Ngaba i-beta blockers inganceda ngoxinzelelo?

Ulwazi lweziyobisi

Ngo-Matshi ka-2020, ndaye ndadibana nogqirha wam. Ndamchazela ukuba, nangona bendiseLexapro, i-serotonin reuptake inhibitor (SSRI) ekhethiweyo, yoxinzelelo kunye noxinzelelo, bendiziva ndikhathazekile ngamanye amaxesha. Ngo-5 emva kwemini. yonke imihla, xa abantwana besekhaya, belambile, kwaye befuna ukuhoywa, ndaziva ndiphakuzela esifubeni. Ndandibila kwaye ngamanye amaxesha ndiziva ndinesiyezi. Ngamanye amaxesha bendibabetha abantwana bam, okanye bendifuna ukuthatha ikhefu kwindawo ethe cwaka, kude nabanye. Umbulelo wokugqibela, bendilungiselela kwaye ndipheka iintsuku ezimbini, kuphela ukuchitha uninzi lwesidlo kwigumbi lam lokulala. Ndixelele umboneleli wam ukhathalelo lwempilo ndifuna ukukwazi ukujongana noxinzelelo olungenakuphepheka ebomini bam ngaphandle kokuziva ngathi nditshona.

Ugqirha wam undixelele ukuba ndinempendulo yendiza kwaye iimpawu zam zomzimba zibonisa uhlaselo loxinzelelo. Undimisele ipropranolol, a beta blocker , yoxinzelelo. Olu hlobo lonyango luqhele ukusetyenziswa kulawulo lwexinzelelo lwegazi kunye neemeko zentliziyo. Andizange ndibenembali yoxinzelelo lwegazi oluphezulu okanye iingxaki zentliziyo, kodwa wandixelela ukuba ndithatha idosi encinci yale Rx yindlela elungileyo yokujongana namaxhala ngamanye amaxesha. Njengomntu oqheleke kakhulu ukuziva amayeza, bendingafuni ukuthatha into eyomeleleyo okanye enokuba likhoboka. Ndigqibe kwelokuba ndizame.

Ndonwabile ukuba ndenzile! Ubhubhane uvale izikolo (nayo yonke into) ngeveki emva kokuqeshwa kwam. Ndazifumana ndisekhaya nge-24/7 nabantwana bam, kwaye kwavakala ngathi isiphelo sehlabathi sasilungile kwikona. Ndibulele kakhulu ngepropranolol yoxinzelelo kwiinyanga zokuqala zobhubhane kwaye ngoku, ndikhuselekile ekhaya phantse unyaka emva koko.

Ezinxulumene: Ukuhlaselwa kwexhala ngokuchasene nokuhlaselwa kukothuka

Ngaba iibhloko ze-beta ziyasebenza kuxinzelelo?

Iibhlokhi zeBeta azenzelwanga injongo yokunciphisa uxinzelelo.Iibhloko blocker zihlala zimiselwe off-ileyibheli yoxinzelelo, uyacacisa USpencer Kroll, MD , KwiF.D. kwi-pharmacology, iumlawuli we-Northeast Lipid Association.[Ukusetyenziswa kwelebheli] kuthetha ukuba azivunyelwanga yi-US FDA kunyango lwexhala.

Nokuba azenzelwanga ngokuthe ngqo njengeyeza lokulwa unxunguphalo, iibhloko ze-beta zinokunceda ekwenzeni imeko yokuzola xa uzithatha. I-Beta blockers inokunciphisa ukubetha kwentliziyo, ugqirha wezifo zengqondo waseHouston UJared Heathman , MD, uyacacisa. Xa sixhalabile, intliziyo yethu ibetha phezulu. Oku kuphakama kunika ingxelo yengqondo ukuba umzimba wethu uyothuka ngokufanelekileyo. Oku kuqinisa uxinzelelo. Ukuba uthintela isakhono sokunyusa izinga lokubetha kwentliziyo yakho ngokukhawuleza, intliziyo yakho inokunika ingxelo kwingqondo yakho ukuba ayothuki, ngakumbi hayi njengoko bekulindelwe ngenye indlela. Ukuba intliziyo nomzimba wethu zizolile, inika ingxelo ethomalisayo kwingqondo. Oku kunciphisa uxinzelelo.

USheldon Zablow, MD , ugqirha wengqondo oqinisekiswe yibhodi, ubiza le nkqubo ukuba ibe yingxelo engalunganga. Ubeka i-beta blocker yoxinzelelo kuba bayayaphula lo mjikelo ngokuthintela amandla omzimba okubonisa iimpawu ezibonakalayo. Ukujongana nokuphendula komzimba kuxinzelelo kunceda ingqondo yomntu oxhalabileyo ukuba izole kwaye ilawuleke.

