I-Zyban vs. Chantix: Umahluko, ukufana kwaye yeyiphi engcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
Izibonelelo zempilo zokuyeka ukutshaya zininzi. Uxinzelelo lwegazi olusezantsi kunye nokubetha kwentliziyo kuza phantse kwangoko kwaye umngcipheko wokuhlaselwa sisifo sentliziyo uyehla kwiiyure nje ezingama-24. Ngapha koko, icholesterol iya kuphucula, umngcipheko womhlaza uyancipha kwaye amajoni akho omzimba kunye namathambo aya komelela.
Ngamanye amaxesha ufuna uncedo olongezelelekileyo lokuyeka, kwaye amayeza kagqirha anokunceda. Amachiza amabini amayeza aqhelekileyo okuyeka ukutshaya aquka iZyban (bupropion Hcl Er) kunye neCantix. Omabini la mayeza avunyiwe yi-US Food and Drug Administration (i-FDA) kwaye asetyenziselwa ukunceda abaguli abanokuyeka ukutshaya, kodwa basebenza ngeendlela ezahlukeneyo kwaye baneziphumo ebezingalindelekanga ezahlukeneyo.
Nguwuphi umahluko ophambili phakathi kweZyban kunye neCantix?
I-Zyban (bupropion Hcl Er) iyafumaneka ngokwesiqhelo, njenge-150 mg yeepilisi zokukhupha ezandisiweyo. UZyban akasafumaneki kwigama lophawu; yayenziwe nguGlaxoSmithKline kuqala. Isetyenziswa kwizigulana ezili-14 nangaphezulu; abaguli nabo kufuneka benobunzima ubuncinci i-89 lbs. UZyban uqalwe kwiveki enye ngaphambi kokuyeka ukutshaya, kwaye uthathwa iiveki ezi-7 ukuya kwezi-12, ngokomndilili.
I-Chantix (varenicline) ifumaneka ngegama lophawu kuphela, njenge-0.5 mg kunye ne-1 mg yeepilisi, kwaye yenziwa yinkampani yeziyobisi iPfizer. I-Chantix, esetyenziswa kubantu abadala kuphela, iqalwa kwiveki enye ngaphambi komhla wokuyeka ukutshaya kwaye ithathwa iiveki ezili-12; abaguli banokuqhubeka nezinye iiveki ezili-12 ukuba umjikelo wokuqala uphumelele.
| Umahluko ophambili phakathi kweZyban kunye neChantix | ||
|---|---|---|
| Chantix | Zyban | |
| Iklasi yeziyobisi | I-Aminoketone yokulwa noxinzelelo, ukutshaya uncedo lokuyeka ukutshaya | I-Nicotinic agonist, ukutshaya uncedo lokuyeka ukutshaya |
| Uhlobo lweBrith / generic | Ngokwesiqhelo | Igama lebrand |
| Ngubani igama eliqhelekileyo? | IBupropion | Uluhlu lweVarenicline |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yokukhululwa | Amacwecwe |
| Ithini idosi esemgangathweni? | Qala iveki enye ngaphambi kokutshaya usuku lokuyeka ukutshaya: I-150 mg yonke imihla yeentsuku ezi-3, emva koko i-150 mg kabini yonke imihla (ubuncinci iiyure ezi-8 ukwahlukana) emva koko | Qala iveki enye ngaphambi kokutshaya usuku lokuyeka ukutshaya: 0.5 mg yonke imihla ngeentsuku ezi-3, emva koko i-0.5 mg kabini yonke imihla ngeentsuku ze-4, emva koko i-1 mg kabini yonke imihla emva koko |
| Lude kangakanani unyango oluqhelekileyo? | Iiveki 7-12; iyahluka | Iiveki ezili-12, zinokuqhubeka nezinye iiveki ezili-12 |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala kunye nolutsha oluneminyaka eli-14 nangaphezulu ubudala, kufuneka babe ngaphezulu kwama-40.5 kg | Abantu abadala abaneminyaka eli-17 ubudala nangaphezulu |
Iimeko eziphathwe nguZyban kunye noChantix
IZyban (bupropion) kunye neChantix (varenicline) zombini zibonisiwe njengoncedo ekuyekeni ukutshaya unyango. Akukho nalinye ichiza elinenikotini.
Zyban i-aminoketone antidepressant; indlela echanekileyo yokuyeka ukutshaya okanye yoxinzelelo ayaziwa kodwa kucingelwa ukuba kuthintela ukuthathwa kwe-norepinephrine kunye ne-dopamine. Ngokwenza njalo, iminqweno ye-nicotine iyancipha kwaye iimpawu zokurhoxa ziyancipha.
Ayifanele idideke ne-Wellbutrin, ekwanayo ne-bupropion, iZyban isetyenziselwa kuphela ukuyeka ukutshaya ngelixa uhlobo lwe-Wellbutrin lwe-bupropion lusetyenziselwa i-Major Depression Disorder kunye ne-Seasonal Affective Disorder. Amachiza amabini awatshintshi. Nangona kunjalo, abanye oogqirha bamisela i-Wellbutrin off-ileyibheli ukuyeka ukutshaya.
I-Chantix isebenza ngokuthintela ii-nicotine receptors. Ngokwenza njalo, inkqubo ye-nervous central ayizukusebenzisa inkqubo yokuqinisa / yokufumana umvuzo ehambelana nenicotine, kwaye uya kuziva ungonwabanga ngokwengqondo nangokwasemzimbeni ngokutshaya. I-Chantix iyanciphisa iimpawu zokurhoxisa ukutshaya.
| Imeko | Zyban | Chantix |
| Ukuyeka ukutshaya | Ewe | Ewe |
Ngaba iZyban okanye iCantix isebenza ngakumbi?
Ukhuseleko kunye nokusebenza kweZyban kwafundwa ngeendlela ezininzi izilingo , usebenzisa iZyban kunye neengcebiso. Kwisifundo seeveki ezisixhenxe, uZyban waboniswa ukuba usebenze ngokukuko ngakumbi kune-placebo. Kwiinyanga ezintandathu, abaguli benze ngcono ekugcineni ukuyeka emva kokuba baphathwe ngoZyban. Kwesinye isifundo, unyango kunye neZyban lwalusebenza ngempumelelo ngakumbi kune-placebo, ukunciphisa umnqweno wokutshaya, kunye nokunciphisa iimpawu zokurhoxa (njengokucaphuka, umsindo, kunye noxinzelelo).
Kwiklinikhi izilingo I-Chantix, iyeza lafunyanwa ukunciphisa umnqweno wokutshaya, ukunciphisa iimpawu zokurhoxa, kunye nokunceda abaguli bagcine ukuyeka. Olunye uphononongo lufanisa iChantix neZyban kwi-placebo. Uphononongo lufumene ukuba zombini iziyobisi zingcono kune-placebo, kwaye yagqitywa kwelokuba iChantix yayisebenza ngakumbi kuneZyban.
Olona nyango lusebenzayo kufuneka lumiselwe kuphela ngugqirha wakho, kuthathelwa ingqalelo imeko yakho yezonyango, imbali, kunye namanye amayeza owathathayo anokusebenzisana noZyban okanye uCantix.
Umyinge kunye neendleko zokuthelekisa iZyban vs. Chantix
Ii-generics ze-Zyban zihlala zigutyungelwe yi-inshurensi kunye ne-Medicare Part D. Ngaphandle kwe-inshurensi, unikezelo lwenyanga enye lwe-generic Zyban lubiza malunga ne- $ 90. Ungalithoba eli xabiso ukuya kuthi ga kwi-50-80 yeedola nge-singleCare coupon ngokuxhomekeke kwikhemesti yakho yasekuhlaleni.
NgeChantix, uya kuqala ngethamo elisezantsi (ipakethe yenyanga yokuqala), emva koko uye ugcwalise inyanga epakishayo inyanga yesibini neyesithathu. I-Chantix ihlala igutyungelwe yi-inshurensi kunye necandelo leMedicare D, kunye neepopay eziguqukayo. Ngaphandle kwe-inshurensi, ipakethi yenyanga yokuqala ixabisa malunga ne- $ 515 kunye nepakethi yenyanga eqhubekayo ibiza malunga ne- $ 500. Ungalinciphisa ixabiso leemveliso zeChantix ngesigqebhezana esisodwa.
