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Iziphumo ebezingalindelekanga zepropranolol kunye nonxibelelwano, kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

Ipropranolol (igeneric Inderal) sisiyobisi esinyangiweyo esiphatha iimpawu zoxinzelelo lwegazi oluphezulu, ezinjengeentlungu esifubeni. Ngaphambi kokuba uthathe eli yeza, abaguli kufuneka bazi ngeziphumo ebezingalindelekanga zepropranolol, izilumkiso kunye nonxibelelwano. Funda ngendlela yokuthintela le miphumela ingezantsi.

Yintoni ipropranolol?

Ipropranolol liyeza eliqhelekileyo elithengiswa njengegama lophawu Inderal LA , Inderal XL, InnoPran XL, kunye neHemangeol. Yeyayo i-beta-adrenergic blocking agents (okanye beta-iibhlokhi ) iklasi yeziyobisi, enceda ukubetha kwentliziyo ngokulula nangamandla amancinci. Ipropranolol ifumaneka kuphela ngugqirha. Nazi ezinye zeemeko zempilo ezivunyiweyo Ulawulo lokutya kunye neziyobisi (i-FDA) ipropranolol ukunyanga:

Arrhythmia: Ukubetha kwentliziyo okungaqhelekanga okucothayo okanye okukhawulezayo.
UAngina: Intlungu yesifuba eyenzeka xa igazi lingahambi kakuhle entliziyweni.
Iinyikima: Ukuhamba ngokungakhathali kunye nesingqi kwamalungu, ubuso, iintambo zezwi, okanye intloko.
Uxinzelelo lwegazi: Igazi elonyukayo ngenxa yegazi elinxamnye nemithambo yeendonga liphezulu kakhulu. Amanqanaba oxinzelelo lwegazi aphezulu angaphezulu kwe-140/90. Ipropranolol-HCTZ , iziyobisi ezidibanisa ipropranolol ne-diuretic, inyanga uxinzelelo lwegazi.
Ukuhlaselwa yintliziyo: Ukuhlaselwa kwentliziyo (i-myocardial infarction) kwenzeka xa ukuphuma kwegazi kuye entliziyweni kuvaliwe. Ipropranolol inokunceda ekuthinteleni nasekunyangeni isifo sentliziyo.
Intloko ye-Migraine: Imigraines ziintloko ezibandezelayo ukuba iprranolol inokukunceda ukuthintela. Abaphandi bacinga ukuba ipropranolol ilungile kwimigraines kuba ibhloka i-hormone adrenaline ekubangeleni impendulo yoxinzelelo emzimbeni.
Umntwana hemangioma: Ithumba lesitya segazi elinobungozi elinokuchaphazela iintsana ukuya kwiinyanga ezintlanu ubudala.

Ipropranolol inokunyanga ezinye iimeko, ezinje unxunguphalo kunye noloyiko , kwimeko ngetyala. Abaphandi baphonononga ukuba ipropranolol inokunyanga njani iintlobo ezithile ze umhlaza . Imilinganiselo yepropranolol iya kwahluka ngokuxhomekeke kwimeko kwaye inokuba ukusuka kwi-10 mg ukuya kwi-160 mg.

ZIQHELEKILEYO: Yintoni i-Inderal LA? | Yintoni iPropranolol?

Iziphumo eziqhelekileyo ezichaphazelekayo zepropranolol

Njengawo nawaphi na amayeza, kuhlala kukho iziphumo ebezingalindelekanga. Nazi ezinye iziphumo ebezingalindelekanga eziqhelekileyo zepropranolol:

Ukuba nesiyezi
Ubumhlophe
Ukudinwa
Ukuncipha kwesondo
Isicaphucaphu
Intlungu yesisu
Urhudo
Ukuqunjelwa

Iziphumo ebezingalindelekanga ezimandundu zepropranolol

Ukuthatha ipropranolol kunokubangela iziphumo ebezingalindelekanga ezimandundu. Nazi ezinye zeempembelelo ezibukhali kunye ezinokubakho zexesha elide ukuba uziqaphele xa ucinga okanye uthatha ipropranolol:

Ukuba nemibono
Izandla okanye iinyawo ezibandayo
Ubuthathaka bemisipha
Iintlanzi zemisipha
Ukuqhawukelwa ngumphefumlo
Ukuphulukana nenkumbulo
Ukugcina ulwelo
Iswekile yegazi iyatshintsha
Ukuphuthelwa namaphupha amabi
Ukuphendula ngokuchaseneyo
Ukuhlanza
Ukuxakeka
Ukutyeba kwakho
Ukudumba kolusu

Abanye abantu baziva bexhalabile ukuba ubuntu babo buza kutshintsha ekuthatheni ipropranolol, kwaye nangona kunqabile, oku kunokwenzeka. Ipropranolol inokubangela ukutshintsha kwemood kunye nokudakumba. Inokubangela iingxaki zememori ngenxa yendlela echaphazela ngayo i-norepinephrine kunye ne-epinephrine, ebotshelelwe kwimemori. Naluphi na utshintsho lweemvakalelo kufuneka luchazwe kugqirha ngokukhawuleza.

