Iziphumo ebezingalindelekanga zeLatuda kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

Iziphumo ebezingalindelekanga zeLatuda | Ukutyeba kwakho | Ukurhoxa | Zide kangakanani iziphumo ebezingalindelekanga? | Izilumkiso | Unxibelelwano | Ungaziphepha njani iziphumo ebezingalindelekanga

ILatuda (isithako esisebenzayo: i-lurasidone hydrochloride) ligama elinegama lokuthintela i-antipsychotic evunyiweyo ukunyanga i-schizophrenia kulutsha nakubantu abadala kunye nokunyanga uxinzelelo kubantu abadala nakubantwana abali-10 nangaphezulu abafunyaniswe ukuba bane-bipolar disorder. Inokudityaniswa ne-lithium okanye i-valproate yokunyanga uxinzelelo lwe-bipolar kubantu abadala. I-Lurasidone, into esebenzayo eLatuda, ichaphazela umsebenzi we-dopamine kunye ne-serotonin, iikhemikhali ezinceda ukudlulisa imiqondiso phakathi kwemithambo-luvo. Njengawo onke amayeza atshintsha ikhemistri yengqondo, iLatuda inokuvelisa iziphumo ebezingalindelekanga, zenze mandundu imeko ezithile zonyango, kwaye zinxibelelane namanye amayeza.

ZIQHELEKILEYO: Funda ngakumbi malunga neLatuda | Fumana izaphulelo zeLatuda

Iziphumo eziqhelekileyo zeLatuda

Njengawo onke amayeza, iLatuda inokubangela iziphumo ebezingalindelekanga ezincinci okanye zexeshana. Ngaphezulu kwe-1 kubantu abangama-20 uya kuba neziphumo ebezingalindelekanga njengokulala, isicaphucaphu, ukungonwabi, isisu, okanye iintshukumo ezingazibandakanyiyo.

Kwizigulana ezithatha iLatuda, iziphumo ebezingalindelekanga ezixeliweyo zezi:

• Isicaphucaphu
• I-Akathisia (inkanuko engenakuphikiswa yokuhamba)
• Iimpawu ze-extrapyramidal (ukungcangcazela, ukushukuma, iintshukumo ezingazibandakanyiyo, ukuvuza amathe)
• Kunzima ukuhamba okanye ukuhamba kancinci
• Ukulala
• Ukozela
• Ukuphuthelwa
• Umlomo owomileyo
• Urhudo
• Isisu sikhathazekile
• Ukuhlanza
• Ixhala
• Ukuphazamiseka
• Ukuxinana kwempumlo
• Umbono omfiliba

Uninzi lweziphumo ebezingalindelekanga zilingana nedosi-ephezulu idosi, umngcipheko omkhulu kunye nobukhali beziphumo ebezingalindelekanga ezincinci. Funa ingcebiso ngonyango ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezincinci xa uthatha iLatuda.

Iziphumo ebezingalindelekanga ezimandundu zeLatuda

Onke amayeza antipsychotic anokubangela iziphumo ebezingalindelekanga ezibi kunye nezexesha elide. Iziphumo ebezingalindelekanga ezibi zeLatuda zibandakanya:

• Utshintsho lweMetabolic olukhokelela kwiswekile yegazi ephezulu, i-triglycerides ephezulu, icholesterol ephezulu, isodiyam ephantsi yegazi, okanye isifo seswekile
• IHyperthermia
• Iprolactin engaphezulu
• Ukuhla kweeseli ezimhlophe zegazi
• Ingxaki yokuginya
• Isifo esibuhlungu se-Neuroleptic
• Ukufika kade kwedyskinesia
• Imania
• Iingcinga zokuzibulala kunye nokuziphatha
• Ukuxhuzula
• Ukubetha
• Ukufa

Njengamanye amayeza e-antipsychotic, iLatuda inokubangela utshintsho kwimetabolism kunye nokufumana ubunzima, nangona oku kunqabile kwaye kunokubhengezwa kancinci kunamayeza afanayo. ILatuda isenokungabi lonyango olufanelekileyo kubantu abanembali yosapho yesifo seswekile okanye isifo se-metabolic syndrome.

