Eyona >> Ulwazi Lweziyobisi >> Iziphumo ebezingalindelekanga zeFurosemide kunye nendlela yokuzikhusela

Iziphumo ebezingalindelekanga zeFurosemide kunye nendlela yokuzikhusela

Ulwazi lweziyobisi iFurosemide sisifo esinyanga i-edema kunye noxinzelelo lwegazi kodwa sinokuvelisa iziphumo ebezingalindelekanga. Jonga uluhlu lwethu lwezinto eziqhelekileyo kunye neziphumo ebezingalindelekanga.

I-Furosemide (igama lebrand: Lasix ) sisichazi esiqhelekileyo esichaza i-edema (ukugcinwa kwamanzi) ngenxa yokusilela kwentliziyo, ukuqina kwesibindi, okanye isifo sezintso. I-Furosemide ikwanyanga uxinzelelo lwegazi (uxinzelelo lwegazi oluphezulu) kunye ne-edema yemiphunga (ulwelo kwimiphunga).

IFurosemide inyusa isixa samanzi kunye netyuwa ekhutshwe kumchamo, ukunciphisa ulwelo kwizicwili zomzimba nakwigazi. Njenge-diuretic loop, i-furosemide isebenza kwindawo ethile ye-anatomical kwizintso, eyenza ukuba isebenze kubantu abanomsebenzi wokungasebenzi kakuhle kwezintso.

Njengazo zonke i-diuretics, i-furosemide inokuvelisa iziphumo ebezingalindelekanga, inxibelelane namanye amachiza, kwaye ibe mandundu imeko esele ikhona.

Ezinxulumene: Funda ngakumbi malunga ne-furosemide

Iziphumo eziqhelekileyo ezichaphazelekayo ze-furosemide

I-Furosemide ineziphumo ebezingalindelekanga ezinokuchaphazela enye okanye iinkqubo ezingaphezulu emzimbeni.Toqhelekileyo okwexeshana imiphumela zibandakanya:

Ukwanda komchamo
Amanqanaba e-electrolyte aphantsi (i-sodium ephantsi, i-magnesium, i-calcium, okanye amanqanaba e-potassium)
Ukuba nesiyezi
Isicaphucaphu
Ukuhlanza
Urhudo
Iintlanzi zesisu
Ukuphelelwa ngumdla wokutya
Ukuhla ngesiquphe koxinzelelo lwegazi xa umile (orthostatic hypotension)
Iintlanzi zemisipha
Ubuthathaka
Ubumdaka
Iyakhala ezindlebeni
Intloko ebuhlungu
Umbono omfiliba
Amanqanaba eswekile aphakamileyo egazi (hyperglycemia)
I-cholesterol ephakanyisiweyo kunye namafutha (triglycerides) egazini
Uric acid engaphezulu (hyperuricemia)
Ukwanda kwee-enzymes zesibindi
Intlungu yendawo yesitofu (xa unikwe inaliti ye-furosemide)
Irhashalala okanye ukurhawuzelela
Ubuntununtunu ekukhanyeni (photosensitivity)

Iziphumo ezibi kakhulu zefososemide

I-Furosemide ineziphumo ebezingalindelekanga ezinobungozi. Oku kubandakanya:

Ukuphelelwa ngamanzi emzimbeni
Ukuphelelwa ngamandla kwe-electrolyte
Umthamo wegazi eliphantsi (hypovolemia)
I-pH ephezulu yegazi (i-alkalosis ye-metabolic)
Umonakalo wendlebe (ototoxicity) kunye nelahleko lokuva
Ukuhla okanye ukulahleka kwengqondo ngenxa yokungasebenzi kwesibindi (i-hepatic encephalopathy) kubantu abanezifo zesibindi
Ukudumba kwepancreas ( ukudumba komzimba )
I-jaundice
Ukuphazamiseka kwegazi kubandakanya i-anemia, aplastic anemia, hemolytic anemia, agranulocytosis, eosinophilia, thrombocytopenia, kunye neukopenia
Iziphumo ezibi kakhulu ezifana ne-anaphylaxis, ulusu olunamandla kunye nokudumba kwemithambo yegazi (inkqubo ye-vasculitis)

Zithatha ixesha elingakanani iziphumo ebezingalindelekanga ze-furosemide?

