Iziphumo ebezingalindelekanga zeTopamax kunye nendlela yokuzikhusela

Ulwazi lweziyobisi

Iziphumo ebezingalindelekanga zeTopamax | Izilumkiso | Unxibelelwano | Ungaziphepha njani iziphumo ebezingalindelekanga

I-Topamax (i-topiramate) yigama lophawu lwe-anticonvulsant drug elisebenza kwingqondo ukukhusela ukuxhuzula. Ivunyiwe yi-FDA ukusukela ngo-1996 unyango lwesifo sokuwa kubantwana nakubantu abadala. I-Topamax nayo isetyenziswa rhoqo kuthintela intloko ebuhlungu kubantu abadala . Isetyenziswa kwakhona ngaphandle kwelebheli ukunyanga abaguli abanesifo esiyibipolar (ekwabizwa ngokuba luxinzelelo lwe-manic) kwaye uncede ukunciphisa umzimba. Isilwanyana sihlala simiselwe kwi-25 mg ukuya kwi-400 mg doses.

I-Topamax ikhuselekile ekusebenziseni ixesha elide xa ithathwa njengoko kumiselwe. Nangona kunjalo, uninzi lweziphumo ebezingalindelekanga ezinokubakho zixeliwe linani elincinci lezigulana. Kukwakho nezinye iziyobisi ezininzi ezinokubangela ukuhlangana okuyingozi okanye zingasebenzi xa zithathwa ngokudibeneyo neTopamax. Nantsi yonke into ekufuneka uyazi ngokuthatha ngokukhuselekileyo i-Topamax, kubandakanya nento onokuyenza ukunciphisa umngcipheko wokuba neziphumo ebezingalindelekanga ezibi.

Ezinxulumene: Yintoni iTopamax? | Fumana amatikiti e-Topamax

Iziphumo eziqhelekileyo ezichaphazelekayo ze-Topamax

Uninzi lweziphumo ebezingalindelekanga ezinxulunyaniswa neTopamax zithathwa njengeziphakathi ukuya kuthi xhaxhe. Uninzi luya kunyamalala okanye luphele njengoko uhlengahlengisa amayeza. Ukuba ufumana nayiphi na le mpawu, yazisa ugqirha wakho ngokukhawuleza kuba banokubonisa iziphumo ezibi kakhulu. Ezi ziziphumo eziqhelekileyo zeTopamax, ngokutsho komenzi :

• Ukuphelelwa ngumdla, ukutshintsha incasa, ukwehla kobunzima, iintlungu esiswini kunye neanorexia
• Iziphumo ebezingalindelekanga ze-GI (isicaphucaphu, urhudo, ukungancedi)
• Ukudinwa
• I-Paresthesia (ukubetha okanye ukubetha)
• Iingxaki zentetho
• Ukungasebenzi kakuhle kwengqondo (ingxaki ngememori nasekucingeni)
• Usulelo oluphezulu lokuphefumula
• Ukuba nesiyezi
• Uvalo
• Ukuphendula kancinci
• Utshintsho olubonakalayo (ukungaboni kakuhle, umbono onamafu, ukuhamba kwamehlo okungazibandakanyi)
• Ifiva
• Ukwehla kobuntununtunu okanye ukuba ndindisholo

Ngaba i-Topamax ikwenza ulale?

Ukuthatha i-Topamax kunokukwenza wozele kwaye ube nesiyezi. Kuya kufuneka uphephe ukuqhuba, ukusebenzisa oomatshini abanzima, okanye ukwenza eminye imisebenzi efuna ukuphaphama de ube uyazi indlela ekuchaphazela ngayo la mayeza. Ngenxa yokuba kunokubangela ukozela, i-Topamax ihlala ithathwa ebusuku.

Ngaba i-Topamax ibangela inkungu yengqondo?

Izigulana zihlala zifumana inkungu yengqondo, okanye ukwehla ukuqonda , xa uqala iTopamax. Abanye baxela ukungakwazi kokukhawuleza ukucubungula ulwazi, iingxaki zolwimi, okanye ukucinga ngokucacileyo. Kweminye, olu phawu lusombulula njengoko umzimba uhambelana nedosi. Abanye banokufuna ukukhangela ezinye iindlela zeTopamax.

Ngaba i-Topamax yenza ukuba iinwele zakho ziwe?

Ngokwe- Amaziko kaZwelonke wezeMpilo , Ukulahleka kweenwele kuyimpembelelo yecala le-topiramate, kodwa umenzi weTopamax akayidwelisi njengesiqhelo. Izinwele zihlala zikhula ngokukhawuleza ukuba uyeka unyango.

