ICymbalta vs.Lyrica: Umahluko, ukufana, kwaye yeyiphi efanelekileyo kuwe
Iziyobisi ngokuchasene neCymbalta yeziyobisi kunye neLyrica zombini ziqhele ukumiselwa ukuba zinyange iintlungu zemisipha kunye nentliziyo. Sithelekisa icala elinye nelinye, ukuze uthathe isigqibo nogqirha wakho loluphi ukhetho olulungele wena.Ukujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
ICymbalta kunye neLyrica ziphatha iimeko ezahlukeneyo zempilo, kodwa zozibini unyango oluvunyiweyo lwesifo seswekile se-peripheral neuropathy kunye ne-fibromyalgia. ICymbalta yi-serotonin norepinephrine reuptake inhibitor (SNRI) ngelixa iLyrica iyi-analgesic kunye ne-anticonvulsant. Zisebenza ngokwahlukileyo kodwa zombini zinokusetyenziselwa ukunyanga iintlungu zemisipha kunye nentliziyo. Sebenzisa esi sikhokelo ukuthelekisa iCymbalta kunye neLyrica kwaye ufunde okungakumbi ngendlela abasebenza ngayo, iimeko abazinyangayo, kunye neziphumo ebezingalindelekanga ezinokubakho.
Nguwuphi umahluko ophambili phakathi kweCymbalta neLyrica?
ICymbalta (i-duloxetine) sisiyobisi esikhutshwa ngugqirha esisetyenziselwa ukunyanga iingxaki ezahlukeneyo kubandakanya isifo seswekile kunye ne-fibromyalgia. Mhlawumbi isaziwa ngokuxhaphakileyo njengophawu lokunyanga uxinzelelo kunye noxinzelelo ngokubanzi. Ihlelwe njenge-serotonin norepinephrine reuptake inhibitor (SNRI) kwaye isebenza ngokwandisa i-serotonin kunye ne-norepinephrine, ii-neurotransmitters ezimbini ezaziwa ngendima yazo kwimood nakwisimo. Indima yayo ekupheliseni iintlungu kucingelwa ukuba kungenxa yesenzo sayo kwi-serotonin kunye ne-norepinephrine.
Ezinye ii-SNRI ezinje ngePristiq (desvenlafaxine), i-Effexor (venlafaxine), kunye ne-Savella (milnacipran) azivunyelwanga kwizalathiso ezinxulumene nentlungu ye-neuropathic. I-cymbalta ifumaneka kwiifomsile zomlomo kumandla we-20 mg, 30 mg, 40 mg, kunye ne-60 mg.
ILyrica (pregabalin) sisiyobisi esikhutshiweyo esivunyiweyo kunyango lwesifo seswekile kunye ne-fibromyalgia. ILyrica ikwanazo nezinye izinto ezibonisa iingxaki ezinje ngokuxhuzula kunye nezinye iintlobo zentlungu ye-neuropathic. I-Lyrica ihlelwa njenge-analgesic, okanye i-reliever pain, kunye ne-anticonvulsant. ILyrica isebenza ngokucotha ukuhambisa umqondiso kwiindlela zemithambo-luvo. Iyafana ngekhemikhali nelinye ichiza, iNeurontin (gabapentin).
ILyrica ithathwa njengesixhobo esilawulwayo yiArhente yokuNyanzeliswa kweziyobisi (i-DEA) ngenxa yokuxhomekeka kwayo kunye nokusetyenziswa gwenxa. ILyrica ixhomekeke kwimanyano kunye nakurhulumente ukumisela imithetho yezinto ezilawulwayo.
ILyrica ifumaneka njengephilisi yomlomo ngeendlela ezahlukeneyo zamandla kubandakanya i-25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, kunye ne-300 mg. Ikwafumaneka njengesisombululo somlomo se-20 mg / ml kunye neepilisi zokukhupha ezandisiweyo kwi-82.5 mg, 165 mg, kunye ne-330 mg.
