Eyona >> Ulwazi Lweziyobisi >> Iziphumo ebezingalindelekanga ze-Omeprazole kunye nendlela yokuzikhusela

Iziphumo ebezingalindelekanga ze-Omeprazole kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

I-Omeprazole (igama lophawu lwe-Prilosec) lunyango kunye namayeza e-counter athengisa i-asidi yesisu. Ukuba lilungu losapho lweziyobisi ekuthiwa yiproton pump inhibitors, omeprazole inxenye ibhloka isisu ukukwazi ukukhupha iasidi. Eyona nto ihlala ithathwa njengephilisi okanye ithebhulethi, i-omeprazole isetyenziselwa ukunyanga isilungulela , isifo se-reflux sesifo se-gastroesophageal ( IGERD ), i-esophagitis erosive, izilonda zesisu, izilonda zesisu, izilonda ze-Helicobacter pylori zesisu esiswini, kunye neemeko zonyango ezinqabileyo ezinje ngesifo seZollinger-Ellison esibangela ukuveliswa kwesisu esiswini.

Nangona i-omeprazole inokuthengwa ngaphandle kokuyalelwa, iyeza lineziphumo ebezingalindelekanga ezininzi, ezinye zinobuzaza. Uphengululo olubanzi lweziphumo ebezingalindelekanga, izilumkiso, ukungqinelana, kunye nokuhlangana kweziyobisi kunokunceda ukumisela ukuba ngaba omeprazole sisiyobisi esifanelekileyo na.

ZIQHELEKILEYO: Funda ngakumbi malunga ne-omeprazole | Fumana izaphulelo ze-omeprazole

Iziphumo eziqhelekileyo ezichaphazela omeprazole

Iziphumo eziqhelekileyo ezinokubakho ze-omeprazole zezi:

Intloko ebuhlungu
Intlungu zesisu
Isicaphucaphu
Urhudo
Ukuhlanza
Ukuqunjelwa sisisu
Usulelo oluphezulu lokuphefumula
Ukuqunjelwa

Ngamanye amaxesha i-Omeprazole idityaniswa ne-antibiotics eclithromycin kunye ne-amoxicillin ukunyanga usulelo lwe-p. Pylori lwesisu esiswini, usulelo olunxulunyaniswa ne-gastritis (ukucaphuka kwesisu esiswini) kunye nokwakheka kwezilonda. Xa zidityaniswe nala mayeza okubulala iintsholongwane, ezona ziphumo zixhaphakileyo zonyango lwe-omeprazole yile:

Urhudo
Ngcamla utshintsho
Intloko ebuhlungu
Ukujika kolwimi
Ukuxinana kwempumlo

Iziphumo ebezingalindelekanga ezimandundu ze omeprazole

Iziphumo ebezingalindelekanga ezinqabileyo zinqabile kwi-omeprazole kwaye zibandakanya:

IClostridium usulelo olunzima: C. difficile ngu usulelo lwebhakteria lwekholoni olubangela urhudo kunye nefiva.
Isifo sesibindi: I-Omeprazole inokutshintsha ukusebenza kwesibindi kwaye ngamanye amaxesha ikhokelele kwisifo sesibindi, ukusweleka kwezicubu zesibindi, okanye ukusilela kwesibindi okunokubulala.
Lupus: I-Omeprazole inokubangela ukuqala okanye ukwanda kwe-lupus erythematosus, imeko yokuzimela komzimba ephawulwe kukungxama kunye nokubomvu kwesikhumba.
Ukunyanga komzimba: Ukusabela kwe-Hypersensitivity kunokuba mnene ukuya kubukhali kubandakanya i-anaphylaxis, ukudumba kwesikhumba ngokukhawuleza (i-angioedema), ukusabela okunamandla kwesikhumba, ingxaki yokuphefumla, kunye nokudumba kwimibhobho yokuhluza izintso (interstitial nephritis).

