Eyona >> Iziyobisi Vs. Umhlobo >> I-Pravastatin vs.Lipitor: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

I-Pravastatin vs.Lipitor: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

Iziyobisi Vs. Umhlobo

I-Pravastatin kunye neLipitor (atorvastatin) ngamayeza amiselweyo asetyenziselwa ukunyanga i-cholesterol ephezulu. Amanqanaba e-cholesterol aphezulu kunesiqhelo anokunyusa umngcipheko wesifo sentliziyo, isifo semithambo, isifo sentliziyo kunye nemivumbo. Ikholesterol iveliswa ikakhulu kwisibindi ngokusebenzisa i-enzyme ye-HMG-CoA reductase.

I-Pravastatin kunye ne-atorvastatin ngamachiza ahlelwa njenge-HMG-CoA reductase inhibitors. Eyaziwa nangokuthi iziyobisi ze-statin, i-pravastatin kunye ne-atorvastatin inhibit, okanye ibhlokhi, i-enzyme ye-HMG-CoA reductase, ekhokelela ekunciphiseni imveliso ye-cholesterol esibindini. Ukusetyenziswa kwe-statins kukonyusa inani le-LDL (low-density lipoprotein) receptors kwisibindi, esinceda amanqanaba asezantsi e-LDL, okanye uhlobo olubi lwe-cholesterol, egazini.

Zombini iipravastatin kunye neatorvastatin zisebenza ngeendlela ezifanayo, kodwa zinomahluko ekufuneka bezazi.

Yintoni umahluko ophambili phakathi kwepravastatin kunye neLipitor?

I-Pravastatin ligama eliqhelekileyo le-Pravachol. Ngokungafaniyo nezinye iziyobisi ze-statin, ipravastatin ayixutywanga kakhulu, okanye yenziwe, yi-CYP3A4 enzymes esibindini. Endaweni yoko, ipravastatin yiyo yaphuka esiswini .

Iipilisi ze-Pravastatin generic ziyafumaneka kumandla we-10 mg, 20 mg, 40 mg, kunye no-80 mg. I-Pravastatin ihlala imiselwe ukuba ithathwe kanye yonke imihla ngokuhlwa. Kubonakalisiwe ukuba ipravastatin isebenza ngakumbi xa ithathwa ngokuhlwa kunoba kusasa.

I-Lipitor ligama elinegama lebrendi kwaye liyafumaneka kuhlobo oluqhelekileyo olubizwa ngokuba yi-atorvastatin. Ngokungafaniyo nepravastatin, i-atorvastatin icutshungulwa kakhulu yi-CYP3A4 enzyme esibindini. Ke ngoko, i-atorvastatin inokuthi isebenzisane namayeza ngakumbi kune-pravastatin.

I-Lipitor ifumaneka kumacwecwe omlomo kunye namandla e-10 mg, 20 mg, 40 mg, kunye no-80 mg. I-Lipitor inokuthathwa kusasa okanye ngokuhlwa, kwaye ihlala ithathwa kanye yonke imihla.

Umahluko ophambili phakathi kwepravastatin kunye neLipitor
	IPravastatin	Lipitor
Iklasi yeziyobisi	I-HMG-CoA ukunciphisa i-inhibitor	I-HMG-CoA ukunciphisa i-inhibitor
Uhlobo lweBrith / generic	Ibhranti kunye nohlobo oluqhelekileyo olukhoyo	Ibhranti kunye nohlobo oluqhelekileyo olukhoyo
Ngubani igama eliqhelekileyo? Ngubani igama lophawu?	Igama lebrand: Pravachol Igama lesiqhelo: Pravastatin	Igama lebrand: Lipitor Igama lesiqhelo: Atorvastatin
Zeziphi iifom eza nalo iziyobisi?	Ithebhulethi yomlomo	Ithebhulethi yomlomo
Ithini idosi esemgangathweni?	I-10 ukuya kwi-80 mg kanye yonke imihla	I-10 ukuya kwi-80 mg kanye yonke imihla
Lude kangakanani unyango oluqhelekileyo?	Ixesha elide	Ixesha elide
Ngubani oqhelekileyo usebenzisa amayeza?	Abantu abadala; abantwana kunye nolutsha oluneminyaka eli-8 ukuya kweli-18 ubudala	Abantu abadala; abantwana kunye abafikisayo abaneminyaka eli-10 ukuya kweli-17 ubudala

Iimeko eziphathwe yipravastatin kunye neLipitor

I-Pravastatin kunye ne-atorvastatin inokunceda ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye imivumbo kubantu abanesifo senhliziyo. Omabini la mayeza anokunceda ukunciphisa umngcipheko wokufa isifo sentliziyo . Imingcipheko yesifo sentliziyo ibandakanya uxinzelelo lwegazi oluphezulu, ukutshaya, kunye namanqanaba aphezulu e-cholesterol.