| Umahluko ophambili phakathi kweCymbalta kunye neLyrica | ||
|---|---|---|
| ICymbalta | ILyrica | |
| Iklasi yeziyobisi | ISNRI | I-analgesic / i-anticonvulsant |
| Uhlobo lweBrith / generic | Brand kunye generic ziyafumaneka | Brand kunye generic ziyafumaneka |
| Ngubani igama eliqhelekileyo? | Duloxetine | IPregabalin |
| Zeziphi iifom eza nalo iziyobisi? | Iphilisi | Ngokukhawuleza kunye nokukhululwa kweepilisi, isisombululo somlomo |
| Ithini idosi esemgangathweni? | 60 mg kanye yonke imihla | 50- 100 mg kathathu yonke imihla |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide | Ixesha elide |
| Ngubani oqhelekileyo usebenzisa amayeza? | Ulutsha kunye nabantu abadala | Abantwana kunye nolutsha (ukuxhuzula kuphela), abantu abadala |
Imiqathango ephathwa yiCymbalta neLyrica
ICymbalta inezinto eziqhelekileyo ezisetyenziswayo kuluhlu olubanzi lweempawu. Isetyenziselwa unyango lokudakumba kunye nokudakumba ngokubanzi. Kukwabonakalisiwe kunyango lwe-fibromyalgia, iintlungu ezinxulunyaniswa nesifo seswekile, kunye nentlungu engapheliyo enxulunyaniswa nokuphazamiseka kwemisipha njenge-osteoarthritis kunye nentlungu engapheliyo. ICymbalta ngamanye amaxesha isetyenziselwa ngaphandle kwelebheli ukunyanga uxinzelelo lomchamo wokuchama (i-SUI). Ukusetyenziswa kwelebheli engasebenziyo kubhekisa ekusebenziseni umqondiso ekungakhange kuvunywe kuwo kuLawulo lwezoKutya kunye noLawulo lweziyobisi (FDA).
ILyrica isetyenziswa njenge-analgesic kwi-neuropathic enxulumene neentlungu ezinje ngesifo seswekile, i-postherpetic neuralgia, i-fibromyalgia, kunye nokwenzakala kwethambo lomqolo. ILyrica ikwamkelwe njengonyango olongezelelekileyo lokuthimba inxenye. ILyrica inezinto ezimbalwa ezisetyenziswayo ngaphandle kwelebheli, kubandakanya ukuphazamiseka koxinzelelo kwezentlalo kunye noxinzelelo ngokubanzi lokuphazamiseka.
| Imeko | ICymbalta | ILyrica |
| Intlungu yeswekile yesifo se-neuropathic | Ewe | Ewe |
| Iintlungu ezinxulunyaniswa ne-postherpetic neuralgia | Hayi | Ewe |
| Intlungu ehambelana nokulimala kwentambo yomgogodla | Hayi | Ewe |
| Intlungu engapheliyo yesifo semisipha | Ewe | Hayi |
| Fibromyalgia | Ewe | Ewe |
| Unyango oludibeneyo lokubamba ngokukodwa | Hayi | Ewe |
| Uxinzelelo olukhulu lokudakumba | Ewe | Hayi |
| Ukuphazamiseka koxinzelelo ngokubanzi | Ewe | Ngaphandle kwelebheli |
| Ukuphazamiseka koxinzelelo kwezentlalo | Hayi | Ngaphandle kwelebheli |
| Uxinzelelo ukungahambi kakuhle komchamo | Ngaphandle kwelebheli | Hayi |
Ngaba iCymbalta okanye iLyrica iyasebenza ngakumbi?
Iklinikhi engenamsebenzi ityala eyaziwa ngokuba yi-Combo-DN Study ithelekisa iziphumo zedosi ephezulu yeCymbalta kunye neLyrica kuphela, kunye nokudityaniswa kwabo kwizigulana ekungekho monotherapy kuzo ezingasebenziyo kunyango lwentlungu enxulumene nesifo seswekile. Olu pho nonongo lufumene ukuba ukuphuculwa kweentlungu kwakufana nezigulane kwiCymbalta kunye, eLyrica yedwa, kunye nokudibanisa kwezi zimbini. Ngelixa isilelayo ukubonisa ukuba naliphi na iqela elinye lonyango liphezulu, ibinike ubungqina bokuba zontathu iindlela zokhetho zonyango zikhuselekile kwaye zisebenza kwintlungu enxulumene nesifo seswekile.
Ukuqwalaselwa okwahlukileyo ukufunda ugqibe kwelokuba iCymbalta inokusebenza ngakumbi ekunyangeni iintlungu ze-neuropathic ezinxulumene nesifo seswekile, nangona iLyrica inokuba nokunyamezeleka okungcono kwizigulana ngokwempembelelo yecala.
