IMetformin vs.Metformin ER: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
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I-Metformin liyeza eliqhelekileyo elisetyenziselwa ukunyanga uhlobo lwe-2 yeswekile. Yeyona arhente ye-antidiabetic eyiklasi yamachiza abizwa ngokuba yi-biguanides. Isebenza ngokunciphisa i-glucose (iswekile yegazi) kwimveliso yesibindi, ukunciphisa ukufunxwa kweglucose emathunjini, kunye nokunyusa ubuntununtunu be-insulin. I-Metformin iphucula ubuntununtunu be-insulin ngokwandisa ukuthathwa kweglucose kwizicubu zomzimba.
Uhlobo lwe-2 lwe-diabetes mellitus lufunyaniswa xa umzimba unganyangeki kwiziphumo ze-insulin. I-insulin yihomoni ebalulekileyo eveliswa yipancreas kwaye isetyenziselwa ukuhambisa iswekile kwiiseli zomzimba zamandla. Xa umzimba ungakwazi ukusebenzisa i-insulin ngokufanelekileyo, amanqanaba eswekile egazini anyuka anokubangela ukonakala kwimithambo yegazi kunye nemithambo-luvo. Ngaphandle konyango olufanelekileyo, isifo seswekile singakhokelela iingxaki kunye nomonakalo kumalungu afana nentliziyo nezintso.
I-Metformin ifumaneka ngokukhutshwa kwangoko (i-IR) kunye nefom yokukhululwa (ER). Nangona zombini iifom ze-metformin ziqukethe isithako esifanayo, zithathwa ngeendlela ezahlukeneyo. Banokwahluka nakweziphumo ebezingalindelekanga.
Nguwuphi umahluko ophambili phakathi kwe-metformin kunye ne-metformin ER?
I-Metformin okanye i-metformin hydrochloride ligama eliqhelekileyo leGlucophage. I-metformin ekhutshwa kwangoko ihlala ichazwa njengepilisi ye-500 mg ethathwa kabini ngemini ngokutya. Kukho ithebhulethi ye-850 mg enokuthathwa kube kanye yonke imihla. Elona dosi liphezulu le-metformin ngama-2550 mg ngosuku ngeedosi ezahluliweyo. I-Metformin inokunyanga uhlobo lwesifo seswekile kubantu abadala nakubantwana.
IMetformin ER ikwaziwa njengegama lophawu iGlucophage XR. Inguqulelo ekhutshiweyo ye-metformin kwaye kufuneka ithathwe kube kanye yonke imihla kunye nokutya. Elona nani liphezulu lemihla ngemihla yemetformin ER yi-2000 mg. Ngokungafaniyo nokukhululwa kwangoko kwe-metformin, i-metformin ER iboniswa kuphela kubantu abadala abanesifo seswekile sesi-2. Ineziphumo ebezingalindelekanga ezimbalwa kwaye ihlala ixesha elide kune-metformin yesiqhelo.
ZIQHELEKILEYO: Iinkcukacha zeMetformin | Iinkcukacha zeMetformin ER
| Umahluko ophambili phakathi kwe-metformin kunye ne-metformin ER | ||
|---|---|---|
| IMetformin | IMetformin ER | |
| Iklasi yeziyobisi | IBiguanide | IBiguanide |
| Uhlobo lweBrith / generic | Inguqulelo yesiqhelo iyafumaneka | Inguqulelo yesiqhelo iyafumaneka |
| Ngubani igama lophawu? | Iswekile yeglucophage | IGlucophage XR, iFortamet, iGlumetza |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo | Ithebhulethi yomlomo, ukukhutshwa okwandisiweyo |
| Ithini idosi esemgangathweni? | I-500 mg kabini yonke imihla okanye i-850 mg kanye yonke imihla ngokutya | 500 mg kanye yonke imihla ngesidlo sangokuhlwa |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide kulawulo lweswekile | Ixesha elide kulawulo lweswekile |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala nabantwana abaneminyaka eli-10 ubudala nangaphezulu | Abantu abadala |
Iimeko eziphathwe nge-metformin kunye ne-metformin ER
Zombini i-metformin kunye ne-metformin ER zivunyiwe yi-FDA ukulawula uhlobo lwesifo seswekile seswekile. Ngokwe- Umbutho weSwekile yaseMelika (ADA) , I-metformin yonyango lodidi lokuqala lwesifo seswekile sesi-2. Kwizigulana ezine-A1c engaphantsi kwe-9% ngexesha lokuchongwa, i-metformin kufuneka iqalwe njenge-monotherapy nge Imigangatho yoKhathalelo lwezoNyango kwiSwekile . I-Metformin inokukunceda ukuphucula ulawulo lwe-glycemic kwaye ekugqibeleni kuthintele iingxaki ezinokuvela kwisifo seswekile.
