Yintoni ekufuneka abazali bayazi malunga neReye's syndrome

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Yintoni iReye's syndrome? | Iimpawu | Uxilongo | Unyango | Uthintelo

Ukuba ungumzali, uyazi ukuba ungaze unike iasprini kumntwana onerhashalala okanye umkhuhlane. Isizathu soku kukunciphisa umngcipheko wesimo esibi kunye nesifo esinokubulala esibizwa ngokuba yiReye's syndrome, okanye isifo seReye, esinokubangela ukungasebenzi kakuhle kwesibindi kunye nokudumba kwengqondo kwaye kunxulunyaniswe nokusetyenziswa kweasprini ebantwaneni nakwishumi elivisayo Usulelo olunjengomkhuhlane, i-varicella (ebangela irhashalala), usulelo oluphezulu lokuphefumla, kunye ne-COVID-19, ebangelwa yinoveli coronavirus.

Ngo-1980, amaZiko okuLawula nokuThintela izifo (CDC) arekhoda iimeko ezingama-555 ze Isifo sikaReye eUnited States. Ngethamsanqa, kwakuloo nyaka Kwaqala izilumkiso malunga nokusetyenziswa kweasprini ebantwaneni , kwaye ukusukela ngo-1994 kunikelwe ingxelo ngamatyala angaphantsi kwesibini ngonyaka kwilizwe lonke.

Ngama-80s, malunga nomntwana omnye kwabali-100 000 wayifumana- ngoku, imalunga nesisigidi esinye, utshilo u-Amy Cram, MD, ugqirha wabantwana Iqela lezonyango laseMantla . Oko ikakhulu kungenxa yokuba siyazi ukuba ukusebenzisa iasprini njengesinciphisi ifiva okanye ukuthintela ukudumba kwandisa umngcipheko.

Uninzi lwabantwana (malunga ne-80%) abafumana i-Reye's syndrome bayasinda, kodwa kufuneka inyangwe ngokukhawuleza, rhoqo kwigumbi lokunyamekela esibhedlele. Ukuba ishiywe inganyangwa, iReye's syndrome inokukhokelela ekonakaleni okungapheliyo kwengqondo okanye ekufeni kwiintsuku nje ezimbalwa.

Ezinxulumene: Yeyiphi eyona ntlungu yokunciphisa okanye yokunciphisa umkhuhlane ebantwaneni?

Yintoni iReye's syndrome?

Isifo sikaReye sisifo esidla ngokufumaneka ebantwaneni nakwishumi elivisayo abangaphantsi kweminyaka eli-18- ikakhulu abo baneminyaka emi-4 ukuya kweli-12 ubudala —Kodwa inokuchaphazela abantu nabuphi na ubudala. Oogqirha abazi kanye kanye ukuba yintoni ebangela iReye's syndrome, kodwa ihlala ilandela okunye ukugula kwaye ihlala inxulunyaniswa nokusetyenziswa kwamayeza aqukethe iasprini kubantwana abanosulelo lwentsholongwane.

I-Aspirin, ekwabizwa ngokuba yi-acetylsalicylic acid, i-salicylic acid, okanye i-acetylsalicylate, yiyo uninzi lweziyobisi ezisetyenziselwa ukuphelisa iintlungu kwimbali . Isebenza ngokuthintela ukuveliswa komzimba kwee-prostaglandins, eziyimixube eveliswa zii-enzymes emzimbeni ezidlala indima ephambili ekuphenduleni komzimba ekungeneni kwintsholongwane okanye ukwenzakala.

Xa isetyenziselwa ukugula kwintsholongwane, i-aspirin inokuchaphazela i-mitochondria yomntu, ezakhiwana ezincinci kwiiseli ezibizwa ngokuba zivelisa amandla okuqhuba iseli.

I-Aspirin kwimeko yokugula kwintsholongwane, njengomkhuhlane okanye inkukhu, ibangela ukulimala kwesibindi se-mitochondrial, utsho uNathan ngoLwesihlanu, i-Pharm.D., Usokhemisi Kroger . Kwaye oku kubangela ukungasebenzi kwesibindi.

Ukungasebenzi kakuhle kwe-mitochondrial kungakhokelela ekwakhiweni kwe-ammonia-imveliso ye-metabolism-egazini. Le meko, ibizwa ngokuba yi-hyperammonemia, inokukhokelela ekudumbeni kwengqondo kunye nokunyusa uxinzelelo kwingqondo njengoko icinezela ukhakhayi. Inani lokudumba kunye noxinzelelo kumisela ubukrakra beempawu zomntu ze-neurologic.