Iziphumo ebezingalindelekanga zepropranolol ezifuna ukhathalelo lonyango kwangoko zibandakanya ukuphefumla, ukubila, ukudumba kwezandla okanye ubuso, kunye nerhashalala. Ezi mpawu zibonisa ukusabela okungafunekiyo, okunokusongela ubomi.

Kuya kufuneka uyeke ukuthatha ipropranolol ukuba kwenzeka iziphumo ebezingalindelekanga ezimbi, kodwa kuphela phantsi kwesikhokelo sikagqirha, ngokuxhomekeke kwidosi kunye neziphumo ebezingalindelekanga, ugqirha wakho unokufuna ukuba uyicothise kancinci ipropranolol, utshilo uRuben Elovitz, MD, umsunguli kunye CEO ye Ezempilo zabucala zaseDallas . Kukho iziphumo ezinokubakho ngokumisa ngesiquphe amayeza kuxhomekeke kwisizathu sokuba uqale amayeza.

Nangona ukuthatha ipropranolol kunokubangela iziphumo ebezingalindelekanga, iselilo iyeza elinokwenza okuhle kakhulu. Inceda ukusebenza kwentliziyo, ayiyi konakalisa intliziyo, kwaye inefuthe elihle kumajoni omzimba ngokwandisa inani leeseli ze-T emzimbeni. Kuza kuhlala kukho ubuhle kunye neengozi kuwo onke amayeza, kwaye kubantu abaninzi, izibonelelo zepropranolol zigqithise kakhulu ezantsi.

Zithatha ixesha elingakanani iziphumo ebezingalindelekanga zepropranolol?

Iziphumo ebezingalindelekanga zepropranolol zinokuhlala naphi na ukusuka kwiintsuku ukuya kwiiveki. Uninzi lweziphumo ebezingalindelekanga ziya kuhamba zingaphelanga iintsuku ezimbalwa njengoko umzimba uhlengahlengisa amayeza. Kwabanye, eli xesha lohlengahlengiso linokuthatha ixesha elide. Iziphumo ebezingalindelekanga ziya zisiba mbi okanye zibengcono njengoko idosi inyuka okanye yehla. Iziphumo ebezingalindelekanga zexesha elide zinokwenzeka, kodwa oku akwenzeki kuwo wonke umntu.

Izilumkiso zepropranolol

Ipropranolol ayiyiyo eyomntu wonke. Ugqirha Elovitz ucacisa ukuba abantu abanezi meko zilandelayo zonyango akufuneki bathathe ipropranolol:

I-Bradycardia (inqanaba lentliziyo elicothayo ngokungaqhelekanga)
Isifo sombefu (ukuphefumla nzima ngenxa yomoya)
Ukusilela kwentliziyo okungalawulekiyo (intliziyo ayimpomli kakuhle)
Isifo se-vascular peripheral (ivalwe okanye iqhube imithambo yegazi)
Isifo seswekile (isifo seswekile ephezulu yegazi)
I-Pheochromocytoma (i-tumor ye-adrenal gland tissue)
I-Myasthenia gravis (isifo semisipha esibuthathaka)
Hypotension (uxinzelelo lwegazi olusezantsi)
I-Orthostatic hypotension (uxinzelelo lwegazi oluphantsi olwenzekayo xa umile uhleli okanye ulele)

Abantu abaphila ne-hyperthyroidism (i-thyroid engasebenzi), isifo sikaRaynaud, isifo sesibindi, isifo sezintso, isifo semiphunga, okanye isifo senhliziyo, kufuneka bathethe nomboneleli wabo wezempilo ngaphambi kokuba bathathe ipropranolol. Ukuba nezi meko zonyango kunokubangela ukusabela okungalunganga kwipropranolol, ekhokelela kwiingxaki ezongezelelweyo zempilo.

Ipropranolol ngexesha lokukhulelwa

Ipropranolol isenokungakhuseleki kubafazi abakhulelweyo. Khange kubekho zifundo zaneleyo zenziweyo zokuqinisekisa ukuba ipropranolol izichaphazela njani iimveku, kodwa izifundo zibonisa ukuba ichiza linokudlula ukusuka kumama liye kwiintsana ngobisi lwebele. Abafazi abakhulelweyo okanye abo banokukhulelwa kufuneka babonisane nabanikezeli babo bezempilo ngaphambi kokuba bathathe okanye bayeke ngequbuliso ukuyeka ipropranolol.