Oko kunokwenza umahluko omkhulu kumgangatho wobomi xa uxinzelelo lukuchaphazela yonke imihla. Ezinye iimpawu zoxinzelelo ziziva zinzima kakhulu, kwaye ziyacaphukisa, kangangokuba abantu abazifumanayo besiya kwisibhedlele esikufutshane. Zininzi iimpawu ezizisa izigulana kugqirha okanye kwigumbi likaxakeka eziba luxhalaba, utshilo uGqirha Kroll. Ezi mpawu zibonakalisa:

• Ukubetha kwentliziyo
• Ukubila
• Ukurhawuzelela
• Ukuqhawuka kolusu
• Igazi elonyukayo
• Umlomo owomileyo
• Kunzima ukugwinya
• Imiba yesisu njengokukhathazeka sisisu okanye iintlungu

Njengoko kuvela, ukunciphisa uxinzelelo emva kokuthatha ibhlokhi ye-beta eneneni sisiphumo secala leziyobisi. Ke, nangona uxinzelelo lwegazi lwam lungekho kuluhlu olufuna amayeza xa ndingaziva ndinxunguphalo, i-PCP yam ekrelekrele yenza le nto ithethwa nguGqirha Kroll ihlala iluncedo njengogqirha, oko kukuthi ukusebenzisa ezo ziphumo bezingalindelekanga njengenxalenye unyango oluthile kwisigulane ngasinye. Bendinexhala lokuba i-benzodiazepine (efana neXanax) yoxinzelelo inokundenza ndizive ndithomalalisile ukukhathalela abantwana bam. Ke, endaweni yoko i-PCP yam ihamba ne-beta blocker.

Kuthatha ixesha elingakanani ukuvimba i-beta kuxinzelelo?

Ngokusesikweni ubomi obulicla Ipropranolol ziiyure ezintathu ukuya kwezintandathu, kodwa ngokwe uziva njani, qhubeka uye ucwangcise iiyure ezimbalwa zoncedo. Iibhloko blocker zihlala zimiselwe kwifom yeepilisi ukuba zithathwe ngomlomo. Iyeza lisebenza ngokukhawuleza, lifikelela kumanqanaba aphezulu ngokukhawuleza njengeyure enye. Nje ukuba ikwinkqubo yakho, iziphumo zokuthomalalisa idosi esezantsi ye-beta blocker ihlala iiyure ezimbalwa.

Umthamo oqhelekileyo we-beta blocker uyahluka ngokusekwe kwiimpawu zakho, isifo, kunye nezinye iimeko zonyango. Ukuxhalaba, yedwa, ababoneleli bezempilo bahlala beqala ipropranolol kwiqondo eliphantsi, ukunyuka kancinci ukuba kukho imfuneko. Kukwakho nohlobo olwandisiweyo lokukhutshwa kwepropranolol, kodwa ngenxa yoxinzelelo, kuhlala kungasetyenziswanga uhlobo olwandisiweyo.

Ngaba i-beta blocker ikwenza uzive njani?

I-Beta blocker zinokunceda abantu abanamaxhala ukuba bazive bezolile kwaye ngakumbi kulawulo lweemvakalelo zabo ngaphandle kokubenza bazive bephantsi kwempembelelo. Injongo yonyango loxinzelelo kukuba ukwazi ukuhlala ubomi bakho ngaphandle kwempawu emi endleleni yakho. I-Beta blockers zinokuhlisa impendulo ye-adrenaline yomzimba koxinzelelo oluqhelekileyo, ukuze ukwazi ukugxila kwezinye izinto.

Ngokungafaniyo nee-SSRI-ezilawula uxinzelelo kunye noxinzelelo lwexesha elide kwaye zithathe iiveki ezininzi ukuqala ukusebenza-iibhloko ze-beta ziyasebenza kusetyenziso lokuqala kwaye zinokusetyenziswa ngamaxesha athile ngaphandle kweziphumo ebezingalindelekanga. Zinciphisa iimpawu zoxinzelelo zexesha elifutshane, kodwa azilunyangi unxunguphalo. Ukuba ufumana iimpawu zoxinzelelo ubusuku nemini, unokufuna iyeza elahlukileyo, okanye ukusebenzisa ibhloko blocker ukongeza elinye iyeza.

Iibhlokhi zeBeta zinokuba lunyango olusebenzayo lokoyikwa kwinqanaba phambi kweminyhadala okanye ukubandakanyeka ekuthetheni esidlangalaleni- kunye noxinzelelo lokulala. Ngokwembali, bahlala benikwa abantu 'ngokuxhalaba kokusebenza' ngaphambi kokuthetha nokuthetha esidlangalaleni, utshilo uGqirha Kroll. Qiniseka nje ukuba uyizame ekhaya kuqala ukubona indlela amayeza anokuchaphazela ngayo ngaphambi kokuyisebenzisa kwisiganeko soxinzelelo oluphezulu.Banokusebenza kuxinzelelo lwasentlalweni ukuba bathathwe ngaphambi kwamaqela okanye imihla-ukhetho olukhuselekileyo ngalo lonke ixesha kuvela uxinzelelo.