Oku ayenzelwanga ukuba yingcebiso yezonyango. Ngugqirha wakho kunye neqela lokhathalelo lwempilo kuphela elinokumisela ukuba loluphi unyango olulungele wena kunye nemeko yakho.
Ukufunda kunye nokuthelekisa iindleko kweCymbalta vs.Lyrica
ICymbalta lunyango olunikwa amayeza generic ahlala egutyungelwe zizicwangciso zeinshurensi zorhwebo kunye neMedicare. Ngaphandle kweinshurensi, ukuhanjiswa kwenyanga enye kunokukuxabisa i-470 yeedola. Kunye ikhuphoni kwi-generic Cymbalta (Duloxetine Hcl), iindleko zakho zijikeleze i- $ 10.
ILyrica lunyango lonyango eligutyungelwe zizicwangciso ze-inshurensi zorhwebo kunye nezoNyango kwifom yesiqhelo. Ukuhanjiswa kwenyanga enye eLyrica kunokukuxabisa kangange- $ 287 ngaphandle kweinshurensi. Ikhuphoni uhlobo oluqhelekileyo unokunciphisa iindleko zakho zingaphantsi kwe- $ 15.
| ICymbalta | ILyrica | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Ubungakanani | 30, 60 mg njengezingxobo | 30, 75 mg njengezingxobo |
| I-Medicare copay eqhelekileyo | Iyahluka ngokuxhomekeke kwisicwangciso | Iyahluka ngokuxhomekeke kwisicwangciso |
| Ixabiso elilodwa | $ 8 + | $ 14 + |
Iziphumo eziqhelekileyo zeCymbalta vs.Lyrica
Iziphumo zesiphumo secala seCymbalta kunye neLyrica ziyahluka ngokwazo kwezinye iinkalo. Umzekelo, i umenzi yeCymbalta ixele ukuba inani lezigulana elinentloko ebuhlungu ngexesha lovavanyo lweklinikhi, ngelixa esi siganeko sichasene neLyrica kwaphela. Ukubila kunye nohudo kwaxelwa kwiCymbalta kodwa hayi ngeLyrica.
ILyrica inxulunyaniswa nesiyezi esikhulu kunye nokozela, kwaye oku kunokwenza ukuba kube nzima ukuqhuba kunye nokwenza imisebenzi yemihla ngemihla. ILyrica ikwanxulunyaniswe nombono ongacacanga, ukuzuza ubunzima, kunye nokugcinwa kwamanzi okuchaphazela umgangatho wobomi.
Oku ayenzelwanga ukuba ibe luluhlu olubandakanya konke lweziphumo ezibi. Ukuba ufumana ezi okanye ezinye iziphumo ebezingalunganga kwaye ziyakhathaza okanye azinyamezeleki, kuya kufuneka unxibelelane nommeli wakho.
| ICymbalta | ILyrica | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Isicaphucaphu | Ewe | 2. 3% | Hayi | n / A |
| Umlomo owomileyo | Ewe | 13% | Ewe | 5% |
| Ukubila | Ewe | 6% | Hayi | n / A |
| Urhudo | Ewe | 9% | Hayi | n / A |
| Ukuqunjelwa | Ewe | 9% | Ewe | 4% |
| Ukuqunjelwa sisisu | Hayi | n / A | Ewe | Mbini% |
| Ukuba nesiyezi | Ewe | 9% | Ewe | amashumi amabini ananye% |
| Ukozela | Ewe | 10% | Ewe | 12% |
| Intloko ebuhlungu | Ewe | 14% | Hayi | n / A |
| Ukunyusa uxinzelelo lwegazi | Ewe | Mbini% | Hayi | n / A |
| Ukunciphisa ukutya | Ewe | 7% | Hayi | n / A |
| Ukudumba kwemida | Hayi | n / A | Ewe | 9% |
| Ukutyeba kwakho | Hayi | n / A | Ewe | 4% |
| Edema | Hayi | n / A | Ewe | Mbini% |
| IAtaxia | Hayi | n / A | Ewe | 3% |
| Vertigo | Hayi | n / A | Ewe | 3% |
| Ukudideka | Hayi | n / A | Ewe | Mbini% |
| Umbono omfiliba | Hayi | n / A | Ewe | 4% |
Umthombo: ICymbalta ( Yonke imihla ILyrica ( Yonke imihla )
Ukudibana kweziyobisi neCymbalta vs.Lyrica
ICymbalta kufuneka isetyenziswe ngononophelo nezinye iziyobisi ze-serotonergic. Ukonyuka kwe-serotonin kunxulunyaniswe ne-serotonin syndrome. Iserotonin syndrome ibonakaliswa ziimpawu ezinjengeentloko, ukudideka, ukubila, isicaphucaphu, kunye norhudo. Amachiza eSerotonergic abandakanya i-serotonin reuptake inhibitors ekhethiweyo (i-SSRIs) enjenge-fluoxetine okanye i-paroxetine, isityalo esincedisa i-St. ILyrica ayinxibelelani namachiza e-serotonergic.
