I-Atorvastatin vs simvastatin: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
I-Atorvastatin kunye ne-simvastatin ngamachiza amabini amiselweyo esiqhelo anyanga i-cholesterol ephezulu. Ugqirha wakho unokumisela elinye lala mayeza ukuba unamazinga aphezulu e-LDL (low-density lipoprotein) cholesterol, ekwabizwa ngokuba yi-cholesterol embi. Ngokunciphisa amanqanaba e-cholesterol, i-atorvastatin okanye i-simvastatin inokunceda ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokubetha.
Ngokukodwa, i-atorvastatin kunye ne-simvastatin isebenza njenge-HMG-CoA reductase inhibitors. Ngokuthintela i-HMG-CoA yokunciphisa i-enzyme, ezi iimimiselo ukunciphisa imveliso yecholesterol esibindini. Nge-cholesterol encinci ejikeleza egazini, umzimba uyakwazi ukubuyisela kwakhona i-cholesterol engaphezulu kunye nokunciphisa amanqanaba e-cholesterol.
I-Atorvastatin kunye ne-simvastatin inokusebenza ngeendlela ezifanayo kodwa banomahluko okhoyo kumthamo, ulawulo, kunye neziphumo ebezingalindelekanga ezinokubakho.
Yintoni umahluko ophambili phakathi kwe-atorvastatin kunye ne-simvastatin?
I-Atorvastatin ikwaziwa ngegama layo, iLipitor, eyayivunyiwe yi-FDA ngo-1996. Phakathi kwezinye izinto ezisetyenziswayo, kuyalelwe ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo okanye ukubetha kwabo isifo sentliziyo .
I-Atorvastatin (Yintoni iAtorvastatin?) Inobude obude beyure ezili-14. Iyeza liyasebenza xa sele lithathiwe, kwaye umsebenzi wayo wokunciphisa i-lipid unokuhlala 20 ukuya kwiiyure ezingama-30 emva kolawulo. Kunye ne-rosuvastatin, okanye i-Crestor, i-atorvastatin sisiyobisi esinamandla ngakumbi kuneminye imithetho efana ne-simvastatin kunye ne-pravastatin.
I-Atorvastatin iyafumaneka kwi-10 mg, 20 mg, 40 mg, kunye neepilisi ezingama-80 mg. Idosi yokuqala ekucetyiswa ukuba yi-10 okanye i-20 mg kanye yonke imihla nangona idosi eqhelekileyo inokusuka kwi-10 ukuya kwi-80 mg kanye yonke imihla. I-Atorvastatin ingathathwa nanini na emini.
ISimvastatin (Yintoni iSimvastatin?) Ikwabizwa ngegama lalo igama, iZocor. Xa kuthelekiswa ne-atorvastatin, i-simvastatin sisiyobisi esidala esaqala ukwamkelwa yi-FDA ngo-1991. Njengezinye ii-statins, isetyenziselwa ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokufa icala kwabo baneengozi zentliziyo.
Ngaba ufuna elona xabiso lilungileyo kwi-simvastatin?
Bhalisela izilumkiso zamaxabiso e-simvastatin kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Ngokungafaniyo neatorvastatin, I-simvastatin yiprodrug . Intsingiselo, ayisebenzi de ibe yenziwe umzimba, okanye iqhubekeke, esibindini. Emva kokulungiswa, i-simvastatin ijika ibe yimo esebenzayo, i-simvastatin acid, enesiqingatha sobomi beyure enye ukuya kwezimbini.