Iziphumo ebezingalindelekanga ezimandundu zeTopamax

Kukho nemiphumo emibi ekufuneka uyiqaphele xa uthatha i-Topamax. Iziphumo ebezingalindelekanga zihlala zifuna ukulaliswa esibhedlele okanye ngoncedo lwezonyango, kwaye zinokukhokelela ekonzakaleni ngokusisigxina okanye zisongele ubomi.

• I-Metabolic acidosis (ukudinwa, ukungabinamdla wokutya, ukubetha kwentliziyo ngokungaqhelekanga, inkungu yengqondo)
• Ukugqithisa kwe-ammonia egazini (xa i-Topamax ithathwa ngamayeza ane-valproic acid)
• Ukudakumba okutsha okanye okubaxekileyo, uxinzelelo, okanye iingcinga zokuzibulala / indlela yokuziphatha (eyenzeka kwizigulana ezi-1 kwezingama-500)
• Ukuncipha kokubila kodwa ukonyusa ubushushu bomzimba
• Iglaucoma
• Isifo i-Stevens-Johnson syndrome (irhashalala elukrakra, iblister, peeling skin)
• Ukukhula okungathethekiyo kubantwana
• Ukubanjwa ngokukhawuleza kokurhoxa (ukuba iTopamax imiswe ngesiquphe)

Ngaba i-Topamax ingabutshintsha ubuntu bakho?

Ii-anticonvulsants ezinje ngeTopamax, zinokuchaphazela kakhulu imeko, negalelo kwizifo zengqondo ezinje ngoxinzelelo, uxinzelelo, okanye imania. I-Topamax inokuba neziphumo ebezingalunganga ze-neurocognitive kunye ne-neuropsychiatric, kubandakanya eli tyala Isifo esinganyangekiyo esibangelwa yi-Topamax . Izigulana kufuneka zilwazi utshintsho olukhulu kwiimvakalelo okanye kwiimvakalelo kwaye zifune unyango ukuba zifumana utshintsho kubuntu.

Ngaba i-Topamax ingabangela ukulahleka kwememori okungapheliyo?

I-Topamax inokudityaniswa nesifo sengqondo esixhalabisayo kwaye kufuneka isetyenziswe ngononophelo kwi abaguli abadala . Okwangoku, khange kuqinisekiswe kakuhle ukuba iTopamax inokubangela ukulahleka kwememori ngokusisigxina.

I-Topamax kunye ne-metabolic acidosis

I-Topamax inokubangela isixa esigqithileyo seasidi egazini, ekuthiwa metabolic acidosis . Xa oku kusenzeka, umzimba uvelisa iasidi ngokukhawuleza okukhulu, kwaye izintso azinakho ukuqhubeka nokucoca. Ngesi sizathu, abaguli abanesifo sezintso okanye isifo sezintso kufuneka bajongwe ngokusondeleyo xa bethatha i-Topamax.

Kwiimeko ezimbi kakhulu, i-metabolic acidosis inokukhokelela ekonakaleni kwezintso, ukothuka okanye ukufa. Le meko inokubangela amathambo athambileyo okanye aphuke kunye namatye ezintso, acothise ukukhula kwabantwana, kwaye alimaze umntwana ngexesha lokukhulelwa. Iimpawu eziqhelekileyo ze-acidosis zibandakanya ukuphefumla ngokukhawuleza, uxinzelelo lwegazi oluphantsi, ukonqena nokudideka, kunye nokuphelelwa ngumdla.

Iingxaki zeTopamax kunye neliso

I-Topamax inokubangela iimeko zamehlo ezinzima ezinokubangela ukungaboni. I-Acute myopia, ebangela ukuba kude kufuphi, kunokubangela iintloko okanye ukungaboni kakuhle ngenxa yokunyuka koxinzelelo kwiso. Izigulana zikwachaze iimeko ezininzi zokuvalwa kweglaucoma yekona yesibini, ethi, ukuba ishiywe inganyangwa, ingakhokelela ekuphulukaneni nombono. Izigulana ezithatha i-Topamax kufuneka zifune iingcebiso zonyango ukuba zikhe zeva iintlungu zamehlo okanye ukungonwabi.

Izilumkiso zeTopamax

Musa ukuthatha i-Topamax ukuba:

• ayidibani nayo okanye nasiphi na isithako sayo
• usele utywala ngaphakathi kweeyure ezingama-6 zokuthatha i-Topamax
• unayo okanye unayo nayiphi na le miqathango:
  • I-glaucoma okanye ezinye iingxaki zamehlo
  • Isifo sezintso
  • I-metosis acidosis
  • Isifo semiphunga okanye iingxaki zokuphefumla
  • Iingxaki zemood, uxinzelelo, iingcinga zokuzibulala okanye isenzo
  • Ukuphazamiseka ekukhuleni
  • Amathambo athambileyo okanye amancinci (i-osteoporosis, i-osteomalacia)
• uceba ukukhulelwa okanye xa uncancisa

Indlela yokuziphatha yokuzibulala kunye nemibono

Njenge-anticonvulsant, i-Topamax inefuthe ngqo kwimisebenzi yobuchopho. Malunga 1 kwi-500 abaguli abathatha iziyobisi ezichasene ne-antiepileptic njenge-Topamax baxele ukuba bafumana iingcinga zokuzibulala kunye notyekelo, ngakumbi xa beqala unyango okanye ukutshintsha amanqanaba emilinganiselo.