Ugqirha Zablow uthi i-beta blocker inokusetyenziswa endaweni okanye ngezixhobo zokulala ukunciphisa uxinzelelo ngaphambi kokulala. Ukuba amaxhala omhla odlulileyo okanye inkxalabo malunga nosuku olulandelayo yonyusa ukubetha kwentliziyo, ukuthintela utshintsho lwendalo ekulaleni, le blocker ye-beta ithintela olo phazamiso.

Iziphumo ebezingalindelekanga ze-beta blockers

Iibhlokhi zeBeta azibonakali ngathi zinangxaki okanye inkxalabo kubantu abachaphazelekayo be-COVID-19, utshilo uGqirha Kroll. Ukuba unexhala lokuba i-beta blocker inokuchaphazela umngcipheko we-coronavirus, buza umboneleli wakho wezempilo ngaphambi kokuba uqalise ngonyango. Kukho ukubakho kwezinye izehlo ezingalunganga ezivela kolu hlobo lwamayeza.

Iziphumo eziqhelekileyo

Njengawo onke amayeza, kunokwenzeka imiphumela :

• Ukuba nesiyezi
• Ubumhlophe
• Ukudinwa
• Ukuncipha kwesondo
• Isicaphucaphu
• Intlungu yesisu
• Urhudo
• Ukuqunjelwa

Iziphumo ebezingalindelekanga ezimandundu

Ngaphantsi okuqhelekileyo, kodwa ngamanye amaxesha iziphumo ebezingalindelekanga ziyenzeka:

• Ukuba nemibono
• Izandla okanye iinyawo ezibandayo
• Ubuthathaka bemisipha
• Iintlanzi zemisipha
• Ukuqhawukelwa ngumphefumlo
• Ukuphulukana nenkumbulo
• Ukugcina ulwelo
• Iswekile yegazi iyatshintsha
• Ukuphuthelwa namaphupha amabi
• Ukuphendula ngokuchaseneyo
• Ukuhlanza
• Ukuxakeka
• Ukutyeba kwakho
• Ukudumba kolusu
• Utshintsho lwemood

Funa unyango kwangoko ukuba ubonakalisa iimpawu zokungalungelani ezibandakanya: ukuphefumla, ukubila, ukudumba kwezandla okanye ubuso, kunye / okanye irhashalala.

Ngokungafaniyo amayeza oxinzelelo ngokwesiko , ii-beta blockers azikhoboka. Ipropranolol kunye nezinto ezinjalo azibangeli ukuxhomekeka kwiziyobisi (okanye iimpawu zokurhoxa xa uyeka ukuzithatha) kwaye zikhuselekile ukuzithatha ngamanye amaxesha ixesha elide.

Ipropranolol ilungile ngeendlela ezininzi kuba ngokungafaniyo ne-benzodiazepines ehlala isetyenziselwa ukunyanga uxinzelelo, inokuthathwa ngaphandle kokukhathalela ukuqhuba, isetyenziswe ngamayeza eentlungu, okanye isetyenziswe ngotywala, utshilo uGqirha Zablow. Ndiyimisele ngempumelelo ukunciphisa idosi ye-benzodiazepines, i-antidepressants, kunye ne-antipsychotic.

Nditsaleleke kwesi siphumo sihle sesiyobisi njengomzali ekuhlala kufuneka kubekhona naphakathi kobusuku. Ndingathatha ipropranolol kwaye andinangxaki ndiziva ndonwabile ngokwaneleyo ukuqhuba okanye ukunxibelelana nabantwana bam, into endingenakuyithetha ngamanye amayeza anje nge-benzodiazepines, njengeXanax.

Ngenxa yokuba i-beta blocker isebenza ngokukhawuleza kodwa ayithinteli abasebenzisi ukuya kwinqanaba elibalulekileyo, uGqr.Zablow uthi kuyanceda ukuba umntu onesifo sokukhathazeka aqhubeke nokuphatha epokothweni yakhe malunga nesiqendu sexhala esingalindelekanga- ukuyazi nje Ngaba ikhona imeko enokunciphisa ukwenzeka kweempawu zoxinzelelo.

Ndigcina amayeza kwigumbi lam lokulala ebusuku xa ndingenakucothisa ingqondo yam exakekileyo. Ndigcina nebhotile ekhitshini xa amaxhala emini endigcina ekubeni ndingoyena mntu ubalaseleyo kum. Andizidingi yonke imihla, kodwa ndiyavuya ukuba ziyafumaneka xa ndizifuna.

Yeyiphi i-beta blocker efanelekileyo yokuxhalaba?