Zombini i-pravastatin kunye ne-atorvastatin zi-FDA ezivunyiweyo zokunciphisa amanqanaba aphezulu e-cholesterol kunye ne-LDL amanqanaba (ekwabizwa ngokuba yi-hyperlipidemia okanye i-hypercholesterolemia). Amayeza e-Statin anokunceda ekunyangeni amanqanaba aphezulu e-triglycerides , Olunye uhlobo lwamafutha okanye i-lipids emzimbeni. Umntu onamanqanaba aphezulu e-triglycerides une-hypertriglyceridemia.

I-Pravastatin kunye neLipitor zinokunyusa amanqanaba e-HDL egazini. I-cholesterol ye-HDL yinto eyaziwa ngokuba yi-cholesterol elungileyo esegazini.

Imeko	IPravastatin	Lipitor
Hyperlipidemia	Ewe	Ewe
Isifo sehypercholesterolemia	Ewe	Ewe
Hypertriglyceridemia	Ewe	Ewe

Ngaba ipravastatin okanye iLipitor isebenza ngakumbi?

Zombini i-pravastatin kunye ne-atorvastatin ngamayeza asebenzayo kunyango lwe-cholesterol ephezulu yegazi. Iyeza elisebenzayo ngakumbi lixhomekeke kwimeko yakho iyonke, ubunzima bemeko yakho, ezinye iziyobisi onokuthi uzithathe, kunye nezinye izinto.

Nye isifundo sokuthelekisa ifumanise ukuba akukho mahluko ubalulekileyo phakathi kwepravastatin, simvastatin, kunye neatorvastatin yokuthintela imicimbi yentliziyo. Ngamanye amagama, la mayeza e-statin ayesebenza ngokufanayo ukunciphisa isifo sentliziyo kunye nesifo sentliziyo.

UKUYA uphononongo olucwangcisiweyo Ukudibanisa ngaphezulu kwe-90 yezilingo zonyango xa kuthelekiswa iziyobisi ze-statin ezinje nge-fluvastatin, atorvastatin, pravastatin, simvastatin, kunye ne-rosuvastatin. Uphengululo luqukumbele ukuba i-atorvastatin, i-fluvastatin, kunye ne-simvastatin zinamathuba aphezulu okuba lolona nyango lulungileyo lokuthintela imicimbi yentliziyo.

Nxibelelana nomboneleli wezempilo ukumisela iyeza elifanelekileyo le-statin. Emva kokwenza uvavanyo lwegazi kunye nokuvavanya imeko yakho iyonke, umboneleli uya kuba nakho ukufumanisa ukuba ipravastatin okanye i-atorvastatin sisiyobisi esisebenzayo kuwe. Banokuyalela ichiza elahlukileyo lomthetho ofana neZocor (simvastatin) okanye iCrestor (rosuvastatin).

Umyinge kunye neendleko zokuthelekisa ipravastatin vs.Lipitor

I-Pravastatin liyeza eliqhelekileyo elihlala ligutyungelwe ngamayeza kunye nezicwangciso zeinshurensi. Ixabiso eliphakathi lemali lepravastatin lijikeleze i-129,99 yeedola kunikezelo lweentsuku ezingama-30. Ikhadi lokugcina i-SingleCare linakho ukwehlisa indleko zeprastastatin prescription ibe ngaphantsi kwe- $ 15.

I-Lipitor ligama elinegama lebrendi elikwafumaneka ngexabiso eliphantsi, elenziwa lafana nalawo aveliswe ngumenzi. Inguqulelo yesiqhelo yeLipitor, i-atorvastatin, ihlala igutyungelwe luninzi lwezonyango kunye nezicwangciso zeinshurensi. Igama leBrand Lipitor linokugqunywa zizicwangciso zeinshurensi nge-copay ephezulu. Ixabiso lemali likaLipitor lijikeleze i- $ 249.99. Amakhuphoni e-singleCare anokunciphisa iindleko ayi- $ 15 kwii-pharmacy ezithatha inxaxheba.

	IPravastatin	Lipitor
Ngokuqhelekileyo i-inshurensi?	Ewe	Ewe
Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare?	Ewe	Ewe
Ubungakanani	Iipilisi ezingama-30 (40 mg)	Iipilisi ezingama-30 (40 mg)
I-Medicare copay eqhelekileyo	$ 0- $ 20	$ 0- $ 16
Ixabiso elilodwa	$ 12 +	$ 15 +

Iziphumo eziqhelekileyo ezichaphazelekayo zepravastatin vs.Lipitor

Iziphumo ebezingalindelekanga eziqhelekileyo zepravastatin ziintlungu zemisipha okanye zezihlunu, isicaphucaphu, ukugabha, urhudo kunye nentloko ebuhlungu. Iziphumo eziqhelekileyo ezichaphazelekayo ze-atorvastatin ziintlungu ze-musculoskeletal okanye ze-muscle, isifo sohudo, kunye nentlungu edibeneyo (arthralgia). Zombini i-pravastatin kunye ne-atorvastatin nazo zinokubangela ezinye iziphumo ebezingalindelekanga ezifana nokugaya isisu, isiyezi, ukudinwa, irhashalala kunye nosulelo lomchamo.

