IGlipizide vs metformin: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
I-Glipizide kunye ne-metformin ngamayeza amabini asetyenziselwa ukunyanga i-Type 2 diabetes mellitus. Abantu abanesifo seswekile sohlobo lwe-2 banengxaki yehomoni insulin, enoxanduva lokuhambisa iswekile yegazi (iswekile) kwiiseli zomzimba zamandla. Xa i-insulin ingasebenzi kakuhle, ukumelana ne-insulin kunokukhula kwaye kukhokelele kumanqanaba eswekile anyukayo, anokukhokelela kwezinye iingxaki zempilo. IGlipizide kunye ne-metformin inokunceda ukulawula amanqanaba aphezulu eswekile ukunciphisa umngcipheko weengxaki kwisifo seswekile.
Xa kuthelekiswa neearhente ezintsha, i-glipizide kunye ne-metformin ziyeza ezingabizi mali ininzi. Zombini zisetyenziselwa ulawulo lwexesha elide lohlobo 2 lweswekile. Nangona banokufana kwiziphumo zizonke, i-glipizide kunye ne-metformin zinomahluko okwahlukileyo, ngakumbi kwindlela abasebenza ngayo, iziphumo ebezingalindelekanga ezinokubakho, kunye nokunxibelelana kweziyobisi.
Nguwuphi umahluko ophambili phakathi kwe-glipizide kunye ne-metformin?
IGlipizide
IGlipizide ligama eliqhelekileyo leGlucotrol. Inxalenye yodidi lwamayeza abizwa ngokuba yi-sulfonylureas, kwaye ayasebenza ukukhuthaza ukugcinwa kwe-insulin ukusuka kwipancreas. Ukwanda kwe-insulin kunceda ukunciphisa amanqanaba eglucose egazini emzimbeni.
IGlipizide iyafumaneka njenge-5 mg okanye 10 mg ithebhulethi yomlomo. I-generic glipizide iza neepilisi zokukhupha ezandisiweyo kumandla e-2.5 mg, 5 mg, kunye no-10 mg. IGlipizide ihlala ithathwa kanye yonke imihla ngaphambi kwesidlo sakusasa.
IMetformin
I-Metformin ligama elenziwa lafana neGlucophage okanye iRiomet, kwaye lelodidi lweziyobisi ekuthiwa zii-biguanides. IMetformin isebenza ukunyanga udidi 2 lweswekile ngokuthi ukunciphisa imveliso yeglucose esibindini kunye nokunciphisa ukufunxeka iswekile emathunjini. Ikwasebenza ngokwandisa uvakalelo lwe-insulin kunye nokwandisa ukuthathwa kweswekile kwizicwili zomzimba.
I-Metformin ifumaneka njengecwecwe lomlomo kumandla e-500 mg, 850 mg, kunye ne-1000 mg. Iipilisi zemetformin ezandisiweyo ziyafumaneka kwaye ziyilelwe ukuba zithathwe kanye yonke imihla. Ukukhutshwa kwangoko kwe-metformin kuhlala kumiselwe ukuba kuthathwe kabini yonke imihla.
| Umahluko ophambili phakathi kwe-glipizide kunye ne-metformin | ||
|---|---|---|
| IGlipizide | IMetformin | |
| Iklasi yeziyobisi | Isulfonylurea | IBiguanide |
| Uhlobo lweBrith / generic | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo |
| Ngubani igama lophawu? | Iswekile yeglucotrol | Iswekile yeglucophage IRiomet |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo | Ithebhulethi yomlomo |
| Ithini idosi esemgangathweni? | 5 mg kanye yonke imihla ngaphambi kwesidlo sakusasa. Isisombululo sinokuhlengahlengiswa ngokwempendulo kunye nemeko yonyango. Idosi ephezulu ye-40 mg ngosuku. | I-500 mg kabini yonke imihla okanye i-850 mg kanye yonke imihla ngokutya. Isisombululo sinokuhlengahlengiswa ngokwempendulo kunye nemeko yonyango. Idosi ephezulu ye-2,550 mg ngosuku. |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide kulawulo lweswekile | Ixesha elide kulawulo lweswekile |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala abaneminyaka eli-18 nangaphezulu | Abantu abadala nabantwana abaneminyaka eli-10 nangaphezulu |
Iimeko eziphathwe nge-glipizide kunye ne-metformin
I-Glipizide kunye ne-metformin zombini zivunyelwe yi-FDA ukunyanga i-Type 2 diabetes mellitus. Ukulawula amanqanaba eswekile egazi kunokunceda ukunciphisa umngcipheko weengxaki kwisifo seswekile. Ezi ngxaki zinokubandakanya isifo sentliziyo, isifo sezintso, isifo sesibindi, ukonakala kwamehlo kunye nosulelo lwenyawo.