Iimpawu zesifo sikaReye

Nangona ichaphazela onke amalungu omzimba, isifo sikaReye senza owona monakalo mkhulu kwingqondo nakwisibindi. Kungenxa yoko le nto, ngokwemiqathango yezonyango, ichazwa njenge: encephalopathy ebukhali yokungaphembi kunye nokusilela kwesibindi esinamafutha. I-Encephalopathy, imeko eguqula ukusebenza kwengqondo okanye ulwakhiwo, lolona phawu luyingozi kakhulu kwiReye's syndrome, kodwa kunzima kakhulu ukuyibona de umonakalo sele wenziwe kwingqondo kwaye imiqondiso yokugula ibonakale.

Iimpawu zihlala zivela kwiintsuku ezintathu ukuya ezintlanu emva kokuqala kosulelo lwentsholongwane kwaye zihlala ziqala ngokugabha ngesiquphe, ngokuqhubekayo, nangona kubantwana abangaphantsi kweminyaka emi-2 ubudala, uphawu lokuqala inokuba urhudo . Ukuhlanza kuhlala kulandelwa kukuwozela okanye ukozela okungaqhelekanga; Nangona kunjalo, abantwana abangaphantsi kweenyanga ezili-12 banokubonisa ngaphandle kokugabha. Iimpawu ze-Neurologic emva koko ziqala ukubonakala ngaphakathi kweeyure ezingama-24 ukuya kwezingama-48 kwaye zinokubandakanya:

• ukucaphuka
• ukungazinzi
• ukudideka
• utshintsho kubuntu
• imemori ephazamisekileyo

Njengoko isifo siqhubeka ngokukhawuleza kwaye nengqondo iyaqhubeka ukonakala ngenxa yokudumba kunye noxinzelelo, ezinye iimpawu zinokubandakanya:

• abafundi abaxubileyo
• ukudideka okanye ukudideka
• nemibono
• nzulu okanye uphefumle ngokukhawuleza
• ukukhawuleza kwentliziyo
• ukulahleka kwengqondo

Ukongeza kwiimpawu zayo ze-neurologic, i-Reye's syndrome inokubangela ukuqokelelwa okukhulu kwamafutha esibindini nakwamanye amalungu. Ubungqongqo beempawu kunye nokuxela ukubuyela kwimeko yesiqhelo kuyahluka kakhulu kwaye kuxhomekeke kubungakanani bomonakalo owenziwe kwingqondo. Abanye abantu baneempawu ezinobulali kwaye bachacha ngokupheleleyo. Abanye bashiyeka benomlinganiselo othile wokuphazamiseka engqondweni okanye emzimbeni.

Kwiimeko ezimandundu, ukonakala kwengqondo kunokukhokelela ekuxhuzulekeni, ukukhubazeka ezingalweni nasemilenzeni, isiqaqa, nasekufeni ekugqibeleni. Inkqubo ye- izinga lokusweleka kwesifo sikaReye Ibe malunga neepesenti ezingama-50, kodwa elo nani lehlile laya ngaphantsi kwe-20% kule minyaka idlulileyo.

Isifo sikaReye's sifunyanwa njani?

Ukuxilongwa kwangoko kunye nonyango kubaluleke kakhulu kwiReye's syndrome, ke naluphi na usana, umntwana, okanye ulutsha osandula ukuba nosulelo lwentsholongwane kwaye abonise naziphi na iimpawu zeReye's syndrome kufuneka asiwe kwigumbi likaxakeka esibhedlele ngokukhawuleza. Ukufumana isifo esifanelekileyo, kubalulekile ukuba abanonopheli babonelele ngembali yonyango eneenkcukacha konke amayeza, kubandakanya i-counter, i-supplements, kunye neivithamini, ezithathwa ngumguli.

Uxilongo luqala kuvavanyo lwegazi kunye novavanyo lomchamo ukujonga izinto ezinjenge-fatty-acid okanye amanqanaba e-ammonia egazini. Uvavanyo lwe-chemistry yesibindi, ngakumbi, lunokuba luncedo. Iziphumo zinokulunga ngaphakathi kweeyure ezimbalwa, kwaye iimvavanyo zinokubona amanqanaba aphakamileyo e-enzymes ezithile eziveliswe sisibindi egazini. Amanqanaba aphezulu ezi enzymes luphawu olunokubakho lweReye's syndrome.

Inani lezinye iingxaki zinokubangela iimpawu ezifanayo neReye's syndrome, ke icandelo lokuxilongwa liya kuba nemeko yokulawula iimeko ezinje:

• ukuphazamiseka kwe-acid oxidation kunye neminye imiba yokusebenza kwesibindi
• iimpazamo ezizelwe kwimetabolism kunye nokunye ukuphazamiseka komzimba
• Ukusetyenziswa kweziyobisi, ukungenisa, okanye ukubhencwa kwityhefu
• usulelo lwenkqubo esembindini efana ne-encephalitis (ukudumba kwengqondo) kunye ne-meningitis (ukudumba kwenwebu ekhuselayo ejikeleze ingqondo kunye nentambo yomqolo)
• isifo sengqondo

Kwezinye iimeko, umpompo womqolo unokwenziwa ukufumana uxinzelelo olonyukayo kwi-cerebrospinal fluid yomzimba (CSF). Kule nkqubo, ekwabizwa ngokuba kukugqobhoza i-lumbar, inaliti ifakwe kumqolo ongezantsi kwisithuba ecaleni kwentsika yomqolo, kwaye inani elincinci le-CSF liyasuswa kuvavanyo. Ukonyuka koxinzelelo lwe-intracranial ngamanye amaxesha ngamanye amaxesha kunokufunyanwa ngemifanekiso yokujonga ngemagneti (i-MRI) okanye i-computerised tomography (CT) scan, kwaye oogqirha banoku-odola olunye lolo vavanyo kuvavanyo lwonobangela.

