ICymbalta vs.Zoloft: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango iphathwe | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
ICymbalta kunye neLexapro ngamayeza amabini amiselweyo asetyenziselwa ukunyanga isifo sokudakumba (MDD) kunye nokunye ukuphazamiseka kwempilo yengqondo. Uxinzelelo, uxinzelelo kunye nokuphazamiseka okunxulumene noku kuchaphazela izigidi zabantu baseMelika ngokwe Ixhala kunye noMbutho woXinzelelo eMelika .
Ukuphazamiseka kwengqondo kuchaphazela imood, imveliso, kunye nokukwazi komntu ukuphatha uxinzelelo. Kwabanye, izinto ezinjengokuzilolonga, ukucamngca, okanye unyango lunokubonelela ngesiqabu, kodwa kuninzi, amayeza aya kufuneka ukufezekisa ukuxolelwa kweempawu. Ngelixa iCymbalta kunye neLexapro ziphatha iingxaki ezininzi ezifanayo, ngamayeza ahlukeneyo, kwaye siza kuthetha ngalo mahluko apha.
Yintoni umahluko ophambili phakathi kweCymbalta kunye neZoloft?
ICymbalta (duloxetine) lunyango lonyango oluboniswe kunyango lwazo zombini iingxaki zokudakumba kunye noxinzelelo ngokubanzi (GAD). ICymbalta yeqela lamayeza abizwa ngokuba yi-serotonin-norepinephrine reuptake inhibitors (SNRIs) ekhethiweyo. ICymbalta ibhloka ukuphinda kuthathwe kwakhona zombini i-norepinephrine kunye ne-serotonin kwi-neuronal synapse ishiya i-serotonin yasimahla kunye ne-norepinephrine. Ezi neurotransmitters emva koko ziyafumaneka ngokulula ukuze zidlale indima elungileyo kwimood kunye nefuthe. Ezinye ii-SNRI onokuthi uqhelene nazo yi-Effexor (venlafaxine) kunye nePristiq (desvenlafaxine). ICymbalta ifumaneka njenge-20 mg, 30 mg, kunye ne-60 mg capsule yomlomo.
I-Zoloft (sertraline) ikwalunyango lonyango oluboniswe kunyango lwe-MDD. I-Zoloft ihlelwe njenge-serotonin reuptake inhibitor ekhethiweyo kwaye isebenza ngokuthintela ukuphinda kuthathwe kuphela i-serotonin kwi-neuronal synapse. Amanqanaba aphezulu e-serotonin ekhoyo ayanyaniswa nophuculo lwenqanaba kunye namandla amanqanaba. Ezinye ii-SSRI onokuthi uqhelene nazo zibandakanya iProzac (i-fluoxetine), iPaxil (paroxetine), iCelexa (citalopram), kunye neLexapro (escitalopram).
I-Zoloft ifumaneka njengecwecwe lomlomo ngamandla e-25 mg, 50 mg, kunye ne-100mg. Ikwafumaneka kwisisombululo somlomo esigxile kwi-20 mg / ml.
| Umahluko ophambili phakathi kweCymbalta kunye neZoloft | ||
|---|---|---|
| ICymbalta | Zoloft | |
| Iklasi yeziyobisi | Ukukhetha i-serotonin norepinephrine reuptake inhibitor | Ukukhetha kwakhona i-serotonin reuptake inhibitor |
| Uhlobo lweBrith / generic | Brand kunye generic ziyafumaneka | Brand kunye generic ziyafumaneka |
| Ngubani igama eliqhelekileyo? | Duloxetine | Sertraline |
| Zeziphi iifom eza nalo iziyobisi? | Iifomsile zomlomo | Amacwecwe omlomo kunye nesisombululo |
| Ithini idosi esemgangathweni? | 60 mg kanye ngemini | 50 mg kanye ngemini |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha elide (iinyanga ukuya kwiminyaka) | Ixesha elide (iinyanga ukuya kwiminyaka) |
| Ngubani oqhelekileyo usebenzisa amayeza? | Ulutsha kunye nabantu abadala | Abantwana, abafikisayo kunye nabantu abadala |
Imiqathango ephathwa yiCymbalta kunye neZoloft
ICymbalta kunye neZoloft nganye yamkelwe ukunyanga uxinzelelo olukhulu lokudakumba, kodwa ichiza ngalinye lineempawu ezizodwa. ICymbalta yamkelwe ukuze inyange uxinzelelo ngokubanzi loxinzelelo. ICymbalta ikwavunyiwe ukunyanga iintlungu zentlungu kunye nentlungu engapheliyo. Oku kuseta iCymbalta ngaphandle kwamanye amayeza athomalalisa uxinzelelo kuba yiyo kuphela evunyiweyo kwizifo ezinxulumene nentlungu.