Onke amayeza antipsychotic aphazamisa ukukwazi komzimba ukulawula ubushushu bomzimba. Ngenxa yoko, abantu abathatha iLatuda basemngciphekweni okhulayo we-heatstroke (hyperthermia), imeko yezonyango esongela ubomi. Isilumkiso kufuneka sithathwe ukuthintela imozulu eshushu okanye i-overexertion xa uthatha iLatuda.

ILatuda yonyusa umngcipheko weengcinga zokuzibulala kunye nokuziphatha ebantwaneni, kwinqanaba lokufikisa, nakubantu abadala abancinci abanyangelwa uxinzelelo lwe-bipolar. Xa unika uLatuda ngoxinzelelo, kubalulekile ukuba ujonge imiqondiso yokuzibulala kubandakanya:

• Umbono wokuzibulala okanye izimvo
• Imizamo yokuzibulala
• Imood iyatshintsha
• Umsindo, ukucaphuka, okanye ubundlongondlongo
• Ukudakumba okukhulayo
• Ukuxhalabisa ngakumbi
• Uloyiko
• Ukuthatha umngcipheko wokuziphatha

Ezinye iziphumo ebezingalindelekanga ezinzulu kunye neengxaki ezivela eLatuda kunye nokusetyenziswa gwenxa kweziyobisi ezichasene nengqondo zibandakanya:

• Hyperprolactinemia
• I-Orthostatic hypotension
• IDysphagia
• Isifo esibuhlungu se-Neuroleptic
• Ukufika kade kwedyskinesia

Amayeza amaninzi antipsychotic anciphisa umda wokubamba, ukubeka izigulana kumngcipheko okhulayo wokubanjwa ngenxa yezinye izizathu. Kwezilingo zeklinikhi , abaguli abathatha iLatuda babenomgangatho ophantsi kakhulu wokubamba, okwenza iLatuda ibe sisiyobisi esisesichengeni sokuxhuzula. Nangona kunjalo, umenzi, iSunovion Pharmaceuticals Inc., ucebisa ukuba iLatuda isetyenziswe ngononophelo kwizigulana ezinembali yokuxhuzula.

Okokugqibela, uLatuda uphakamisa umngcipheko wokubetha kunye nokufa kwizigulana ezingaphezulu kweminyaka engama-65 enesifo sengqondo esihambelana nesifo sengqondo esixhalabisayo. Ngesi sizathu, uLatuda akavunyelwe ukunyanga isifo sengqondo esihambelana nesifo sengqondo.

Ukufumana ubunzima kweLatuda

Amayeza e-Antipsychotic abangela utshintsho kwimetabolic kunye nokufumana ubunzima njengeziphumo ebezingalindelekanga, kodwa ubungakanani bokufumana ubunzima buyahluka ngokwamachiza. Nangona kunjalo, ngokwetyala elinye leklinikhi elidweliswe apha ngasentla, amanqaku e-Latuda kwisiphelo esisezantsi, ebangela ukutyeba okuphakathi kwesisindo esinye sephawundi kwixesha elifutshane kunye neepawundi ezimbini kwixesha elide (unyaka omnye). Phantse i-4.8% yezigulana kolu vavanyo zifumene ngaphezulu kwe-7% yobunzima bomzimba xa kuthelekiswa ne-3.3% ebithatha i-placebo.

Oko konke oku kuthetha ukuba umngcipheko wokufumana ubunzima xa uthatha iLatuda ungaphantsi kunokuba kunjalo nezinye i-antipsychotic. Oku kungenxa yeempembelelo ezibuthathaka zeLatuda kwiindidi ezithile zeemithambo-luvo ezenza ukuba amanye amayeza antipsychotic asebenzisane nawo. Ngenxa yoko, iziphumo ebezingalindelekanga njengokufumana ubunzima, ukungcangcazela, kunye ne-orthostatic hypotension aziqhelekanga kwaye azibi qatha kunezinye iziyobisi ezichasene nengqondo. Nangona kunjalo, umenzi ucebisa ukuba ubunzima bujongwe ngononophelo xa uthatha iLatuda.

