Ngaba kukhuselekile ukuthatha iTrulicity kunye ne-metformin kunye?

Ulwazi lweziyobisi

Abo baphila nesifo seswekile bayayazi indlela enokuthi ibuchaphazele ngayo ubomi bomntu. Ezi ndidi zimbini zeswekile, Uhlobo lwe-1 kunye nohlobo 2 , Zombini zinokwenza ubomi bemihla ngemihla bube noxinzelelo ngakumbi. Iindaba ezimnandi zezokuba unyango lwesifo seswekile luphuculwe kakhulu kumashumi eminyaka. Amayeza lolunye lolona khetho lufanelekileyo kunyango kubantu abanesifo seswekile kuba banokunceda ekulawuleni amanqanaba eswekile yegazi kunye nokugcina umzimba usempilweni. Amayeza amabini asaziwa seswekile yiTrulicity kunye ne-metformin. Zombini ziphatha udidi 2 lweswekile, kwaye ngamanye amaxesha, zithathwa kunye.

Ngaba iTrulicity kunye ne-metformin yinto enye?

IMetforminlunyango lweswekile olunyanga isifo seswekile ngokunceda ukulawula ubuntununtunu bomzimba kwi-insulin. Yenzelwe ukuba yinxalenye yesicwangciso sonyango esikhulu kuDidi 2 lweswekile olubandakanya ukutya kunye nokuzilolonga. Lunyango lonyango lonyango lodidi lokuqala lweswekile kwaye lunokudityaniswa namanye amayeza asetyenziselwa ukunyanga isifo seswekile sohlobo lwe-2.

Ubunzimaliyeza elinegama lophawu elisetyenziselwa ukunyanga udidi 2 lweswekile ngokudibanisa nokutya okusempilweni kunye nokuzilolonga umzimba. I-Trulicity inceda ukunciphisa amanqanaba eswekile esegazini ngokuphucula ukugcinwa kwe-insulin. Ingasetyenziselwa yona okanye ngamanye amayeza anyanga uhlobo lweswekile yesibini. Ikwanciphisa umngcipheko weziganeko ezinkulu zentliziyo ezinje ngokuhlaselwa kwentliziyo kunye nemivumbo yohlobo lweswekile eneempawu zengozi yesifo sentliziyo.

Ngamanye amaxesha iTrulicity ingathathwa ngaxeshanye ne-metformin, ekhuselekileyo ukuyenza phantsi kweemeko ezifanelekileyo. Makhe sijonge ngakumbi kwi-Trulicity kunye ne-metformin ukuqonda ngcono xa kukhuselekile ukuzithatha kunye.

Ngaba i-Trulicity okanye i-metformin ingcono?

Umbutho we-American Diabetic Association ucebisa i-metformin njengonyango lokuqala lohlobo lwe-2 yeswekile. Kwi Ngo-2014 , I-Trulicity yaziswa e-US njenge-inaliti enokunceda ukuphucula ulawulo lwe-glycemic kubantu abadala abane-Type 2 diabetes. Kwanasemva kokuba iTrulicity ibekwe kwintengiso, i-metformin isabambe isikhundla sayo njengonyango lokuqala lokukhetha kuhlobo lwe-2 yeswekile kuba ibonakalisiwe ukuba iyasebenza kwaye ayibizi. I-Metformin inokuwisa amanqanaba e-HbA1C (hemoglobin) nge-1.5%, ngokwe Unyango lukaJohn Hopkins . I-FDA ayisacebisi iTrulicity kunyango lokuqala lwesifo seswekile sesi-2, kodwa iyasebenza ekunyangeni le meko kwaye ibonakalisiwe ukuwisa amanqanaba e-HbA1C ngokungangoko 0.5% ukuya kwi-1.5% kwizilingo zonyango.

Iklasi yeziyobisi

I-Metformin yeqela lamayeza abizwa ngokuba yi-biguanides anciphisa inani leswekile etsalwe kukutya kwaye yenziwe sisibindi. I-Metformin ingasetyenziselwa yodwa okanye idityaniswe namanye amayeza, kubandakanya i-insulin.

I-Trulicity ligama lophawu lweyeza eliqhelekileyo elibizwa ngokuba yi-dulaglutide, eliliqela lamayeza abizwa ngokuba yi-GLP-1 receptor agonists. Olu hlobo lonyango lunyanga i-Type 2 diabetes ngokukhuthaza ukuveliswa komzimba kwe-insulin nangokunciphisa isibindi sokwenza iswekile. I-Trulicity yinto engenayo i-insulin engenayo inkulu yokulawula amanqanaba eglucose egazini enomngcipheko ophantsi we-hypoglycemia. Ayisiyonto ithatha indawo ye-insulin kwaye ayinakunyanga udidi 1 lweswekile. Xa kuthelekiswa nezinye i-GLP-1 receptor agonists ezinjeBydureon (exenatide) kunye UVictoza (I-liraglutide), i-Trulicity iyasebenza ngokuthoba amanqanaba e-Hgb-A1c.

