflammatory drug (NSAID) okanye i-anticoagulant. Ukuthatha la mayeza kunye kunokunyusa umngcipheko wokopha.
Ngenxa yokuba i-Viibryd kunye ne-Lexapro ngokuyintloko zidibene esibindini, ukufunxeka kwabo kunokuchaphazeleka kwiziyobisi eziguqula ii-enzymes ezithile zesibindi. Ezinye ii-antifungals kunye ne-antibiotics zinokunyusa amanqanaba e-Viibryd kunye ne-Lexapro egazini, enokunyusa umngcipheko weziphumo ezibi. Amanye amachiza anje nge-anticonvulsants anokunciphisa amanqanaba egazi e-Viibryd kunye ne-Lexapro, anokunciphisa ukusebenza kwawo ngokupheleleyo.
ILexapro yaziwa ngokuba inokubangela ukuphazamiseka kwesingqisho sentliziyo ekuthiwa kukwandiswa kweQT. Ukuthatha iLexapro ngamayeza athile antipsychotic afana ne-aripiprazole okanye i-quetiapine kunokunyusa umngcipheko wokwandiswa kwe-QT.
| Iziyobisi | Iklasi yeziyobisi | Viibryd | ILexapro |
| Selegilin IPhenelzine I-Rasagiline | I-Monoamine oxidase inhibitors (i-MAOIs) | Ewe | Ewe |
| Paroxetine Sertraline IFluoxetine | Ukukhetha i-serotonin reuptake inhibitors (i-SSRIs) | Ewe | Ewe |
| IVenlafaxine I-Desvenlafaxine Duloxetine | I-Serotonin norepinephrine reuptake inhibitors (SNRIs) | Ewe | Ewe |
| Amitriptyline Clomipramine Umgca weNortriptyline | I-Tricyclic antidepressants (TCAs) | Ewe | Ewe |
| IBupropion | Aminoketone | Ewe | Ewe |
| Ibhayiprone | Anxiolytic | Ewe | Ewe |
| I-Aspirin Ibuprofen INaproxen Diclofenac | Izidakamizwa ezichasayo ezichasayo (i-NSAID) | Ewe | Ewe |
| IWarfarin | Iintsholongwane | Ewe | Ewe |
| I-Digoxin | Iglycoside yentliziyo | Ewe | Ewe |
| ISumatriptan Rizatriptan Eletriptan | IiTriptans | Ewe | Ewe |
| Ketoconazole Itraconazole | Izinto zokubulala iintlungu | Ewe | Ewe |
| Ritonavir | Iprotease inhibitors | Ewe | Ewe |
| Clarithromycin | Amayeza okubulala iintsholongwane | Ewe | Ewe |
| ICarbamazepine IPhenytoin | IiAnticonvulsants | Ewe | Ewe |
| Aripiprazole IClozapine IQuetiapine | Iintsholongwane | Hayi | Ewe |
Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi.
Izilumkiso ngeViibryd kunye neLexapro
I-anti-depressants efana neVibryd okanye iLexapro inokunyusa umngcipheko wokucinga ngokuzibulala, ngakumbi kwizigulana zabantu abadala. Abo bathatha iViibryd okanye iLexapro kufuneka babekwe esweni ngokudodobala koxinzelelo kunye neengcinga zokuzibulala.
I-serotonin reuptake inhibitors ekhethiweyo (i-SSRIs) inokubangela isifo se-serotonin, imeko enokubakho enokwenzeka xa kukho i-serotonin eninzi kwingqondo. Umngcipheko uyonyuka xa i-anti-depressants ithathwa kunye nezinye iziyobisi ze-serotonergic. Iimpawu kunye neempawu zesifo se-serotonin zinokubandakanya ukukhawuleza kwentliziyo, ukonyuka koxinzelelo lwegazi, ukubila, ukungcangcazela kunye nomkhuhlane.
Abanye abantu banokuvavanywa kwimbali yesifo esiyibipolar ngaphambi kokuqala unyango ngeVibryd okanye iLexapro. Ezi ziyobisi zinokusebenzisa i-mania okanye i-hypomania kwabanye abantu abanesifo se-bipolar.
I-Viibryd kunye neLexapro kufuneka icocwe okanye ziyekwe kancinci kancinci xa kufuneka njalo. Ukuyekiswa ngesiquphe kwe-anti-depressants kunokunyusa umngcipheko weempawu zokurhoxa.
Qhagamshelana nomboneleli wezempilo malunga nezinye izilumkiso kunye nezilumkiso.
Imibuzo ebuzwa rhoqo malunga neVibryd vs. Lexapro
Yintoni iVibryd?
I-Viibryd ligama lonyango elinegama lebrendi elisetyenziselwa ukunyanga isifo sokudakumba (MDD). Ligama lophawu lwe vilazodone. I-Viibryd isebenza njenge-serotonin reuptake inhibitor ekhethiweyo (SSRI) kunye nenxalenye ye-5-HT1A receptor agonist. Ihlala ithathwa njengecwecwe le-20 mg kanye yonke imihla ngokutya.
Yintoni iLexapro?
ILexapro liyeza elinegama lebrendi elivunyiweyo yi-FDA ukunyanga isifo sokudakumba (MDD). Kukwavunyiwe ukunyanga isifo soxinzelelo ngokubanzi (GAD). Igama eliqhelekileyo leLexapro yi-escitalopram. ILexapro sisiyobisi se-SSRI esithathwa kanye yonke imihla.
Ngaba iVibryd kunye neLexapro ziyafana?
I-Viibryd kunye neLexapro basebenza ngeendlela ezifanayo zokunyanga iimeko zempilo yengqondo, kodwa azifani. I-Viibryd isebenza njenge-SSRI kunye nenxalenye ye-5-HT1A agonist ngelixa iLexapro isebenza ikakhulu njenge-SSRI. Nangona iViibryd kunye neLexapro zivunyiwe ukuba zinyange uxinzelelo olukhulu, iLexapro ikwavunyiwe ukunyanga uxinzelelo.
Ngaba iVibryry okanye iLexapro ingcono?
I-anti-depressant ebhetele kukuba uphendule ngcono. I-Viibryd kunye neLexapro zozibini iziyobisi ezisebenzayo zokumisela uxinzelelo. Xa kuthelekiswa neLexapro, iViibryd inokubangela iziphumo ebezingalindelekanga ezimbalwa.
Ndingayisebenzisa iViibryd okanye iLexapro ngelixa ndikhulelwe?
Ukudakumba okufana neVibryd okanye iLexapro unokukhuseleka ukuthatha ngelixa ukhulelwe. Nangona kunjalo, abukho ubungqina obaneleyo beklinikhi obubonisa ukuba iViibryd okanye iLexapro zikhuselekile ngokupheleleyo okanye ziyingozi ukuzithatha ngexesha lokukhulelwa. La machiza kufuneka athathwe kuphela ukuba izibonelelo zingaphezulu komngcipheko. Qhagamshelana nomboneleli wezempilo malunga neengcebiso zonyango xa uthatha i-anti-depressants ngelixa ukhulelwe.
Ndingayisebenzisa iViibryd okanye iLexapro ngotywala?
Ukusela ngokumodareyitha akunakubangela monakalo ukuba ubunyango olufanayo neVibryd okanye iLexapro. Nangona kunjalo, ukusetyenziswa kotywala kunokwandisa umngcipheko weziphumo ezibi, njengesiyezi, ukozela kunye nokudideka. Nxibelelana nomboneleli wezempilo ngokhuseleko lwe-anti-depressants ngelixa usela utywala.
Ngaba i-Viibryd ilungile kwixhala?
Isithako esisebenzayo eViibryd, vilazodone, sifundelwe unyango lwexhala. Ngokweemvavanyo zeklinikhi, i-vilazodone isenokuba unyango olusebenzayo yokuphazamiseka koxinzelelo ngokubanzi (GAD). Uphando oluthe kratya luyafuneka nangona. Okwangoku, i-Viibryd ayivunyelwanga yi-FDA ukunyanga uxinzelelo.
Leliphi elona xesha lilungileyo lokuthatha iViibryd?
I-Viibryd kufuneka ithathwe ngaxeshanye yonke imihla. Kuxhomekeke ekuphenduleni komzimba wakho kunyango, kungangcono ukuthatha iViibryd kusasa okanye ngokuhlwa. Uninzi loogqirha bacebisa ukuthatha iViibryd kusasa ngesidlo sakusasa.
Kwenzeka ntoni ukuba ndithatha iViibryd ngaphandle kokutya?
I-Viibryd isenokungasebenzi kakuhle ukuba ithathwa ngaphandle kokutya. Kungenxa yokuba iViibryd ifunxwe ngcono xa ilawulwa ngesidlo. Xa kuthelekiswa nokufunxwa kwayo kukutya, ukufunxwa kweViibryd ngaphandle kokutya kusezantsi phantse Amashumi amahlanu% .