I-Metformin ngamanye amaxesha isetyenziswa ngaphandle kwelebheli ukunyanga ezinye iimeko, ezinje ngesifo seswekile sokukhulelwa, okanye isifo seswekile ngexesha lokukhulelwa, kunye I-polycystic ovary syndrome (i-PCOS) . I-Metformin ikwasetyenziselwa ngaphandle kwelebheli ukunyanga ukutyeba okubangelwa sisiphumo secala lamayeza athile antipsychotic.
Akukho zifundo zibalulekileyo zenziweyo kwilebheli engasetyenziswanga ye-glipizide.
| Imeko | IGlipizide | IMetformin |
| Uhlobo lwe-2 yeswekile | Ewe | Ewe |
| Isifo seswekile | Hayi | Ngaphandle kwelebheli |
| Isifo sePolycystic ovary | Hayi | Ngaphandle kwelebheli |
| Ukutyeba ngenxa yokunyanga ngokunyanga | Hayi | Ngaphandle kwelebheli |
Ngaba i-glipizide okanye i-metformin isebenza ngakumbi?
I-Glipizide kunye ne-metformin zombini amayeza eswekile asebenzayo ukuphucula ulawulo lwe-glycemic kubantu abane-Type 2 diabetes. Zingasetyenziswa njenge-monotherapy okanye njengepilisi yokudibanisa ebizwa ngokuba yiMetaglip. I-Glipizide kunye ne-metformin zisebenza kakuhle xa zisetyenziswa kwisidlo esifanelekileyo kunye nerejimeni yomthambo.
I-Metformin ihleli iyeza lonyango lokuqala kuhlobo lwe-2 yeswekile, ngokwezikhokelo ezivela Umbutho weSwekile yaseMelika . Xa kuthelekiswa nokusebenza kwabo bane-Type 2 yeswekile kunye nesifo se-coronary disease, i-metformin inciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokubetha ngaphezu kwe-glipizide. Ngokokungaboni kabini, uvavanyo lweklinikhi, i-metformin ibonise enkulu ukusebenza kwentliziyo kune-glipizide emva kweminyaka emihlanu.
Enye ityala lokuthelekisa ifumanise ukuba i-metformin ibonelela ngolawulo lweswekile olungcono kune-glipizide. Abo bathatha i-metformin kwisifundo babezila ukutya ngcono amanqanaba eglucose kune-glipizide emva kwe-24, 36, kunye ne-52 iiveki. Abo bathatha i-metformin nabo banamazantsi Inqanaba le-HbA1c Kunabo bathatha i-glipizide emva kweeveki ezingama-52. I-Metformin ibangele ukwehla kobunzima kunye ne-glipizide ibangele ukutyeba kubathathi-nxaxheba abaphathwayo.
Nxibelelana nomboneleli wezempilo malunga nonyango olungcono kuwe ukuba unodidi 2 lweswekile. Kuxhomekeke kwimeko yakho yonyango iyonke, amanqanaba eswekile yegazi , kunye namanye amayeza onokuthi uwathathe, elinye ichiza linokukhethwa kunelinye.
Ngaba ufuna elona xabiso lilungileyo kwiGlipizide?
Bhalisela izilumkiso zamaxabiso eGlipizide kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Umyinge kunye nokuthelekiswa kwexabiso le-glipizide vs.metformin
IGlipizide lunyango oluqhelekileyo lwe-antidiabetic oluhlala lugqunywe yi-Medicare kunye nezicwangciso zeinshurensi. Unikezelo oluqhelekileyo lwe-glipizide, i-copay inokusukela kwi- $ 0 ukuya kwi- $ 9. Ixabiso eliphakathi lokuthengisa nge-glipizide linokuba malunga ne- $ 30. Ikhuphoni ye-singleCare glipizide inokunceda ukuthoba iindleko ukuya kwi- $ 4 kwii-pharmacy ezithatha inxaxheba.