Unyango lwesifo sikaReye

Unyango lwe-Reye's syndrome kufuneka luqale ngokukhawuleza ukunceda ukuqhubela phambili kokugula.

Ngexesha abantwana abane-Reye's syndrome [okanye umntwana one nayiphi na ukugula] banotshintsho kubume babo bengqondo (inqanaba labo lokuphapha kunye nokwazisa), kufuneka baye kwigumbi likaxakeka, utshilo uGqirha Cram. Kwaye emva koko banokuphelela kwigumbi lokunyamekela abagadiweyo kwaye bazinziswe ngononophelo lwexesha lonke.

Akukho lonyango lweReye's syndrome, ke unyango lujolise ekukhuseleni ingqondo ukuba ingaphinde yenzeke, izama ukubuyisela umva kwimicimbi ebangela ukuba ingqondo idumbe, iqinisekise ukuba imiphunga iyaqhubeka nokusebenza ngeendlela ezifana netyhubhu yokuphefumla okanye i-ventilator, kwaye ukunciphisa uxinzelelo lomzimba ngokubanzi olunokubangela ukubanjwa kwentliziyo.

Ungasebenzisa i-ventilator ukunyanzela umntu one-Reye's syndrome, enokukunceda ekukhuleni kwengqondo, utshilo uGqirha Cram. Kukwakho amayeza (anje imanitol okanye dexamethasone ungabanika ezinokunceda ngokudumba.

Unyango lunokunceda ukucothisa ukuqhubela phambili kwesifo sikaReye, kwaye iimeko ezinobulali ezingahambeli phambili kunokubangela ukuba kungabikho ngxaki yexesha elide.

Ungayikhusela njani iReye's syndrome

1. Iziyobisi oza kuziphepha (ukongeza kwiasprini)

Kungenzeka ukuba akunakwenzeka ukuthintela zonke iimeko zeReye's syndrome, njengoko ezinye iimeko zinganxulunyaniswa ne-aspirin. Nangona kunjalo, amathuba okufumana esi sifo sinqabileyo esihla kakhulu ngokuqinisekisa ukuba abantwana abanesifo sentsholongwane abayithathi nawaphi na amayeza ane-acetylsalicylic acid, salicylic acid, acetylsalicylate, okanye salicylate compounds. Ukongeza kwi-aspirin, oku kubandakanya la machiza:

• UAlka-Seltzer
• Anacin
• Isicatshulwa
• IBufferin
• Doan ’s
• Ecotrin
• Excedrin
• Kaopectate
• Maalox
• IPamprin
• I-Pepto-Bismol

Olu ayilo luhlu lupheleleyo. Thetha nomboneleli wabantwana bakho okanye usokhemisti ngolwazi olongezelelweyo. Kubalulekile ukuba abazali kunye nolutsha olufundayo bafunde zonke iilebhile zamayeza angaphaya kwekhawuntareni ngaphambi kokuba bawathathe.

2. Ukugonywa

Ukongeza ekuthinteleni loo mayeza, ungawunciphisa umngcipheko womntwana wakho ekufumaneni usulelo lwentsholongwane kwindawo yokuqala ngokugonya abantwana bakho kuzo zonke izifo ezinokuthintelwa ngokugonya, kodwa ngakumbi umkhuhlane (umkhuhlane) okanye i-varicella (irhashalala) njengoko ezi zimbini ezona zifo zixhaphakileyo zithintelwa zizitofu zokugonya. Abantwana bafumana amayeza okugonya i-varicella kwiinyanga ezili-12 kunye neminyaka emi-4 kwaye kufuneka bafumane iyeza lokugonya unyaka nonyaka.

3. Ukuthomalalisa iintlungu kunye nokunciphisa umkhuhlane

Ngaphandle komgaqo we-no-aspirin ngabantwana abaneemeko eziphendula kakuhle kunyango lwe-aspirin, njengesifo se-Kawasaki. Kwiimeko ezinjalo, abazali kufuneka babonane nogqirha ngaphambi kokwenza amayeza okubulala iintlungu okanye amayeza okulwa nokudumba. Abanye abantwana, i-acetaminophen (iTylenol) okanye ibuprofen (Motrin) zihlala zicetyiswa endaweni yeasprini, ngakumbi ngezifo zentsholongwane.