Ukurhoxa kweLatuda

Akukho zifundo okanye kuvavanyo lweklinikhi olujolise kwiimpawu zokurhoxa kweLatuda, nangona kukho iingxelo zokurhoxa kweLatuda. Nokuba umenzi okanye iNgxelo yeDesika yoGqirha ayikhankanyi ukurhoxa njengempembelelo esecaleni okanye ukucebisa irejimeni yethayiphu yokuthayipha xa uyeka iLatuda.

Nangona kunjalo, iziyobisi ezichasene nengqondo ezisebenza ngendlela efanayo neLatuda, ebizwa ngokuba zii-dopamine antagonists, zinokubangela iimpawu zokurhoxa xa zinqunyanyisiwe, kodwa ayizizo zonke izigulana eziza kuba neziphumo zokurhoxa xa uyeka i-antipsychotic atypical. Ezo zenzayo zinokuba neempawu zokurhoxa ezinobumnene okanye ezinzima. Nangona kunjalo, Umbutho wezengqondo zaseMelika icebisa ukunciphisa idosi nge-10% inyanga nganye xa uyeka amayeza e-antipsychotic ukunciphisa umngcipheko wokurhoxa okanye ukubuyela kweempawu.

Olona phawu luqhelekileyo lokurhoxa xa uyeka i-antipsychotic luphawu olubuyileyo. Ukuba isigulana besingenalo uphawu kangangexesha elithile, ukubuya kweempawu kunokubonakala kukubi ngakumbi kunaphambi konyango. Ezinye iimpawu zokurhoxiswa kwe-antipsychotic zibandakanya ukungahambelani ngokunganyanzelekanga, ukujija, ukuhamba kancinci, ukunyanzelwa ukuba uhambe, isicaphucaphu, ukugabha, urhudo, kunye nentlungu esiswini. Umboneleli wezempilo unokumisela amayeza kaParkinson ukunciphisa ukurhoxa kwe-antipsychotic.

Zide kangakanani iziphumo ebezingalindelekanga zeLatuda?

Iziphumo ebezingalindelekanga zinokuhlala ixesha elide kuthathwa iLatuda, kodwa ezinye iziphumo ebezingalindelekanga ezincinci zinokuhla ngokuhamba kwexesha. Emva konyango lwexesha elide, iLatuda iya kuthatha malunga iintsuku ezimbini ukuya kwezine ukucacisa ngokupheleleyo emzimbeni. Uninzi lweziphumo ebezingalindelekanga ezininzi ziya kuqala ukusombulula malunga nelo xesha. Ngelishwa, ezinye iziphumo ebezingalindelekanga ezinzulu zinokuthatha ixesha elide ukuzisombulula kwaye ezinye, ezinje nge-tardive dyskinesia, zinokungaguquki.

Ukuphikiswa kweLatuda kunye nezilumkiso

ILatuda iza nebhokisi emnyama ye-FDA elumkisa ukuba ayisetyenziselwa ukunyanga isifo sengqondo esihambelana nesifo sengqondo esixhalabisayo ngenxa yomngcipheko wokufa okanye ukubetha. ILatuda nayo akufuneki ithathwe ngu:

• Abantu abaphikisayo kwi-lurasidone okanye nayiphi na into engasebenziyo
• Abantu abathatha iziyobisi okanye izinto eziya kuthi ziphazamise ngamandla imetabolism yomzimba ye-lurasidone

Ezinye izilumkiso zibandakanya:

• Isifo esibuhlungu se-Neuroleptic
• Ukufika kade kwedyskinesia
• Iseli yegazi emhlophe esezantsi iyabala
• I-Orthostatic hypotension
• Iingcinga zokuzibulala okanye indlela yokuziphatha
• Ukuphakama kweswekile yegazi, amafutha, okanye icholesterol

Abantwana

ILatuda inyanga abakwishumi elivisayo abayi-13 nangaphezulu kwischizophrenia kunye nabantwana nakwishumi elivisayo abadala kuneminyaka eyi-10 yoxinzelelo lwe-bipolar. Ukhuseleko lweLatuda alufundiswanga kubantwana abangaphantsi kwe-10.