Iziphumo ezibi ezibi zinxulunyaniswa nokusetyenziswa kwexesha elide kwe-omeprazole. Ngenxa yoku, ulwazi lokumisela luchaza ukuba i-omeprazole kufuneka isetyenziswe kwelonaqondo lisezantsi elilelona lifutshane. Ezi ziphumo zinokubandakanya:

Ukuqhekeka kwamathambo : Ukusetyenziswa okungapheliyo, i-omeprazole inciphisa i-calcium egazini ngokunciphisa inkqubo yokutya yokutya yokufunxa i-calcium. Umzimba ulinganisa le lahleko ngokutsala i-calcium emathanjeni, ekhokelela kwi-osteoporosis kunye nomngcipheko owandayo wokophuka. Izigulana ezithatha i-omeprazole ngokuqhubekayo ngaphezulu kwexesha elide (unyaka omnye okanye ngaphezulu) zinokucetyiswa ukuba zithathe izongezo zekhalsiyam kunye / okanye amayeza kagqirha ukunceda ukuthintela i-osteoporosis kunye nomngcipheko ophantsi wokophuka.
Ukukhula : I-Omeprazole inxulunyaniswa nophuhliso lwee-polyp gland polyps zesisu esiswini. Okubi kakhulu kodwa kunqabile, i-omeprazole ikwanxulunyaniswa namathumba akhula kancinci (ii-carcinoids) kwi-duodenum, eyinxalenye yokuqala yamathumbu amancinci, kwizigulana ezine-Zollinger-Ellision syndrome.
I-magnesium esezantsi : Ukusetyenziswa kwexesha elide kwe-omeprazole nako kunokuthoba amanqanaba e-magnesium emzimbeni. I-magnesium ephantsi (i-hypomagnesemia) ikhokelela kwiziphumo ezinobuzaza ukuya kwiziphumo ezibi kubandakanya iingxaki zesingqisho sentliziyo okanye ukuxhuzula.
I-atrophic gastritis kunye ne-vitamin B ephantsi - 12 : Ukusetyenziswa okungapheliyo kwe-omeprazole kunokubangela i-atrophic gastritis (ukudumba kunye nokucaphuka kwesisu esiswini). I-atrophic gastritis ikhokelela kunqongophalo lwevithamini B-12, imeko ethi ibangele ukuba ibenonemia (ukunqongophala kweeseli ezibomvu ezisempilweni). Ekuhambeni kwexesha, gastritis atrophic utshabalalisa isisu esiswini kwaye iphakamisa umngcipheko womhlaza wesisu.
Ukutyeba kwakho : Ukusetyenziswa kwexesha elide kwe-omeprazole kwandisa umngcipheko wokufumana ubunzima kwizigulana ezine-GERD.

I-Omeprazole kunye nokufumana ubunzima

Ukutyeba komzimba okubalulekileyo kunxulunyaniswe nokusetyenziswa kweminyaka emininzi omeprazole kunye nezinye ii-PPIs (Proton pump inhibitors) ukunyanga isitshisa okanye iimpawu zeGERD. Izizathu azicacanga kodwa kucingelwa ukuba zinokwenzeka ngenxa yokwanda kokutya xa iimpawu zilawulwa ngcono. Gcina ukhumbula ukuba i-omeprazole yenzelwe kuphela unyango lwexeshana lokutshisa, i-GERD, kunye nezinye iimeko zesisu. Ukusetyenziswa kwexesha elide kucetyiswa kuphela kubantu abaneemeko ezinqabileyo zonyango ezibangela i-hypersecretion yesisu esiswini. Ukuba ukubetha kwentliziyo okanye i-GERD ifuna unyango lwe-omeprazole yexesha elide, thetha nengcali yezempilo malunga nezinye iziyobisi, ukutya, okanye indlela yokuphila yokukhetha ukulawula iimpawu.