| Zyban | Chantix | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe (generic) | Ngokwesiqhelo; inokufuna ugunyaziso lwangaphambili kunye / okanye ube ne-copay ephezulu |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe (generic) | Ngokwesiqhelo; Iikopayi ziyahluka kakhulu |
| Umthamo osemgangathweni | I-150 mg yonke imihla yeentsuku ze-3 emva koko i-150 mg kabini yonke imihla | I-0.5 mg yonke imihla yeentsuku ze-3, emva koko i-0.5 mg kabini yonke imihla ngeentsuku ze-4, emva koko i-1 mg kabini yonke imihla (ukuqala kwepakethi kusetyenziswa inyanga enye, emva koko kusetyenziswa ipakethi eqhubekayo) |
| Uhlobo lweMedical Medicare Part D | Umyinge we-3-64 weedola; iyahluka | $ 25-578; iyahluka |
| Ixabiso elilodwa | $ 58 | $ 400 yokupakisha, $ 452 yokuqhubeka kwepakethi |
Iziphumo eziqhelekileyo ezichaphazela uZyban noChantix
Ukongeza kwiziphumo ebezingalindelekanga / izilumkiso, ezichazwe ngezantsi, ichiza ngalinye liza neziphumo ebezingalindelekanga. I-Zyban ihlala ichazwa kunye ne inicotine patch (ekwabizwa ngokuba lunyango lokutshintsha inicotine, okanye i-NRT), kunye neepesenti zempembelelo yecala zinokuphakama xa iZyban isetyenziswa ngokudibanisa nenicotine.
Iziphumo ebezingalindelekanga eziqhelekileyo zeZyban kukungalali, umlomo owomileyo, kunye nesiyezi. Iziphumo ezibi kakhulu ezichaphazelekayo ze-Chantix isicaphucaphu, iintlungu zesisu, intloko ebuhlungu kunye nokuqaqanjelwa sisisu.
Isikhokelo samayeza, sinolwazi oluneenkcukacha malunga nonyango, uya kunikwa ngomrhumo omtsha okanye wokugcwalisa kwakhona iZyban okanye iCantix. Nxibelelana nomboneleli wakho wezempilo ukuze ufumane uluhlu olupheleleyo lweziphumo ebezingalindelekanga.
| Imiphumela | Zyban: iyasebenza? | Zyban: ipesenti | I-Chantix: iyasebenza? | I-Chantix: ipesenti |
| Isicaphucaphu | Ewe | 9% | Ewe | 30% |
| Intlungu yesisu | Ewe | 3% | Ewe | 7% |
| Ukuphuthelwa / ingxaki yokulala | Ewe | 40% | Ewe | 18% |
| Amaphupha angaqhelekanga | Ewe | 5% | Ewe | 13% |
| Intloko ebuhlungu | Hayi | - | Ewe | Shumi elinantlanu% |
| Ukudinwa | Kunqabile | % ayinikiwanga | Ewe | 7% |
| Ukuba nesiyezi | Ewe | 10% | Ewe | Rhoqo:% ayinikiwe |
| Umlomo owomileyo | Ewe | 10% | Ewe | 6% |
Imithombo: Mihla le (Chantix) kwaye Yonke imihla (iZyban)
Ukudibana kweziyobisi kweZyban vs. Chantix
UZyban unexabiso elibonakalayo lokunxibelelana kweziyobisi, ezichazwe kwitshathi engezantsi. Unxibelelwano oluninzi lweziyobisi lubangelwa zii-enzymes ezibizwa ngokuba yi-CYP2B6 kunye ne-CYP2D6. Eminye imizekelo kukuthimba amayeza kunye neDigoxin, iyeza lentliziyo. Utywala kufuneka buthintelwe ngelixa useZyban.
Ngokusekelwe kwiimpawu zesilwanyana, i-Chantix ayinakho ukusebenzisana kweziyobisi. I-Chantix ayifundanga ngokhuseleko ngokudibeneyo neZyban. Xa uChantix wayefundwa ngokudibeneyo kunye nonyango lokutshintsha endaweni ye-nicotine, izehlo zeziphumo ebezingalindelekanga, isicaphucaphu, intloko ebuhlungu, ukugabha, isiyezi, ukungaginyisi mathe nokudinwa, kwakuphakame kakhulu kune-nicotine yodwa.