Ngenxa yezi zinto zibekiweyo, izigulana kufuneka zijongwe rhoqo kwaye zifune unyango ukuba zinexhala, uloyiko, ukuqala okanye ukonyuka koxinzelelo. Nangona kunqabile, i-Topamax inokubangela notshintsho lwemood okanye lokuziphatha, njengobundlongondlongo okanye ubundlobongela, ukuphazamiseka, ukungakhathali, ukungakhathali, okanye ukucaphuka. Xelela umsebenzi wezempilo malunga naluphi na olu tshintsho.

I-Topamax kunye nokukhulelwa

Ukuba ukhulelwe okanye uceba ukukhulelwa, kuya kufuneka wazise ugqirha wakho ngokukhawuleza. I-Topamax inyusa umngcipheko wokukhubazeka komlomo njengokuzala komlomo kunye nenkalakahla ecandekileyo ngamaxesha ali-16 . Sebenzisa i-Topamax ngexesha lokukhulelwa kunokubangela nentliziyo, imiphunga, ukhakhayi, kunye nokungaqhelekanga kwamathambo njengemilenze engalunganga. Ezinye iziphene zokuzalwa zinokubandakanya ukuphakama koxinzelelo lwegazi kwimiphunga yosana olusandul 'ukuzalwa (PPHN), spina bifida, kunye nezinye iziphene zetyhubhu ye-neural, enokusongela ubomi.

Ngenxa yoko, kubalulekile ukuthatha amanyathelo okhuseleko ukunciphisa umngcipheko wezi ngxaki ngokulawula amathamo e-Topamax namanye amayeza ngexesha lokukhulelwa. Ngokukhawuleza ukuyeka amayeza afana neTopamax ngexesha lokukhulelwa akukhuthazwa, ke musa ukuhlengahlengisa idosi yakho okanye uyeke ukuyithatha ungakhange uthethe nogqirha wakho. I-Topamax kufuneka isetyenziselwe kuphela ukunyanga iimeko ezinokusongela ubomi kwizigulana ezikhulelweyo.

Unxibelelwano lweTopamax

Zininzi izinto ezithengiswa ekhawuntareni kunye nezamayeza asebenzisana neTopamax. Iziphumo ebezingalindelekanga zokunxibelelana nokusetyenziswa kweziyobisi ukusuka kubumnene ukuya kubunzima, zinika enye okanye enye isebenze ngokungaphantsi. Buza ugqirha ngaphambi kokuba uthathe i-Topamax ukuba ukwelinye lala mayeza:

• Iipilisi zokulawula inzala: I-Topamax inokunciphisa amandla kunye nefuthe lokukhulelwa komlomo okanye iziyobisi ezinqamleza ukuya exesheni ezine-estrogen. Ifom yokuthintela ulawulo lokuzalwa njengekhondom okanye i-diaphragm ene-spermicide indlela engcono yokukhusela ngelixa uthatha i-Topamax.
• Ukuhlutha iziyobisi: Tegretol (carbamazepine), Dilantin (phenytoin), Depakote (valproate), lamotrigine, kunye ne phenobarbital kunokunciphisa amanqanaba kunye neziphumo zeTopamax emzimbeni wakho. Ukuthatha i-Depakote (valproate) ngokudibeneyo ne-Topamax kunokuphakamisa amanqanaba e-ammonia egazini lakho. Ukuba oku kuyenzeka, unokufumana ukudideka, ukuphazamiseka, okanye ube nengxaki yokucinga.
• Iicarbonic anhydrase inhibitors: Amachiza afana neacetazolamide, dichlorphenamide, methazolamide, kunye ne-dorzolamide zinokunyusa umngcipheko wamatye ezintso xa zithathwa kunye neTopamax.
• Iyeza lokunyanga: Ezinye iziyobisi ezichaseneyo ezifana ne-diphenhydramine, i-chlorpheniramine, i-hydroxyzine inokunyusa umngcipheko weziphumo ebezingalindelekanga ezinje ngesiyezi, ukulala, okanye ingxaki yokujonga.
• Ukuphelisa iintlungu: Izigulana ezithatha i-Topamax zinokufumana ukozela, isiyezi, okanye ingxaki yokucinga xa imiselwe ngokudibeneyo kunye neziyobisi ezinjenge-hydrocodone, i-oxycodone, i-morphine, okanye i-hydromorphone.
• Amayeza ebipolarI-Topamax inokunyusa amanqanaba e-lithium emzimbeni xa ithathwa kunye.
• Iziyobisi zeswekile: I-Glyburide okanye i-pioglitazone inokungasebenzi kakuhle ekulawuleni iswekile yegazi ukunyanga isifo seswekile. Ukuthatha i-metformin kunye ne-Topamax kunokuba yingozi, ngakumbi ukuba isigulana sine-metabolic acidosis.