Ayisiyiyo kuphela i-metformin enokusetyenziselwa ukuphatha uhlobo lwe-2 yeswekile, kodwa inokusetyenziselwa iinjongo zelebheli engekhoyo. Abo bane kwisifo seswekile kunye nokuzila ukutya okuphezulu kweplasma glucose (FPG) kunokucetyiswa i-metformin ukunqanda ukuqala kweswekile. I-Metformin iyacetyiswa xa amanqanaba eswekile egazi engalawulwa ngokutya kunye nokuzilolonga kuphela.
I-Metformin inokusetyenziswa njengenketho yeelebheli engeyiyo ukunyanga isifo seswekile. Olu hlobo lwesifo seswekile lwenzeka kubafazi abakhulelweyo abafanele ukuba nesifo seswekile. Nangona kunjalo, i-insulin ihlala izanywa kuqala.
IMetformin nayo ibikhona wafunda ukunyanga i-polycystic ovary syndrome (POCS). Esi sifo sibonakaliswa kukungalingani kwamahomoni esini anokubangela ii-cysts ze-ovari, utshintsho kumjikelo wokuya exesheni, imiba yokukhulelwa, amabala kunye nokumelana ne-insulin. I-Metformin inokumiselwa ukunceda ukunciphisa ukunganyangeki kwe-insulin, ukunciphisa amanqanaba e testosterone, kunye nokuphucula imijikelezo yokuya exesheni kunye nokuzala.
Ukusetyenziswa kwamayeza antipsychotic, njenge-olanzapine, risperidone, kunye ne-clozapine, kunokukhokelela ekuzuzeni ubunzima. Ngokwezifundo ezithile, iMetformin ibonakalisiwe iyasebenza ekunyangeni ukunyusa ubunzima obukwi-antipsychotic. Olunye uphononongo lufumanise ukuba i-metformin incede ukunciphisa ubunzima bomzimba (BMI), ubunzima bomzimba, kunye nokumelana ne-insulin xa kuthelekiswa ne-placebo kwabo bane-antipsychotic-indased weight weight.
| Imeko | IMetformin | IMetformin ER |
| Uhlobo lwe-2 lwesifo seswekile | Ewe | Ewe |
| Uhlobo lwesibini lweswekile yokuthintela isifo | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| Isifo seswekile sesifo seswekile | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| Isifo sePolycystic ovary | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
| Ukutyeba ngenxa yonyango lwe-antipsychotic | Ngaphandle kwelebheli | Ngaphandle kwelebheli |
Ngaba i-metformin okanye i-metformin ER iyasebenza ngakumbi?
Ngokusekwe kwizifundo ngokuthelekisa i-metformin kunye ne-metformin ER yohlobo lwe-2 yeswekile, i-metformin ER ifunyenwe ifaniswa ne-metformin ngokusebenza. Ngapha koko, i-metformin ER inokuphakama kune-metformin eqhelekileyo esekwe kwiziphumo ebezingalindelekanga kunye nokusetyenziswa ngokulula. Abo banesifo seswekile sesifo seswekile banokuba notyekelo lokuthatha ipilisi yemetformin yemihla ngemihla endaweni yeepilisi zemihla ngemihla.
Ngenye indlela, isifundo seklinikhi , I-metformin ER yafunyanwa isebenza ngakumbi kune-metformin IR xa inyanga abaguli abanesifo seswekile sesi-2. Abo bathatha i-metformin ER bafumana ulawulo olungcono lwe-glycemic kunye ne-lipid metabolism xa kuthelekiswa ne-metformin IR.
Olunye uludwe, ityala elingaboni kabini ifumanise ukuba kanye-imihla ngemihla i-metformin ER yayisebenza ngokuchanekileyo kunye nokhuseleko kwi-metformin eqhelekileyo. Ukongeza, uphononongo luqaphele isibonelelo sokulinganisa kanye-imihla nge-metformin ER. Zombini i-metformin kunye ne-metformin ER ziphucule amanqanaba e-HbA1c ngaphezulu kweeveki ezingama-24 kwizifundo ezingazange zizame naluphi na unyango lwesifo seswekile.
Imetformin yokukhululwa eyandisiweyo inokukhethwa ngaphezulu kokukhutshwa kwangoko kwe-metformin. Kubonakalisiwe ukuba kunokunyamezeleka okungcono nangona kunokuba kubiza kakhulu kunamacwecwe okukhululwa kwangoko. Kubalulekile ukubonisana neengcebiso zonyango xa ukhetha unyango kwindlela yohlobo lwe-2 yeswekile.
Umyinge kunye nokuthelekiswa kweendleko ze-metformin vs metformin ER
I-Metformin yinguqulelo yesiqhelo yeGlucophage. I-generic metformin igutyungelwe yinxalenye ye-Medicare icandelo D kwaye uninzi lwezicwangciso zeinshurensi Igama leBrand Glucophage linokubiza kakhulu kwaye lixabise ixabiso eliphakathi lokuthengisa ngaphezulu kwe- $ 150. Ezi ndleko zinokuncitshiswa ngokuzisa ikhadi lesaphulelo kwi-SingleCare kwikhemesti. Ikhadi le-singleform le-metformin linokuzisa iindleko ukuya kuthi ga kwi-4 yeedola kunikezelo lweentsuku ezingama-30 zokukhutshwa kwangoko kwe-metformin.
Phantse onke amayeza kunye nezicwangciso zeinshurensi ziya kubandakanya i-generic metformin ER. Igama leBrand Glucophage XR linokubiza malunga ne- $ 80 ngokuxhomekeke kwikhemesti oya kuyo. Ngekhadi lekhuphoni le-SingleCare, i-generic metformin ER inokuthengwa ngexabiso eliphantsi njenge- $ 4 yokubonelela ngeentsuku ezingama-30 zeepilisi ze-metformin ze-ER zosuku olunye. Nokuba unayo i-inshurensi, i-SingleCare inakho ukubonelela ngexabiso eliphantsi. Jonga ikhemesti yakho ukuze ubone ukuba ungasithatha na isaphulelo esingcono nge-SingleCare.
Fumana ikhadi lesaphulelo somntu ongatshatanga
| IMetformin | IMetformin ER | |
| Ngokuqhelekileyo i-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo igutyungelwe yiMedicare? | Ewe | Ewe |
| Umthamo osemgangathweni | Iipilisi ezingama-500 mg (ubuninzi beepilisi ezingama-60) | Iipilisi ezingama-500 mg (ubuninzi beepilisi ezingama-30) |
| I-Medicare copay eqhelekileyo | $ 0- $ 8 | $ 0- $ 8 |
| Ixabiso elilodwa | $ 4 | $ 4 |
Iziphumo eziqhelekileyo ezichaphazelekayo ze-metformin vs metformin ER
I-Metformin ibangela iziphumo ebezingalindelekanga ezichaphazela inkqubo ye-gastrointestinal (GI). Ezi imiphumela zibandakanya urhudo, isicaphucaphu, ukugabha, igesi (ukuqunjelwa), ukungagayeki kokutya, ukungonwabi esiswini okanye ukukhathazeka esiswini. I-Metformin IR ikwabangela ukudinwa okanye ukungabikho kwamandla (i-asthenia) kunye neentloko.
I-Metformin ER ineempembelelo ezimbalwa xa kuthelekiswa ne-metformin. Iziphumo eziqhelekileyo ezichaphazelekayo kunye ne-metformin ER isifo sohudo, isicupunu kunye nokuhlanza. I-Metformin ER inokubangela nokuqunjelwa kwabanye abantu. Nangona i-metformin ER inokubangela ezinye iziphumo ebezingalindelekanga njenge-indigestion kunye ne-flatulence, ezi ziphumo bezingalindelekanga azenzeki rhoqo xa kuthelekiswa ne-metformin yesiqhelo.
Ezinye iziphumo ebezingalindelekanga ezinokuthi zenzeke nge-metformin kunye ne-metformin ER zibandakanya ukuba nesiyezi, ukuba nentloko elula, kunye nokuphazamiseka kwencasa. Eminye imiphumo emibi kakhulu ye-metformin kunye ne-metformin ER zibandakanya ukulimala kwesibindi kunye ne-hypoglycemia (iswekile esezantsi yegazi).