I-Simvastatin iyafumaneka kumandla e-5 mg, 10 mg, 20 mg, 40 mg, kunye ne-80 mg. Idosi yokuqala ekucetyiswa ukuba yi-10 okanye i-20 mg kanye yonke imihla, kwaye idosi eqhelekileyo inokubakho ukusuka kwi-5 kuye kwi-40 mg ngosuku. I-Simvastatin icetyiswa ukuba ithathwe ebusuku.
| Umahluko ophambili phakathi kwe-atorvastatin kunye ne-simvastatin | ||
|---|---|---|
| Atorvastatin | Simvastatin | |
| Iklasi yeziyobisi | I-HMG-CoA ukunciphisa i-inhibitor Statin | I-HMG-CoA ukunciphisa i-inhibitor Statin |
| Uhlobo lweBrith / generic | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo |
| Ngubani igama lophawu? | Lipitor | IZocor |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo | Ithebhulethi yomlomo |
| Ithini idosi esemgangathweni? | I-10 ukuya kwi-80 mg kanye yonke imihla | I-5 ukuya kwi-40 mg kanye yonke imihla |
| Lude kangakanani unyango oluqhelekileyo? | Unyango nge-atorvastatin lixesha elide ukulawula amanqanaba e-cholesterol kunye nokugcina umngcipheko osezantsi wokuhlaselwa sisifo sentliziyo kunye nokubetha. | Unyango nge-simvastatin lixesha elide ukulawula amanqanaba e-cholesterol kunye nokugcina umngcipheko osezantsi wokuhlaselwa sisifo sentliziyo kunye nokubetha. |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala; abantwana kunye nabakwishumi elivisayo abaneminyaka eli-10 ukuya kweli-17 ubudala abane-heterozygous Family hypercholesterolemia (HeFH) | Abantu abadala; abantwana kunye nabakwishumi elivisayo abaneminyaka eli-10 ukuya kweli-17 ubudala abane-heterozygous Family hypercholesterolemia (HeFH) |
Iimeko zonyango lwe-atorvastatin kunye ne-simvastatin
I-Atorvastatin kunye ne-simvastatin zisetyenziselwa iinjongo ezifanayo. Zombini ziphatha amanqanaba aphezulu e-cholesterol (hypercholesterolemia), amanqanaba aphezulu eepidid (hyperlipoproteinemia), kunye amanqanaba aphezulu e-triglyceride (hypertriglyceridemia). Kwangelo xesha, ii-statins zinokunceda ukwandisa i-cholesterol ye-HDL, uhlobo lwe-cholesterol elungileyo eneziphumo ezikhuselayo kwisifo sentliziyo.
I-Atorvastatin kunye ne-simvastatin nazo zinokunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokufa icala kwezi zinto zilandelayo:
- Abantu abadala ngaphandle kwesifo sentliziyo (i-CHD) abanezinto ezininzi ezinobungozi
- Abantu abadala abanesifo seswekile sesi-2 ngaphandle kwe-CHD, kodwa banobungozi obuninzi
- Abantu abadala abane-CHD efunyanisiweyo
Izinto ezinobungozi kwiziganeko zentliziyo zingabandakanya uxinzelelo lwegazi oluphezulu (uxinzelelo lwegazi) kunye neswekile ephezulu yegazi (isifo seswekile).
I-Atorvastatin kunye ne-simvastatin inokunciphisa i-cholesterol kunye neepidid level kwabo bane Ukuphazamiseka kwemfuza , ezinje ngehomozygous Family hypercholesterolemia (HoFH). Ezi ziqulatho zinokunyanga abantwana kunye nolutsha (iminyaka eli-10-17 ubudala) nge-heterozygous Family hypercholesterolemia (HeFH).
Unyango lwe-atherosclerosis, okanye i-fatty deposits kwiindonga zemithambo yegazi, sesinye isizathu sokuba i-atorvastatin okanye i-simvastatin inokumiselwa. Ngokunciphisa i-plaque kwiindonga zemithambo yegazi, ezi statins zinokunceda ukunciphisa iimpawu ezinjengeentlungu zesifuba (angina).
| Imeko | Atorvastatin | Simvastatin |
| Isifo sehypholeholeoleolemia | Ewe | Ewe |
| Hyperlipoproteinemia | Ewe | Ewe |
| Hypertriglyceridemia | Ewe | Ewe |
| Ukuhlaselwa yintliziyo kunye nokuthintela ukubetha | Ewe | Ewe |
| I-atherosclerosis | Ewe | Ewe |
Ngaba i-atorvastatin okanye i-simvastatin iyasebenza ngakumbi?