Xa isetyenziselwa ukunyanga uxinzelelo lwe-bipolar, uLatuda uphakamisa kakhulu umngcipheko wokucinga ngokuzibulala kunye nokuziphatha ebantwaneni nakwishumi elivisayo. Abantwana kunye nezigulana ezisencinci kufuneka zibekwe esweni ngokudodobala koxinzelelo okanye iimpawu zokuzibulala.

Ukukhulelwa kunye nokuncancisa

Akukho zifundo zokhuselo zokusetyenziswa kweLatuda kwabasetyhini abakhulelweyo okanye oomama abangabongikazi. Kukho ubungqina be-anecdotal yeentsana ezinengxaki yokuhamba kunye neempawu zokurhoxa xa i-antipsychotic ithathwa kwikota yesithathu yokukhulelwa. ILatuda inokuthi ifihlwe kubisi lwebele, kodwa imali eyiyo ayichongwanga. Njengalo naluphi na unyango lwe-antipsychotic, abasetyhini kufuneka baxoxe ngeenzuzo kunye neengozi zokuthatha iLatuda ngelixa ukhulelwe okanye unesi.

Abadala

Ukhuseleko lweLatuda kubantu abangaphezu kweminyaka engama-65 khange kufundwe kakuhle kwaye ulwazi lokumisela luyalumkisa ekumiseleni abantu abadala (abaneminyaka engama-65 nangaphezulu). Ke ngoko, ukhetho lokumisela la mayeza kule minyaka ingama-65 nangaphezulu, ngokufunyaniswa kwesifo sengqondo okanye uxinzelelo lwe-bipolar, lwenziwa kwimeko-nge-imeko ngokubonisana nomboneleli wezempilo. ILatuda inyusa umngcipheko wokubethwa sisifo kunye nokufa kwizigulana esele zikhulile ezinesifo sengqondo esihambelana nesifo sengqondo esixhalabisayo, ngenxa yoko iLatuda ayamkelwa kwezi zigulana.

Unxibelelwano lweLatuda

Amachiza afana neLatuda, ukuhlangana kweziyobisi kuyinkimbinkimbi kwaye kuyabhidisa. Ukwenza lula ukusebenzisana kweLatuda, ezinye iziyobisi akufuneki zithathwe okanye zithathwe ngononophelo kuba zinako:

• Ukuphazamisa amandla omzimba okuphula i-lurasidone, isithako esisebenzayo eLatuda okanye
• Iziphumo ebezingalindelekanga zeWorsen

I-CYP3A4 inducers kunye nee-inhibitors

ILatuda ayivumelekanga ekusebenziseni kunye namayeza anamandla e-CYP3A4 inducers kunye nee-inhibitors. Ukubeka ngokulula, la machiza akhawulezisa ukophuka kwe-lurasidone ngumzimba (i-CYP3A4 inducers) okanye ukuthintela kunye nokucothisa ukonakala kwe-lurasidone (CYP3A4 inhibitors).

Iziyobisi ezikhawulezisa ngamandla ukonakala kwelurasidone kuya kunciphisa ukusebenza kwayo. Oku kubandakanya:

• I-wort yaseSt
• Amayeza okubulala iintsholongwane : rifampin, rifaximin, kunye ne-rifamycin
• Iindidi ezithile ze-anticonvulsants : carbamazepine, phenytoin, primidone, kunye nefosphenytoin
• IiBarbiturates : i-pentobarbital kunye ne-phenobarbital
• Dexamethasone, Lysodren (mitotane), Xtandi (enzalutamide), Erleada (apalutamide), Orkambi (lumacaftor), kunye neRydapt (midostaurin)

Iziyobisi ezithi ngokuthe chu okanye buthathaka zikhawuleze ukonakala kwe-lurasidone zinokuthathwa, kodwa oogqirha banokufuna ukuguqula unyango okanye izixa zedosi.