I-Metformin sisiyobisi esichazwa ngokuchaseneyo neswekile esigutyungelwa luninzi lwezonyango kunye nezicwangciso zeinshurensi. I-Medicare copay eqhelekileyo inokuvela kwi- $ 0 kuye kwi-8 yeedola, kwaye ixabiso lokuthengisa linokujikeleza i- $ 25 ngokuxhomekeke kwikhemesti oya kuyo. I-coupon ye-metformin evela kwi-SingleCare inokunciphisa ixabiso ukuya kuthi ga kwi-4 yeedola.
| IGlipizide | IMetformin | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Umthamo osemgangathweni | 5 mg kanye yonke imihla (ubuninzi beepilisi ezingama-60) | I-500 mg kabini yonke imihla (ubuninzi beepilisi ezingama-60) |
| I-Medicare copay eqhelekileyo | $ 0- $ 9 | $ 0- $ 8 |
| Ixabiso elilodwa | $ 4 + | $ 4 + |
Iziphumo eziqhelekileyo zeglipizide vs.metformin
Iziphumo zixhaphakileyo zeglipizide zibandakanya iswekile esezantsi yegazi ( hypoglycemia ), ukuqhina, urhudo, isicaphucaphu, kunye nesiyezi.
Iziphumo eziqhelekileyo ezichaphazelekayo ze-metformin zibandakanya isifo sohudo, isicaphucaphu, ubuthathaka (asthenia), i-hypoglycemia kunye nentloko.
Iziphumo ebezingalindelekanga ezimandundu ze-glipizide zibandakanya i-hypoglycemia kunye ne-hemolytic anemia. Iziphumo ezibi kakhulu ze-metformin zibandakanya I-lactic acidosis kunye nokusilela kwe-vitamin B12. Nxibelelana nomboneleli wezempilo malunga nezinye iziphumo ezinokubakho ze-glipizide okanye i-metformin.
| IGlipizide | IMetformin | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Hypoglycemia | Ewe | * | Ewe | 1% –5% |
| Ukuqunjelwa | Ewe | * | Hayi | - |
| Urhudo | Ewe | * | Ewe | 53% |
| Isicaphucaphu | Ewe | * | Ewe | 26% |
| Ukuba nesiyezi | Ewe | * | Hayi | - |
| Ubuthathaka | Hayi | - | Ewe | 9% |
| Intloko ebuhlungu | Ewe | * | Ewe | 6% |
* akuxelwa
Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( IGlipizide ), Yonke imihla ( IMetformin )
Ukudibana kweziyobisi glipizide vs.metformin
IGlipizide kunye ne-metformin inokusebenzisana namayeza afanayo. Amachiza athile anokunyusa iswekile esehla kwiziphumo ze-glipizide kunye ne-metformin, enokuthi inyuse umngcipheko we-hypoglycemia. La machiza aquka ezinye iziyobisi ezichasene nesifo seswekile kunye noxinzelelo oluthile lokwehlisa uxinzelelo lwegazi njenge-ACE inhibitors kunye ne-angiotensin yohlobo lwe-II block blockers.
Amanye amachiza anokunciphisa ukusebenza kakuhle kwe-glipizide kunye ne-metformin, enokunciphisa iswekile yegazi. Ezi ziyobisi zingabandakanya i-calcium channel blockers, i-diuretics, i-corticosteroids, i-beta blockers kunye ne-contraceptive ngomlomo. Iimpawu zehypoglycemia zinokugqunqwa ngelixa kuthathwa iibhlokhi ze-beta, ke kufuneka zibekwe esweni kubantu abathatha la mayeza.