I-Zoloft yamkelwe yi-Food and Drug Administration (FDA) kunyango lokuphazamiseka koxinzelelo kwezentlalo kunye nokuphazamiseka okungafunekiyo (OCD). Isetyenziselwa ngaphandle kwelebheli kukuphazamiseka koxinzelelo ngokubanzi kunye nokwahlulahlula uxinzelelo. Ukusetyenziswa kwelebheli engaphandle kwelebheli kubonisa ukuba ukusetyenziswa okujolise kuko akuvunyelwanga yi-FDA.
Le theyibhile yolwazelelo yenzelwe ulwazi kuphela kwaye ayenzelwanga ukuba yingcebiso yezonyango. Nceda undwendwele umsebenzi wakho wezempilo ukuze ubone ukuba loluphi unyango olulungele imeko yakho.
| Imeko | ICymbalta | Zoloft |
| Uxinzelelo olukhulu | Ewe | Ewe |
| Uxinzelelo ngokubanzi | Ewe | Ngaphandle kwelebheli |
| Iintlungu ezinxulunyaniswa nesifo seswekile | Ewe | Hayi |
| Intlungu ehambelana nefibromyalgia | Ewe | Hayi |
| Intlungu engapheliyo yemisipha | Ewe | Hayi |
| Uxinzelelo ukungahambi kakuhle komchamo | Ngaphandle kwelebheli | Hayi |
| Ukuphazamiseka koxinzelelo kwezentlalo | Hayi | Ewe |
| Ubume obungalunganga obuphambanisayo | Hayi | Ewe |
| Ukwahlukana koxinzelelo lwexhala | Hayi | Ngaphandle kwelebheli |
| Ukuphazamiseka koxinzelelo lwasemva kwexesha | Hayi | Ewe |
| Ukuphazamiseka kovalo | Hayi | Ngaphandle kwelebheli |
| Ukutshisa okushushu ngenxa yokuyeka ukuya exesheni | Hayi | Ngaphandle kwelebheli |
| Ukunyuka kwangaphambili | Hayi | Ngaphandle kwelebheli |
Ngaba iCymbalta okanye iZoloft iyasebenza ngakumbi?
UKUYA ukufunda epapashwe ngo-2016 ngokuthelekisa ngokuthe ngqo iCymbalta kunye neZoloft ekusebenzeni kwabo kunyango loxinzelelo, kwaye isifundo sijonge kwiimpawu ezithile zoxinzelelo. Ngokubanzi, omabini la machiza aboniswa ukuba ayasebenza ekunyangeni uxinzelelo, elinye lingangcono kakhulu kunelinye lilonke. Nangona kunjalo, xa ujonga iimpawu ezithile, iyeza ngalinye libonakala linoncedo olwahlukileyo lweempawu ezithile. Iqela elanyangwa ngeCymbalta libonakalise ukuphucuka ngakumbi ngokubhekisele kukhubazeko lwe-psychomotor, somnolence, kunye nokukhubazeka ngokwesondo. Iqela leZoloft libonise ukuphucuka ngakumbi kwiimpawu ezinje ngokuxhalaba, ixhala, kunye nehipochondriasis. Zombini iiCymbalta kunye neZoloft ziyasebenza ekunyangeni uxinzelelo, kodwa olu phononongo lubonisa ukuba amagqirha kufuneka anike ingqalelo ekhethekileyo kwiimpawu zomntu ezixhaphakileyo xa kukhethwa unyango.