Inzima iziphumo ebezingalindelekanga zamachiza endlela zibandakanya isifo semisipha (myopathy) kunye nokonakala ngokukhawuleza kwethishu yemisipha (rhabdomyolysis). Nxibelelana nomboneleli wezempilo kwangoko ukuba ufumana iintlungu eziqhubekayo okanye ezingachazwanga zentlungu, ubuthathaka, okanye isisa.

I-Pravastatin kunye ne-atorvastatin nayo inokubangela ii-enzyme zesibindi eziphakamileyo. Amanqanaba e-enzyme yesibindi anokufuna ukujongwa ngaphambili kwaye abekwe iliso kulo lonke unyango.

	IPravastatin	Lipitor
Imiphumela	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Ubuhlungu beMusculoskeletal	Ewe	10%	Ewe	4%
Isihlunu / ukugabha	Ewe	7%	Ewe	4%
Urhudo	Ewe	7%	Ewe	7%
Ukutya	Ewe	3%	Ewe	5%
Ukuba nesiyezi	Ewe	4%	Ewe	*
Intloko ebuhlungu	Ewe	6%	Hayi	-
Ukudinwa	Ewe	3%	Ewe	*
Irhashalala	Ewe	5%	Ewe	*
IArthralgia	Ewe	*	Ewe	7%
Usulelo lwe-Urinary tract	Ewe	3%	Ewe	6%

Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( IPravastatin ), Yonke imihla ( Lipitor )
* akuxelwa

Ukudibana kweziyobisi kwipravastatin vs.Lipitor

I-Pravastatin kunye ne-atorvastatin bayasebenzisana namayeza afanayo. Nangona kunjalo, kuba i-atorvastatin ibethelelwe ikakhulu yi-CYP3A4 enzyme esibindini, inokusebenzisana nezinye iziyobisi ezichaphazela ii-enzyme ze-CYP3A4 esibindini.

Ukuthatha amayeza afana ne-cyclosporine, i-clarithromycin, okanye i-ritonavir kunye nepravastatin okanye i-atorvastatin ingakhokelela kumanqanaba okwanda kwe-statin egazini, enokunyusa umngcipheko weziphumo ezibi.

I-Antacids inokuphazamisa ukufunxwa kwamayeza e-statin kunye nokunciphisa ukusebenza kwawo. Ukulawulwa kwe-antacids kunye ne-statins kufuneka kwahlulwe ubuncinci iiyure ezimbini. I-Cholestyramine nayo inokunciphisa ukufunxwa kunye nokusebenza kweempawu. Ukulawulwa kwecholestyramine kunye ne-statins kufuneka kwahlulwe ngeeyure ezine.

I-Niacin kunye ne-fibrate inokunyusa umngcipheko we-myopathy kunye ne-rhabdomyolysis xa ithathwa kunye nepravastatin okanye i-atorvastatin.

Ukusetyenziswa kwe-atorvastatin kufuneka kuthintelwe okanye kubekwe esweni ngelixa usitya Ijusi yeediliya . Ijusi yamagilebhisi isebenza njenge-CYP3A4 inhibitor enokuthi ikhokelele kwinqanaba elonyukayo le-atorvastatin egazini kunye nokunyusa umngcipheko weziphumo ebezingalindelekanga.

Iziyobisi	Iklasi yeziyobisi	IPravastatin	Lipitor
ICclosporine	Amajoni omzimba	Ewe	Ewe
Clarithromycin Erythromycin	Amayeza okubulala iintsholongwane	Ewe	Ewe
Ketoconazole Itraconazole Voriconazole Posaconazole	Izinto zokubulala iintlungu	Hayi	Ewe
Ritonavir Simeprevir Ledipasvir Unokongeza IDarunavir	Izinto zokulwa neentsholongwane	Ewe	Ewe
Niacin	Iiarhente ezichasayo	Ewe	Ewe
Fenofibrate Gemfibrozil	Iifibhethi	Ewe	Ewe
I-Digoxin	Glycosides zentliziyo	Ewe	Ewe
ICholestyramine	Ukulandelelana kwe-asidi yeBile	Ewe	Ewe
Aluminium hayidroksayidi Magnesium hayidroksayidi	IiAntacids	Ewe	Ewe

Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi.