Uninzi lweempembelelo ezincinci ze-furosemide, ezinjengokwanda kokuchama okanye iingxaki zenkqubo yokwetyisa, zibangcono njengoko iyeza liphela, iiyure ezintandathu ukuya kwezisibhozo . Ezinye iingxaki ezinjengokuphelelwa ngamanzi emzimbeni, ukungalingani kwe-electrolyte, i-hyperglycemia, i-cholesterol ephakamileyo, kunye neempendulo ezinobungozi ezithatha ixesha elide ukusombulula kwaye kunokufuna unyango.

Iziphumo ebezingalindelekanga ezimandundu ezinje ngepancreatitis okanye ukuphazamiseka kwegazi kunokufuna unyango esibhedlele. Ukuva ilahleko kunye ne-tinnitus inokuphinda ibuye xa i-furosemide iphelisiwe, kodwa inokuba yimeko esisigxina kwabanye abantu. I-Hepatic encephalopathy sisiphumo esisesichengeni sobomi esifuna ukulaliswa esibhedlele kwaye iqhubeke ngomndilili Iiyure ezingama-48 . I-hepatic encephalopathy yi ingathityazwa imeko, kodwa izinga lokusinda liphantsi.

Izichaso zeFurosemide kunye nezilumkiso

I-Furosemide ayinakulungela wonke umntu. Ukusetyenziswa gwenxa, ukugqithisa, kunye notshintsho kwiimeko ezikhoyo zonyango zizinto zonke ezimisela ukhuseleko lale nyango.

Ukuphathwa gadalala kunye nokuxhomekeka

I-Furosemide ayibangeli ukuxhomekeka ngokwasemzimbeni nangokwasengqondweni. I-Furosemide inokuthi, nangona kunjalo, ibangele iimpawu zokurhoxa okwethutyana xa iphelisiwe. I-Furosemide iguqula inkqubo yehomoni yomzimba yokulawula ukuchama (diuresis), ebizwa ngokuba yinkqubo ye-renin-angiotensin-aldosterone, okanye i-RAAS. Xa i-furosemide ithathwa ixesha elide kwaye iyekwe ngesiquphe, umzimba uyagqitha ngokugcina amanzi kunye netyuwa eninzi, ibangele ukuba kwakhiwe ulwelo okanye igazi elonyukayo . Iziphumo ziyaphela kwiintsuku ezimbalwa, kodwa abantu abanesifo sentliziyo esibi banokufuna ukubekwa esweni ngeli xesha.

Ukugqithisa

I-furosemide overdose iya kubangela i-diuresis ekhawulezayo (ukupheliswa kwamanzi) ekhokelela ekuphelisweni kwamanzi emzimbeni kunye nokuphela kwe-electrolyte. Iimpawu zibandakanya ukunxanwa okugqithisileyo, ukuziva ushushu, ubuthathaka, ukubila, okanye ukuphelelwa ngamandla. Ukugqithisa ngokweqile kuphakamisa umngcipheko wokulahleka kwendlebe. Ukuba kurhanelwa ukuba ungaphaya, kwangoko yiya kwigumbi likaxakeka.

Izithintelo

I-Furosemide ivunyiwe yi-FDA ukuba isetyenziswe kuluhlu olubanzi lwabantu, ukusuka kwiintsana ezisandula ukuzalwa ukuya kubantu abadala. Ngenxa yamandla okuphelelwa ngamanzi emzimbeni kunye nokuphela kwe-electrolyte, wonke umntu othatha i-furosemide uya kujongwa ngeqondo le-fluid kunye namanqanaba e-electrolyte. Umboneleli wezempilo uya kufundisa abaguli iimpawu zokuphela kwamanzi emzimbeni okanye ukupheliswa kwe-electrolyte. Izongezo zePotassium zinokucetyiswa ukuthintela i-potassium esezantsi yegazi (hypokalemia).

I-Furosemide ayinakunikwa abantu:

Abazintso zabo zingavelisi umchamo (anuria)
Ngoobani abaye bafumana ukungahambi kakuhle kweziyobisi

I-Furosemide isetyenziswa ngononophelo kumaqela athile eminyaka okanye iimeko zonyango:

Iintsana ezisandula ukuzalwa inokufuna ukubekwa kweliso ngenxa yomngcipheko amatye ezintso (nephrolithiasis) okanye i-calcium deposits kwizintso (nephrocalcinosis).
Abantu abadala kunama-65 ingaqalwa ngeyona dosi iphantsi kwaye ibekwe esweni rhoqo.
Abantu abanembali yeentliziyo arrhythmias kufuneka bajongwe.
Abantu abane iingxaki zezintso (ukuphazamiseka kwezintso) okanye iingxaki zesibindi banokunikwa iidosi ezincinci kwaye zibekwe esweni rhoqo.
Abantu abane iingxaki zokugcina umchamo banokubona iimpawu zabo zisiba mandundu ngenxa yokwanda kwevolumu yomchamo kwisinyi.
I-Furosemide isenokungasebenzi kakuhle kwaye inokubangela ukulahleka kwendlebe kubantu abane nephrotic yesifo .
Abantu abane isifo seswekile Uya kulunyukiswa malunga nokunyuka okunokwenzeka kwiswekile yegazi. Banokucelwa ukuba babeke esweni amanqanaba eswekile yegazi rhoqo.
Abantu abane igawuthi banokubona iimpawu zabo zisiba mandundu. Amanqanaba eUric acid egazini anokufuna ukubekwa esweni.
I-Furosemide inokusebenza okanye ibe mandundu ilupus .

I-Furosemide ayimiselwanga njengekhuselekileyo ukuyithatha ngexa ukhulelwe okanye uncancisa. Oogqirha bayacetyiswa ukuba babeke esweni ngononophelo ukukhula komntwana kwabasetyhini abathatha i-furosemide. Isilumkiso siya kufuneka kwakhona xa uthatha i-furosemide ngelixa unesi. I-Furosemide zombini idlula kubisi lwebele kwaye inciphisa ukuncancisa. Kuzo zonke iimeko, ugqirha uya kuthi achaze ngononophelo umngcipheko kunye nezibonelelo zokuthatha i-furosemide ngelixa ukhulelwe okanye unesi.

Ukudibana kweFurosemide

Elinye iyeza kunye ne-over-the-counter (OTC) iziyobisi zinonxibelelwano olubalulekileyo kunye ne-furosemide. Ugqirha, usokhemesti, okanye umboneleli wezempilo uya kuba nolwazi malunga nokuhlangana kweziyobisi kwaye akwazi ukulungiselela abantu ukuba banxibelelane neziyobisi.

Ngenxa yokuhlangana kweziyobisi, i-furosemide ayisetyenziswanga nayo yoshop okanye IMarplan (isocarboxazid). Ukudibanisa i-furosemide kunye ne-desmopressin kunokubangela amanqanaba asezantsi e-sodium, ngelixa i-isocarboxazid kunye ne-furosemide inokubangela uxinzelelo lwegazi oluyingozi.

Olunye unxibelelwano lweziyobisi luya kufuna ulumkiso kunye nokujonga ngononophelo. La mayeza aquka:

I-Laxatives, i-corticosteroids, i-proton-pump inhibitors, kunye ne-bronchodilators (i-beta-2 agonists): Ukudibanisa i-furosemide kunye nawaphi na amayeza aya kuphakamisa umngcipheko wokuphelelwa ngamanzi emzimbeni kunye nokungalingani kwe-electrolyte.
Aminoglycoside antibiotics: Ukudibanisa i-furosemide kunye nezinye iziyobisi ze-ototoxic kwandisa umngcipheko wokonzakala kwendlebe kunye nokulahleka kwendlebe.
Ii-NSAID (iziyobisi ezichasayo ezingasebenziyo) kunye nee-salicylates
Iziyobisi zomhlaza esePlatinam: Ukudibanisa i-furosemide kunye neziyobisi ezinje cisplatin okanye icarboplatin kwandisa ukubakho kwala machiza onakalisayo izintso, umongo wethambo, okanye iindlebe.
Uxinzelelo lwegazi iziyobisi: Ukudibanisa i-furosemide namanye amachiza anciphisa uxinzelelo lwegazi kunokubangela uxinzelelo lwegazi oluyingozi (hypotension).
I-Antipsychotic, sedatives, barbiturates, opioids, kunye ne-erectile dysfunction yeyeza: Ukudibanisa la machiza kunye ne-furosemide kwandisa umngcipheko we-hypotension, ke abantu abanexinzelelo lwegazi olusezantsi banokujongwa rhoqo okanye iidosi ziguqulwe.

Ungaziphepha njani iziphumo ebezingalindelekanga ze-furosemide

I-Furosemide ihlala inikwa ngaphakathi kwizigulana ezibhedlele, kodwa uninzi lwabantu luya kulithatha iyeza njengethebhulethi okanye isisombululo somlomo kanye okanye nangaphezulu ngemini. Akukho mda kubude bexesha elinokuthathwa, kodwa abantu abahlala bethatha i-furosemide kufuneka balandele iingcebiso ezimbalwa zokunceda ukulawula iziphumo ebezingalindelekanga.

1. Xelela ugqirha malunga nazo zonke iimeko zonyango kunye namayeza

Ngaphambi kokuba i-furosemide imiselwe, xelela ugqirha okanye ugqirha wezonyango malunga:

Zonke iimeko zangoku zonyango, ngakumbi isifo sezintso, isifo sesibindi, iingxaki zokuchama (ezinje ngeprostate okanye isinyi), igawuthi, lupus, isifo seswekile, ukungalingani kwe-electrolyte, i-arrhythmias yentliziyo, uxinzelelo lwegazi oluphantsi, okanye i-aleji ye-sulfonamides (iziyobisi zesulfa)
Ukukhulelwa, ukuncancisa, okanye naziphi na izicwangciso zokukhulelwa
Naluphina uvavanyo lwegazi oluya kwiglucose
Nawuphi na uvavanyo lwezonyango oluzayo oluza kubandakanya idayi yokutshintsha kwemitha
Naluphina utyando oluzayo
Zonke i-OTC kunye namayeza amiselweyo, izongezo, kunye namayeza esintu ayathathwa, ngakumbi i-desmopressin okanye iMarplan (isocarboxazid)

2. Thatha i-furosemide njengoko kuyalelwe

Landela yonke imikhombandlela kwileyibhile yonyango okanye enikezwe yingcali yezempilo. Musa ukuthatha ngaphezulu okanye ngaphantsi kokumiselweyo de ube udibene nogqirha okanye ingcali yezempilo.

3. Kunqande ukuba ungabikho manzi emzimbeni okanye ube sezantsi kwii-electrolyte

I-Furosemide inokubangela ukuba amanzi kunye ne-electrolyte emzimbeni wehle kakhulu. Ukuphelelwa ngamandla emzimbeni kunokubangela ukonakala kwezintso kunye nokuwa kwegazi emzimbeni. Ukupheliswa kwe-Electrolyte kunokunyuka kuye kwiingxaki ezinzulu kubandakanya isiqaqa, ukuxhuzula, kunye nokuhlaselwa sisifo sentliziyo. Buza kwingcali yezempilo ukuba malini kwaye luhlobo luni lwamanzi olunokuthathwa emva kwethamo le-furosemide. I-Potassium okanye ezinye izongezo nazo ziyafuneka.

Xa uthatha i-furosemide, jonga imiqondiso yokuphelelwa ngamanzi emzimbeni njengomlomo owomileyo, amehlo owomileyo, inkampu yezihlunu, iintlungu zemisipha, ukozela, ukudinwa kunye nobuthathaka. Unokwazi ukusela utywala ukusombulula ingxaki, kodwa ukuba ulwelo luthintelwe, tsalela iingcali kwezempilo ngengcebiso yezonyango.

4. Ukubeka iliso kwiziphumo

Abanye abantu banokucelwa ukuba babeke esweni iimeko zabo zonyango ezinje ngegazi okanye amanqanaba eglucose egazini. Jonga la maxabiso ngokuthembeka kwaye uwarekhode kwidayari yamayeza. Ukuba amaxabiso aqhelekanga, tsalela ugqirha okanye omnye umboneleli wezempilo akuncede.

5. Kuphephe ii-NSAIDs kunye neepilisi zokuhambisa

Ukuthomalalisa iintlungu njenge-aspirin kunye ne-ibuprofen kunokunciphisa ukusebenza kwe-furosemide kwaye kwandise umngcipheko kwizintso okanye ekuveni. Kuyafana nakwi bismuth subsalicylate , isithako esisebenzayo kwi I-Pepto-Bismol . Idibene ne-aspirin kwaye iya kubangela iingxaki ezifanayo xa zidibene ne-furosemide.

I-Laxatives yonyusa ukulahleka kwamanzi, ke yonyusa umngcipheko wokuphelelwa ngamanzi emzimbeni, ukuphela kwe-electrolyte, kunye nokonakala kwezintso xa uthatha i-furosemide. Thetha ugqirha okanye olunye uqeqesho kwezempilo ngaphambi kokuba uthathe naziphi na iziyobisi ze-OTC ngelixa uthatha i-furosemide.

6. Yima kancinci

Ukuba ukuphakama kubangela ukuba ube nesiyezi, zama ukuma kancinci. Isiyezi sinokufuna ukuhlala phantsi ixesha elithile. Lala phantsi ukuba isiyezi siba sibi kakhulu.