Umyinge kunye nokuthelekiswa kwexabiso leCymbalta vs Zoloft
ICymbalta sisiyobisi sikagqirha esigqunywe ziinkqubo zorhwebo kunye nezonyango. Ixabiso eliphuma epokothweni leCymbalta 60 mg lingangaphezulu kwe- $ 300, kodwa ngekhuphoni evela kwi-SingleCare, unokufumana i-generic yexabiso eliphantsi njenge- $ 15 kwiikhemesti ezithatha inxaxheba.
I-Zoloft ikwalichiza likagqirha elijongwa ngokubanzi ziMedicare kunye nezicwangciso zamachiza orhwebo. Ixabiso elingaphandle kwepokotho legama legama elinguZoloft linokuba ngaphezulu kwe- $ 400, kodwa ungasebenzisa isigqebhezana esivela kwi-SingleCare ukufumana inguqulelo yesiqhelo ye $ 10.
Fumana ikhadi lesaphulelo somntu ongatshatanga
| ICymbalta | Zoloft | |
| Ngokuqhelekileyo i-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Umthamo osemgangathweni | 30, 60 mg njengezingxobo | Iipilisi ze-30, 50 mg |
| I-Medicare copay eqhelekileyo | Ngaphantsi kwe- $ 10 | Ngaphantsi kwe- $ 10 |
| Ixabiso elilodwa | $ 15 + | $ 10 + |
Iziphumo eziqhelekileyo zeCymbalta vs.Zoloft
ICymbalta kunye neZoloft zombini ziyaziwa ukuba zibangela ukuphazamiseka kwamathumbu anje ngesicaphucaphu, urhudo kunye nokuqunjelwa. Isicaphucaphu sesona siphumo siqhelekileyo sonyango kuzo zombini iziyobisi ngokubanzi kwaye sinokuchaphazela umgangatho wobomi. Ukuba ufumana isicaphucaphu esichaphazela imisebenzi yakho yemihla ngemihla, kuya kufuneka wazise umyaleli wakho.
Ukudinwa, okanye ukulala kakhulu okanye ukozela, ikwayenye yeziphumo ezibi zeCymbalta kunye neZoloft. Izigulana ezithatha iCymbalta zinokufumana iintloko kunye nokunyusa uxinzelelo lwegazi. ICymbalta, nangona kunjalo, ayibonakali ichaphazela i-libido, ngelixa ukusetyenziswa kweZoloft kunakho.
Le tafile ayenzelwanga ukuba ibe luluhlu olupheleleyo lweziphumo ebezingalindelekanga ezinokubakho kwaye yenzelwe ulwazi kuphela. Nceda uqhagamshelane neengcali zonyango ukuba ufumane uluhlu olupheleleyo.
| ICymbalta | Zoloft | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Isicaphucaphu | Ewe | 2. 3% | Ewe | 26% |
| Umlomo owomileyo | Ewe | 13% | Ewe | 14% |
| Ukubila | Ewe | 6% | Ewe | 7% |
| Urhudo | Ewe | 9% | Ewe | 4% |
| Ukuqunjelwa | Ewe | 9% | Ewe | 6% |
| Dyspepsia | Hayi | n / A | Ewe | 8% |
| Ukuba nesiyezi | Ewe | 9% | Ewe | 12% |
| Ukozela | Ewe | 10% | Ewe | Shumi elinanye% |
| Intloko ebuhlungu | Ewe | 14% | Hayi | n / A |
| Ukunyusa uxinzelelo lwegazi | Ewe | Mbini% | Hayi | n / A |
| Ukunciphisa ukutya | Ewe | 7% | Ewe | 3% |
| Ukuncipha kwe-libido | Hayi | n / A | Ewe | 6% |
Umthombo: ICymbalta ( Yonke imihla IZoloft ( Yonke imihla )
Ukudibana kweziyobisi neCymbalta vs.Zoloft
ICymbalta kunye neZoloft zabelana ngokuhlangana okuxhaphakileyo kweziyobisi, kodwa kukho ezinye ezichaphazela ichiza ngalinye ngokunjalo. ICymbalta inhibit CYP2D6, i-enzyme ejongene nemetabolism yamachiza amaninzi kubandakanya iziyobisi ezinxulumene ne-amphetamine. Ii-Amphetamines zisetyenziselwa unyango lweengxaki zokunqongophala kwengqondo, ezinokuthi zenzeke kwizigulana ezinokudakumba okanye uxinzelelo ngokunjalo. Ukuvinjelwa kweCymbalta kwale enzyme kunokubangela ukonyuka kwamanqanaba egazi ee-amphetamines. Izigulana ezizo zombini ezi ntlobo zeziyobisi kufuneka zijongwe ngokusondeleyo.