Omeprazole kunye nomhlaza

Kukho umbono odumileyo wokuba i-omeprazole kunye nezinye ii-PPI zinokunyusa umngcipheko womhlaza wesisu. Uphando malunga nombutho we-omeprazole kunye nomhlaza wesisu uxutywe. Ezinye izifundo bonisa i-omeprazole (okanye nayiphi na i-PPI) inokunyusa umngcipheko womhlaza wesisu. I-Omeprazole inyusa umngcipheko we-atrophic gastritis, okanye ukucaphuka kunye nokudumba kwesisu esiswini. I-atrophic gastritis ithathwa njengesandulela somhlaza wesisu.

Okubaluleke ngakumbi, i-omeprazole inokuzifihla iimpawu zomhlaza wesisu. Oku kubaluleke kakhulu. Abantu bangaqala ukuthatha i-omeprazole for ukutsha, kodwa iimpawu zinokubangelwa sisifo esibi. Iimpawu ezinje ngokuqaqamba rhoqo kufuneka zivavanywe ngumboneleli wezempilo.

Iziphumo zeecala le-omeprazole zihlala ixesha elingakanani?

Umzimba uyayicoca i-omeprazole kwiiyure ezimbalwa, uninzi lweziphumo ebezingalindelekanga ziya kuphela ngelo xesha. Kuba iimpembelelo ze-omeprazole esiswini esiswini, nangona kunjalo, zihlala iintsuku ezintathu okanye nangaphezulu, iziphumo ebezingalindelekanga zesisu zinokuhlala iintsuku ezimbalwa emva kokuyeka i-omeprazole. Iziphumo ebezingalindelekanga ezibangelwa kukudibanisa i-omeprazole kunye ne-antibiotics, enjengokungcamla okugqwethekileyo okanye ukutshintsha kolwimi, kuya kusombulula kwiintsuku ezimbalwa emva kokuba i-antibiotics iphelile. Iziphumo ebezingalindelekanga ezimandundu ezinxulunyaniswa ne-omeprazole, nangona kunjalo, njengokuphulukana nethambo, ukubala kweeseli ezimhlophe ezisezantsi, isifo sesibindi, okanye iingxaki zezintso, kungathatha ixesha elide ukuzisombulula. Xela iziphumo ebezingalindelekanga kumboneleli wakho wezempilo.

Izimo kunye nezilumkiso ze-Omeprazole

I-Omeprazole kunye nezinye iiproton pump inhibitors ngamayeza asebenzayo kwaye aneziganeko ezisezantsi zeziphumo ebezingalindelekanga xa zisetyenziswa kwixesha elifutshane. Nangona kunjalo, i-omeprazole isenokungabi yeyomntu wonke, ngakumbi xa isetyenziswa kwixesha elide.

Ukuxhomekeka

Ukusetyenziswa gwenxa kwe-omeprazole kunokukhokelela kwiziphumo ebezingalindelekanga ezibi kunye nezothusayo. Ngokukodwa, abantu abaphatha i-omeprazole ixesha elide baya kuphuhla uhlobo lokuxhomekeka emzimbeni . I-Omeprazole yenza i-loop loop yempendulo esiswini. Emva kokusetyenziswa okungapheliyo kwe-omeprazole, isisu siqala ukuvelisa ngaphezulu kwesisu esiswini. Kubantu abaninzi, ukuyeka ukusebenzisa ixesha elide i-omeprazole kuthetha ukubuya ngokukhawuleza kwe-acid reflux kunye nesitshisa.

Umzimba

I-Omeprazole akufuneki ithathwe nangubani na one-hypersensitivity kakhulu kwi-omeprazole okanye nasiphi na isithako esingasebenziyo kunyango.

Abantu abaneengxaki zesibindi

UOmeprazole unjalo iqhutywa sisibindi . Izigulana ezineengxaki zesibindi ngokubanzi zinokuthatha i-omeprazole (ukuba yamkelwe ngugqirha wakho), kodwa idosi inokuba nencinci kunesiqhelo.