Izilumkiso zepravastatin kunye neLipitor

I-Pravastatin kunye ne-atorvastatin kufuneka ithintelwe kwabo banesifo esisebenzayo sesibindi okanye amanqanaba aphezulu e-enzyme yesibindi. Amayeza e-Statin anokubangela ukonakala kwesibindi kumntu onesifo sesibindi.

I-Pravastatin kunye ne-atorvastatin akufuneki isetyenziswe kwabo banembali ye-hypersensitivity reaction to statin amayeza. Iimpawu kunye neempawu zempendulo ye-hypersensitivity zibandakanya irhashalala, ukurhawuzelela, ukudumba, kunye nengxaki yokuphefumla.

Amayeza e-Statin anomngcipheko wokonzakala kwemisipha kunye neentlungu zomzimba. Kunokubakho umngcipheko owandayo wokuqaqanjelwa yimisipha kwabo bangaphezulu kweminyaka engama-65 ubudala okanye abo bangalawulekiyo nge-hypothyroidism okanye iingxaki zezintso.

I-Pravastatin kunye ne-atorvastatin akufuneki zisetyenziswe kwabo bakhulelweyo okanye abanyisayo.

Thetha nomboneleli wezempilo ukuba axoxe ngezinye izilumkiso okanye izilumkiso ezinxulumene nepravastatin okanye i-atorvastatin.

Imibuzo ebuzwa rhoqo malunga nepravastatin vs.Lipitor

Yintoni ipravastatin?

I-Pravastatin liyeza eliqhelekileyo elisetyenziselwa ukunciphisa i-cholesterol kunye nokuthintela iingxaki ezibangelwa ngamanqanaba aphezulu e-cholesterol. Igama lophawu lwepravastatin yiPravachol. Imiselwe ukuba ithathwe kanye yonke imihla ngokuhlwa. I-Pravastatin iyafumaneka njengecwecwe lomlomo.

Yintoni iLipitor?

I-Lipitor ligama elinegama lomenzi elenziwa yiPfizer. Igama eliqhelekileyo leLipitor yiatorvastatin. Isetyenziselwa ukunyanga amanqanaba aphezulu e-cholesterol kunye nokunciphisa umngcipheko wokuhlaselwa yintliziyo kunye nokubetha. I-Lipitor imiselwe ukuba ithathwe kanye yonke imihla kusasa okanye ngokuhlwa. Iyafumaneka njengecwecwe lomlomo.

Ngaba ipravastatin kunye neLipitor ziyafana?

Zombini i-pravastatin kunye ne-atorvastatin ngamayeza asetyenziselwa ukunciphisa amanqanaba aphezulu e-cholesterol. Nangona kunjalo, azifani. I-Atorvastatin ikakhulu i-metabolism kwi-CYP P450 inkqubo ye-enzyme esibindini ngelixa ipravastatin yophukile esiswini. I-Pravastatin ihlala ithathwa ebusuku ngelixa iLipitor ithathwa kusasa okanye ngokuhlwa.

Ngaba ipravastatin okanye iLipitor ingcono?

Zombini iipravastatin kunye neLipitor ziindlela ezisebenzayo zonyango lwe-statin. Omabini la mayeza anokunceda ukuthintela iingxaki kumanqanaba aphezulu e-cholesterol, anje nge-atherosclerosis, isifo sentliziyo kunye nokubetha. Ezinye izifundo ezivela Ijenali zentliziyo bafumene ukuba i-atorvastatin, isithako esisebenzayo kwi-Lipitor, sisebenza ngakumbi kunezinye iziyobisi ze-statin zokuthintela imicimbi ye-cardiovascular like heart attack and stroke. Umboneleli wezononophelo lwempilo unokubonelela ngeengcebiso zonyango kunyango olusemgangathweni kuwe.

Ndingayisebenzisa ipravastatin okanye iLipitor ngelixa ndikhulelwe?

I-Pravastatin kunye ne-atorvastatin azikhuthazwa ukuba zithathwe ngelixa ukhulelwe. Omabini la mayeza anomngcipheko omkhulu wokubangela iziphene zokuzalwa. Nxibelelana nomboneleli wezempilo ukuze akukhokele kunyango olulungileyo lwe-cholesterol ephezulu ngelixa ukhulelwe.

Ndingayisebenzisa ipravastatin okanye iLipitor ngotywala?

Akukho bungozi kwezempilo buchaphazelekayo ekusetyenzisweni ngokulinganisela kotywala kunye nemimiselo. Iziyobisi zestatin kunye nokusela kakhulu utywala inokonakalisa isibindi . Thetha nomboneleli wezempilo ukuvavanya ukuba kukhuselekile na kuwe ukusela utywala ngelixa uthatha amayeza e-statin.