Ixabiso elixabisekileyo ngokuchasene neRepatha: Umahluko ophambili kunye nokufana

Iziyobisi Vs. Umhlobo

Ixabiso kunye neRepatha ngamachiza atofelwayo asetyenziselwa ukunyanga i-LDL-cholesterol esezantsi (LDL-C) kwabo bane-hypercholesterolemia, okanye i-cholesterol ephezulu. Omabini la machiza ahlelwa njenge-PCSK9 inhibitors esebenza ngokuphucula amandla esibindi okususa i-LDL-C egazini. Ngaphandle kokusebenza kwabo, bobabini ngamayeza abiza kakhulu.

Ixabiso

Ixabiso (Lixabise ngantoni?) Ligama elingu-alirocumab. I-FDA ivunyiwe ukunyanga i-heterozygous Family hypercholesterolemia (HeFH) kunye nonyango lwe-atherosclerotic isifo sentliziyo. Kuyacetyiswa ukuba isetyenziswe ukongeza kwindlela yokutya kunye nonyango lwe-statin yomlomo.

Ixabiso liqhutywa njenge-75 mg / mL okanye i-150 mg / mL inaliti rhoqo kwiiveki ezi-2. Iyafumaneka njengesiba esizaliswe kwangaphambili okanye isirinji. Elona dosi liphezulu yi-150 mg / mL inaliti rhoqo kwiiveki ezi-2. Ukuba unqwenela, inokuthathwa kanye ngenyanga ngokuyalela ugqirha wakho.

Ngaba ufuna elona xabiso lixabisekileyo kwiXabiso?

Bhalisela izilumkiso zamaxabiso axabisekileyo kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Repatha

Ukuphindaphinda (Yintoni iRepatha?) Yaziwa ngegama laso elenziwe generic, evolocumab. Isetyenziselwa ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokufa icala kulabo abanesifo sentliziyo esaziwayo. Njengexabiso, inokunyanga abantu abadala abane-HeFH. Nangona kunjalo, inokunciphisa i-cholesterol ye-LDL kulabo abane-homozygous family hypercholesterolemia (HoFH), uhlobo olubi kakhulu lwe-cholesterol ephezulu. Ngokungafaniyo neXabiso, inokusetyenziswa yodwa ukunciphisa i-cholesterol kwezinye iimeko.

Ukuphinda kulawulwe njenge-140 mg / mL inaliti rhoqo kwiiveki ezi-2 okanye ngenyanga. Ukuphindaphinda kuyafumaneka njengesirinji ekhethiweyo, ipeni ye-SureClick autoinjector, kunye nenkqubo ye-Pushtronex infusor yenkqubo enye. Inkqubo ye-infusor igcina isisombululo se-420 mg / 3.5 mL esinokulawulwa ngaphezulu kwemizuzu eli-9. Abanye abantu banokukhetha iPushtronex ngenxa yokusebenziseka kwayo ngokulula.

ikhadi lesaphulelo semithi

Ngaba ufuna elona xabiso lilungileyo kwiRepatha?

Bhalisela izilumkiso zamaxabiso e-Repatha kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Ixabiso elixabisekileyo ngokuchasene neRepatha esecaleni ngokuthelekisa icala

Ixabiso kunye neRepatha ngamayeza afanayo ngokusetyenziswa okufanayo. Ukufana kunye nokungafani kwabo kunokuphinda kuvavanywe apha ngezantsi.