Izithintelo zobudala

Ipropranolol ngamanye amaxesha isetyenziselwa ukunyanga iimeko zonyango njenge-infantile hemangioma yabanye abantwana, kodwa oku akuthethi ukuba sisiyobisi esifanelekileyo kuwo wonke umntwana. Ugqirha uya kumisela ipropranolol emntwaneni kuphela xa kukho imfuneko yoko.

Ipropranolol inikwa abantu abadala ukuba balumke, ngakumbi abo banesibindi, izintso kunye nentliziyo. Abanye izifundo cebisa ukuba abantu abadala abadala kunama-60 abanesifo soxinzelelo lwegazi akufuneki bathathe ipropranolol, kodwa ezinye izigulana ezinesifo sentliziyo zingayidinga. Oogqirha baya kuhlala bemisela ipropranolol kwimeko-nge-imeko.

Ukusetyenziswa kwexesha elide kwepropranolol

Njenge-beta-blocker, ukusetyenziswa kwepropranolol yexesha elide kunokuthintela uhlaselo lwentliziyo kunye nokugcina amanqanaba oxinzelelo lwegazi olusempilweni. Akuqhelekanga ukuba umntu athathe i-beta-blockers iminyaka emininzi, ngakumbi emva kokuhlaselwa yintliziyo, kodwa oogqirha baqala umbuzo ingaba ukusetyenziswa kwexesha elide kuyafuneka.

Ukusetyenziswa kwexesha elide kwe-beta-blockers kunokubangela iziphumo ebezingalindelekanga eziqhelekileyo iba mandundu . Ingazifihla iimpawu zeswekile esezantsi yegazi kubantu abanesifo seswekile, ezinokubusongela ubomi. Iidosi eziphezulu zepropranolol ezithathwa ixesha elide zinokukwenza ukuba iingxaki zentliziyo zibe mbi ngakumbi kwaye zibangele ukungaqhelekanga kwentliziyo.

Ipropranolol ayisosisiyobisi umntu anokuyeka ukusithatha kwangoko, nokuba ngaba uneziphumo ebezingalindelekanga. Ukuyekisa ngesiquphe iprranranol kunokubangela ukuhlaselwa yintlungu kunye neentlungu zesifuba. Ukubonisana nodokotela yindlela efanelekileyo yokugcina oku kungenzeki.

Ezinxulumene: Ungaluhlisa njani uxinzelelo lwegazi ngokukhawuleza kwaye ngokwendalo

Unxibelelwano lwepropranolol

Kanye njengepropranolol ayenzelwanga ukuba ithathwe ngumntu wonke, ayifanelanga nokuba ithathwe ngamanye amayeza. Ukuthatha ipropranolol ngala mayeza kunokubangela ukuhlangana okungalunganga:

Iibhlokhi zeAlfa: Iprazosin
Anticholinergics: I-Scopolamine
Olunye unyango lwegazi oluphezulu: Clonidine , acebutolol , nebivolol, Yogco , imoloprolol
Olunye unyango lwentliziyo: Iquinidine , Yogco , mzantsi
Amayeza eSteroid: IPrednisone
Izidakamizwa ezichasayo ezichasayo (i-NSAID): I-Aspirin , ibuprofen
Ezinye iziyobisi: IFluoxetine , fluvoxamine

Olu luhlu lwamayeza alugqitywanga. Iingcali zokhathalelo lwempilo zinokubonelela ngoluhlu olupheleleyo lokunxibelelana kweziyobisi. Uninzi lweevithamini kunye nezongezo zikhuselekile ukuba uzithathe kunye nepropranolol, kodwa ezinye zinje ngeSt.

Ngaphandle kwamayeza, ipropranolol akufuneki ithathwe ngotywala. Utywala bunokunyusa amanqanaba egazi lepropranolol, ibangele ukuba ingakhuselekanga. Ukusela kakhulu icaffeine kufuneka kuthintelwe kuba icaffeine inokunyusa uxinzelelo kunye noxinzelelo lwegazi.

Fumana ikhadi lesaphulelo somntu ongatshatanga

Ipropranolol vs.propranolol iziphumo ebezingalindelekanga

Ipropranolol iza ngeendlela ezimbini ezahlukeneyo ezisebenza kancinci ngokwahlukileyo. Ukukhutshwa kwangoko kwepropranolol kufuneka kuthathwe amaxesha ngamaxesha ngemini ukuqinisekisa ukuba iyasebenza. Ipropranolol eyandisiweyo-yokukhululwa (i-ER) kufuneka ithathwe kube kanye ngemini kuba ikhupha kancinci ipropranolol hydrochloride emzimbeni.