Iziyobisi kunye nokutya okucothisa umzimba kwimetabolism ye-lurasidone, nangona kunjalo, inyusa uxinzelelo lweLatuda egazini kwaye ke yonyusa umngcipheko weziphumo ebezingalindelekanga. Ezona zinhibitors zomeleleyo ezingafanele kuthathwa kunye neLatuda zibandakanya:

• I-grapefruit, curcumin, kunye negolide
• Iindidi ezithile zentsholongwane : i-clarithromycin, i-erythromycin, i-troleandomycin, kunye ne-telithromycin
• Iziyobisi ze-Antifungal (azole) : econazole, ketoconazole, voriconazole, methimazole, kunye ne-posaconazole
• Unyango lwegazi : diltiazem kunye neverapamil
• Iindidi ezithile zamayeza antiviral : ritonavir, atazanavir, darunavir, lopinavir, efavirenz, tipranavir, Incivek (telaprevir), Invirase (saquinavir), Rescriptor (delavirdine), Crixivan (indinavir), Vitekta (elvitegravir), Victrelis (ncepcevir)
• Iindidi ezithile zamasosha omzimba amodareyitha amayeza e-anticancer ezifana neTasigna (nilotinib), Kisqali (ribociclib) iZydelig (idelalisib), kunye neRydapt (midostaurin)
• Ergotamine, terfenadine, nefazodone, loperamide, cobicistat, Vaprisol (conivaptan), Diacomit (stiripentol), naloxone, danazol, kunye lonafarnib

Isiqhamo samagilebhisi sinazo izinto ezikwi-CYP3A4 inhibitors. Nangona kunjalo, ezi zinto aziphazamisani namandla omzimba wokucoca i-lurasidone emzimbeni, kodwa kunoko vimba inkqubo efanayo emathunjini . Oku kuthetha ukuba umzimba ubamba i-lurasidone engaphezulu kunesiqhelo, ukwandisa umngcipheko weziphumo ebezingalindelekanga. Iziphumo ze grapefruit kwiiseli zamathumbu zinokuhlala ixesha elide kangangeeyure ezingama-24, ngenxa yoko igrapefruit kufuneka ithintelwe ngokupheleleyo ngelixa uthatha iLatuda.

Uxinzelelo

ILatuda yinkqubo yoxinzelelo lweemvakalelo ephakathi. Iyacothisa ingqondo. Ezi ziphumo ziya kuphuculwa ukuba iLatuda ithathwa kunye nezinye iinkqubo zokudakumba kwenkqubo ye-neva. Iziphumo zinokuba yingozi emzimbeni. Ukuba abekho, ukudinwa kunye nelahleko yolawulo lweemoto kunokunyusa umngcipheko wengozi okanye wokonzakala. Xa uthatha iLatuda, ezinye izinto zokudakumba ze-CNS kufuneka zithintelwe okanye zisetyenziswe ngononophelo kubandakanya:

• Utywala, intsangu, ii-cannabinoids, i-ginseng, okanye i-Gotu kola
• AmaNtsholongwane ezifana neBenadryl (diphenhydramine), doxylamine, kunye ne-pheniramine
• Iziyobisi njenge codeine, morphine, okanye tramadol
• Izindlela (izixhobo zokulala) njenge midazolam okanye estazolam
• Amayeza okuxhalabisa njenge buspirone okanye diazepam
• Iziyobisi zentlungu ezinje ngegabapentin, gabapentin enacarbil, okanye pregabalin
• Iziyobisi Anti-isicaphucaphu ezinje nge-metoclopramide okanye i-ondansetron
• IiAnticonvulsants njenge carbamazepine ( kuchasene ), phenytoin, lamotrigine, okanye levetiracetam

Ayizizo zonke ezi ziyobisi ekufuneka zithintelwe ngokuthe ngqo, kodwa zonke kufuneka zithathwe ngononophelo olukhulu nangokubonisana nogqirha okanye omnye umboneleli wezempilo. Kuphephe ukuqhuba, ukusebenzisa oomatshini, okanye ukubandakanyeka kwimisebenzi eyingozi xa udibanisa ezimbini okanye nangaphezulu zokudakumba kwe-CNS.