I-Chantix akufuneki isetyenziswe ngokudibeneyo utywala , ubuncinci de ube uyazi ukuba iChantix ichaphazela njani ukubanakho kwakho ukubunyamezela utywala. Qhagamshelana nomboneleli wakho wezempilo ngolwazi olungakumbi.
| Iziyobisi | Iklasi yeziyobisi | Zyban | Chantix |
| Inikotini | Unyango oluthatha indawo yeNicotine | Hayi | Ewe |
| Tegretol (carbamazepine), Neurontin (gabapentin), Lamictal (lamotrigine), Phenobarbital, Dilantin (phenytoin), Trileptal (oxcarbazepine), Topamax (topiramate), Depakote (divalproex sodium) | Amayeza okuhlutha, ezinye zikwasetyenziselwa ukuphazamiseka kwengqondo | Ewe | Hayi |
| IKlonopin (clonazepam), Valium (diazepam), Ativan (lorazepam) | IiBenzodiazepines | Ewe | Hayi |
| IPlavix (iclopidogrel) | Antiplatelet | Ewe | Hayi |
| Utywala | Utywala | Ewe | Ewe |
| ILanoxin (digoxin) | Iglycoside yentliziyo | Ewe | Hayi |
| I-Lopressor okanye i-Toprol XL (metoprolol), iTenormin (atenolol), Inderal (propranolol) | Beta-iibhlokhi | Ewe | Hayi |
| Risperdal (risperidone), Haldol (haloperidol) | Iintsholongwane | Ewe | Hayi |
| Effexor (venlafaxine), Pamelor (nortriptyline), Paxil (paroxetine), Prozac (fluoxetine), Zoloft (sertraline) | Ukudakumba | Ewe | Hayi |
| I-Ultram (tramadol), iCodeine | Iintlungu | Ewe | Hayi |
| I-Eldepryl (selegiline), iParnate (tranylcypromine) | I-MAO Inhibitors | Ewe | Hayi |
Uluhlu lokunxibelelana kweziyobisi eZyban lude kakhulu ukuba luluhlu apha; qhagamshelana nomboneleli wakho wezempilo ngolwazi olungakumbi.
Izilumkiso Zyban kunye neCantix
Izilumkiso zikaZyban:
UZyban uza nesilumkiso sebhokisi emnyama (isilumkiso esomeleleyo njengoko kufunwa yi-FDA, ebonisa umngcipheko weziganeko ezinobuzaza okanye ezisongela ubomi) zokuzibulala. IZyban iqulethe i-bupropion, i-anti-depressant, kunye ne-anti-depressants inokunyusa umngcipheko wokucinga ngokuzibulala kunye nokuziphatha kwizigulana ezineminyaka engama-24 ubudala nangaphantsi. Izigulana kunye nabakhathaleli babo kufuneka babenolwazi ngalo naluphi na utshintsho lweemvakalelo, ukubona izinto ezingekhoyo, paranoia, inkohliso, umbono wokubulala, ubundlongondlongo, ubutshaba, ukuphazamiseka, ixhala kunye noloyiko. Nasiphi na isigulana esithatha uZyban, nokuba ungakanani na ubudala, kufuneka sibekwe esweni. Nazi ezinye izilumkiso:
- Umngcipheko weemania okanye isifo sengqondo; umngcipheko unokuphakama kwizigulana ezinesifo sokuphazamiseka kwengqondo.
- UZyban unokubangela ukuxhuzula; umngcipheko unxulumene nedosi. Umthamo kufuneka ungagqithi kwi-300 mg ngosuku. Ezinye iimeko zonyango zinokunyusa umngcipheko wokubanjwa.
- UZyban unokubangela uxinzelelo lwegazi oluphezulu; jonga uxinzelelo lwegazi ngelixa uthatha iZyban.
- Abanye abaguli banokuba semngciphekweni we-glaucoma; Nxibelelana nodokotela wakho wamehlo ngolwazi oluthe kratya.
- Ukujamelana nolusu olunobuzaza, nolusongela ubomi (iStevens-Johnson syndrome) lunokwenzeka; Nxibelelana nomboneleli wakho wezempilo kwangoko ukuba uvela irhashalala.
I-Zyban kufuneka isetyenziswe kuphela ngexesha lokukhulelwa ukuba isibonelelo esinokubakho siqinisekisa ubungozi obunokubakho kwimveku. Abatshayayo abakhulelweyo kufuneka bakhuthazwe ukuba bayeke ukutshaya ngeendlela zokuziphatha ngaphambi kokusebenzisa iZyban. IZyban faka iphakheji ithi ngenxa yomngcipheko wosana, oomama abancancisayo kufuneka bayeke ukuncancisa okanye bayeke uZyban. Qhagamshelana nomboneleli wakho wezempilo ngengcebiso.