ICymbalta kunye neZoloft zinokubangela i-serotonin syndrome xa ixutywe namanye amachiza aneentshukumo ze-serotonergic. Isifo seSerotonin sisiphumo samanqanaba aphezulu ngokungaqhelekanga e-serotonin yasimahla kwaye inokubangela ukuphazamiseka, isiyezi, kunye nokunyuka kwentliziyo. Iziyobisi ezinje ngamayeza e-migraine eletriptan okanye isongezo iSt.John's Wort sinokubangela olu nxibelelwano.
I-Zoloft inokubangela uhlobo oluthile lwe-cardiac arrhythmia eyaziwa njengexesha elide le-QTc xa lithathwa kunye neeklasi ezithile zonyango. Kubalulekile ukuba ukhathalelo lwempilo kunye nosokhemesti banoluhlu olupheleleyo lwamayeza owathathayo ukuze ukhangele ngokufanelekileyo unxibelelwano olunokubakho.
Olu luhlu lulandelayo alwenzelwanga ukuba lube luluhlu olupheleleyo lokunxibelelana kweziyobisi. Ugqirha wakho okanye usokhemesti unokubonelela ngoluhlu olupheleleyo.
| Iziyobisi | Iklasi yeziyobisi | ICymbalta | ILexapro |
| IAlmotriptan Eletriptan I-Oxitriptan | I-5HT Agonist / Triptans (iiarhente zentsholongwane) | Ewe | Ewe |
| Amphetamine ityuwa Dexmethylphenidate Imethylphenidate | IiAmphetamines | Ewe | Ewe |
| IAlosetron Ondansetron NdinguRamosetron | 5HT3 Abachasi (izixhobo zokulwa isicaphucaphu) | Hayi | Ewe |
| Aripiprazole | Intshutshiso yengqondo | Ewe | Ewe |
| I-Aspirin Ibuprofen INaproxen Diclofenac | Izidakamizwa ezichasayo ezichasayo (i-NSAID) | Ewe | Ewe |
| Enoxaparin IHeparin | Iintsholongwane | Hayi | Ewe |
| Ibhayiprone | Ukuxhalaba | Ewe | Ewe |
| ICarbamazepine | I-Anticonvulsant | Hayi | Ewe |
| Esomeprazole Omeprazole | Impompo Proton inhibitor | Hayi | Ewe |
| IFluconazole | Ukubola | Hayi | Ewe |
| IFluoxetine Citalopram Paroxetine I-Escitalopram | SSRIs | Ewe | Ewe |
| IHydroxychloroquine | Aminoquinolone / Antimalarial | Hayi | Ewe |
| Umgca we-Linezolid | Zintsholongwane | Ewe | Ewe |
| Imetaxalone | Izihlunu zezihluli | Ewe | Ewe |
| IPimozide | Intshutshiso yengqondo | Hayi | Ewe |
| Selegiline IPhenelzine I-Rasagiline | I-Monoamine oxidase inhibitor (MAOI) | Ewe | Ewe |
| Wort eSt | Ukongezwa kweHerbal | Ewe | Ewe |
| IHydrochlorothiazide IChlorthalidone Imetolazone | I-Thiazide yomchamo | Hayi | Ewe |
| I-Tramadol | Ukukhupha iintlungu | Ewe | Ewe |
| Amitriptyline Clomipramine Doxepin Umgca weNortriptyline | I-Tricyclic yoxinzelelo | Ewe | Ewe |
Izilumkiso zeCymbalta kunye neZoloft
Kubalulekile ukuba uqonde ukuba i-Cymbalta okanye i-Zoloft ayizukuvelisa uxolelo kwangoko lweempawu zokuphazamiseka koxinzelelo okanye ukuphazamiseka koxinzelelo. Kuya kuthatha ubuncinci beeveki ezimbini ukuqaphela naluphi na utshintsho kwizigulana ezininzi zeposi, kwaye ukuya kuthi ga kwiiveki ezine ukuya kwezintandathu ukuqonda isiphumo esipheleleyo sonyango. Musa ukuyeka ngaphambi kwexesha amayeza akho ngenkolelo yokuba ayisebenzi ngaphandle kokuqala uthethe nommiseli wakho.