Zombini iCymbalta kunye neLyrica kufuneka zisetyenziswe ngononophelo nge-tricyclic antidepressants ezinje nge-amitriptyline kunye nortriptyline. Kuya kufuneka zisetyenziswe ngononophelo okanye zithintelwe nge-monoamine oxidase inhibitors (i-MAOIs) efana ne-selegiline.
Oku ayenzelwanga ukuba ibe luluhlu olubanzi lokunxibelelana kweziyobisi. Kuya kufuneka unxibelelane nosokhemesti okanye ugqirha wakho kuluhlu olupheleleyo.
| Iziyobisi | Iklasi yeziyobisi | ICymbalta | ILyrica |
| IAlmotriptan Eletriptan I-Oxitriptan | I-5HT Agonist / Triptans (iiarhente zentsholongwane) | Ewe | Hayi |
| Iityuwa zeAmphetamine Dexmethylphenidate Imethylphenidate | IiAmphetamines | Ewe | Ewe |
| Aripiprazole | Intshutshiso yengqondo | Ewe | Ewe |
| I-Aspirin Ibuprofen INaproxen Diclofenac | Izidakamizwa ezichasayo ezichasayo (i-NSAID) | Ewe | Hayi |
| Ibhayiprone | Ukuxhalaba | Ewe | Ewe |
| IFluoxetine Citalopram Paroxetine I-Escitalopram | SSRIs | Ewe | Hayi |
| IHydroxychloroquine | Aminoquinolone /Antimalarial | Hayi | Ewe |
| Umgca we-Linezolid | Zintsholongwane | Ewe | Hayi |
| Imetaxalone | Izihlunu zezihluli | Ewe | Ewe |
| IPimozide | Intshutshiso yengqondo | Hayi | Ewe |
| Selegiline IPhenelzine I-Rasagiline | I-Monoamine oxidase inhibitor (MAOI) | Ewe | Ewe |
| Wort eSt | Unyango lweherbal | Ewe | Hayi |
| I-Tramadol | Opiate iintlungu | Ewe | Ewe |
| Amitriptyline Clomipramine Doxepin Umgca weNortriptyline | I-Tricyclic yoxinzelelo | Ewe | Ewe |
Izilumkiso zeCymbalta kunye neLyrica
ICymbalta ayizukuvelisa ukuxolelwa kwangoko kwentlungu, ukuphazamiseka koxinzelelo, okanye ukuphazamiseka koxinzelelo. Kuya kuthatha ubuncinci iiveki ezimbini ukuqaphela naluphi na utshintsho kwizigulana ezininzi, kwaye ukuya kuthi ga kwiiveki ezine ukuya kwezintandathu ukuqonda isiphumo esipheleleyo sonyango. Musa ukuyeka ngaphambi kwexesha amayeza akho unenkolelo yokuba ayisebenzi ngaphandle kokuqala uthethe nommiseli wakho.
Izigulana ezinokudakumba zinokufumana ukonyuka koxinzelelo okanye iingcinga zokuzibulala nokuba ngaba bathatha amayeza oxinzelelo. Ezi meko zinokuba mandundu kude kube kufezekisiwe ukuxolelwa. ICymbalta inokunyusa umbono wokuzibulala kunye neengcinga phakathi kolutsha nakwabantu abadala abancinci, ngakumbi kwinqanaba lokuqala lonyango. Ezi zigulana kufuneka zijongwe ngeliso elibukhali ukuba olu nyango lubonwa luyimfuneko kwezonyango. Utshintsho kunyango lunokuba yimfuneko ukuba iimpawu zivela ngesiquphe okanye ziba mandundu.