Ngaba ungasela ikhafeyini kunye neTopamax?

I-Topamax inokunyusa izinga lokukhutshwa kwe-caffeine, enokunciphisa ukusebenza kwayo emzimbeni, kodwa ngokubanzi kukudibanisa okukhuselekileyo.

Yintoni endifanele ndiyidle ngelixa ndithatha i-Topamax?

Ungathatha i-Topamax kunye okanye ngaphandle kokutya. Ekubeni enye yezona ziphumo ezibi kakhulu zokuthatha i-Topamax yi-metabolic acidosis, kuphephe ukutya i-ketogenic (i-carbohydrate ephantsi, iprotein eyonyukayo) yokutya. Ukutya ukutya okukhuthaza i-ketosis kunokunyusa umngcipheko wamatye ezintso, anokuqhubela phambili ukurhafisa izintso zakho.

Indlela yokuphepha iziphumo ebezingalindelekanga zeTopamax

Ngolwazi oluthe kratya lweziyobisi, funda i- Isikhokelo samayeza e-Topamax ngaphambi kokuqala unyango lwakho.

1. Ukuba ufumana nayiphi na imiphumo emibi, qhagamshelana nomboneleli wakho wezempilo. Uvavanyo oluhambelanayo lwe-serum lokujonga rhoqo ukusebenza kwezintso kunye nesibindi, umzekelo, kunokunciphisa umngcipheko weengxaki ezinzima.
2. Lumka lonke unxibelelwano lweziyobisi. Ezinye iziyobisi ezinje ngomlomo zokuthintela ukukhulelwa azisebenzi kakuhle xa zithathwa ngeTopamax, kwaye ezinye, njengeyeza lokungezwani komzimba, zinokunyusa iziphumo ebezingalindelekanga zeTopamax.
3. Musa ukuthatha i-Topamax kwisithuba seeyure ezintandathu usela utywala.
4. Gwema ukusebenzisa oomatshini abanzima, ukuqhuba, okanye ukwenza eminye imisebenzi eyingozi ukuba i-Topamax ikwenza wozele okanye utyhafe.
5. Sela amanzi amaninzi kwaye wenze umgudu wokuphepha ukuphelelwa ngamanzi emzimbeni kunye nokuqhinwa. Oku kunokunceda ukunciphisa umngcipheko wokwenziwa kwamatye ezintso, anokunceda ekuthinteleni i-metabolic acidosis.
6. Gwema ukulandela ukutya kwe-ketogenic ukukhusela ukukhula kwamatye eentso kunye ne-acidosis ye-metabolic.
7. Funa unyango olukhawulezileyo ukuba uphawula naluphi na utshintsho olwenzekayo ngesiquphe okanye ukukhula koxinzelelo okanye ukucinga ngokuzibulala.
8. Ukuba ungumfazi kwizicwangcisi zomlomo, cinga ngokusebenzisa enye indlela yothintelo ukukhusela ukukhulelwa. Leyo yenye yeendlela ezifanelekileyo zokuthintela umngcipheko weziphene zokuzalwa ezinxulumene nokuthatha i-Topamax.
9. Ukuba uphosa idosi, yithabathe kwangoko xa ukhumbula. Ukuba phantse lixesha ledosi yakho elandelayo, yeqa kwaye uthathe idosi ezayo. Sukuthatha isixa esiphindwe kabini ukwenza idosi ephosiweyo.
10. Ungayeki ukuthatha i-Topamax ngokukhawuleza, njengoko oko kunokubangela ukuxhamla, nangona ungenayo ngaphambili. Ukuba ufuna ukuyeka ukuthatha i-Topamax, ugqirha wakho uya kunciphisa ngokuthe ngcembe idosi yakho ukuze akukhusele ngokukhuselekileyo kunyango.

Nini ukubona ugqirha kwiziphumo ebezingalindelekanga zeTopamax

Iziphumo ezininzi zeTopamax zinokuba nzima kwaye zisongele ubomi. Yazisa ukhathalelo lwakho lwempilo kwaye ufune unyango kwangoko ukuba uqala ukufumana nayiphi na kuzo, ngakumbi ezo zithathwa njengezinzulu.