I-Celebrex vs. ibuprofen: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
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Isifo samathambo saziwa ngokubangela iintlungu. Kukho amayeza amaninzi phaya kwiintlungu zesifo samathambo ezinokudideka ukuba zithathwa ngubani. Amayeza amabini aqhelekileyo kwi-NSAID (ichiza elichasayo elichasayo) yiCelebrex (celecoxib) kunye ne-ibuprofen.
Ii-NSAID zinokusebenza ngokunyanga i-osteoarthritis kunye ne-rheumatoid arthritis, kunye nezinye iimeko ezahlukeneyo. Zombini iiCelebrex kunye ne-ibuprofen ziyafumaneka kwifom yohlobo oluqhelekileyo. Ngelixa iCelebrex ifumaneka kuphela ngugqirha, ungathenga iidosi ezisezantsi ze-ibuprofen ngaphezulu kwekhawuntare. Iidosi eziphezulu ze-ibuprofen ziyafumaneka ngugqirha. Ngenxa yokuba iCelebrex kunye ne-ibuprofen bakudidi olunye lwamachiza, ziyafana, kodwa banokwahluka okuphawulekayo.
Nguwuphi umahluko ophambili phakathi kweLexapro vs Zoloft?
| Umahluko ophambili phakathi kweCelebrex vs ibuprofen | ||
|---|---|---|
| ICelebrex | Ibuprofen | |
| Iklasi yeziyobisi | I-NSAID, i-COX-2 inhibitor | NSAID |
| Uhlobo lweBrith / generic | Brand kunye generic | Rx: generic I-OTC: uphawu kunye nohlobo oluqhelekileyo |
| Ngubani igama eliqhelekileyo? Ngubani igama lophawu? | Isizukulwana: celecoxib | Igama lebrand: Motrin, Advil (OTC) |
| Zeziphi iifom eza nalo iziyobisi? | Iicapsules (50, 100, 200, 400 mg) Ifom yotywala yabantwana ihlanganiswe yikhemesti | Iipilisi zamandla amiselweyo: 400 mg, 600 mg, 800 mg I-OTC: Iipilisi ze-200 mg / iicapsule / i-softgels, iitshizi ezahlukeneyo, ulwelo, kunye nethontsi |
| Ithini idosi esemgangathweni? | Abantu abadala: 200 mg yonke imihla ngokutya; ubuninzi ngama-400 ngosuku Enye indlela: 100 mg kabini yonke imihla Abantwana abaneminyaka emibini nangaphezulu: kuxhomekeke kubunzima | Abantu abadala: 200 ukuya ku-800 mg kathathu ukuya kumaxesha amane ngokutya; idosi ephezulu iyahluka ngokuxhomekeka kwimeko Abantwana: yahluka ngokusekwe kubudala, ubunzima, kunye nokwenziwa |
| Lude kangakanani unyango oluqhelekileyo? | Iyahluka: iiveki ukuya kwiminyaka | Iyahluka: iintsuku ukuya kwiiveki, ezinye izigulana zithatha iinyanga okanye iminyaka |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantwana abaneminyaka emibini nangaphezulu; abantu abadala | Abantwana iinyanga ezintandathu nangaphezulu; abantu abadala |
Ngaba ufuna elona xabiso lilungileyo kwiCelebrex?
Bhalisela izilumkiso zamaxabiso eCelebrex kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Imiqathango iphathwa yiCelebrex kunye neIbuprofen
I-Celebrex, ichiza elichasayo (i-nonsteroidal anti-inflammatory drug (NSAID)) kubonisiwe kwezi meko zilandelayo: i-osteoarthritis, isifo samathambo, isifo samathambo esinezigulana ezineminyaka emibini nangaphezulu, i-ankylosing spondylitis, iintlungu eziqaqambayo, idysmenorrhea ephambili, kunye nosapho lwe-adenomatous polyposis njengesiqhelo kunyango oluqhelekileyo.
I-Ibuprofen ikwayi-NSAID kwaye ibonakalisiwe ukukhululeka kweempawu kunye neempawu ze-osteoarthritis kunye ne-rheumatoid arthritis, iintlungu eziphakathi ukuya kweziphakathi, kunye ne-dysmenorrhea ephambili.
| Imeko | ICelebrex | Ibuprofen |
| Osteoarthritis | Ewe | Ewe |
| Irheumatoid Arthritis | Ewe | Ewe |
| I-juvenile rheumatoid arthritis (kwizigulana ezineminyaka emibini nangaphezulu) | Ewe | Hayi |
| I-Ankylosing spondylitis | Ewe | Hayi |
| Intlungu ebuhlungu | Ewe | Hayi |
| I-dysmenorrhea ephambili | Ewe | Ewe |
| I-adenomatous polyposis eqhelekileyo njengonyango olongezelelekileyo | Ewe | Hayi |
| Intlungu ethambileyo ukuya kumodareyitha | Hayi | Ewe |
Amachiza e-NSAID asebenza ngokuthintela i-prostaglandins (i-prostaglandins ibangela iintlungu kunye nokudumba) ekubeni yenziwe. Iprostaglandin yenziwa zii-enzymes ezimbini, i-cyclooxygenase-1 (COX-1) kunye ne-cyclooxygenase-2 (COX-2).
Ngaba iCelebrex okanye i-Ibuprofen iyasebenza ngakumbi?
I-Celebrex yaziwa njenge-COX-2 inhibitor ekhethiweyo. Ngelixa iseyi-NSAID efana ne-ibuprofen, iCelebrex ibhloka kuphela i-COX-2, ngokuchasene ne-ibuprofen, ethintela zombini i-COX-1 kunye ne-COX-2. Ithetha ntoni le nto? I-COX-2 inhibitor inokuba lula kwisisu, ngomngcipheko ophantsi wokubangela izilonda zesisu.
Kwi izifundo zonyango ngokusebenza kakuhle, uCelebrex ubonise:
- Ukunciphisa iintlungu ezidibeneyo kwizigulana ze-osteoarthritis
- Ukunciphisa iintlungu ezidibeneyo kunye nokudumba kwizigulana zamathambo
- Ukuphuculwa kwezigulana ezine-rheumatoid arthritis yolutsha
- Ukuphuculwa kwezigulana ezine-ankylosing spondylitis (kubunzima beentlungu, umsebenzi wezifo, kunye nokungasebenzi kakuhle)
- Uncedo lweentlungu ezilinganiselweyo ukuya kwintlungu ebangelwa ziintlungu zotyando okanye idysmenorrhea
Kwizifundo zonyango olusebenzayo, ibuprofen ibonakalisiwe :
- Iziphumo ezifanayo kwi-aspirin kwizigulana ezine-osteoarthritis kunye ne-rheumatoid arthritis yeentlungu kunye nokudumba
- Uncedo lwentlungu evela kwi-episiotomy, iinkqubo zamazinyo, kunye nedysmenorrhea
Loluphi unyango olusebenzayo? Kunzima ukutsho. Ngenye ukufunda , I-Celebrex ibonakaliswe ukuba iyasebenza njenge-ibuprofen kwizigulana ezine-osteoarthritis yamadolo. Olunye uphando lubonisa ibuprofen ukuze usebenze ngakumbi, ngelixa abanye begqiba ICelebrex inokusebenza ngakumbi.
Ngokwokhuseleko, uvavanyo lwezonyango lweCelebrex, kunye neeNSAID ezingakhethiyo (ezinje nge-ibuprofen) ukuya kuthi ga kwiminyaka emithathu zibonise umngcipheko okhulayo weziganeko ezinesifo sentliziyo, ukubetha kwentliziyo nokufa icala, okunokubulala. Ke ngoko, zonke ii-NSAID (kubandakanya zombini iCelebrex kunye ne-ibuprofen) zinokuthi zinxulunyaniswe nalo mngcipheko. Zonke ii-NSAIDs, kubandakanya i-Celebrex kunye ne-ibuprofen, zinomngcipheko okhulayo weziganeko ze-GI, ezinje ngegazi kunye nezilonda.
Elona chiza libalaseleyo unokumiselwa kuphela ngumboneleli wakho wezempilo, onokuthi athathele ingqalelo umfanekiso opheleleyo weemeko zakho zonyango, izinto ezinobungozi, imbali yezempilo, kunye namanye amayeza owathathayo.
Ngaba ufuna elona xabiso lilungileyo kwi-Ibuprofen?
Bhalisela izilumkiso zamaxabiso e-Ibuprofen kwaye ufumane ukuba amaxabiso atshintsha nini!
Fumana izilumkiso zamaxabiso
Ukufunyanwa kunye nokuthelekiswa kweendleko zeCelebrex vs Ibuprofen
I-Celebrex igutyungelwa yi-inshurensi kunye ne-Medicare Icandelo D ngohlobo lwayo lwe-celecoxib. Ummiselo oqhelekileyo uya kuba ziifomsile ezingama-30 ze-celecoxib engama-200 mg. Ixabiso elingaphandle kwepokotho li malunga ne- $ 217.49 kodwa ungafumana i-celecoxib ye- $ 105-145 kwiikhemesti ezithatha inxaxheba kunye nekhuphoni ye-SingleCare.
I-Ibuprofen ihlala igutyungelwe yi-inshurensi kunye ne-Medicare Icandelo D, kumandla kagqirha ka-400 mg, 600 mg, no-800 mg. Imigqaliselo kagqirha iyahluka. Umzekelo, ixabiso lokuthengisa kwiipilisi ezingama-30 ze-800 mg ibuprofen zibiza naphi na ukusuka kwi-6-30 yeedola. Ngekhuphoni ye-SingleCare, iindleko ze-ibuprofen yi- $ 4-8.
| ICelebrex | Ibuprofen | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe; generic | Ewe; amandla kagqirha |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe; generic | Ewe; amandla kagqirha |
| Umthamo osemgangathweni | 30, 200 mg njengezingxobo ze-generic celecoxib | Iipilisi ezingama-30, 800 mg ze-ibuprofen |
| Uhlobo lweMedical Medicare Part D | $ 0-150 | $ 0-14 |
| Ixabiso elilodwa | $ 105-145 | $ 4-8 |
Iziphumo ebezingalindelekanga zeCelebrex vs Ibuprofen
Iziganeko eziqhelekileyo eziqhelekileyo zeCelebrex kunye ne-ibuprofen zibandakanya iintlungu zesisu, isifo sohudo, isisu, kunye neentloko. Jonga icandelo lesilumkiso ngolwazi oluthe kratya malunga nomngcipheko wentliziyo kunye nomngcipheko wokopha kwe-GI.
| ICelebrex | Ibuprofen | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo * |
| Intlungu zesisu | Ewe | 4.1% | Ewe | 3-9% |
| Urhudo | Ewe | 5.6% | Ewe | 3-9% |
| IDyspepsia (ukungagqwali) | Ewe | 8.8% | Ewe | 3-9% |
| Intloko ebuhlungu | Ewe | 15.8% | Ewe | 3-9% |
* Ukuphindaphinda kweziphumo ezibi ze-ibuprofen akubonelelwa ngolwazi lweziyobisi; kuphela ukuba ezi ziphumo zenzeke kwi-3-9% yezigulana.
Umthombo: Yonke imihla (iCelebrex) , Yonke imihla ibuprofen )
Olu ayilo luhlu olupheleleyo; ezinye iziphumo ebezingalindelekanga zinokwenzeka. Nxibelelana nomboneleli wakho wezempilo ngeenkcukacha.
Ukudibana kweziyobisi kweCelebrex kunye neIbuprofen
ICelebrex kunye ne-ibuprofen zinokunxibelelana okufanayo namanye amayeza amiselweyo. Omabini la mayeza ayasebenzisana nabacoci begazi abanjengoCoumadin (warfarin), amayeza athile oxinzelelo lwegazi (i-ACE inhibitors, ii-ARBs, kunye ne-beta blockers), i-antidepressants, kunye ne-diuretics efana ne-hydrochlorothiazide kunye ne-methotrexate. Qhagamshelana nomboneleli wakho wezempilo ukuze akukhokele.
Utywala kufuneka kuthintelwe xa uthatha iCelebrex okanye ibuprofen. Sebenzisa elinye lala mayeza ngotywala kunokunyusa umngcipheko we-GI (isisu) ukuphuma kwegazi okanye ukudumba. Ukudityaniswa kunokubangela nokonzakala kwezintso okanye ukusilela kwezintso.
Olu luhlu olukhethiweyo lokusebenzisana kweziyobisi. Nxibelelana nomboneleli wakho wezempilo ngolwazi oluthe kratya.
| Iziyobisi | Iklasi yeziyobisi | ICelebrex | Ibuprofen |
| ICoumadin (iwarfarin) | I-Anticoagulant | Ewe | Ewe |
| Zestril (lisinopril), Cozaar (losartan), njl | Ii-ACE inhibitors, ii-ARBs | Ewe | Ewe |
| I-Tenormin (atenolol), iTrolrol XL okanye iLopressor (metoprolol) | Ibhlokhi yeBeta | Ewe | Ewe |
| I-Diflucan (i-fluconazole) | Ukubola | Ewe | Hayi |
| I-Lasix (i-furosemide), i-hydrochlorothiazide | Womchamo | Ewe | Ewe |
| I-Naproxen, iMobic (meloxicam) | Ezinye ii-NSAID | Ewe | Ewe |
| Imethotrexate | Antimetabolite | Ewe | Ewe |
| Zoloft (sertraline), Paxil (paroxetine), Prozac (fluoxetine), Effexor (venlafaxine), Desyrel (trazodone), Elavil (amitriptyline), njl. | Ukudakumba | Ewe | Ewe |
| Utywala | Utywala | Ewe | Ewe |
Izilumkiso zeCelebrex kunye neIbuprofen
I-Celebrex kufuneka ithintelwe kwizigulana ezichasene nee-NSAIDs, kunye nezigulana ezingalungelani nesulfa. I-Ibuprofen kufuneka ithintelwe kwizigulana ezichasene nee-NSAID.
Kuba omabini la machiza zii-NSAID, iCelebrex kunye ne-ibuprofen zinezilumkiso ezifanayo. Banesilumkiso esibhokisiweyo (esona silumkiso someleleyo njengoko kufunwa nguLawulo lokutya noLawulo lweziyobisi, okanye i-FDA). I-Celebrex okanye ibuprofen inokunyusa umngcipheko weziganeko ezinzulu zentliziyo, i-MI (i-myocardial infarction, okanye isifo sentliziyo), kunye nokubetha, konke okunokubulala. Zonke ii-NSAID zinomngcipheko ofanayo, owonyusa ixesha olisebenzisa ngalo. Izigulana ezinesifo sentliziyo okanye ezinengxaki yomngcipheko wentliziyo zisemngciphekweni omkhulu. I-Celebrex okanye ibuprofen akufuneki isetyenziselwe iintlungu ngexesha lotyando lwe-coronary bypass graft (CABG).
Kwisilumkiso esibhokisiweyo kukho umngcipheko we-GI, okanye izehlo zesisu, kubandakanya ukopha, ulceration, kunye nokubola kwesisu okanye amathumbu, anokubulala. Nasiphi na kwezi ziganeko sinokwenzeka nangaliphi na ixesha, kwaye ngaphandle kweempawu zesilumkiso. Izigulana ezisebekhulile kunye nabo banembali yezilonda okanye i-GI egazini basemngciphekweni omkhulu weziganeko ezinzulu ze-GI.
Ezinye izilumkiso zeCelebrex kunye ne-ibuprofen zibandakanya:
- Umngcipheko wee-enzyme zesibindi eziphakamileyo kwaye, kunqabile, ukusabela okubukhali.
- Amatyala amatsha okanye ukwanda koxinzelelo lwegazi (uxinzelelo lwegazi oluphezulu). Sebenzisa ngononophelo kwizigulana ezixinzelelekileyo; jonga uxinzelelo lwegazi ngokusondeleyo ngexesha lonyango.
- Ukugcinwa kwamanzi kunye ne-edema. Sebenzisa ngononophelo kwizigulana ezinokugcina amanzi okanye ukusilela kwentliziyo
- I-renal papillary necrosis / enye into eyonzakeleyo yezintso ngokusetyenziswa kwexesha elide. Sebenzisa ngononophelo kubantu abadala, abaguli abangasebenzi kakuhle kwezintso, ukusilela kwentliziyo, ukungasebenzi kwesibindi, kunye nezigulana ezithatha i-diuretics, i-ACE inhibitors, okanye ii-angiotensin II blockers.
- Impendulo ye-Anaphylactoid. Sukuyisebenzisa kwizigulana ezine Ubuthathu bukaSamter .
- Ukuphendula okunzulu kolusu kunokwenzeka njenge-exfoliative dermatitis, iStevens-Johnson syndrome (SJS), kunye ne-epidermal necrolysis (TEN) enetyhefu, enokubulala kwaye yenzeke ngaphandle kwesixwayiso. Yeka iCelebrex kwaye ufune unyango kwangoko ukuba ngaba kukho irhashalala okanye ulusu lwenzeka.
Kukho idatha encinci kwii-NSAID ezisetyenziswayo xa ukhulelwe. Ukusetyenziswa kwazo zonke ii-NSAID, kubandakanya zombini i-Celebrex kunye ne-ibuprofen, ngexesha lesithathu lokukhulelwa, kukonyusa umngcipheko woku Ukuvalwa kwangaphambi kwexesha komntwana okhulelweyo . Ngoko ke, ii-NSAID akufanele zisetyenziswe emva kweeveki ezingama-30 zokukhulelwa.
Nxibelelana nomboneleli wakho wezempilo malunga nokusetyenziswa kweCelebrex okanye ibuprofen xa ukhulelwe. Ukuba sele uthatha iCelebrex okanye ibuprofen kwaye ufumanisa ukuba ukhulelwe, nxibelelana nomboneleli wakho wezempilo ukuze akukhokele.
Kukho idatha encinci kwiCelebrex kunye ne-ibuprofen ngokuncancisa; dibana nogqirha wakho ukuze akukhokele.
Imibuzo ebuzwa rhoqo malunga neCelebrex vs Ibuprofen
Yintoni iCelebrex?
I-Celebrex sisiyobisi esichasayo (i-NSAID) esichazwe kwezi meko zilandelayo: i-osteoarthritis, i-rheumatoid arthritis, i-juvenile rheumatoid arthritis kwizigulana ezineminyaka emibini nangaphezulu, i-ankylosing spondylitis, iintlungu eziqaqambayo, i-dysmenorrhea ephambili kunye nosapho lwe-adenomatous polyposis njengesiqhelo kwisiqhelo. inkathalo.
Yintoni ibuprofen?
I-Ibuprofen yi-NSAID kwaye isetyenziselwa ukunyanga iimpawu kunye neempawu ze-osteoarthritis, i-rheumatoid arthritis, iintlungu eziphakathi ukuya kweziphakathi, kunye ne-dysmenorrhea ephambili.
Ngaba iCelebrex kunye neIbuprofen ziyafana?
Ngenxa yokuba omabini la machiza zii-NSAID, ziyafana kwaye zinemiphumo efanayo kunye nezilumkiso. Ziyahluka ngokubonisa kunye nexabiso. Jonga ngasentla ukuze ufumane okungakumbi malunga nokufana nokwahluka.
Ngaba iCelebrex okanye i-Ibuprofen ingcono?
Omabini la machiza anokusebenza ngokunyanga isifo samathambo kunye nezinye iimeko. Kuxhomekeka ekubeni yeyiphi imeko oyinyangayo, kwaye uthathela ingqalelo naziphi na ezinye iimeko zonyango kunye nemingcipheko onayo, kunye namanye amayeza owathathayo, ugqirha wakho unokunceda ukucebisa amayeza afanelekileyo.
Ndingayisebenzisa iCelebrex okanye i-Ibuprofen ngelixa ndikhulelwe?
Ukuba ufumanisa ukuba ukhulelwe kwaye usebenzisa uCelebrex okanye ibuprofen qhagamshelana nomboneleli wakho wezempilo ukuze ufumane iingcebiso.
Abafazi abakhulelweyo akufuneki basebenzise ezi-NSAID emva kweeveki ezingama-30 zokukhulelwa. Sebenzisa iCelebrex kunye ne-ibuprofen ngexesha lesithathu lokukhulelwa kungonyusa umngcipheko wokuvalwa ngaphambi kwexesha kwe-fetus ductus arteriosus.
Ndingayisebenzisa iCelebrex okanye i-Ibuprofen ngotywala?
Hayi . Sebenzisa elinye lala mayeza ngotywala kunokunyusa umngcipheko we-GI (isisu) ukopha okanye ukudumba kwesisu. Ukudityaniswa kunokubangela nokonzakala kwezintso okanye ukusilela kwezintso.
Ngaba iCelebrex isebenza ngakumbi kune-ibuprofen?
Omabini la machiza anokusebenza ngokunyanga iintlungu zesifo samathambo kunye nezinye iimeko. Nxibelelana nomboneleli wakho wezempilo ukuze ufunde ukuba leliphi iyeza elilungele wena xa unikwe imeko (iimeko) zakho, imbali yezempilo, kunye namanye amayeza onokuthi uwathathe.
Kutheni le nto bethathe iCelebrex kwintengiso?
ICelebrex isekhona kwintengiso njenganamhlanje. IVioxx (rofecoxib), ichiza elifanayo neCelebrex, yayinjalo isuswe ukusuka kwintengiso ngumenzi wayo, uMerck, ngo-2004, ngenxa yomngcipheko owandileyo weziganeko zentliziyo kunye nokusetyenziswa okungapheliyo. Ngo-2005, elinye ichiza elifanayo, iBextra (valdecoxib), yayingu washiya imarike ngumenzi wePfizer ngenxa yezizathu ezifanayo.
Ngaba iCelebrex yintlungu?
I-Celebrex sisiyobisi se-NSAID (nonsteroidal anti-inflammatory) esinceda kwiimpawu zentlungu kunye nokudumba okuvela kwiimeko ezahlukeneyo (jonga ngasentla). Kuba isebenza kuphela kwii-enzymes ze-COX-2, inokukhuseleka esiswini, nangona kusekho umngcipheko we-GI.
