Eliquis vs Warfarin: Umahluko ophambili kunye nokufana

Iziyobisi Vs. Umhlobo

Usenokuba ukhe weva nge-Eliquis (apixaban) kunye ne-warfarin ukuba ukhe wafunyaniswa unesifo esivumela ukuba kusetyenziswe i-anticoagulant. Ngaphandle koko kwaziwa njengabacoci gazi, i-Eliquis kunye ne-warfarin zinokusetyenziselwa ukuthintela ukwenziwa kwamahlwili egazi. Ngokuthintela amahlwili egazi, la mayeza anokunciphisa umngcipheko weemeko ezinje nge-vein thrombosis (i-DVT) kunye nokubetha kwi-fibrillation ye-atrial. Ngelixa omabini la mayeza enemisebenzi efanayo, ahluka ngeendlela ezininzi.

UEliquis

U-Eliquis (Yintoni u-Eliquis?) Igama lophawu lwe-apixaban. Isebenza njenge-inhibitor ekhethiweyo ye-factor Xa, icandelo elibalulekileyo kulwakhiwo lwe-clot. Ngokuthintela ngokuthe ngqo eli candelo, kuncitshiswe iplatelet kunye nophuhliso lwe-thrombus ethi ekugqibeleni inciphise ukujiya kwegazi.

I-Eliquis iboniswa ukunciphisa umngcipheko wokubetha kunye ne-systemic embolism kwizigulana ezine-nonvalvular atrial fibrillation. Ingasetyenziselwa ukuthintela nokunyanga i-vein thrombosis (DVT) kunye ne-pulmonary embolism (PE) kubantu abathile.

I-Eliquis inokulawulwa njenge-2.5 mg kunye ne-5 mg yeepilisi zomlomo. Okwangoku, akukho pilisi yomlomo yohlobo oluqhelekileyo ekhoyo. Idosi ekhuthazwayo iyahluka ngokuxhomekeke kwimeko yokunyangwa. Nokuba ungomelela kangakanani, ihlala ichazwa kabini ngosuku. Ukubeka iliso kumaxabiso elebhu kunye ne-INR akufuneki rhoqo ngala mayeza.

Uhlengahlengiso lweedosi kufuneka lwenziwe kwabo banobuncinci be-2 yezi mpawu zilandelayo: ubudala beminyaka engama-80 ubudala nangaphezulu, ubunzima bomzimba obungaphantsi kwe-60 kg (malunga ne-132 lbs), okanye i-serum creatinine okanye engaphezulu kwe-1.5 mg / dL . Ukusetyenziswa kwe-Eliquis akukhuthazwa kwizigulana ezikhulelweyo okanye abo banesifo esibi.

Ngaba ufuna elona xabiso lilungileyo ku-Eliquis?

Bhalisela izilumkiso zamaxabiso e-Eliquis kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

IWarfarin

IWarfarin (Yintoni iWarfarin?) Ligama eliqhelekileyo leCoumadin. Ithintela i-clotting yegazi ngokusebenza njengomchasi we-vitamin K. IVitamin K yinto ebalulekileyo efunekayo kunye nezinye izinto zokwenza amahlwili emzimbeni. Ngokuthintela ivithamin K, amahlwili amatsha angenakwenziwa.

I-Warfarin ibonakalisiwe ukunyanga nokukhusela ii-DVT kunye nee-PEs njenge-Eliquis. Isetyenziselwa ukunyanga kunye nokuthintela iingxaki zokugubungela ezinokuvela nge-atrial fibrillation kunye nokutshintsha kwevalvey yentliziyo. Ukongeza, i-warfarin inokunciphisa umngcipheko wexesha lokuhlaselwa sisifo sentliziyo kunye nokubetha emva kokuhlaselwa sisifo sentliziyo sokuqala.

Ngokungafaniyo ne-Eliquis, i-warfarin iyafumaneka njengeyeza eliqhelekileyo kwiipilisi zomlomo ezinamandla e-1 mg, 2 mg, 2.5 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7.5 mg, kunye no-10 mg. I-Warfarin dosing iyahluka kakhulu kuxhomekeke kwisibonakaliso sonyango. Ngenxa yoluhlu olubanzi lwamandla akhoyo, i-warfarin dosing iyaguquguquka kwaye iphakanyiswe ngokukodwa.

I-INR, okanye umlinganiso oqhelekileyo kwilizwe jikelele, kufuneka ubekwe esweni rhoqo xa usela la mayeza njengoko la manqanaba enovakalelo kutshintsho lwedosi, ukutya, kunye nezinye izinto. Uluhlu lwenqanaba lonyango lwe-INR oluqhelekileyo luphakathi kwe-2.0 kunye ne-3.0.