Izigulana ezine-MDD zinokufumana ukwanda kokudakumba okanye iingcinga zokuzibulala nokuba zithatha amayeza oxinzelelo. Ezi meko zinokuba mandundu kude kube kufezekisiwe ukuxolelwa. Unyango lweCymbalta kunye neZoloft lunokunyusa umbono wokuzibulala kunye neengcinga phakathi kolutsha nakubantu abadala abancinci, ngakumbi kumanqanaba okuqala onyango. Ezi zigulana kufuneka zijongwe ngeliso elibukhali ukuba olu nyango lubonwa luyimfuneko kwezonyango. Utshintsho kunyango lunokuba yimfuneko ukuba iimpawu zivela ngesiquphe okanye ziba mandundu.
Kukho iingxelo ngokusilela kwesibindi, ngamanye amaxesha kuyabulala, kunye neCymbalta. Ezi meko zinokubonisa iintlungu zesisu kunye ne-enzyme zesibindi eziphakamileyo kunye okanye ngaphandle kwe-jaundice. Ukusela utywala kunokwandisa lo mngcipheko, kwaye ke olu dibaniso kufuneka luphetshwe.
I-Zoloft inokubangela uhlobo oluthile lwe-cardiac arrhythmia eyaziwa njengexesha elide le-QTc xa lithathwa kunye neeklasi ezithile zonyango. Kubalulekile ukuba ukhathalelo lwempilo kunye nosokhemesti banoluhlu olupheleleyo lwamayeza owathathayo ukuze ukhangele ngokufanelekileyo unxibelelwano olunokubakho. Nceda ufune iingcebiso zonyango kumboneleli wakho wezempilo ngaphambi kokuba uqale naluphi na unyango olutsha.
Isifo seSerotonin Kuxelwe ngazo zonke ii-SSRI kunye nee-SNRI, kubandakanya iCymbalta kunye neZoloft. Le yimeko enxulumene namanqanaba aphezulu ngokungaqhelekanga e-serotonin kwaye inokubangela ukuba isigulana sizive siphazamisekile, siba nesiyezi, kwaye sibe nokunyuka kwentliziyo.
Imibuzo ebuzwa rhoqo malunga neCymbalta vs Zoloft
Yintoni iCymbalta?
ICymbalta (yintoni iCymbalta?) Lunyango olusetyenziselwa ukunyanga uxinzelelo olukhulu, ukuphazamiseka koxinzelelo ngokubanzi, kunye ne-neuropathic kunye ne-musculoskeletal pain. ICymbalta ikwiklasi yeziyobisi ezaziwa njenge-serotonin-norepinephrine reuptake inhibitors ekhethiweyo (SNRIs). ICymbalta ifumaneka njengephilisi yomlomo kwi-20 mg, 30 mg, kunye ne-60 mg yamandla.
Yintoni iZoloft?
UZoloft (yintoni uZoloft?) Lunyango olunokusetyenziswa ukunyanga isifo sokudakumba kunye nolunye uxinzelelo kunye nokuphazamiseka kwengqondo. UZoloft ukwiklasi yamachiza abizwa ngokuba yi-serotonin reuptake inhibitors (SSRIs) ekhethiweyo. I-Zoloft iyafumaneka njengecwecwe lomlomo kwi-25 mg, 50 mg, kunye ne-100 mg yamandla, kunye nomxube wamanzi omlomo.