| IMetformin | IMetformin ER | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Urhudo | Ewe | 53% | Ewe | 10% |
| Isihlunu okanye ukugabha | Ewe | 26% | Ewe | 7% |
| Ukuqunjelwa sisisu | Ewe | 12% | Ewe | 1% -5% |
| I-Asthenia | Ewe | 9% | Hayi | - |
| Ukutya | Ewe | 7% | Ewe | 1% -5% |
| Isisu esimoshakele | Ewe | 6% | Ewe | 1% -5% |
| Intloko ebuhlungu | Ewe | 6% | Ewe | 1% -5% |
| Ukuqunjelwa | Hayi | - | Ewe | 1% -5% |
| Ngcamla ukuphazamiseka | Ewe | 1% -5% | Ewe | 1% -5% |
| Ukuba nesiyezi / ukuba nentloko elula | Ewe | 1% -5% | Ewe | 1% -5% |
Olu alunakuba luluhlu olupheleleyo. Dibana nogqirha wakho okanye usokhemesti malunga neziphumo ebezingalindelekanga ezinokubakho.
Umthombo: DailyMed ( IMetformin ), Yonke imihla ( IMetformin ER )
Ukudibana kweziyobisi kwe-metformin vs metformin ER
I-Metformin kunye ne-metformin ER inokusebenzisana namayeza ahlukeneyo. Ukudibana kweziyobisi kuhlala kukhokelela kutshintsho lweswekile yegazi, umngcipheko okhulayo I-lactic acidosis , okanye ingqokelela yemetformin egazini enokunyusa umngcipheko weziphumo ezibi.
Ukuthatha i-metformin ngamachiza abizwa ngokuba yi-carbonic anhydrase inhibitors kungonyusa umngcipheko we-lactic acidosis, imeko enokubusongela ubomi kwi-lactate eninzi emzimbeni. La machiza abandakanya i-topiramate kunye ne-acetazolamide phakathi kwabanye.
Iziyobisi ezinje nge-dolutegravir, cimetidine, kunye ne-ranolazine zinokunciphisa ukususwa kwe-metformin. Oku kunokubangela amanqanaba aphezulu e-metformin egazini kunye nokunyusa umngcipheko weziganeko ezimbi.
Amanye amachiza afana ne-diuretics, i-corticosteroids, i-phenothiazines, ii-estrogens, izinto zokucwangcisa ngomlomo, kunye ne-calcium channel blockers zinokuphazamisa ulawulo lweglucose. Ukuthatha naliphi na la mayeza nge-metformin kunokubangela i-hyperglycemia (iswekile yegazi ephezulu eyingozi). Sebenzisa i-insulin okanye i-sulfonylurea okanye i-glinide drug kunye ne-metformin kunokubangela umngcipheko okhulayo hypoglycemia .
| Iziyobisi | Iklasi yeziyobisi | IMetformin | IMetformin ER |
| Ipiramidi ephezulu Acetazolamide Zonisamide Dichlorphenamide | Iicarbonic anhydrase inhibitors | Ewe | Ewe |
| I-Dolutegravir Cimetidine IVandetanib Ranolazine | Iziyobisi ezinciphisa ukucocwa kwe-metformin emzimbeni | Ewe | Ewe |
| I-insulin | I-insulin | Ewe | Ewe |
| IGlimepiride IGlipizide IGlyburide I-Repaglinide Isigaba | Imfihlo ye-insulin | Ewe | Ewe |
| IHydrochlorothiazide IChlorthalidone Indapamide Furosemide Bumetanide I-Torsemide I-acid ye-Ethacrynic | Womchamo | Ewe | Ewe |
| IPrednisolone IPrednisone IHydrocortisone Dexamethasone Fludrocortisone | ICorticosteroids | Ewe | Ewe |
| Chlorpromazine UMesoridazine Iprochlorperazine Thioridazine | Iiphenothiazines | Ewe | Ewe |
| I-Levothyroxine | Amayeza e-thyroid | Ewe | Ewe |
| Ukudibana kwee-estrogens I-Ethinyl estradiol I-Levonorgestrel Indawo encinci Desogestrel | I-Estrogens kunye nezinto zokucwangcisa zomlomo | Ewe | Ewe |
| IPhenytoin | Isifo sephepha | Ewe | Ewe |
| Niacin | Nicotinic acid | Ewe | Ewe |
| Ephedrine | Uvelwano | Ewe | Ewe |
| Amlodipine Diltiazem Felodipine UNicardipine Nifedipine I-Verapamil | Isikhululo seCalcium blocker | Ewe | Ewe |
| Isoniazid | Zintsholongwane | Ewe | Ewe |
Olu alunakuba luluhlu olupheleleyo lwazo zonke izinto ezinokubakho xa kusenziwa iziyobisi. Dibana nogqirha nawo onke amayeza onokuthi uwathathe.