Ixabiso	Repatha
Umiselwe i
I-Heterozygous Family hypercholesterolemia (HeFH) ngokudibeneyo nonyango lwe-statin Ukunciphisa i-Lipid kwisifo se-atherosclerotic senhliziyo ngokudibanisa nonyango oluphezulu lwethamo	Uthintelo lwe-myocardial infarction, stroke, kunye ne-coronary revascularization I-Heterozygous Family hypercholesterolemia (HeFH) iyodwa, okanye ngokudibanisa nonyango oluphezulu lwe-statin therapy IHomozygous Family hypercholesterolemia (HoFH) ngokudibeneyo nonyango lwe-statin
Ulwahlulo lweziyobisi
PCSK9 inhibitor	PCSK9 inhibitor
Umenzi
ISanofi	Amgen
Iziphumo eziqhelekileyo
Ukuphendula kwendawo yenaliti Nasopharyngitis Umkhuhlane	Ukuphendula kwendawo yenaliti Nasopharyngitis Umkhuhlane Usulelo oluphezulu lokuphefumula Umqolo obuhlungu Isifo seswekile
Ngaba ikhona igeneric?
Akukho generic ikhona	Akukho generic ikhona
Ngaba ihlawulwa yi-inshurensi?
Iyahluka ngokomboneleli wakho	Iyahluka ngokomboneleli wakho
Iifom zedosi
Isisombululo senaliti engaphantsi (ipeni ekhethiweyo, isirinji ekhethiweyo)	Isisombululo senaliti engaphantsi (isirinji ekhethiweyo, SureClick autoinjector, Pushtronex system)
Ixabiso leMali eliPhakathi
$ 671 (nge-140 mg / ml yenaliti)	$ 1,346 (nge-2, 1 mL ipeni yexabiso)
Ixabiso lesaphulelo esisodwa
Ixabiso lesingxobo	Ixabiso elixabisekileyo
Ukusebenzisana kweziyobisi
Akukho ndibano ibalulekileyo	Akukho ndibano ibalulekileyo
Ngaba ndingasebenzisa ngelixa ndicwangcisa ukukhulelwa, ukukhulelwa, okanye ukuncancisa?
Akukho datha yaneleyo yokubonisa umngcipheko kubafazi abakhulelweyo okanye abancancisayo. Qhagamshelana nogqirha malunga nokuthatha ixabiso elixabisekileyo ngelixa ukhulelwe okanye uncancisa	Akukho datha yaneleyo yokubonisa umngcipheko kubafazi abakhulelweyo okanye abancancisayo. Nxibelelana nogqirha malunga nokuthatha iRepatha ngelixa ukhulelwe okanye uncancisa

Isishwankathelo

Ukuphindaphinda kunye nokuxabisa amagama amabini e-PCSK9 inhibitors anokunciphisa kakhulu i-cholesterol ye-LDL. Ngelixa zombini zisebenza ngokunyanga i-cholesterol ephezulu, zibiza kakhulu xa kuthelekiswa nonyango lwemveli lwe-statin.

Ixabiso elicetyiswayo ngokudibeneyo nonyango lwe-statin ukunciphisa i-cholesterol. Ukuphindaphinda, kwelinye icala, kunokusetyenziswa kuphela ukunyanga i-cholesterol ephezulu. Ukuphindaphinda kunokunciphisa umngcipheko wokuhlaselwa yintliziyo, ukubetha, kunye ne-coronary vascularization ngaphezu kwe-HeFH ne-HoFH.

Nangona omabini la machiza anokulawulwa qho ngeeveki ezi-2 okanye ngenyanga, iRepatha inokukhetha ngakumbi ngenaliti. Ixabiso kunye neRedatha ziyafumaneka kwiisirinji ezizaliswe ngaphambili nakwiiyunithi zepeni. Nangona kunjalo, i-Repatha inokuphinda ilawulwe ngenkqubo yokungena emzimbeni emzimbeni enokuba luncedo kumntu ongakhethi inaliti ethe ngqo.

La mayeza ahlala esetyenziswa njengendawo yokugqibela ngenxa yamaxabiso aphezulu. Kodwa, banokuba luncedo ekunciphiseni i-cholesterol kunye nokuthintela ukufa kwezinye iimeko. Kukwacetyiswa ukuba uxoxe ngala mayeza kunye nazo zonke iindlela zonyango onokukhetha kuzo nogqirha.