Ngaba iCymbalta kunye neZoloft ziyafana?
Ngelixa zombini iCymbalta kunye neZoloft ziphatha uxinzelelo kunye nokuphazamiseka kwempilo yengqondo, azilulo uhlobo olufanayo lweziyobisi. ICymbalta ikwiklasi yeziyobisi ezaziwa njenge-serotonin-norepinephrine reuptake inhibitors (SNRIs), kwaye ibangela ukonyuka kokubini kwe-serotonin kunye ne-norepinephrine. I-Zoloft ikwiklasi yeziyobisi ezaziwa njenge-serotonin reuptake inhibitors (SSRIs) ekhethiweyo kwaye ibangela ukwanda kwe-serotonin ekhoyo.
Ngaba iCymbalta okanye iZoloft ingcono?
ICymbalta kunye neZoloft zithelekiswa nokukwazi kwabo ukunyanga uxinzelelo. ICymbalta inesibonakaliso esongezelelweyo soxinzelelo ngokubanzi. Kubalulekile ukujonga iimpawu zoxinzelelo ezithile kunye neziphumo ebezingalindelekanga ezinokubakho xa usenza isigqibo sokuba leliphi ichiza elilungele isigulana esithile.
Ndingayisebenzisa iCymbalta okanye iZoloft ngelixa ndikhulelwe?
I-FDA ithathela ingqalelo zombini iCymbalta kunye neLexapro (yintoni iLexapro) yokukhulelwa kudidi C, okuthetha ukuba khange kubekho zifundo zoluntu zaneleyo ukumisela ukhuseleko. NgeCymbalta, iimpembelelo ezingezizo ezomhlaba ziye zabonwa kwiintsana emva kolawulo lweCymbalta ngelixa ukhulelwe. Oku kubandakanya uxinzelelo lokuphefumla, ubunzima bokondla, kunye neenyikima. Ngokubanzi, naliphi na ichiza kufuneka lisetyenziswe kuphela kunye noncedo kunina ngokucacileyo ngaphezu komngcipheko kwimveku engekazalwa.
Ndingayisebenzisa iCymbalta okanye iZoloft ngotywala?
Izigulana kufuneka zikuphephe ukuselwa kotywala xa kuthathwa iCymbalta okanye iZoloft. Utywala bunokunyusa iziphumo ezinetyhefu kuwo omabini amayeza kwaye kunokubangela ukonakala kwengqondo. NgeCymbalta ngokuthe ngqo, utywala bonyusa imeko yokukhubazeka kwesibindi.
Yeyiphi eyona nto iphambili yoxinzelelo kunye neziphumo ebezingalindelekanga?
Amayeza okulwa noxinzelelo kwimarike e-United States aye avavanywa ngokucokisekileyo ukuqinisekisa ukuba ayasebenza ekunyangeni uxinzelelo. Zombini zineziphumo ebezingalindelekanga ezenzeka ngokuxhaphaka okungafaniyo. Ugqirha wakho uya kujonga iimpawu zakho zoxinzelelo kunye neziphumo ebezingalunganga ezikukhathaza kakhulu xa ukhetha unyango.
Ngaba uZoloft uyakuchaphazela ngokwesondo?
Umvelisi uxela ukuba kangange-6% yezigulana ezinokuba namava okunciphisa i-libido, okanye ukunciphisa ukuqhuba ngesondo, ngelixa uthatha iCymbalta. Izigulana ezinamava oku kufuneka zithethe noochwephesha bezonyango malunga nezinye iindlela ezinokubakho.
Kukuphi okungcono: iProzac okanye iZoloft?
Nantsi lapho idatha ukucebisa ukuba iZoloft ingangaphezulu kweProzac (yintoni iProzac) ngokubhekiselele ekusebenzeni kakuhle xa kunyangwa uxinzelelo. Nangona kunjalo, abagqirha baya kuthatha iimeko ezininzi xa bejonga unyango. Ngugqirha wakho kuphela onokugqiba ukuba yeyiphi eyona nto ingakulungela.