Izilumkiso zemetformin vs. metformin ER
I-Metformin inokubangela i-lactic acidosis kwiimeko ezinqabileyo. I-Lactic acidosis yenzeka xa kukho i-lactate eninzi egazini. Le meko inokubangela uxinzelelo lwegazi oluphantsi, i-hypothermia, kunye nokufa. Ezinye iimpawu ze-lactic acidosis zibandakanya ubuthathaka obungaqhelekanga, urhudo, iintlungu zesisu, kunye necramp. Funa unyango kwangoko ukuba ubonakalisa ezi mpawu.
I-Metformin inokuhla ivithamini B12 amanqanaba emzimbeni. Ngokuhamba kwexesha oku kungakhokelela ekuswelekeni kwe-vitamin B12. Amanqanaba eVitamin B12 kufuneka abekwe esweni yonke iminyaka emi-2 ukuya kwemi-3 xa uthatha i-metformin ixesha elide.
Nangona kunqabile, i-metformin inokubangela i-hypoglycemia ukuba ithathwa nge-insulin okanye i-insulin secretagogue efana ne-glipizide okanye i-repaglinide. Kwiimeko ezinqabileyo, i-metformin inokubangela i-hypoglycemia xa ithathwa ngotywala okanye ukutya okungonelanga.
Imibuzo ebuzwa rhoqo malunga ne-metformin vs metformin ER
Yintoni imetformin?
I-Metformin liyeza eligqirha elamkelweyo ukunyanga isifo seswekile kubantu abadala kunye nabantwana abaneminyaka eli-10 nangaphezulu. I-metformin ekhutshwa kwangoko ihlala ithathwa kabini imihla ngemihla kunye nokutya. Kuqwalaselwa njengonyango lodidi lokuqala lodidi 2 lweswekile xa idityaniswe efanelekileyo ukutya kunye nokuzilolonga .
Yintoni i-metformin ER?
I-Metformin ER yindlela ekhulisiweyo yokukhululwa kwe-metformin. Kukwaziwa nangamagama egama leGlucophage XR, iGlumetza, okanye iFortamet. I-Metformin ER ihlala ixesha elide kune-metformin eqhelekileyo kwaye ineziphumo ebezingalindelekanga. Imiselwa kanye yonke imihla ngesidlo sangokuhlwa.
Ngaba i-metformin kunye ne-metformin ER ziyafana?
Hayi. IMetformin kunye ne-metformin ER azifani. IMetformin luguqulelo lokukhululwa kwangoko ngelixa i-metformin ER inguhlobo lokukhululwa olwandisiweyo. I-Metformin ivunyiwe ukuba inyange uhlobo lwesifo seswekile kubantu abadala kunye nabantwana abaneminyaka eli-10 nangaphezulu ngelixa i-metformin ER ivunyiwe kuphela ukunyanga uhlobo lweswekile yesibini kubantu abadala.
Ngaba i-metformin kunye ne-metformin ER zibhetele?
I-Metformin ER ithathwa njengeyona nto ibhetele kuba ifuna ukuthathwa kube kanye yonke imihla. Kuyafana okanye kuyasebenza ngakumbi kune-metformin kwaye akunakufane kubangelwe ziziphumo ebezingalindelekanga ezithile.
Ndingayisebenzisa i-metformin kunye ne-metformin ER ngelixa ndikhulelwe?
I-Metformin ingasetyenziselwa ngexesha lokukhulelwa ukuba izibonelelo zingaphezulu komngcipheko. Izifundo zezilwanyana bonisa ukuba akukho ziphumo zingalunganga kwimveku engekazalwa. Nangona kunjalo, umngcipheko weziphene zokuzalwa awunakukhutshwa. Thetha nogqirha ukuze ubone ukuba i-metformin ilungile na xa ukhulelwe okanye uncancisa.
Ndingayisebenzisa i-metformin kunye ne-metformin ER ngotywala?
Akukhuthazwa ngokubanzi ukuthatha i-metformin okanye i-metformin ER ngotywala. Ukusela utywala kunokutshintsha amanqanaba eswekile yegazi kukhokelela kumngcipheko okhulayo we-hyperglycemia okanye i-hypoglycemia.
Ithetha ntoni i-metformin HCl ER?
I-Metformin HCl ER iqulethe i-metformin hydrochloride kulwandiso olwandisiweyo.
Ngaba i-metformin ER iyafana neGlucophage XR?
I-Metformin ER iqulethe izinto ezifanayo njengeGlucophage XR. I-Metformin ER ligama eliqhelekileyo leGlucophage XR.