Iziyobisi Antiepileptic, ezifana ILyrica , ziye zanxulunyaniswa nembono yokuzibulala. Izigulana eziqala iLyrica kufuneka zibekwe esweni ukuvela okanye ukwanda koxinzelelo.
Kubekho iingxelo ukusilela kwesibindi, ngamanye amaxesha kuyabulala, kunye neCymbalta. Ezi meko zinokubonisa iintlungu zesisu kunye ne-enzyme zesibindi eziphakamileyo kunye okanye ngaphandle kwe-jaundice. Ukusetyenziswa kotywala kunokwandisa lo mngcipheko, kwaye ke olu dibaniso kufuneka luphetshwe.
ILyrica yinto elawulwayo ngenxa yokusetyenziswa gwenxa kwayo kunye nokusetyenziswa gwenxa. Isilumkiso kufuneka sisetyenziswe ngaphambi kokuqala unyango ngeNgoma kwisigulana esinembali yobuqu okanye yosapho yokusetyenziswa gwenxa kweziyobisi.
Imibuzo ebuzwa rhoqo malunga neCymbalta vs.Lyrica
Yintoni iCymbalta?
ICymbalta lunyango olunokusetyenziswa ukunyanga uxinzelelo olukhulu, ukuphazamiseka koxinzelelo ngokubanzi, kunye nokuphazamiseka kwentlungu kunye nemisipha. ICymbalta ikwiklasi yeziyobisi ezaziwa njenge-serotonin-norepinephrine reuptake inhibitors (SNRIs) ekhethiweyo. ICymbalta ifumaneka njengephilisi yomlomo kwi-20 mg, 30 mg, kunye namandla e-60 mg.
Yintoni iLyrica?
I-Lyrica yinyango yonyango echazwe njenge-analgesic kunye ne-anticonvulsant. Isetyenziselwa ukunyanga ukuxhuzula kunye neentlungu ezinxulumene nokuphazamiseka kwengqondo kunye ne-fibromyalgia. ILyrica iyafumaneka kumandla ohlukeneyo kuzo zombini kunye neepilisi ezikhutshiweyo, kunye nesisombululo somlomo.
Ngaba iCymbalta kunye neLyrica ziyafana?
Ngelixa iCymbalta kunye neLyrica ziluncedo kwiindidi ezifanayo zeengxaki ezinxulumene nentlungu, azifani. ICymbalta yi-antidepressant enezenzo eziphakathi ngezenzo zayo kwi-serotonin kunye ne-norepinephrine. I-Lyrica yi-analgesic kunye ne-anticonvulsant enezenzo ezithatha ukuhambisa isignali ye-nerve.
Ngaba iCymbalta okanye iLyrica ingcono?
ICymbalta kunye neLyrica zombini zibonisiwe ukuba zikhuselekile kwaye zisebenza zombini njenge-monotherapy kunye nonyango oludibeneyo. Loluphi unyango olulungele wena oluya kuxhomekeka kwimeko yakho, imbali yakho yezonyango, kwaye ugqirha wakho ucinga ukuba kukulungele ntoni.
Ndingayisebenzisa iCymbalta okanye iLyrica ngelixa ndikhulelwe?
I-FDA ithathela ingqalelo iCymbalta yokukhulelwa kodidi C, okuthetha ukuba khange kubekho zifundo zoluntu zaneleyo ukumisela ukhuseleko. NgeCymbalta, iimpembelelo ezingezizo ezomhlaba ziye zabonwa kwiintsana emva kolawulo lweCymbalta ngelixa ukhulelwe. Oku kubandakanya uxinzelelo lokuphefumla, ubunzima bokondla, kunye neenyikima. Ngokubanzi, nokuba leliphi na ichiza kufuneka lisetyenziswe kuphela kuncedo lomama ngokucacileyo ligqithile kumngcipheko wosana olungekazalwa.
Ndingayisebenzisa iCymbalta okanye iLyrica ngotywala?
Izigulana kufuneka zikuphephe ukuselwa kotywala xa kuthathwa iCymbalta okanye iLyrica. Utywala bunokunyusa iziphumo ezinetyhefu kuwo omabini amayeza kwaye kunokubangela ukonakala kwengqondo. NgeCymbalta ngokuthe ngqo, utywala bonyusa imeko yokukhubazeka kwesibindi.