Ababoneleli ngezempilo ngokubanzi bamisela nokuba yipropranolol okanye i-atenolol yonyango lweelebhile engabikho kwilebhile.Buza umboneleli wakho wezempilo ukuba leliphi iyeza elinokulungela wena kwaye uqiniseke ukuba unika imbali yezempilo epheleleyo.Nazi umahluko osisiseko phakathi kwezi zimbini:

Ipropranolol vs atenolol yoxinzelelo
Igama lebrand	Inderal LA , Inderal XL , InnoPran XL	Tenormin
Igama lesiqhelo	Ipropranolol	Atenolol
Umgangatho omiselweyo woxinzelelo	Imilinganiselo iyahluka ngokuxhomekeke kwimeko kwaye inokubakho ukusuka kwi-10 mg ukuya kwi-80 mg. Ngoxinzelelo lodwa, idosi esezantsi ihlala imiselwa.	25-100 mg
Iziphumo eziqhelekileyo	Ubumhlophe obukhanyayo, isiyezi, imiba yesisu	Izandla kunye neenyawo ezibandayo, ukudinwa, ubuthathaka
Funda nzulu	Funda nzulu	Funda nzulu
Ugcino olulodwa	Fumana isigqebhezana	Fumana isigqebhezana

Xa ii-beta blocker zingakulungelanga

Ukuba unesifo esinganyangekiyo, esingalawulekiyo, unokufuna unyango oluqhelekileyo kunesiqhelo se-beta blocker-njengamayeza emihla ngemihla. Abanye abantu, njengam, basebenzisa i-beta blocker ukongeza kwi-SSRI. UGqr Kroll uthi,Ngokubanzi, iibhlokhi ze-beta ziyanyamezeleka, kwaye unxibelelwano lweziyobisi olunomqondiso alufane lubekho.

Iibhlokhi zeBeta zisenokungabi lukhetho olufanelekileyo kuwe ukuba unazo naziphi na kwezi zinto zilandelayo:

• Isifuba: I-Beta blockers inokuphazamisa isifuba, utshilo uGqirha Heathman. Banokubangela imicimbi ukuba unayo Iindlela zomoya ezibaxekileyo ngenxa yokuba ii-beta receptors zinokuzandisa iingxaki zokuphefumla.
• Isiseko sezonyango ezifuna amayeza: I-Beta blockers inokusebenzisana nenani elikhulu leziyobisi ezichaziweyo, utshilo uGqirha Kroll. Oku kubandakanya iziyobisi ezithile ezichasene noxinzelelo lwegazi kunye ne-antianginal, iziyobisi ezichasayo, iziyobisi ezichasayo, iziyobisi zengqondo, amayeza e-ulcer, i-anesthetics, iiarhente zokunciphisa i-cholesterol, i-warfarin, amayeza eswekile, kunye namanye amayeza esifo sephepha. Xelela umboneleli wakho wezempilo malunga nawo onke amayeza owathathayo, ukuze aqiniseke ukuba akukho kunxibelelana kweziyobisi.
• Indoda okanye umntu omdala: I-Beta blocker inokusebenza ngakumbi kwizigulana ezincinci ezinesifo soxinzelelo kunezigulana ezindala kwaye zinokusetyenziselwa ukulawula uxinzelelo lwegazi kubantu ababhinqileyo beminyaka yokuzala, ucacisa uGqirha Kroll. Apha, ubhekisa kuyo njengechiza loxinzelelo lwegazi kunye nesibonelelo esongeziweyo sokuphumla koxinzelelo. Ibhlokhi yeBetaakufuneki isetyenziswe ekukhulelweni ngaphandle kokuba inzuzo ingaphezulu komngcipheko. Ke, thetha nogqirha wakho ukuba ukhulelwe okanye ucwangcisa ukukhulelwa.

Akukho siyobisi sigqibeleleyo kwaye akukho mntu ufanayo. Kum, njengabanye abaninzi abafana nam, ibhloko blocker yayisindisa ubomi ngokweemvakalelo ngexesha elinzima kakhulu kwimbali. Iziphumo ezilungileyo zokukwazi ukugcina ukuphola kwam ngelixa ndisekhaya nabantwana bam, ngexesha elingazange libonwe, kwaye xa ujongene noxinzelelo lomntu, yayixabiseke kakhulu. Ndiyabulela kakhulu iPCP yam yokucinga ukuba indinike i-beta blocker. Awunakubulawula ubomi kwaye ngamanye amaxesha bunokubangela uxinzelelo-nokuba kukwenzeka kumnyhadala omkhulu wehlabathi, okanye kwiminutia yemihla ngemihla yomsebenzi kunye nosapho. Iibhloko blocker zinokukunceda ufundise umzimba wakho, nokuba ubomi bunomdla kakhulu, unokujongana nawo, ujongane nawo, kwaye uphumelele.