Ukuxhuzula

Ukuhluthwa kukungalawulwa, okungahleliwe, kunye nokuphindaphinda ukudubula kwemijikelezo yeethambo kwingqondo. Banokuhluka ukusuka ekutyibilikeni kwengqondo okungafane kuqapheleke ukuya kwimixokelelwane yomzimba opheleleyo. Kwizifundo zeklinikhi , ukuxhuzula kwakuyimpembelelo yeLatuda kwinqanaba elifanayo babenalo kwi-placebo, okwenza iLatuda iyeza elikhuselekileyo lokunyanga i-antipsychotic. Okwangoku, iLatuda kunye nawo onke amanye amayeza e-antipsychotic anciphisa umqobo wokubamba, ukubeka abaguli emngciphekweni omkhulu wokubanjwa. Ngesi sizathu, ababoneleli ngezempilo baya kuthintela ukudibanisa iLatuda kunye namayeza anokubangela ukuxhuzula kubandakanya iFirdapse (amifampridine), iWellbutrin (bupropion), kunye nezinye iintlobo zamachiza asetyenziselwa i-X-ray okanye enye imaging.

ILatuda inokusebenzisana namanye amayeza kunye neemeko ezinje:

• Amayeza kaParkinson
• Hyperglycemia
• Ukubethwa bubushushu

Ungaziphepha njani iziphumo ebezingalindelekanga zeLatuda

I-Antipsychotic efana neLatuda ibangela iziphumo ebezingalindelekanga. Ngamanye amaxesha, ezi ziphumo bezingalindelekanga zikhokelela kwizigulana ukuba ziyeke ukuthatha iyeza. Gcina ukhumbula ukuba onke amayeza antipsychotic ayarhweba phakathi kwezibonelelo zawo zihlala zibonakala kwaye ngamanye amaxesha zinokubakho iziphumo ezibi.

Landela ezi ngcebiso xa uthatha iLatuda ukunciphisa umngcipheko weziphumo ebezingalindelekanga zeLatuda ngelixa uqinisekisa esona sibonelelo sikhulu ngokuthatha ichiza:

Thatha uLatuda njengoko kuyalelwe

Thatha idosi yemihla ngemihla njengoko kumiselwe. Musa ukunyusa okanye ukunciphisa umthamo. Ngaphezu kwako konke, sukuthatha iholide yosuku olunye okanye ezimbini kwiyeza. Kufuneka ithathwe yonke imihla ixesha elide ukufezekisa izibonelelo zayo. Ukuba iyeza alibonakali lisebenza okanye iziphumo ebezingalindelekanga zinzima kakhulu ukuba zingaphathwa, thetha nomnikezeli ngokumisela malunga nokutshintsha idosi okanye ukutshintshela kunyango olutsha.

2. Thatha uLatuda nokutya

ILatuda kufuneka ithathwe kunye nokutya. Ngapha koko, kufanele ukuba kuthathwe kunye nokutya ubuncinci beekhalori ezingama-350. Ngelixa oku kungathinteli iziphumo ebezingalindelekanga, kuyakuqinisekisa ukufezekisa izibonelelo eziphezulu ekuthatheni iyeza.

3. Xelela umboneleli wakho wezempilo malunga nazo zonke iimeko zonyango kunye namayeza

Ngenxa yomngcipheko weziphumo ebezingalindelekanga, kuya kufuneka uxelele umboneleli wakho wezempilo malunga:

• Naziphi na iimeko zomzimba onokuba nazo, ngakumbi
  • Iswekile yegazi ephezulu, isifo seswekile, okanye isifo se-metabolic
  • Inani leeseli ezimhlophe ezisezantsi
  • Imbali yokuxhuzula okanye ukuxhuzula
  • Iingxaki ze-thyroid
  • Imbali yamanqanaba aphezulu eprolactin
  • Isifo seParkinson okanye iimpawu
  • Iingxaki zentliziyo
  • Iingxaki zesibindi
• Nakuphi na ukusetyenziswa kotywala, ukusebenzisa iziyobisi ngokuzonwabisa, okanye imbali yokusetyenziswa gwenxa kweziyobisi
• Onke amayeza owathathayo ngoku
• Onke amayeza e-counter-counter kunye nezongezelelo ozithathayo

Soloko uthetha nomboneleli wakho wezempilo malunga naziphi na iziphumo ebezingalindelekanga ezifumanekayo xa uthatha iLatuda okanye naliphi na iyeza lonyango.

