ILosartan vs Valsartan: Umahluko ophambili kunye nokufana

Iziyobisi Vs. Umhlobo

ILosartan kunye ne-valsartan ngamayeza amabini asetyenziselwa ukunyanga uxinzelelo lwegazi. Zombini zihlelwa njenge-angiotensin receptor blockers (ARBs) ezisebenza ngendlela efanayo. La machiza asebenza ngokuthintela isenzo se-angiotensin II, imolekyuli yehomoni ebangela ukuba imithambo yegazi icuthe. Ngenxa yeli nyathelo, imithambo yegazi iyakwazi ukwandiswa enceda ukunciphisa uxinzelelo lwegazi kunye nokunciphisa uxinzelelo entliziyweni. Ngelixa omabini la mayeza esebenza ngokufanayo, bobabini baneyantlukwano ekufuneka beyazi.

ILosartan

ILosartan ligama eliqhelekileyo okanye elekhemikhali likaCozaar. Lunyango oluboniswe ukunyanga uxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi) kunye nesifo sesifo seswekile (isifo seswekile nephropathy). Kuyanceda ukunciphisa umngcipheko wokubetha kwizigulana ezithile.

ILosartan ifunxwe kakuhle emzimbeni kwaye ifikelela kumanqanaba aphezulu egazini kwiiyure ezi-4. I-metabolism, okanye idilizwe, yangena kwenye into esebenzayo enesiqingatha sobomi malunga neeyure ezi-6 ukuya kwezi-9. Le nkqubo yemetabolism ivela ikakhulu esibindini.

Iipilisi zomlomo eziqhelekileyo zeLosartan ziza ngamandla e-25 mg, 50 mg, kunye ne-100 mg. Ihlala ichithwe nge-50 mg kanye ngemini. Nangona kunjalo, oku kungahluka ngokuxhomekeke kwimeko yokuphathwa. Iziphumo zeziyobisi zinokufikelela kwiiyure ezingama-24.

Umsebenzi wezintso kufuneka ubekwe esweni xa usebenzisa i-losartan njengoko inokubangela ukonakala kwezintso kubantu abathile abasemngciphekweni. Aba bantu babandakanya abo banezifo zezintso ezinganyangekiyo, i-renal artery stenosis, kunye nokusilela kwentliziyo okuxineneyo. ILosartan inokubangela i-hyperkalemia, okanye amanqanaba aphezulu aphezulu e-potassium, anokukhokelela kwiingxaki zentliziyo engaqhelekanga.

Valsartan

IValsartan ligama eliqhelekileyo okanye elekhemikhali likaDiovan. Ngokungafaniyo ne-losartan, ngelixa isetyenziselwa ukunyanga uxinzelelo lwegazi oluphezulu, ikwasetyenziselwa ukunyanga ukusilela kwentliziyo kubantu abathile. Kukwaboniswa ukunciphisa umngcipheko wexesha elide wokufa emva kokuhlaselwa sisifo sentliziyo.

Njenge-losartan, i-valsartan ikwafikelela kwinqanaba eliphezulu legazi kwiiyure ezi-2 ukuya kwezi-4 emva kolawulo. Iphulwe ikakhulu esibindini kunye nesiqingatha sobomi malunga neeyure ezingama-6. Iziphumo zinokufikelela kwiiyure ezingama-24.

IValsartan iza kwiipilisi zomlomo ezinamandla e-40 mg, 80 mg, 160 mg, kunye ne-320 mg. Amandla omthamo ayahluka ngokuxhomekeka kwimeko yokuphathwa.

Umsebenzi wezintso kunye namanqanaba e-potassium kufuneka abekwe esweni rhoqo kwizigulana ezithile ezithatha i-valsartan. Ukonakaliswa kwezintso kunye namanqanaba aphezulu e-potassium yimingcipheko enokubakho enxulunyaniswa nokuthatha zombini i-valsartan kunye ne-losartan.

Icala leLosartan vs Valsartan ngokuthelekisa icala

ILosartan kunye ne-valsartan ngamayeza amabini afanayo anokunyanga iimeko ezifanayo. Ukufana nokungafani kwabo kunokuvavanywa kwitheyibhile yokuthelekisa engezantsi.