I-Metformin inokusebenzisana ne-carbonic anhydrase inhibitors, njenge-topiramate kunye ne-zonisamide, enokuthi inyuse umngcipheko we-lactic acidosis. Amanye amachiza afana ne-ranolazine kunye ne-vandetanib banokusebenzisana ne-metformin kwaye baphazamise ukupheliswa kwayo kwizintso. La machiza anokunyusa amanqanaba e-metformin egazini kwaye andise umngcipheko we-lactic acidosis.
| Iziyobisi | Iklasi yeziyobisi | IGlipizide | IMetformin |
| Ipiramidi ephezulu Zonisamide Acetazolamide Dichlorphenamide | Iicarbonic anhydrase inhibitors | Hayi | Ewe |
| Ranolazine | Izinto ezingafunekiyo | Hayi | Ewe |
| IVandetanib | I-Tyrosine kinase inhibitors | Hayi | Ewe |
| I-insulin Isitagliptin Dulaglutide Dapagliflozin Imiglitol | Iiarhente ezichasene nesifo seswekile | Ewe | Ewe |
| Lisinopril Enalapril ICaptopril | I-ACE inhibitors | Ewe | Ewe |
| Candesartan Irbesartan ILosartan | Angiotensin II iiarhente zokuvimba | Ewe | Ewe |
| Amlodipine UNicardipine I-Verapamil | Isithinteli seCalcium channel blocker | Ewe | Ewe |
| IHydrocortisone IPrednisone Imethylprednisolone | ICorticosteroids | Ewe | Ewe |
| IHydrochlorothiazide IChlorthalidone Indapamide Furosemide Bumetanide | Womchamo | Ewe | Ewe |
| Atenolol Bisoprolol Imitha | Ibhlokhi yeBeta | Ewe | Ewe |
| Ukudibana kwee-estrogens I-Ethinyl estradiol I-Levonorgestrel Indawo encinci | I-Estrogens kunye nezinto zokucwangcisa zomlomo | Ewe | Ewe |
Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi
Izilumkiso ze-glipizide kunye ne-metformin
Ngenxa yokunciphisa iswekile, i-glipizide kunye ne-metformin zithwala umngcipheko we-hypoglycemia, okanye amanqanaba eswekile esezantsi egazini. Umngcipheko we-hypoglycemia uyanda xa i-glipizide okanye i-metformin ithathwa kunye nezinye ii-antidiabetic agents. Ukuzilolonga ixesha elide kunye nokusela utywala nako kunokuwunyusa umngcipheko. Iimpawu zehypoglycemia zibandakanya ukoyika, ukubila, ukubetha kwentliziyo okukhawulezayo kunye nokudideka.
Abantu abathile abane-glucose 6-phosphate dehydrogenase (G6PD) ukusilela kwabo basemngciphekweni wokuphuhliswa kwe-hemolytic anemia ngelixa bethatha i-glipizide. Nangona kunjalo, abanye abantu ngaphandle kwe-GP6D ukusilela banokuphucula i-hemolytic anemia.
Ukusetyenziswa kwe-metformin kunokukhokelela kwi-lactic acidosis enxulumene ne-metformin. Olu hlobo lwe-lactic acidosis ihlala inxulunyaniswa ne-overdose ye-metformin. Nangona kunjalo, kukho umngcipheko we-lactic acidosis kubantu abanesibindi esinciphileyo okanye imisebenzi yezintso. Iimpawu kunye neempawu ze-lactic acidosis zibandakanya isicaphucaphu, uxinzelelo lwegazi oluphantsi, kunye nentlungu esiswini.
Qhagamshelana nomboneleli wezempilo malunga nezinye izilumkiso kunye nezilumkiso ezinxulumene ne-glipizide okanye i-metformin.
Imibuzo ebuzwa rhoqo malunga ne-glipizide vs metformin
Yintoni i-glipizide?
IGlipizide liyeza elenziwa lavela kudidi lweziyobisi ekuthiwa yi-sulfonylureas. Igama le-glipizide yiGlucotrol. I-Glipizide isebenza ngokwandisa ukukhutshwa kwe-insulin kwi-pancreas ukuya kumanqanaba eswekile esezantsi egazini. Iyafumaneka njengokukhutshwa kwangoko kunye neepilisi zomlomo ezandisiweyo.
Yintoni imetformin?