I-Atorvastatin kunye ne-simvastatin zombini zisebenza ngokunyanga. Izifundo zibonise ukuba abo bathatha amayeza abo e-statin ubuncinci i-90% yexesha unokwehliswa umngcipheko wokufa ngenxa yesifo sentliziyo, ukubetha, okanye nasiphi na isizathu. Ngokubanzi, ii-statins zisebenza kakhulu ekunciphiseni amanqanaba e-cholesterol kunye nokunciphisa imeko yokuhlaselwa yintliziyo kunye nokubetha.
Akukho zilingo zomeleleyo entloko ukuya entloko ngokuthelekisa i-atorvastatin kunye ne-simvastatin esele iqhutyiwe. Nangona kunjalo, i-atorvastatin ithathwa njengechiza elinamandla kune-simvastatin. Kwi Olunye uphando lwamva nje , I-atorvastatin yafunyanwa isebenza ngakumbi ekwehliseni i-LDL cholesterol (LDL-C) kune-simvastatin. Olu pho nonongo luqulunqe iziphumo ezivela kuma-50 angenamsebenzi, iimvavanyo zeklinikhi, kunye nokuthelekisa ezinye iziyobisi ze-statin ezifana ne-fluvastatin, i-pravastatin, i-rosuvastatin kunye ne-lovastatin. I-Rosuvastatin yayinamandla aphezulu okunciphisa amanqanaba e-LDL kwisifundo.
Ngenye uphononongo olucwangcisiweyo , Izifundo ezingama-75 ezahlukeneyo ngokuthelekisa amayeza e-statin zahlaziywa. Ngokweziphumo zeqela lokufunda, idosi yemihla ngemihla ye-atorvastatin 10 mg inokunciphisa i-cholesterol ye-LDL ngama-30% -40% ngelixa idosi yemihla ngemihla ye-simvastatin 10 mg inokunciphisa i-cholesterol ye-LDL ngama-20% -30%. Nangona kunjalo, iziphumo zeklinikhi zalo mahluko zisenokungabonakali.
Nxibelelana nomboneleli wakho wezempilo ukumisela olona nyango lusebenzayo kuwe. Ukusebenza kwama-statins kuya kuxhomekeka kwimbali yakho yezonyango kunye nosapho, phakathi kwezinye izinto.
Ukufunyanwa kunye nokuthelekiswa kweendleko ze-atorvastatin vs simvastatin?
I-Atorvastatin iyafumaneka njengechiza elenza lafana nelihlala ligutyungelwe yiMedicare kunye nezinye izicwangciso zeinshurensi. Imiselwa njengepilisi yemihla ngemihla enokuhanjiswa ngeentsuku ezingama-30 okanye iintsuku ezingama-90. Ixabiso eliphakathi lemali le-atorvastatin linokufikelela kwi- $ 250. Nangona kunjalo, ixabiso linokwehliswa laya kwi-15 yeedola nge-singleCare atorvastatin coupon.
I-Simvastatin ikwafumaneka njengechiza elenziwe lafana nelo. Njengommiselo oqhelekileyo omiselweyo, i-simvastatin ihlala igutyungelwe yi-Medicare kunye nezicwangciso zeinshurensi. Ixabiso eliphakathi lokuthengisa nge-simvastatin lijikeleze i-470 yeedola. Nangona kunjalo, ngekhadi lesaphulelo le-simvastatin, njenge-singleCare, unokulindela ukuhlawula imali engaphantsi kweedola ezili-10 ngonikezelo lweentsuku ezingama-30 lweepilisi ezingama-20 mg kwiikhemesti ezithatha inxaxheba.
| Atorvastatin | Simvastatin | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Umthamo osemgangathweni | 10 mg kanye yonke imihla (ubungakanani be-30) | I-20 mg kanye yonke imihla (ubungakanani be-30) |
| I-Medicare copay eqhelekileyo | $ 0- $ 16 | $ 0- $ 9 |
| Ixabiso elilodwa | $ 15 + | $ 10 + |
Fumana ikhadi lesaphulelo kwikhemesti
Iziphumo eziqhelekileyo ebezingalindelekanga ze-atorvastatin vs simvastatin?
Iziphumo eziqhelekileyo ezichaphazelekayo ze-statins, ezifana ne-atorvastatin kunye ne-simvastatin, zibandakanya iingxaki zokugaya ukutya ezifana nesifo sohudo, ukunyanzelisa isisu kunye nesicaphucaphu. Ezinye iziphumo ebezingalindelekanga zibandakanya ukuba nesiyezi kunye nokudumba kwezandla, imilenze, okanye iinyawo (i-edema). Iitatins zinokubangela iintlungu zemisipha (myalgia) okanye ubuthathaka bemisipha (myopathy).
Umngcipheko wentlungu yemisipha uyanda ngamanani aphezulu ama-statins. Nangona kunjalo, xa kuthelekiswa ne-atorvastatin, i-simvastatin ithathwa njengomngcipheko ophezulu we-myalgia. Abanye abantu banokuba ne- ulwalamano kwimysalgia ukusuka kwi-simvastatin. Nangona zonke ii-statins zinomngcipheko wokubangela iintlungu zemisipha njengempembelelo yecala, i-FDA kunciphise ukusetyenziswa Iipilisi ze-simvastatin ezingama-80 mg ngenxa yomngcipheko owandileyo.
Ezinye iziphumo ebezingalindelekanga ziyafumaneka kwitheyibhile engezantsi.
| Atorvastatin | Simvastatin | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Intlungu edibeneyo | Ewe | 7% | Ewe | 0.1% |
| Urhudo | Ewe | 7% | Ewe | * |
| Ukuqunjelwa | Hayi | - | Ewe | Mbini% |
| Ukutya | Ewe | 5% | Ewe | * |
| Isicaphucaphu | Ewe | 4% | Ewe | 6% |
| Intlungu yezihlunu | Ewe | 4% | Ewe | 4% |
| Usulelo lwe-Urinary tract | Ewe | 6% | Ewe | 3% |
| Nasopharyngitis | Ewe | 8% | Hayi | - |
| Ukuba nesiyezi | Ewe | * | Ewe | 5% |
| Edema | Ewe | * | Ewe | 3% |
* akuxelwa
Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( Atorvastatin ), Yonke imihla ( Simvastatin )
Ukudibana kweziyobisi kwe-atorvastatin vs simvastatin
I-Atorvastatin kunye ne-simvastatin ziqhubekeka ikakhulu kwisibindi yi-CYP3A4 enzyme. Iziyobisi ezithintela, okanye ezivimba, le enzyme inokubangela amanqanaba anyukayo e-atorvastatin okanye i-simvastatin egazini. Xa uthathwa nge-CYP3A4 inhibitor efana ne-clarithromycin okanye i-itraconazole, i-atorvastatin inokubangela ukwanda kwengozi yeentlungu (myalgia) okanye ubuthathaka bemisipha (myopathy). Ijusi yamagilebhisi ikwayinto ye-CYP3A4 inhibitor enokunyusa amanqanaba e-atorvastatin kunye ne-simvastatin. Kwelinye icala, iziyobisi ezinje nge-rifampin kunye ne-carbamazepine ziyi-CYP3A4 inducers ezinokuthi zinciphise amanqanaba e-atorvastatin kunye ne-simvastatin emzimbeni.
Iprotease inhibitors, ezinje nge-ritonavir kunye ne-lopinavir, zinokubangela amanqanaba anyukayo e-statins emzimbeni. Amanqanaba aphezulu e-statin egazini anokukhokelela kumngcipheko okhulayo weziphumo ezibi, kubandakanya i-myalgia. Ukusasaza iziyobisi kunye ne-niacin nako kunokunyusa umngcipheko we-myalgia xa uthathwe nge-atorvastatin okanye i-simvastatin.
Ukuthatha i-atorvastatin ngezinto zokucwangcisa zomlomo kunokubangela ukonyuka kwamanqanaba egazi kunyango lokucwangcisa.
Ukuthatha ii-statins nge-warfarin kuye kwaxelwa ukuba kubangele ukonyuka kwamanqanaba e-warfarin kunye nomngcipheko owandayo wokopha. Nangona kunjalo, i-atorvastatin yiyo Akunakuliphazamisa kunye nefuthe le-warfarin.
| Iziyobisi | Iklasi yeziyobisi | Atorvastatin | Simvastatin |
| Clarithromycin Erythromycin Itraconazole Ketoconazole Ijusi yamagilebhisi | CYP3A4 inhibitors | Ewe | Ewe |
| Rifampin ICarbamazepine | I-CYP3A4 inducers | Ewe | Ewe |
| Ritonavir Lopinavir Simeprevir IDarunavir | Iprotease inhibitors | Ewe | Ewe |
| Gemfibrozil Fenofibrate | Iifibhethi | Ewe | Ewe |
| Niacin | Ukuchasana komzimba | Ewe | Ewe |
| I-Digoxin | Iglycoside yentliziyo | Ewe | Ewe |
| Indawo encinci I-Ethinyl estradiol | Izinto zokucwangcisa ngomlomo | Ewe | Hayi |
| IWarfarin | I-Anticoagulant | Hayi | Ewe |
Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi.
Izilumkiso ze-atorvastatin kunye ne-simvastatin
Zombini i-atorvastatin kunye ne-simvastatin zinokubangela izehlo ezimbi ezibandakanya iintlungu zemisipha (myalgia) okanye ubuthathaka bemisipha (myopathy). Kwiimeko ezimandundu, ezi statins zinokubangela i-rhabdomyolysis, okanye ukonakala ngokukhawuleza kwemisipha yamathambo. Uhlobo olunqabileyo lwe-myopathy, olubizwa ngokuba yi-immune-mediated necrotizing myopathy (IMNM) ikwachazwe ngokusetyenziswa kwe-statin.
I-Atorvastatin kunye ne-simvastatin ikakhulu zixutywe esibindini. Ke ngoko, ukusetyenziswa kwazo kunokubangela ukungaqheleki kumanqanaba e-enzyme yesibindi. Ii-enzyme zesibindi kufuneka zijongwe kulo lonke unyango lwe-statin. Abantu abanesifo sesibindi kufuneka bajongwe okanye banqande i-statins ngokupheleleyo.
I-Atorvastatin kunye ne-simvastatin kufuneka kuthintelwe kubafazi abakhulelweyo kunye noomama abongikazi. Ezi ziqulatho zinokuba nomngcipheko okhulayo wokukhubazeka kokuzalwa.
Imibuzo ebuzwa rhoqo malunga neatorvastatin vs simvastatin?
Yintoni i-atorvastatin?
I-Atorvastatin, ekwabizwa ngegama layo njengeLipitor, lunyango lwe-statin elisetyenziselwa ukunciphisa i-cholesterol kunye nokunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokubetha. Uluhlu oluqhelekileyo lwethamo le-atorvastatin liphakathi kwe-10 ukuya kwi-80 mg ngosuku. I-Atorvastatin ine-half-life length yeeyure ezili-14 kwaye inokuthathwa nanini na emini.
Yintoni iSimvastatin?
ISimvastatin yaziwa ngegama layo, iZocor. Lunyango lwe-statin olunokwehlisa amanqanaba e-cholesterol, anokunceda ukunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo kunye nokubetha. Uluhlu lwethamo eliqhelekileyo le-simvastatin lihlanu ukuya kwi-40 mg ngosuku. ISimvastatin inehafu yobomi emfutshane kwaye kuyacetyiswa ukuba ithathwe ngokuhlwa.
Ngaba i-atorvastatin kunye ne-simvastatin ziyafana?
I-Atorvastatin kunye ne-simvastatin bobabini bakudidi lweziyobisi ekuthiwa yi-HMG-CoA reductase inhibitors, okanye ii-statins. Zombini zisetyenziselwa ukuthoba amanqanaba e-cholesterol ye-LDL. Nangona kunjalo, banomahluko okhoyo kumandla akhoyo kunye nendlela abathathwa ngayo.
Ngaba i-atorvastatin okanye i-simvastatin ibhetele?