IPropranolol ER iyafumaneka ukuze ithengwe njenge-60 mg, 80 mg, 120 mg, kunye ne-160 mg njengezingxobo. Inkqubo ye- idosi esemgangathweni Ipropranolol ER yi-80 mg ithathwa kanye ngemini, ephezulu kunedosi yokukhutshwa kwangoko kwepropranolol kuba ithathwa kube kanye kuphela.

Abanye abantu bayayithanda inguqulelo ekhutshiweyo ngenxa yokuba banexhala lokuthatha amayeza abo kanye ngosuku. Nangona kunjalo, ugqirha uya kuba nakho ukufumanisa ukuba yeyiphi na eyona nguqulelo ilungele umntu ngokuxhomekeke kwiimfuno zabo kunye neempawu.

U-Actavis Elizabeth uvelisa ingxelo yesiqhelo yepropranolol eyandisiweyo. Igama lophawu lwepropranolol HCl ER yiHemangeol. Iinguqulelo zamayeza enziwe afana nalawo aveliswe ngumenzi zihlala zingabizi ngaphezu kwegama lebrendi, kodwa zisebenza ngokufanayo kwaye zisebenza ngokulinganayo.

Iziphumo ebezingalindelekanga zepropranolol eqhelekileyo kunye nepropranolol eyandisiweyo-yokukhululwa iphantse yafana. Izilumkiso ezifanayo, izilumkiso, kunye nokunxibelelana kweziyobisi kwipropranolol nako kumele ipropranolol ER.

Ungaziphepha njani iziphumo ebezingalindelekanga zepropranolol

Eyona ndlela yokuthintela iziphumo ebezingalindelekanga zepropranolol kukulandela imiyalelo yomenzi kunye nayiphi na imiyalelo enikwe yingcali yezonyango.

Iidosi zePropranolol ziya kuxhomekeka kubudala besigulana, iimpawu zomntu ngamnye, kunye nembali yonyango, kodwa idosi esemgangathweni yi-40 mg ithathwa kabini ngemini. Iipilisi zepropranolol ezikhutshwa ngokukhawuleza kufuneka zithathwe kwisisu esingenalutho ukuqinisekisa ukufunxeka emzimbeni. Iipilisi zepropranolol ezandisiweyo-ezikhutshiweyo (i-ER) zinokuthathwa kunye okanye ngaphandle kokutya, kodwa kufuneka zisoloko zithathwa ngokungaguquguqukiyo, nokuba kungatya okanye kungabikho kutya, ukuqinisekisa ukuba iidosi ezingaguquguqukiyo ziyafakwa emzimbeni. Kwakhona, ukuthatha iprranolol ER ngokutya kunokunceda ekuthinteleni isisu esiphazamisayo kwaye khumbula UKUNGAYI ukuhlafuna okanye ukuwaphula la macwecwe e-ER okanye idosi yonke inokufakwa ngokukhawuleza. Ipropranolol ihlala ithathwa kube kanye kusasa kwaye kwakhona ngaphambi kokulala, kodwa oku kungatshintsha ngokusekwe kwizindululo zomboneleli wezempilo.

Idosi ephosiweyo yepropranolol nayo inokubangela iziphumo ebezingalindelekanga. Ukuthatha idosi ephosiweyo kwakamsinya emva kokukhumbula kuya kunceda ukuthintela iziphumo ebezingalindelekanga ukuba zenzeke okanye zisiba mbi. Nangona kunjalo, ukuba sekulixesha lokuthatha idosi elandelayo, isigulana akufuneki sithathe idosi eyongezelelweyo ukwenza isixa esiphosiweyo.

Ipropranolol kufuneka igcinwe kubushushu begumbi kude nobushushu, ilanga ngqo, kunye namaqondo obushushu obushushu. Ezi meko zokusingqongileyo zinokutshintsha amayeza kunye nendlela esebenza ngayo. Gcina iziyobisi kude nabantwana. Funa ingcebiso yezonyango kwangoko ukuba umntwana uthathe ngengozi ipropranolol.

Ukuba iziphumo ebezingalindelekanga zinzima kakhulu, oogqirha banokumisela amayeza ahlukileyo. Kungenxa yokuba umntu eqala ukuthatha i-beta-blocker njengepropranolol, oko akuthethi ukuba kuya kufuneka ayithathe ngonaphakade. Amayeza afana I-ACE inhibitors kwaye ii-ARBs ziphatha ezinye zeemeko ezifanayo ezenziwa yi-beta-blockers, kwaye banokusebenza ngcono kubantu abathile. Nazi ezinye zezona zithintelo zixhaphakileyo ze-ACE kunye nee-ARBs: