Eyona >> Iziyobisi Vs. Umhlobo >> I-Methylprednisolone vs prednisone: Umahluko, ukufana, kwaye yeyiphi engcono

I-Methylprednisolone vs prednisone: Umahluko, ukufana, kwaye yeyiphi engcono

Iziyobisi Vs. Umhlobo

I-Methylprednisolone kunye ne-prednisone zi-synthetic glucocorticoids ezisetyenziselwa ukuphazamiseka ezahlukeneyo. La machiza ayafana kakhulu neehomoni eziveliswa yidrenal gland yomzimba wakho. Xa zilawulwa ngeedosi eziphezulu kunokuba umzimba wakho uqhele ukuzenzela ngokwakho, zisebenza kwiindlela ezahlukeneyo ukunqanda amanqaku athile omzimba kunye nokuvuvukala anje ngeleukotrienes, prostaglandins, kinins, kunye nee histamines. Le ndlela yokusebenza ivumela la machiza ukuba asebenze ngokunyanga izifo zokuphefumla, ukuphazamiseka komzimba, kunye nokuphazamiseka kokudumba, ukubala ezimbalwa. Ngelixa omabini la mayeza anokusetyenziswa kwiziphazamiso ezifanayo, kukho umahluko phakathi kwezi zimbini.

Nguwuphi umahluko ophambili phakathi kwe-methylprednisolone kunye ne-prednisone?

I-Methylprednisolone lunyango lonyango elisetyenziswa kwiziphazamiso ezahlukeneyo kubandakanya isifuba, ulcerative colitis, isifo samathambo, kunye neempendulo ezichaseneyo. I-Methylprednisolone sisiphumo esivela kwi-prednisolone, kwaye indlela esebenza ngayo iyenza ibe luncedo kwiintlobo ezahlukeneyo zokuphazamiseka komzimba kunye nokuphazamiseka komzimba. IMethylprednisolone inqumle inwebu yeselfowuni kwaye ibophelela kwii-receptors ezithintela ukuhlanganiswa kweprotein kunye nokuveliswa kwee cytokines. IiCytokines zidlala indima ephambili kwinkqubo yokuvuvukala. Ngale ndlela inye, ikuyekisa nokungena kweeleukotrienes kunye nezinye iimpawu zokuphendula komzimba. Oku kwenza ukuba ichiza lisebenze njenge-anti-inflammatory kunye ne-agent ye-immunosuppressive agent.

I-Methylprednisolone ifumaneka kwi-4 mg, 8 mg, 16 mg, kunye ne-32 mg yeepilisi zomlomo. Ikwafumaneka kwizisombululo ezinokuthi zinikezwe ngenaliti yegazi okanye yenaliti. Igama lophawu lweepilisi ze-methylprednisolone yiMedrol. I-Methylprednisolone inokusetyenziswa kwiintsana, ebantwaneni nakubantu abadala.

I-Prednisone lunyango lonyango elikwasetyenziselwa ukuphazamiseka kokudumba kunye nokuzivikela komzimba. I-Prednisone sisiphumo se-cortisone kwaye kufuneka silungelelaniswe sisibindi kwifom yaso esebenzayo, i-prednisolone, ukuze uwele inwebu yeselula. Nje ukuba inqumle inwebu, indlela yayo iyafana naleyo ye-methylprednisolone kuba inqanda ukungena kokumakisha kunye nokuphendula komzimba.

I-Prednisone inokubizwa ngegama layo elinguDeltasone. Iyafumaneka kwi-2.5 mg, 5 mg, 10 mg, 20 mg, kunye ne-50 mg iipilisi zomlomo. Ikwafumaneka kwisisombululo somlomo.