Abantu abanemvelaphi yaseAsia

Abantu abanemvelaphi yaseAsia ndinomngcipheko okhulayo wokuba nesifo sengqondo esixhalabisayo ukusuka kwiproton pump inhibitors ezinje nge-omeprazole. Xa kuthelekiswa nabanye abantu, a ipesenti ephezulu yabantu baseAsia yenza i-omeprazole kancinci kancinci-i-20% xa ithelekiswa ne-3%.Ulwazi lokumisela i-omeprazole icebisa idosi esezantsi kwezi zigulana.

Abantwana

I-omeprazole kagqirha yamkelwe ukunyanga iimpawu ze-GERD kunye ne-esophagitis erosive kubantwana abaphakathi kweminyaka eli-1 ukuya kweli-16 . I-omeprazole engaphezulu kwekhawunta ayiyo , ke akufuneki ukuba inikwe abantwana. Ukuba ukwenziwa kolwelo (iipakethi zokumiswa ngomlomo) azifumaneki, amayeza anokudityaniswa yikhemesti ehlanganisayo. Okanye, imixholo yecapsule inokuxutywa kunye nepunipoon yeapile kunye kwaye ityiwe ngokukhawuleza, kunye neglasi yamanzi.

Abadala

Kwezilingo zeklinikhi , I-omeprazole inerekhodi efanayo yokhuseleko kubantu abadala njengakwabanye abantu abadala.

Ukukhulelwa kunye nokuncancisa

Akukho zifundo zichazayo malunga nokhuseleko lokusetyenziswa kwe-omeprazole ngexesha lokukhulelwa. Ulwazi lokumisela lucebisa ukuba abasetyhini abakhulelweyo kufuneka basebenzise i-omeprazole kuphela ukuba kunyanzelekile.

I-Omeprazole ikhona kubisi lwebele ngesixa esincinci. Ngenxa yobungozi obunokubakho kusana olunyisayo, i-FDA icebisa ukuba oomama abatsha abathatha i-omeprazole bayeke ukonga okanye bayeke i-omeprazole.

Unxibelelwano lwe-Omeprazole

Njengazo zonke iziyobisi, omeprazole iyasebenzisana namanye amachiza okanye izinto.

Ngokubanzi, ukutya akuchaphazeli ukufakwa okanye ukusebenza kwe-omeprazole. Nangona kunjalo, kuba injongo kukunciphisa isisu esiswini, kusenokwenzeka ukuba akunangqondo ukuthatha i-omeprazole kwaye emva koko utye ukutya okugqobhoza isisu se-asidi esiswini njengokutya okuqholiweyo, ukutya okunamafutha, iisoda, utywala, okanye ikofu.

Rilpivirine

Amayeza e-HIV i-rilpivirine iyaphikiswa ukuze isetyenziswe ne-omeprazole kuba ifuthe le-omeprazole kwi-asidi yesisu kunciphisa ukufunxwa komzimba kwe-rilpivirine. Oku kulingana nokunciphisa idosi ye-rilpivirine, ichiza elinyanga i-HIV / AIDS, isifo esinokubulala.

Ezinye iziyobisi ezingafakwanga kakuhle emzimbeni xa zidityaniswe ne-omeprazole zibandakanya:

Zininzi amayeza nokubola ezifana ketoconazole
Amanye amayeza okubulala iintsholongwane ezifana ne-amoxicillin kunye ne-ampicillin
Amanye amachiza alwa i-HIV njenge-atazanavir kunye ne-nelfinavir
Ezinye iziyobisi zomhlaza Njenge-erlotinib
Iihomoni zedlala lengqula
Abanye izongezo zentsimbi

Ukusebenzisana kwe-Omeprazole kunye ne-thinner yegazi (i-anticoagulants)

I-Omeprazole inxibelelana negazi elincinci le-warfarin, kwaye linokubangela ukopha ngokungaqhelekanga okanye nokufa. Ukuba uku-omeprazole kunye ne-warfarin, ugqirha wakho uya kukubeka esweni ngokusondeleyo kwaye unokufuna uhlengahlengiso kumayeza (amayeza) akho.