I-Atorvastatin kunye ne-simvastatin zombini zizo iziyobisi ezisebenzayo zokunciphisa i-cholesterol yegazi. Nangona kunjalo, i-atorvastatin ithathwa njengeyona statin inamandla ngakumbi. I-Atorvastatin ihlala ixesha elide emzimbeni kwaye inokuthathwa ekuseni okanye ebusuku. ISimvastatin inobungozi obuphezulu beentlungu zezihlunu okanye ubuthathaka kune-atorvastatin, ngakumbi kwiidosi eziphezulu. Ugqirha omiselweyo uya kumisela owona mgaqo usebenza ngokukuko kwimeko nganye.
Ndingayisebenzisa i-atorvastatin okanye i-simvastatin ngelixa ndikhulelwe?
I-Atorvastatin kunye ne-simvastatin akufuneki zisetyenziswe ngexesha lokukhulelwa. Amanqanaba e-cholesterol anokunyuka ngexesha lokukhulelwa kwaye ayimfuneko ukuxhasa umntwana okhulayo. Ke ngoko, akukho sibonelelo sokuthatha le statins ngexesha lokukhulelwa. Zingabangela ingozi yomntwana ngexesha lokukhulelwa.
Ndingayisebenzisa i-atorvastatin okanye i-simvastatin ngotywala?
Ngoku ka iingcali zentliziyo , Ukusela utywala ngokumodareyitha kukhuselekile ngokubanzi ngokusetyenziswa kwe-statin. Ukusela kakhulu okukhokelele kwisifo sesibindi kulapho iingxaki zinokuvela. I-enzyme zesibindi kufuneka zijongwe kulo lonke unyango kunye ne-statin.
Ngowuphi ummiselo oneziphumo ebezingalindelekanga?
Iingxelo zikhuselekile ngokubanzi kunye neziphumo ebezingalindelekanga. Ngokwe-American Heart Association (AHA), izibonelelo ze-statins ukogqitha umngcipheko onokubakho yeziphumo ebezingalindelekanga. Nangona kunjalo, ii-statins ezithile, ezinje nge ipravastatin kunye nefluvastatin , Unokuba nomngcipheko ophantsi we-myalgia kune-simvastatin kunye ne-atorvastatin. Xa kuthelekiswa nemimiselo enikwe ngeedosi ezisezantsi, ii-statin zedosi ephezulu zinokubangela iziphumo ebezingalindelekanga. Umzekelo, idosi ye-80 mg yesimvastatin inobungozi obukhulu bokubangela i-myalgia. Ngesi sizathu, i-FDA inyine umda wedosi ye-simvastatin kuphela kubantu abathile.
Ziziphi iziphumo ebezingalindelekanga zexesha elide ze-atorvastatin?
Iziphumo ebezingalindelekanga zexesha elide kunyango lwe-statin zinokwahluka ngokuxhomekeka emntwini. Ixesha elide iziphumo ebezingalindelekanga zeemimiselo inokubandakanya iintlungu zemisipha, ukonakala kwesibindi, ukwanda kweswekile yegazi, kunye neengxaki kwimemori. Nangona kunjalo, umngcipheko weziphumo ebezingalindelekanga zexesha elide uthathwa njengephantsi xa ichiza limiselwe kwaye lilawulwa ngokufanelekileyo.
Ngaba i-atorvastatin imbi kwizintso zakho?
Idosi ye-atorvastatin ayidingi kuhlengahlengiswa kwabo baneengxaki zezintso. Abanye abantu abaneengxaki zezintso ezinzima, ukusetyenziswa kwe-atorvastatin kunokufuna ukubekwa esweni.
Ngokubanzi, i-atorvastatin ayinabungozi kwizintso. Nangona kunjalo, ukusetyenziswa kwe-atorvastatin kungakhokelela kumngcipheko okhulayo we-rhabdomyolysis, enokuthi ikhokelele ekusileleni kwe-renal kwiimeko ezinzima. Thetha nogqirha wakho ukuba unembali yeengxaki zezintso ngaphambi kokuqala kwichiza le-statin.