Fumana ikhadi lesaphulelo kwikhemesti

U-Eliquis vs Warfarin ecaleni nguThelekiso olusecaleni

I-Eliquis kunye ne-warfarin zimbini ii-anticoagulants ezineempawu ezifanayo. Banokwahluka okwahlukileyo kwindlela abasebenza ngayo kunye nokunxibelelana namanye amachiza. Oku kufana nokwahluka kunokujongwa ngezantsi.

UEliquis	IWarfarin
Umiselwe i
Stroke kunye ne-embolism emngciphekweni kwi-nonvalvular atrial fibrillation Unyango lwe-DVT kunye ne-PE I-DVT kunye ne-PE prophylaxis	Uthintelo kunye nonyango lweengxaki ezivela kwi-fibrillation ye-atrial kunye nokutshintshwa kwentliziyo yevalve Ukwehlisa umngcipheko wokufa, ukuhlaselwa yintliziyo ephindaphindayo, kunye nesifo emva kokuhlaselwa yintliziyo Unyango lwe-DVT kunye ne-PE I-DVT kunye ne-PE prophylaxis
Ulwahlulo lweziyobisi
I-Anticoagulant Inqaku Xa inhibitor	I-Anticoagulant Umchasi weVitamin K
Umenzi
Bristol-Myers Squibb ixabiso lembali	Ngokwesiqhelo
Iziphumo eziqhelekileyo
Ukopha Ukuthuthuzela Iintsini zokopha Ukuba sexesheni okunzima Impumlo iyopha	Ukopha Ukuthuthuzela Iintsini zokopha Ukuba sexesheni okunzima Impumlo iyopha Alopecia Irhashalala
Ngaba ikhona igeneric?
Akukho generic ikhona	Akukho generic ikhona
Ngaba ihlawulwa yi-inshurensi?
Iyahluka ngokomboneleli wakho	Iyahluka ngokomboneleli wakho
Iifom zedosi
Ithebhulethi yomlomo	Ithebhulethi yomlomo
Ixabiso leMali eliPhakathi
497 (iipilisi ezingama-60)	43 (iipilisi ezili-100)
Ixabiso lesaphulelo esisodwa
Ixabiso likaEliquis	Ixabiso leWarfarin
Ukusebenzisana kweziyobisi
P-gp kunye ne-CYP3A4 inhibitors I-P-gp kunye ne-CYP3A4 inducers Iintsholongwane Iiarhente zeantiplatelet Ii-NSAID	CYP2C9 inhibitors I-CYP2C9 inducers CYP1A2 inhibitors I-CYP1A2 inducers CYP3A4 inhibitors I-CYP3A4 inducers Iintsholongwane Iiarhente zeantiplatelet Ii-NSAID SSRIs
Ngaba ndingasebenzisa ngelixa ndicwangcisa ukukhulelwa, ukukhulelwa, okanye ukuncancisa?
U-Eliquis ukwinqanaba lokukhulelwa B. Akukho zifundo zinikezelweyo zokuvavanya i-Eliquis kubafazi abakhulelweyo. Nxibelelana nogqirha malunga namanyathelo oza kuwathatha ukuba ucwangcisa ukukhulelwa okanye ukuncancisa.	I-Warfarin ikudidi lokukhulelwa X. I-Warfarin inokubangela ukwenzakala komntwana kwaye iyaphikiswa ukuba isetyenziswe kubafazi abakhulelweyo.

Isishwankathelo

I-Eliquis kunye ne-warfarin ngamayeza amabini anticoagulant asebenza ngeendlela ezahlukeneyo. U-Eliquis usebenza njenge-Xa inhibitor ngelixa i-warfarin sisichasi se-vitamin K. Nangona zahlukile kwindlela yokusebenza, zivelisa iziphumo ezifanayo zokunciphisa amahlwili egazi.

Zombini i-Eliquis kunye ne-warfarin zineempawu ezifanayo zokunyanga nokukhusela i-thrombosis (i-DVTs kunye nee-PEs). Ngelixa i-Eliquis inokuthintela iingxaki ezivela kwi-nonvalvular atrial fibrillation, i-warfarin inokunyanga kunye nokukhusela iingxaki ezivela kwi-fibrillation ye-atrial kunye / okanye ukutshintshwa kwe-valve yentliziyo. I-Warfarin ikwavunyiwe yi-FDA ukuthintela ukufa kwentliziyo, ukubetha, kunye nokuhlaselwa sisifo sentliziyo kwabo sele befumene isifo sentliziyo.

I-Eliquis inokukhethwa kumntu ongafuniyo ukuba abekwe esweni rhoqo kwiilebhu ze-INR. Ngokwetyala lika-ARISTOTLE, u-Eliquis ukwabonisiwe ukuba unokwehla okukhulu kwengozi yokufa icala, umngcipheko omncinci wokopha kakhulu, kunye nokunciphisa ukusweleka kwabantu xa kuthelekiswa ne-warfarin. Elinye icala elisezantsi ku-Eliquis lelona xabiso liphezulu ngenxa yokunqongophala kokuveliswa okuqhelekileyo okufumaneka kwintengiso.