ILosartan	Valsartan
Umiselwe i
Uxinzelelo lwegazi I-nephropathy yeswekile Umngcipheko wesifo	Uxinzelelo lwegazi Ukumelwa yintliziyo Ukufa kwentliziyo emva kwentliziyo
Ulwahlulo lweziyobisi
I-Angiotensin receptor blocker (i-ARB) Uxinzelelo lwegazi	I-Angiotensin receptor blocker (i-ARB) Uxinzelelo lwegazi
Umenzi
Ngokwesiqhelo	Ngokwesiqhelo
Iziphumo eziqhelekileyo
Ukuba nesiyezi Usulelo oluphezulu lokuphefumula Ukuxinana kwempumlo Umqolo obuhlungu Khohlela	Ukuba nesiyezi Intloko ebuhlungu Usulelo lwentsholongwane Ukudinwa Intlungu zesisu Umqolo obuhlungu Urhudo IArthralgia Khohlela Uxinzelelo lwegazi
Ngaba ikhona igeneric?
ILosartan ligama eliqhelekileyo	IValsartan ligama eliqhelekileyo
Ngaba ihlawulwa yi-inshurensi?
Iyahluka ngokomboneleli wakho	Iyahluka ngokomboneleli wakho
Iifom zedosi
Ithebhulethi yomlomo	Ithebhulethi yomlomo
Ixabiso leMali eliPhakathi
204 (iipilisi ezingama-30)	$ 130.09 iipilisi ezingama-30 (160 mg)
Ixabiso lesaphulelo esisodwa
Ixabiso leLosartan	Ixabiso leValsartan
Ukusebenzisana kweziyobisi
Agents ukwandisa potassium ILithium Ii-NSAID (i-aspirin, ibuprofen, naproxen) I-COX-2 inhibitors (i-celecoxib, rofecoxib) Ezinye ii-ARBs I-ACE inhibitors (lisinopril, enalapril, benazepril) IAliskiren IFluconazole Rifampin ICclosporine	Agents ukwandisa potassium ILithium Ii-NSAID (i-aspirin, ibuprofen, naproxen) I-COX-2 inhibitors (i-celecoxib, rofecoxib) Ezinye ii-ARBs I-ACE inhibitors (lisinopril, enalapril, benazepril) IAliskiren IFluconazole Rifampin ICclosporine
Ngaba ndingasebenzisa ngelixa ndicwangcisa ukukhulelwa, ukukhulelwa, okanye ukuncancisa?
ILosartan ikudidi lokukhulelwa D. Ke ngoko, akufuneki kuthathwe ngexesha lokukhulelwa. Nxibelelana nogqirha malunga namanyathelo oza kuwathatha ngelixa uceba ukukhulelwa. ILosartan akufuneki ithathwe ngelixa uncancisa.	IValsartan ikudidi lokukhulelwa D. Ke ngoko, akufuneki ukuba ithathwe ngexesha lokukhulelwa. Nxibelelana nogqirha malunga namanyathelo oza kuwathatha ngelixa uceba ukukhulelwa. IValsartan akufuneki ithathwe ngelixa uncancisa.

Isishwankathelo

ILosartan kunye ne-valsartan ziindlela ezimbini ezinokubakho ukunyanga uxinzelelo lwegazi. Bobabini bakudidi olunye lwamayeza abizwa ngokuba zii-ARBs. Ngelixa bobabini benyanga uxinzelelo lwegazi oluphezulu, bahluka kancinane kwiindidi zeemeko zonyango. ILosartan inokuba luncedo kwabo bane-nephropathy yesifo seswekile kunye nomngcipheko wokubetha okuphezulu. IValsartan inokuba luncedo kwabo banesifo sentliziyo okanye umngcipheko owandileyo emva kokuhlaselwa sisifo sentliziyo.

Omabini la mayeza achithwe ngokufanayo neziphumo ezinokuhlala ukuya kwiiyure ezingama-24. Ngelixa i-losartan ihlala ichithwa kanye yonke imihla kuzo zonke izikhombisi, i-valsartan ithathwa kabini yonke imihla ukusilela kwentliziyo. Amandla eethebhulethi yomlomo ahlukile phakathi kwezi ziyobisi zimbini nangona zozibini ziza ngendlela efanayo.

Enye into ebalulekileyo ekufuneka uyiqaphele kukuba omabini la mayeza anokubangela i-hypotension, okanye uxinzelelo lwegazi olusezantsi, xa usiwe nezinye iziyobisi ezifanayo. Banokubangela ukonzakala kwezintso okanye amanqanaba aphezulu e-potassium angakhokelela kwiingxaki xa zingajongwa ngokusondeleyo. Ke ngoko, kubalulekile ukuba uxoxe ngezi ndlela ugqirha ukuze uthathe isigqibo sokuba loluphi unyango olulungele imeko yakho. Olu lwazi lwenzelwe ukukufundisa ngeziyobisi ezibambeleyo ezifanayo ekufuneka zithathwe phantsi kweliso lengcali yezempilo.