I-Omeprazole ikwanxibelelana neearhente ze-antiplatelet Plavix (clopidogrel) kunye ne-Pletal (cilostazol). IPlavix akufuneki ithathwe nge-omeprazole. Elinye ichiza le-antiplatelet kufuneka lisetyenziswe. Ukuba uthatha iPletal nge-omeprazole, idosi yePletal kufuneka ihlengahlengiswe.

Unxibelelwano lwe-Omeprazole olonyusa iziphumo ebezingalindelekanga

I-Omeprazole inyusa ityhefu kunye nomngcipheko weziphumo ebezingalindelekanga zamachiza amiselweyo ngokonyusa ukufunxeka kwazo okanye ukunciphisa ukucola komzimba. La machiza abandakanya:

Inkqubo ye- iziyobisi zokucinezela amajoni omzimba methotrexate kunye netacrolimus
Amayeza e-ADHD
IiBenzodiazepines Njenge diazepam
Ezinye ii-anticonvulsants ezifana ne-phenytoin kunye ne-fosphenytoin
Amayeza e-HIV iqequa
Iyeza lentliziyo idigoxin

La machiza anokuthathwa ngokubanzi kunye ne-omeprazole, kodwa ingcali yezempilo inokufuna ukubeka iliso kunyango kunye nokunciphisa idosi ukuba kukho imfuneko.

Amanye amachiza anyusa umngcipheko weziphumo ze-omeprazole ukuba ngaba zithathwa kunye. Oku kubandakanya:

Ezinye iziyobisi ze-cystic fibrosis
ICannabidiol
Iyeza lokubola i-voriconazole

Ukusebenzisana kwe-Omeprazole okunciphisa ukusebenza

Amanye amachiza akhawulezisa imetabolism yomzimba ye-omeprazole, ukunciphisa ukusebenza kwayo. Oku kubandakanya:

Inkqubo ye- iyeza lokubulala iintsholongwane i-rifampin, i-rifapentine, kunye ne-rifabutin
Iindidi ezithile ze iziyobisi ezichasene ne-anticonvulsant
Ezinye iintlobo ze amachiza antiviral Njenge ritonavir
IiBarbiturates ezinjenge-butalbital kunye ne-phenobarbital
Iziyobisi zeCystic fibrosis I-lumacaftor / ivacaftor
Wort yaseSt

Ukusebenzisana kwe-Omeprazole ne-diuretics (iipilisi zamanzi)

Ukuthatha i-diuretics nge-omeprazole kuphakamisa umngcipheko we-magnesium ephantsi. Unyango lusenokufuna ukubekwa esweni okanye ukulungiswa.

Ungaziphepha njani iziphumo ebezingalindelekanga ze-omeprazole

Xa ithathwa njengoko iyalelwe ixesha elincinci, i-omeprazole ineziphumo ebezingalindelekanga ezincinci. Iingcebiso ezimbalwa zinokukunceda ukugcina iziphumo ebezingalindelekanga ubuncinci:

Thatha i-omeprazole njengoko kuyalelwe

Thatha idosi yemihla ngemihla njengoko kumiselwe ngexesha elimiselweyo. I-omeprazole engaphezulu kwe-counter kufuneka ithathwe kusasa ngaphambi kwesidlo sakusasa. Kwi-omeprazole yonyango, ugqirha omiselweyo okanye omnye umsebenzi wezonyango uya kuchaza ixesha losuku lokuthatha amayeza. Musa ukunyusa okanye ukunciphisa umthamo. Musa ukutsiba idosi usuku olunye okanye ezimbini okanye uthathe idosi ephindwe kabini endaweni yedosi ephosiweyo. Iyeza kufuneka lisetyenziswe yonke imihla kwisithuba esipheleleyo sokuqonda izibonelelo zalo ezipheleleyo.