Umahluko ophambili phakathi kwe-methylprednisolone vs prednisone
	Imethylprednisolone	IPrednisone
Iklasi yeziyobisi	ICorticosteroid	ICorticosteroid
Uhlobo lweBrith / generic	Brand kunye generic ziyafumaneka	Brand kunye generic ziyafumaneka
Ngubani igama lophawu?	IMedrol, iSoluMedrol	Deltasone
Zeziphi iifom eza nalo iziyobisi?	Ithebhulethi yomlomo, Isisombululo ngenaliti	Ithebhulethi yomlomo, isisombululo somlomo
Ithini idosi esemgangathweni?	Umthamo wokuqala we-4 mg ukuya kuma-48 mg kunye nokuhanjiswa ngokusekwe kwimpendulo kunye noxilongo	Idosi yokuqala ye-5 mg ukuya kwi-60 mg ene-titration esekwe kwimpendulo kunye noxilongo
Lude kangakanani unyango oluqhelekileyo?	Iintsuku ezintandathu ukuya kwiiveki ezininzi okanye ngaphezulu kuxhomekeke ekufumanekeni.	Iintsuku ezintlanu ukuya kwiiveki ezininzi okanye ngaphezulu kuxhomekeke kwisifo.
Ngubani oqhelekileyo usebenzisa amayeza?	Iintsana, abantwana kunye nabantu abadala	Iintsana, abantwana kunye nabantu abadala

Ngaba ufuna elona xabiso lilungileyo kwi-prednisone?

Bhalisela izilumkiso zamaxabiso e-prednisone kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Iimeko zonyango lwe-methylprednisolone vs prednisone

I-Methylprednisolone isetyenziselwa unyango lwezifo ezahlukeneyo kunye nezifo. Iziphumo zalo kwinkqubo yokuvuvukala yenza ukuba iluncedo kwizifo zamathambo ezinje nge-rheumatoid kunye ne-psoriatic arthritis, i-spondylitis, kunye ne-bursitis. Isetyenziselwa ukunyanga i-asthma ye-bronchial. Iipropathi zokunyanga ukunganyanzeleki kwimethylprednisolone ziyenza ukuba isebenze ngokufanelekileyo kwizigulo ezinje ngerhinitis ebabayo, isifo soqhakamshelwano, kunye nokuphendula kweziyobisi. Ikwasetyenziswa nakwi-endocrine, collagen, hematologic, emathunjini, kunye nokuphazamiseka kwamehlo.

I-Prednisone ikwasetyenziselwa ukunyanga uluhlu olubanzi lokuphazamiseka komzimba kunye nokuzimela okufana ne-methylprednisolone. Oku kubandakanya isifo samathambo, ukuphefumla, i-aleji, i-endocrine, i-collagen, i-hematologic, isisu kunye nokuphazamiseka kwamehlo.

Le theyibhile ilandelayo, ngelixa ibanzi, ayinakudwelisa konke ukusetyenziswa kwala mayeza mabini. Nceda uqhagamshelane nomboneleli wakho wezempilo ngolwazi oluthe kratya malunga nokubonisa ukusetyenziswa.

Imeko	Imethylprednisolone	IPrednisone
I-hyperplasia yokuzalwa ye-adrenal	Ewe	Ewe
I-thyroiditis engasebenziyo	Ewe	Ewe
Irheumatoid Arthritis	Ewe	Ewe
I-Ankylosing spondylitis	Ewe	Ewe
I-bursitis efanelekileyo	Ewe	Ewe
I-Synovitis ye-osteoarthritis	Ewe	Ewe
Isifo samathambo	Ewe	Ewe
Inkqubo ye lupus erythematosus	Ewe	Ewe
Isifo seborrheic dermatitis	Ewe	Ewe
Psoriasis enamandla	Ewe	Ewe
I-optic neuritis	Ewe	Ewe
Ukudibana komzimba	Ewe	Ewe
Iimpawu zesarcoidosis	Ewe	Ewe
Pneumonitis yokuphefumla	Ewe	Ewe
Idiopathic thrombocytopenic purpura	Ewe	Ewe
Ukudumba okwenziwa sisilonda sikabhobhosi	Ewe	Ewe
Ukunyuka okunamandla kwe-Multiple Sclerosis	Ewe	Ewe

Ngaba i-methylprednisolone okanye i-prednisone isebenza ngakumbi?