Izilumkiso zechantix:
I-Chantix iza nesilumkiso esibhokisi seziganeko ezinzulu ze-neuropsychiatric. Uxinzelelo, umbono wokuzibulala, ukuzama ukuzibulala, kunye nokuzibulala kugqityiwe kwizigulana ezithatha iChantix. Kuya kufuneka uyeke ukuthatha i-Chantix kwaye unxibelelane nomboneleli wakho wezempilo kwangoko ukuba ukhula, ubundlobongela, uxinzelelo lwengqondo, okanye utshintsho kwindlela yokuziphatha okanye ukucinga okungaqhelekanga, okanye ukuba uneengcinga zokuzibulala. Nazi ezinye izilumkiso ezinxulumene neCantix:
- Umngcipheko we-hypersensitivity okanye i-angioedema, kukudumba kobuso, umlomo, (ulwimi, imilebe, neentsini), imiphetho kunye nentamo. Yeka i-Chantix kwaye ufune unyango olungxamisekileyo xa oko kwenzeka.
- NjengoZyban, isifo sikaStevens-Johnson sinokwenzeka. Qhagamshelana nomboneleli wakho wezempilo ngokukhawuleza ukuba uhlakulela ukugqithisa kwesikhumba.
- Ithuba elinokubakho lokunyuka kweziganeko zentliziyo; yazisa umboneleli wakho wezempilo ngempawu ezintsha okanye eziba mandundu zesifo sentliziyo.
- Sebenzisa ukuqhuba ngononophelo okanye usebenze ngoomatshini de ube uyazi indlela iChantix ekuchaphazela ngayo; ukwenzakala ngengozi kwenzeke ngenxa yokulala okanye ukuba nesiyezi.
Oomama abakhulelweyo balumkele iimpembelelo zikaChantix kwimveku engekazalwa. NjengakuZyban, abantu abatshayayo abakhulelweyo kufuneka bakhuthazwe ukuba bayeke ukutshaya ngeendlela zokuziphatha. IChantix faka iphakheji ithi ngenxa yomngcipheko wosana, oomama abancancisayo kufuneka bayeke ukuncancisa okanye bayeke uChantix.
Izigulana kwiChantix kufuneka zijongwe ngononophelo.
Ngo-2016, i Kuxelwe i-FDA ukuba umngcipheko wempembelelo yezempilo yengqondo evela kuZyban kunye neChantix inokuba sezantsi kunokuba bekucingelwa ngaphambili kwaye izibonelelo zokuyeka ukutshaya zingaphezulu komngcipheko wokusebenzisa la mayeza. Nokuba kunjalo, ulwazi ngamachiza lusenezilumkiso ezifanayo kwaye izigulana kufuneka zijongwe ngononophelo ngelixa ziseZyban okanye eCantix.
Imibuzo ebuzwa rhoqo malunga neZyban vs. Chantix
Yintoni uZyban?
UZyban (bupropion) lunyango olusetyenziswa njengoncedo kunyango lokuyeka ukutshaya.
Yintoni iCantix?
I-Chantix (varenicline) lunyango olusetyenziswa njengoncedo kunyango lokuyeka ukutshaya.
Ngaba iZyban kunye neCantix ziyafana?
Hayi. Omabini la machiza asebenza ngeendlela ezahlukeneyo ukunceda kunyango lokuyeka ukutshaya. Inkqubo ngqo kaZyban ayaziwa kodwa kuthathwa ngokuba inxulumene ne-dopamine kunye ne-norepinephrine. I-Chantix isebenza ngokuthintela ii-nicotine receptors, nangokuthintela ukuqiniswa kunye nokufumana imbuyekezo kwinkqubo yovalo. Akukho nalinye ichiza elinenikotini. Banamaxabiso ahlukeneyo, ukusebenzisana kweziyobisi, iziphumo ebezingalindelekanga, kunye nezilumkiso, njengoko kucacisiwe apha ngasentla.
Ngaba iZyban okanye iCantix ibhetele?
Wonke umntu usabela ngokwahlukileyo kumayeza ahlukeneyo. Ngugqirha wakho kuphela onokumisela ukuba leliphi iyeza elilungele wena, kuthathelwa ingqalelo imbali yakho yezonyango, imeko yezonyango, kunye namanye amayeza owathathayo.
Ngaba ikhona enye indlela kuneCantix?
Okwangoku akukho enye indlela yokwenza iChantix.
Ngaba ichantix iyanceda ukuyeka ukutshaya?
Ewe. I-Chantix inokukunceda ukunciphisa umnqweno wakho wokutshaya kunye nokunceda kwiimpawu zokurhoxa.