4. Kulumkele utywala, ii-antihistamines, kunye noxinzelelo

Nayiphi na into ecothisa ingqondo njengotywala, intsangu, ii-antihistamines, kunye nezidambisi ziya kuyenza mandundu imeko yokuthothisa kunye nokuqonda kwengqondo eLatuda, iphakamisa umngcipheko wengozi okanye ukwenzakala. Xa uthatha iLatuda, musa ukuqhuba, ukusebenzisa oomatshini, okanye ukuzibandakanya kwizinto ezinobungozi de ube uyazi ukuba ichiza likuchaphazela njani. Ikwangumbono olungileyo xa uthatha uxinzelelo lwe-CNS njengeLatuda ukususa izithintelo kunye neengozi kwindawo ejikeleze indlu ukunciphisa umngcipheko wokulimala ngengozi.

5. Sukuyitya i-grapefruit okanye usele ijusi yeziqhamo

Isiqhamo samagilebhisi kunye nejusi yeziqhamo azivumelekanga xa uthatha iLatuda. Isiqhamo samagilebhisi sinento eyonyusa inani le-lurasidone efunxwe ngumzimba, ikhulisa umngcipheko kunye nobukhali beziphumo ebezingalindelekanga zeLatuda. Amanye amachiza kunye nezinto zinokunyusa uxinzelelo lweLatuda emzimbeni, ke qiniseka ukuba uyaxoxa nommiseli omiselweyo onke amayeza, izongezo, kunye namayeza esintu athathwayo.

6. Kuphephe ukuba nobushushu

I-Latuda kunye namanye amayeza e-antipsychotic aphazamisa amandla omzimba okulawula iqondo lobushushu, enza ukuba ubushushu bushushu kakhulu. Kuphephe ukufudumeza okanye ukomisa ngamanzi ngokwenza:

• Ukuhlala ngaphakathi xa kushushu
• Ukuphepha ukutyeba kakhulu okanye ukuzilolonga kakhulu
• Ukuphepha ukuba selangeni ixesha elide
• Ukusela amanzi amaninzi
• Gwema utywala-nayo, iphazamisa amandla omzimba okulawula ubushushu bomzimba

Izixhobo:

• • ILatuda , Epocrates
  • ILurasidone , StatPearls
  • Isishwankathelo seLurasidone , ILayibrari yeSizwe yoNyango
  • ILurasidone hydrochloride , PDR
  • Iimpawu eziqinisekileyo zokurhoxa emva kokuyekiswa kwamayeza e-psychotropic , Unyango lweengqondo kunye nePsychosomatics
  • Ukuzuza ubunzima obunxulumene ne-antipsychotic: iindlela zokulawula kunye nefuthe kunyango kunyango , Isifo seNeuropsychiatric kunye nonyango
  • I-Biochemistry, iCytochrome P450 , StatPearls
  • Utshintsho olwenziwe ngeziyobisi kwiglucose icandelo lesi-2: i-hyperglycemia ebangelwa ziziyobisi , Isifo seswekile
  • I-hyperprolactinemia ebangelwa ngamayeza , Ikliniki yaseMayo
  • Ukubaluleka kwonyango lwejusi yeziqhamo kunye nokudibana kwayo neziyobisi ezahlukeneyo , Ijenali yesondlo
  • Isikhokelo sokuziqhelanisa nokunyanga iSchizophrenia Umbutho wezengqondo zaseMelika
  • Ukufika kade kwedyskinesia , StatPearls