Zininzi iindlela zokuthelekisa i-methylprednisolone kunye ne-prednisone ngenxa yoluhlu olubanzi lokusetyenziswa. Kwiinkqubo ezininzi zokuvuvukala, unyango lwe-corticosteroids lilinganiselwe ekusebenziseni ixesha elifutshane ekukhuleni okuqatha nokubi kwesi sifo. Xa uthelekisa i-methylprednisolone kunye ne-prednisone ngqo, i-4 mg ye-methylprednisolone ilingana ne-5 mg ye-prednisone. Nangona kunjalo, xa iidosi zihlengahlengiswa kwaye zibekwe esweni ukuphendula, nganye inokusebenza kunyango.

Olunye uphononongo luzamile ukuthelekisa Iziphumo ze-methylprednisolone efakwa ngaphakathi i-prednisone yomlomo kwi-asthma exacerbation eyandayo ebantwaneni. Amaqela amabini onyango ayekhethiwe ukufumana i-30 mg ye-methylprednisolone okanye i-30 mg ye-prednisone yomlomo. Omabini la maqela afumene i-albuterol, kwaye abaphandi bavavanya ukukhululeka kweempawu, ukuhamba okuphezulu kokuphuma (PEF), kunye nokufundwa kwe-oximetry. Ukufundwa kwathathwa kwiqela ngalinye kwiiyure ezimbini, ezine, kunye neeyure ezintandathu emva kokuqala unyango. Kwakungekho mahluko ngokwezonyango okanye ngokwezibalo kwisithuba ngasinye phakathi kwala maqela mabini. Abaphandi bagqiba kwelokuba i-prednisone yomlomo iya kuba lolona khetho lubalaseleyo ngenxa yexabiso eliphantsi kunye nolawulo olungenabuhlungu.

Ngaba ufuna elona xabiso lilungileyo kwimethylprednisolone?

Bhalisela izilumkiso zexabiso lemethylprednisolone kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Ukuxhamla kunye nokuthelekiswa kweendleko ze-methylprednisolone vs prednisone

IMethylprednisolone lunyango olugqityiweyo olugqityiweyo kuzo zombini izicwangciso zeinshurensi yokuthengisa kunye neMedicare. Ikhosi yeentsuku ezintandathu yeetafile ezingama-21 zamandla e-4 mg zinokubiza ama- $ 100 kwigama lophawu. Ngetikiti elivela kwi-SingleCare, unokufumana i-methylprednisolone ngexabiso eliphantsi njenge- $ 15.

I-Prednisone ikwayiyeza likagqirha eligqunywa ziiplani zeinshurensi yorhwebo kunye neMedicare. Ixabiso lentengiso ye-prednisone ijikeleze i-22 yeedola kwiipilisi ezilishumi ze-20 mg. Unokwazi ukufumana lo myalelo ungaphantsi kwe- $ 4 ngekhuphoni ye-SingleCare.

Kubalulekile ukuba uqaphele ukuba kwizifo ezithile, ii-corticosteroids zisenokungagqunyuthelwa phantsi kwesiyobisi, kodwa zinokugqunywa kwiCandelo leMedicare B. Isokhemesti sakho sinokubonelela ngolwazi oluthe kratya malunga nokugubungela.

	Imethylprednisolone	IPrednisone
Ngokuqhelekileyo ihlawulwa yi-inshurensi?	Ewe	Ewe
Ngokuqhelekileyo igutyungelwe yiMedicare?	Ewe	Ewe
Umthamo osemgangathweni	Iipilisi ze-21, 4 mg	Iipilisi ezili-10, 20 mg
I-Medicare copay eqhelekileyo	Ngokuqhelekileyo<$10 but may vary depending on the plan	Ngokuqhelekileyo<$10 but may vary depending on the plan
Ixabiso elilodwa	$ 15 +	Iidola ezi-4- $ 6

Iziphumo eziqhelekileyo ezichaphazelekayo ze-methylprednisolone kunye ne-prednisone

I-Prednisone imetabolism kwi-prednisolone yayo esebenzayo sisibindi. I-Prednisolone kunye ne-methylprednisolone ziyafana ngokwamachiza, kwaye ke ngenxa yeziphumo ebezingalindelekanga ezinokubakho ngokusondeleyo kwisibuko.