Ezinxulumene: Thelekisa iTrulicity vs.Victoza

Imilinganiselo emiselweyo

I-Metformin ifumaneka njengecwecwe lomlomo kumthamo wamandla e-500 mg, 850 mg, kunye ne-1000 mg. Ikwafumaneka njengecwecwe lokukhutshelwa elandisiweyo kumandla omthamo we-500 mg, i-750 mg, i-1000 mg, kunye nesisombululo somlomo esinokukhetha amandla alinganayo. Inkqubo ye- idosi esemgangathweni yemetformin yohlobo lwesibini lweswekile yi-500 mg ethathwa kabini ngemini okanye i-850 mg ithathwa kube kanye ngemini ngokutya. Inani le-metformin oya kuyithatha liya kwahluka ngokusekwe kwiimpawu zakho ezizodwa kunye nembali yezonyango, ke ihlala ingumbono olungileyo ukuthetha nengcali yezempilo malunga nokuba yeyiphi na idosi yamandla e-metformin ekufaneleyo.

I-Trulicity ifumaneka kuphela njengenaliti kodwa inokunikwa ngamandla e0.75 mg / 0.5 mL, 1.5 mg / 0.5 mL, 3 mg / 0.5 mL, okanye 4.5 mg / 0.5 mL ngepeni enye yedosi. I-dose yokuqala ephakanyisiweyo ye-Trulicity yokunyanga i-Type 2 diabetes mellitus is 0.75 mg inikezwe ngenaliti yangaphantsi kanye ngeveki. Umboneleli wezempilo unokunyusa i-Trulicity dosing ngokuhamba kwexesha kulawulo lwe-glycemic, kodwa iidosi eziphezulu zeTrulicity zinokubangela iziphumo ebezingalindelekanga, ngakumbi isicaphucaphu. Ukuthetha nengcali yezonyango yeyona ndlela ifanelekileyo yokufunda ngakumbi malunga nokuba yeyiphi na amandla eTricicity efanelekileyo kuwe.

Iindleko

I-Metformin liyeza elincinci elingaphantsi kweendleko ukusuka kwi-8 yeedola ukuya kwi-150 yeedola ngaphandle kwe-inshurensi. Njengawo nawaphi na amayeza, ixabiso liya kunyuka okanye lihle ngokuxhomekeke kubungakanani beepilisi ezithengiweyo. Indlela elungileyo yokugcina imali kwi-metformin kukusebenzisa ikhuphoni ye-metformin onokuthi ulahle imali oyihlawule kwi- $ 4.

Trulicity sisiyobisi esibiza kakhulu, ngakumbi kubantu abangenayo i-inshurensi yezempilo. Ngaphandle kweinshurensi yezempilo, kubiza ngaphezulu nje kwe- $ 1,440 ngenaliti enye yeTrulicity. Ezinye izicwangciso zeinshurensi yezempilo zinokunceda ukuhlawula iindleko eziphezulu zeTrulicity, kunye neekhuphoni ezikwi-Intanethi ezinjenge-SingleCare's Ikhuphoni yeTrulicity Ungalahla ixabiso liye kuthi ga kwi-771.34 yeedola ngenaliti nganye. Umvelisi weTrulicity, u-Eli Lilly kunye neNkampani, ukwabonelela ngezaphulelo kwiipeni zeTrulicity kwizigulana ezifanelekileyo.

Imiphumela

I-Metformin inokubangela into ethile imiphumela kulungile ukuba uqaphele. Nazi ezinye zeempembelelo eziqhelekileyo kwimetformin:

• Isicaphucaphu
• Irhasi
• Ukuqhawula
• Isitshisa
• Ukuqunjelwa
• Ukuhla ukusinda
• Urhudo
• Ubuthathaka
• Ukugodola

Nazi iimpembelelo eziqhelekileyo ezichaphazelekayo zeTrulicity ezifunyanwa ngabantu:

• Intlungu zesisu
• Ukunciphisa ukutya
• Isicaphucaphu
• Ukuhlanza
• Urhudo
• Impendulo yendawo yenaliti njengokudumba, iintlungu, okanye ukurhawuzelela

Isicaphucaphu yenye yezona ziphumo zixhaphakileyo zeTrulicity; malunga I-8% ukuya kwi-29% yabantu abathatha ingxelo yamayeza baziva benesicaphucaphu kwiintsuku ezimbini ukuya kwezintathu emva kokufumana idosi. Oku kuyahamba kubantu abaninzi emva kweveki yabo yesibini yonyango, kodwa kwabo basenaso isicaphucaphu emva koko, Nazi ezinye zeendlela zokukunceda ukuba ihambe: Yitya ukutya okuncinci, yitya ukutya okungcolileyo, kwaye uyeke ukutya xa uziva uhluthi.