2. Kunqande ukuthatha omeprazole ixesha elide

Thatha i-omeprazole kuphela okwexeshana, naphina ukusuka kwiintsuku ezili-10 ukuya kwiiveki ezisibhozo. Zimbalwa kakhulu iimeko zonyango ezifuna ukuba i-omeprazole ithathwe ixesha elide. Ukusetyenziswa rhoqo kwe-omeprazole akuphakamisi umngcipheko weziphumo ebezingalindelekanga ngokubanzi, kodwa kukonyusa umngcipheko weziphumo ebezingalindelekanga ezibi kakhulu. Ukuba iyeza libonakala lifuna ukusetyenziswa kwexesha elide, thetha nomboneleli wezempilo malunga nezinye iindlela zonyango.

3. Xelela ugqirha wakho ngazo zonke iimeko zonyango kunye namayeza akho

Ngenxa yomngcipheko weziphumo ebezingalindelekanga, kuya kufuneka uxelele ugqirha wakho malunga:

Naziphi na iimeko zomzimba onokuba nazo, ngakumbi
- Iintlungu zesifuba
- Isihlunu, ukugabha, iintlungu zesisu, okanye ukwehla kobunzima obungachazwanga
- Ukudumba kolusu, ukudinwa, okanye iintlungu ezidibeneyo
- Amanqanaba e-magnesium asezantsi
- Iingxaki zesibindi
- Ukukhulelwa okanye ukuncancisa
Onke amayeza owathathayo ngoku, ngakumbi
- Rilpivirine
- Iimpawu zegazi / ii-antiplatelets
- Methotrexate okanye
- Rifampin
Onke amayeza e-counter-counter kunye nezongezelelo ozithathayo, ngokukodwa
- Wort yaseSt

4. Thetha nomsebenzi wezempilo ngaphambi kokuba uthathe i-OTC omeprazole

I-Omeprazole inokuthengwa ngokulula ngaphandle kommiselo. Okwangoku, ngenxa yomngcipheko wokusebenzisa gwenxa, ukuxhomekeka emzimbeni, kunye neziphumo ebezingalindelekanga, funa ingcebiso kwezonyango ngaphambi kokuba uthathe i-omeprazole ekhawuntareni. Kunokubakho ezinye iindlela ezingcono kubandakanya amanye amayeza, utshintsho kwindlela otya ngayo, kunye notshintsho kwindlela yokuphila.

5. Thatha i-omeprazole kwimizuzu engama-30 ukuya kwengama-60 ngaphambi kokutya

Amathuba kukuba amayeza kagqirha, isikhokelo sonyango, okanye ipakeji iya kuba nomyalelo ofundwayo, Thatha ngaphambi kokutya. Inkqubo eqhelekileyo kukuthatha i-omeprazole Imizuzu engama-30 ukuya kwengama-60 ngaphambi kokutya.

6. Kuphephe ukutya okunyusa iasidi kunye neziyobisi

Ukutya okuninzi okanye iziyobisi kukhuthaza ulusu esiswini ukonyusa imveliso yeasidi. Oku kubandakanya ukutya okuqhwethayo, ukutya okuqhotsiweyo, inyama enamafutha, itshizi, iipepile, iziqhamo ze-citrus, itshokholethi, ikofu, utywala, isoda pop, iasprini, ipermermint, kunye nezinye izongezo zamaminerali. Ukutya ukutya okune-spices kunye nokuthatha i-omeprazole akuyi kuwonyusa umngcipheko weziphumo ebezingalindelekanga ze-omeprazole, nangona kunjalo, ziya kuyonyusa inani leasidi esiswini, ziyichaphazele imiphumo yeyeza.