I-Glucocorticoids yaziwa ngokuba ibangela ukungalingani kwe-fluid kunye ne-electrolyte enokuthi ikhokelele ekugcineni i-sodium kunye ne-fluid, uxinzelelo lwegazi oluphezulu, kwaye kwezinye iimeko, ukusilela kwentliziyo. I-Methylprednisolone kunye ne-prednisone inokukhokelela kubuthathaka bemisipha kunye nokulahleka kobunzima bemisipha. I-Glucocorticoids yaziwa ngokuba iyaphazamisa inkqubo yesisu kwaye inokukhokelela kwisicaphucaphu, ukugabha, okanye isisu esiswini. I-Steroids inokucothisa ukuphola kwamanxeba. Ukusetyenziswa ixesha elide kwe-methylprednisolone kunye ne-prednisone kunokucothisa ukukhula kwabantwana, kwaye ngenxa yesi sizathu, ukusetyenziswa kwabo kufanele kuthintelwe nje kwixesha elifutshane kangangoko ukufezekisa ukuxolelwa kweempawu.

I-Glucocorticoids inokuphazamisa impendulo yomzimba kwi-insulin. Izigulana kunyango lwe-steroid lwexesha elide zinokufikelela amaxesha amane okuba nesifo seswekile. Izigulana ezixhomekeke kwi-insulin ejoyiweyo okanye ezinye iziyobisi ezichasene neswekile zinokunyusa idosi yazo xa zikwi-steroids. Kuqhelekile ukuba abantu abanesifo seswekile abalawulwa kakuhle babone ukunyuka kweswekile yegazi nakwidosi yexesha elifutshane kakhulu ye-steroids.

Le theyibhile ilandelayo ayenzelwanga ukuba ibe luluhlu olubanzi lweziphumo ebezingalindelekanga. Nceda uqhagamshelane nosokhemesti okanye ugqirha wakho ukufumana uluhlu olupheleleyo lweziphumo ebezingalindelekanga.

	Imethylprednisolone	IPrednisone
Ukugcinwa kwesodium	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Ukugcina ulwelo	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Uxinzelelo lwegazi	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukusilela kwentliziyo	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukutyeba kwakho	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ubuthathaka bemisipha	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Unyango	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukophuka kwamathambo amade	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Isilonda Peptic	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ipancreatitis	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukuhamba kwesisu	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukuphilisa amanxeba	Ewe	Ayichazwanga	Ewe	Ayichazwanga
I-erythema yobuso	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukwanda kokubila	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Intloko ebuhlungu	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Vertigo	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Imood iyatshintsha	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukucinezelwa kokukhula	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Ukuxhathisa kwe-insulin	Ewe	Ayichazwanga	Ewe	Ayichazwanga
Iglaucoma	Ewe	Ayichazwanga	Ewe	Ayichazwanga

Umthombo: Imethylprednisolone (Yonke imihla) IPrednisone (Yonke imihla)

Ukusebenzisana kweziyobisi kwe-methylprednisolone kunye ne-prednisone

I-Methylprednisolone kunye ne-prednisone zii-substrates nganye ye-cytochrome P450 enzyme 3A4. Inkqubo ye-enzyme ye-P450 esibindini inoxanduva lokuchaphazela amachiza amaninzi, kwaye ke ngenxa yoko kukho unxibelelwano oluninzi lweziyobisi.

Iicorticosteroids zihlala zisetyenziswa kwizigulana ezikwezinye iiarhente zokuzikhusela emzimbeni. Ukulawula impendulo yomzimba ekufakweni komzimba kunye nokuphazamiseka okuthile okuzenzekelayo kunokufuna ukusetyenziswa kwearhente yokugonyamela ngaphezulu kwesinye. Iarhente enye inokuchaphazela imetabolism yenye, kodwa zisenokusetyenziswa kunye xa kubekwe iliso ngokufanelekileyo. Umzekelo, i-tacrolimus kunye ne-cyclosporine nganye inhibitors ye-CYP 3A4. Oku kungakhokelela ekunyukeni kwe-serum ye-methylprednisolone okanye i-prednisone xa isetyenziswa kunye. Kubekho izehlo zokuxhuzula ezichazwe ngokusetyenziswa ngokufanayo kwe-cyclosporine kunye ne-methylprednisolone, nangona oku kunqabile.