Nangona kunqabile, zombini iTrulicity kunye ne-metformin zinokubangela iziphumo ebezingalindelekanga ezibi kakhulu. Ukuba uthatha naliphi na iyeza kwaye uqala ukufumana ubunzima bokuphefumla, ukudumba kobuso okanye umqala, okanye imingxunya, kuya kufuneka ufune iingcebiso kwezonyango kwangoko. Le yimiqondiso yokuphendula komzimba, enokusongela ubomi ngaphandle konyango olukhawulezileyo.

Ezi ziphumo zecala le-metformin kunye neTrulicity azihlanganisi. Ingcali yezonyango inokukunika uluhlu olupheleleyo lweziphumo ebezingalindelekanga onokuzifumana ukuba uthatha naliphi na iyeza.

Iingozi kunye nezithintelo

Nangona i-metformin isebenza kakuhle kunyango lwe-2 yeswekile, akufuneki ithathwe ngumntu wonke. I-Metformin isenokungabi lonyango olufanelekileyo kubantu abane:

• Ukukhubazeka okukhulu kwezintso
• I-ketoacidosis engapheliyo okanye engapheliyo
• Ukungasebenzi kakuhle kwezintso okanye isibindi
• Ukumelwa yintliziyo

I-Metformin iza nesilumkiso esinebhokisi kumngcipheko okhulayo wokufumana i-lactic acidosis, imeko apho i-lactic acid engaphezulu iyaqokelelana kwigazi kwaye ibangele ubuthathaka, iintlungu zesisu, urhudo kunye nokuphefumla ngokungaqhelekanga. Kuya kufuneka ufune unyango kwangoko ukuba uthatha i-metformin kwaye unazo naziphi na iimpawu ze-lactic acidosis.

Kukho idatha encinci malunga nokuba i-metformin ikhuselekile kubafazi abakhulelweyo nabancancisayo. Izifundo azibonisanga ubudlelwane obaneleyo phakathi kokusetyenziswa kwe-metformin ngexesha lokukhulelwa kunye neziphene zokuzalwa okanye ukuphuphuma kwesisu. Izifundo zonyango ziye zabonisa ukuba i-metformin iveza ubisi lwebele, kodwa akukho datha yaneleyo yokufumanisa ukuba ichaphazela njani iintsana ezincancisayo.

I-Trulicity isenokungabi lonyango olufanelekileyo kwabo:

• Imbali yobuqu okanye yosapho ye-medullary thyroid carcinoma
• Uhlobo lwe-endocrine neoplasia syndrome yohlobo 2 (MEN 2)
• I-ketoacidosis yeswekile
• Iingxaki zepancreas ezifana ne-pancreatitis

I-trulicity ayivunyelwanga kwizigulana ezingaphantsi kweminyaka eyi-18.

Inesilumkiso esinebhokisi, kodwa kumngcipheko owandileyo wokufumana izicwili ze-C-cell.I-GLP-1 i-receptor agonists efana ne-Trulicity iye yabangela ukuba izicubu ze-thyroid zenze iigundane kunye neempuku kwiindawo ezichaphazelekayo, kodwa akungaziwa ukuba i-Trulicity okanye i-Trulicity iya kubangela i-C-cell tumors efanayo kubantu. Ngoko ke, abantu abanomdlavuza we-thyroid akufanele bathathe iTrulicity.

Abantu abathatha iTrulicity banokuba semngciphekweni wokuphazamiseka kwepancreatitis, i-hypoglycemia, ukulimala kwezintso, isifo sesisu kunye neengxaki zesisu.Kukho idatha encinci malunga nendlela iTrulicity ebachaphazela ngayo abasetyhini abakhulelweyo nabancancisayo, kodwa ngokusekwe kwizifundo zezilwanyana, kunokubakho umngcipheko kwiintsana ezivezwe ichiza ngexesha lokukhulelwa.

Abafazi abakhulelweyo kufuneka bathathe iTrulicity kuphela ukuba izibonelelo zayo ezinokubakho zingaphezulu kweziphumo zazo ezinokubakho, ngokwemiyalelo yomenzi.Umboneleli wakho wezempilo angakunika ulwazi oluthe kratya malunga nokuba i-Trulicity ilungile kuwe ngokusekwe kwimbali yakho yonyango.

Thelekisa iTrulicity vs. metformin
	Ubunzima	IMetformin
Iklasi yeziyobisi	I-Glucagon-efana nepeptide-1 agonist	IBiguanide
Idosi esemgangathweni kunye neefom	I-0.75 mg injected subcutaneous kanye ngeveki esiswini, ethangeni, okanye engalweni ephezulu	I-500 mg ithathwa kabini ngemini okanye i-850 mg ithathwa kanye ngemini kunye nokutya
Iingozi / izithintelo ekufuneka ziqwalaselwe	Hayi kubantu abane-medullary thyroid carcinoma Ayenzelwe abantu abane-mI-ultiple endocrine neoplasia syndrome yohlobo 2 Yandisa umngcipheko wokufumana i-pancreatitis, i-hypoglycemia, kunye nokulimala kwezintso	Ubungakanani be-lactic acidosis Hayi kubantu abaneengxaki zesibindi okanye zezintso Akunjalo ngabantu abanokukhubazeka kwezintso
Imiphumela	Isicaphucaphu Urhudo Intlungu zesisu	Isicaphucaphu Urhudo Irhasi
Ixabiso eliphakathi ngaphandle kweinshurensi	$ 1,440+ ngenaliti nganye	$ 100 + ngenyanga
Funda nzulu	Iinkcukacha ezithe kratya	Iinkcukacha ezithe kratya zemetformin

Ukuthatha iTrulicity kunye ne-metformin kunye

Abanye abantu abanesifo seswekile sesi-2 banokufuna iTrulicity kwaye metformin ukufikelela kwiinjongo zeswekile yegazi. Oku kukhuselekile ukuba ukwenze ngemvume kagqirha. Ngamanye amaxesha abaguli bamiselwe zombini i-Trulicity kunye ne-metformin kuba banokuba nefuthe lokusebenzisana, utsho UBen Tanner , PA, umseki we ifastwell.com . I-Trulicity yonyusa ukutyeba, icotha ukukhupha isisu, kwaye yonyusa imveliso yomzimba we-insulin. I-Metformin ngokubanzi inceda ukumodareyitha kunye nokuhambisa amanqanaba eswekile yegazi (ngokunciphisa imveliso yeglucose esibindini, phakathi kwezinye izinto).

Ukuthatha omabini la machiza ngaxeshanye kuya kuthetha ukuthatha idosi yemihla ngemihla ye-metformin kunye nedosi yeveki yeTrulicity. Umboneleli wakho wezempilo unokutshintsha amayeza akho amayeza ngokusekwe kwiinjongo zeswekile yegazi, iimpawu, kunye nembali yezonyango. Landela izikhokelo zikagqirha wakho kunye nemiyalelo yomenzi yokuthatha amayeza, njengokuthatha i-metformin kunye nokutya, ukuqinisekisa ukhuseleko nokusebenza ngokufanelekileyo.

Ezinye izifundo, ezinje nge ISIFUNDO-10 SOKUFUNDA , ibonakalisile ukuba xa iTrulicity idityaniswe ne-metformin kunye ne-SGLT-2 inhibitor, inokuba lunyango olusebenzayo nolunyamezelwayo kubantu abane-Type 2 yeswekile.

Kubalulekile ukuba uqaphele imiphumo emibi ngaphambi kokuba uthathe i-Trulicity kunye ne-metformin ngexesha elifanayo.Kuyenzeka ukuba ube neziphumo ebezingalindelekanga ekuthatheni zombini ngaxeshanye, ezinje ngeswekile esezantsi yegazi. Ngenxa yeso sizathu, kungcono ukuba usebenzise idosi ephantsi ekuqaleni ukuba ubathatha bobabini kunye. Emva koko unokuhlengahlengisa ngokuthe ngcembe, kuxhomekeke kwindlela umzimba wakho ophendula ngayo, utshilo uTanner.

Thetha nomboneleli wakho wezempilo ukuze ufunde okungakumbi ngokuthatha iTrulicity kunye ne-metformin kwangaxeshanye. Unokukuxelela ukuba ngaba kukho nasiphi na isizathu sokuba ungafanelekanga ukuthatha la mayeza mabini ngaxeshanye.