I-Metformin yaziwa nangamagama egama eliqhelekileyo anje ngeRiomet kunye neGlucophage. Ikudidi lweziyobisi ezichasene nesifo seswekile ezibizwa ngokuba zii-biguanides. I-Metformin isebenza ngokwandisa ubuntununtunu be-insulin, ukunciphisa ukuveliswa kweswekile esibindini, kunye nokunciphisa ukufakwa kweglucose emathunjini. I-Metformin ifumaneka njengokukhutshwa kwangoko kunye nokukhululwa kwethebhulethi yomlomo.
Ngaba i-glipizide kunye ne-metformin efanayo?
IGlipizide kunye ne-metformin azifani. I-Glipizide yi-sulfonylurea ephatha i-Type 2 diabetes kubantu abadala kunye ne-metformin yi-biguanide ephatha uhlobo lwe-2 yeswekile kubantu abadala kunye nabantwana abaneminyaka eli-10 nangaphezulu. I-Glipizide kunye ne-metformin isebenza ngeendlela ezahlukeneyo kwaye ineedosi ezahlukeneyo.
Ngaba i-glipizide okanye i-metformin ibhetele?
I-Glipizide kunye ne-metformin zombini zisebenza ukunciphisa amanqanaba eglucose egazini kwabo bane-Type 2 diabetes. Ngokwe American Diabetes Foundation izikhokelo , I-metformin lunyango lokuqala lonyango lweswekile yohlobo lwe-2. I-Glipizide kunye ne-metformin ngamanye amaxesha inokuthathwa kunye kwezinye iimeko apho kufuneka isiphumo sokunciphisa iswekile enkulu. Ngokubanzi, elona chiza lilungileyo leswekile lixhomekeke kwimeko yakho yonke yonyango kunye nokuphendula kwichiza.
Ndingayisebenzisa i-glipizide okanye i-metformin ngelixa ndikhulelwe?
Xa kuthelekiswa ne-metformin, i-glipizide inokubanamandla aphezulu okubangela ityhefu ebusaneni. Ngokwezifundo zezilwanyana, i-metformin inokukhuseleka ukusetyenziswa ngexesha lokukhulelwa; kodwa akukho zifundo ziqinisekileyo ebantwini eziye zaqhutywa. Nxibelelana nomboneleli wezempilo ukumisela olona khetho lonyango olufanelekileyo xa ukhulelwe.
Ndingayisebenzisa i-glipizide okanye i-metformin ngotywala?
Akucetyiswa ukuba ubusele utywala kakhulu ngelixa uthatha i-glipizide okanye metformin . Ukusela utywala kunokubangela amanqanaba eswekile egazi kwaye kwenyuse umngcipheko wehypoglycemia okanye i-hyperglycemia. Utywala bunokunyusa umngcipheko wokuba I-lactic acidosis ngelixa ukwi-metformin.
Leliphi elona xesha lilungileyo losuku lokuthatha i-glipizide?
Elona xesha lilungileyo lokuthatha i-glipizide ngaphambi kokutya ukunciphisa umngcipheko we-hypoglycemia. Ukuba ithathwa kanye ngemini, i-glipizide iyacetyiswa ukuba ithathwe ngaphambi kwesidlo sokuqala sosuku.
Ngaba i-glipizide imbi kwizintso?
Uhlobo lwe-2 lwesifo seswekile olungalawulwayo lungakhokelela kwiingxaki ezinjengokonakala kwezintso. Nangona kunjalo, i-glipizide ayaziwa ukuba ibangele umonakalo kwizintso. Ukupheliswa kwe-glipizide kunokucothiswa kubantu abanomonakalo wezintso. Ukuqokelelwa kwe-glipizide kunokukhokelela kumngcipheko owandileyo wamanqanaba eswekile esezantsi yegazi.
Leliphi elona chiza likhuselekileyo kuhlobo 2 lweswekile?
I-Metformin ihlala ichazwa njengonyango lodidi lokuqala lweswekile yesi-2 kuninzi lwabantu. Kungenxa yokuba i-metformin ayibizi kakhulu, ikhuselekile, kwaye iyasebenza. Xa kuthelekiswa nezinye ii-antidiabetic agents, i-metformin inxulunyaniswa nayo amanqanaba asezantsi okanye afanayo eHbA1c . Ukusetyenziswa kwe-metformin kukwanxulunyaniswa neziganeko ezisezantsi ze-hypoglycemia kunezinye iziyobisi ezinjenge-sulfonylureas.