I-Loop diuretics inceda ukulawula imeko ye-fluid emzimbeni ngokucoca i-potassium. Xa unikwa nge-methylprednisolone okanye i-prednisone, nangona kunjalo, kunokwenzeka ukuba umzimba ulahlekelwe sisixa esikhulu se potassium. Oku kunokuba nefuthe elibi ekusebenzeni kwentliziyo. Izigulana ekufuneka zithathe ezi zinto kunye kufuneka zibekwe esweni imeko yazo ye-electrolyte.

Olu luhlu lulandelayo aluluhlu lwazo zonke iziphumo ebezingalindelekanga ezinokubakho. Nceda uqhagamshelane nomboneleli wakho wezempilo uluhlu olupheleleyo.

Iziyobisi	Iklasi yeziyobisi	Imethylprednisolone	IPrednisone
IBaricitinib Dabrafenib Erdafitinib Ivosidenib Larotrectinib Iyofinit Upadacitinib	I-inhibitors yokuhambisa uphawu (i-STI): ii-Immunosuppressants	Ewe	Ewe
I-Denosumab UNatalizumab INivolumab I-Ocrelizumab USarilumab Siltuximab	Ama-Immunoglobulins: Ama-Immunosuppressants	Ewe	Ewe
ITacrolimus	I-Calcineurin inhibitor: I-Immunosuppressant	Ewe	Ewe
ICclosporine	Icyclic peptide: Immunosuppressant	Ewe	Ewe
Inqabileyo Ifosaprepitant	Umchasi we-NK1 we-receptor: Anti-nausea	Ewe	Ewe
Ketoconazole Itraconazole	I-Azole yokubola	Ewe	Ewe
Unyuselwa	IVasopressin analog	Ewe	Ewe
Diltiazem	Isikhululo seCalcium blocker	Ewe	Ewe
Isoniazid Rifampin	Intsholongwane	Ewe	Ewe
IPhenytoin	I-Anticonvulsant	Ewe	Ewe
Bumetanide Furosemide I-Torsemide	I-Loop Diuretics	Ewe	Ewe
I-Aspirin Ibuprofen INaproxen Diclofenac Meloxicam Umgqube	Ii-NSAID	Ewe	Ewe
IChlorthalidone IHydrochlorothiazide	I-Thiazide yomchamo	Ewe	Ewe

Izilumkiso ze-methylprednisolone kunye ne-prednisone

I-Corticosteroids inokufihla imiqondiso yosulelo kwaye inokucothisa ukufunyanwa kosulelo olutsha. Ukusetyenziswa ixesha elide kwe-methylprednisolone kunye ne-prednisone kunokukhokelela kwikati kunye ne-glaucoma.

Khange kubekho zifundo zilawulwa kakuhle ze-corticosteroids kubafazi abakhulelweyo, ke ukusetyenziswa kwabo ekukhulelweni kufuneka kwenzeke kuphela xa kucacile ukuba isibonelelo sigqitha kubungozi. Iintsana ezizalwe ngoomama abasebenzisa i-corticosteroids ngexesha lokukhulelwa kufuneka zijongwe kwi-hypoadrenalism.

I-Corticosteroids, ngakumbi kwiidosi eziphezulu, iya kuthintela amandla omzimba wokuvelisa ii-antibodies xa kugonyo. Amachiza anokungasebenzi kwizigulana ezifumana i-steroids. Amayeza okugonya aphilayo, anjenge-smallpox, akufuneki anikwe abaguli abafumana unyango lwe-corticosteroid. Izigulana ezithatha iiarhente zokuzikhusela zisemngciphekweni wokonyuka kosulelo kwizitofu zokugonya eziphilayo.

I-Methylprednisolone kunye ne-prednisone inokutshintsha iziphumo zovavanyo lolusu okanye olunye uvavanyo lokungabikho komzimba. Ukufumana ezona ziphumo zichanekileyo, unyango lwe-steroid kufuneka lumiswe kwiintsuku ngaphambi kokwenza ezi mvavanyo.

I-Steroids kufuneka ilawulwe ixesha elifutshane kangangoko ukufezekisa iziphumo ezinqwenelekayo. Ukuba ukusetyenziswa kwexesha elide kwe-steroids kuyimfuneko yonyango, kufuneka igcinwe kwi-dose esebenzayo.

Imibuzo ebuzwa rhoqo malunga ne-methylprednisolone vs prednisone

Yintoni i-methylprednisolone?

I-Methylprednisolone yinkqubo yokwenziwa kweglucocorticoid esetyenziselwa ukunyanga iintlobo ezahlukeneyo zokuphazamiseka komzimba kunye nokuzimela. Iyafumaneka njengecwecwe lomlomo kunye nenaliti. Elona xesha liqhelekileyo lonyango ziintsuku ezintandathu zonyango ngomlomo.

Yintoni i-prednisone?

I-Prednisone yiglucocorticoid edityaniswa sisibindi kwifom esebenzayo, i-prednisolone. Isetyenziselwa kwizifo ezininzi zokukrala kunye nokuzimela komzimba. I-Prednisone ifumaneka kumacwecwe omlomo kunye nakwindlela yokusombulula isisombululo. Ukusetyenziswa ngokukuko kwe-prednisone ngesiqhelo yirejimeni yeentsuku ezintlanu.

Ngaba i-methylprednisolone kunye ne-prednisone efanayo?

Nangona zombini ziyi-glucocorticoids, i-methylprednisolone kunye ne-prednisone azifani ncam. I-Prednisone kufuneka i-metabolized kwifom yayo esebenzayo, i-prednisolone, ukuze ibe nefuthe emzimbeni. Idosi ye-4 mg ye-methylprednisolone ilingana ne-5 mg prednisone.

Ngaba i-methylprednisolone okanye i-prednisone ngcono?

I-Methylprednisolone kunye ne-prednisone nganye inokufezekisa ukuxolelwa kwempawu xa iidosi zazo ziqaliswe ngokufanelekileyo. Ukuqulunqwa komlomo kunokukhethwa kunokwenziwa ngenaliti ngenxa yexabiso eliphantsi kunye nolawulo olulula.

Ndingayisebenzisa i-methylprednisolone okanye i-prednisone ngelixa ndikhulelwe?

I-Methylprednisolone kunye ne-prednisone ziludidi lomngcipheko wokukhulelwa C. Oku kuthetha ukuba akukho zifundo zabantu ezilawulwayo ezingqina ukuba amayeza akhuselekile ekukhulelweni. La mayeza kufuneka asetyenziswe kuphela xa isibonelelo ngokucacileyo sigqithile kumngcipheko.

Ndingayisebenzisa i-methylprednisolone okanye i-prednisone ngotywala?

Utywala buxutywe sisibindi. Ukuqhubekeka nokusela utywala kunokuchaphazela amandla omzimba okwenza i-prednisone kwifom yayo esebenzayo. Utywala kunye ne-glucocorticoids zombini zinokuba neziphumo ezibi kwinkqubo yamathumbu. Ukusetyenziswa kotywala kuncitshisiwe ngexesha lokunyanga i-steroid.

Ngaba i-methylprednisolone yi-steroid eyomeleleyo?

Ngelixa i-methylprednisolone imalunga ne-20% ngakumbi kune-prednisone, inye kuphela kwisihlanu kwisinye sezinye i-glucocorticoids ezinjenge-dexamethasone okanye i-betamethasone. Nangona kunjalo, iphindwe kahlanu ngamandla kunehydrocortisone.

Kuthatha ixesha elingakanani ukusebenza kwe-methylprednisolone? / Ngaba i-methylprednisolone isebenza ngokukhawuleza?

IMethylprednisolone inokuqala ngokukhawuleza. Ifikelela kwincopho yayo kwiyure enye ukuya kwezimbini emva kwethamo lomlomo, nakwiyure enye yedosi efakwa ngaphakathi. Ixutywe sisibindi kwimetabolites engasebenziyo ekhutshwe kumchamo. Isiqingatha sobomi be-methylprednisolone yi-18 ukuya kwiiyure ezingama-36 oko kuthetha ukuba kungathatha iintsuku ezi-2 ukuya kwezi-7 ukuphelisa ngokupheleleyo ichiza emzimbeni.