Yintoni iCelebrex, kwaye isetyenziselwa ntoni?

Ulwazi lweziyobisi

Ukuba wakha waqaqanjelwa yintloko ebuhlungu, izinyo eliqaqambayo, okanye iintlungu zokuya exesheni, uyazi ukuba kunokuba nzima kangakanani ukufumana isiqabu seentlungu. I-Celebrex sisiyobisi sonyango esinciphisa iintlungu kunye nokudumba. Makhe sijonge ukuba yintoni iCelebrex, iziphumo zayo ebezingalindelekanga, ukusebenzisana kweziyobisi, iidosi ezifanelekileyo, kwaye uzithelekise nezinye izinto zokuthomalalisa iintlungu.

Yintoni iCelebrex?

I-Celebrex sisiyobisi esinganyangekiyo sokudumba (i-NSAID), ngakumbi i-COX-2 inhibitor, ephatha iintlungu kunye nokudumba ngokunciphisa iihomoni ezinoxanduva kubo. Ihlala inyanga iintlungu kunye nokudumba okuvela kukuphazamiseka komzimba njenge-rheumatoid arthritis kunye ne-ankylosing spondylitis, kodwa ayisiyiyo kuphela imeko enokukunceda ukunyanga. Ngokungafaniyo nezinye ii-NSAIDs, iCelebrex ayifumaneki kwi-counter: Ugqirha kufuneka amisele. Kungenxa yokuba iyeza elinamandla leentlungu ezinzima kunye nokudumba. I-Cox-2 inhibitors zithintela indlela enokubangela izilonda zesisu ngokusetyenziswa kwexesha elide, ngelixa ii-NSAID zesiko zinokubangela izilonda kunye neminye imiba yesisu ngokusetyenziswa kwexesha elide.

ICelebrex ligama lophawu lonyango lwamayeza enziwe afana nalawo enziwe ngumenzi imvxatyd , Eveliswa yinkampani yamayeza iPfizer. I-Celebrex kunye ne-celecoxib zisebenza ngendlela efanayo kwaye zisebenza ngokulinganayo. Umahluko phakathi kwegama legama lophawu kunye namayeza enziwe afana nalawo enziwa ngumenzi kukuba amagama eebhrendi zihlala zibiza kakhulu kuneegeneric. Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) luvumile zombini iinguqulelo njengokunciphisa iintlungu kunye nokunciphisa ukudumba. Azizizo iziyobisi, kwaye azisebenzi njengezihlaziyi zezihlunu.

I-Celebrex ngamayeza abiza kakhulu kuba ibingafumaneki njengonyango oluqhelekileyo kude kube ngu-2014, kwaye ngenxa yento yokuba ligama lophawu. Ngaphandle kwe-inshurensi, ukuhanjiswa kwenyanga kweCelebrex kubiza i- $ 360 ngokomndilili. Iikhuphoni zeCelebrex zinokunceda abantu ukuba bonge imali kwiCelebrex kwiikhemesti ezithatha inxaxheba. I-Medicare ngokwesiqhelo ayigubungeli iCelebrex, kodwa ibonelela nge-celecoxib.

Ukhuseleko lukaCelebrex luye lwaba ngumbuzo kwiminyaka emininzi, kwaye ngexesha elinye, i-FDA yaphantse yayikhupha kwiimarike. Emva kokufuna ukuba uPfizer enze i isifundo sasemva kwentengiso , I-FDA ivumele iyeza ukuba lihlale kwintengiso, kodwa ileyibhile yokhuseleko ngoku ineenkcukacha ngakumbi ukubonisa ngokuchanekileyo iziphumo ebezingalindelekanga zeCelebrex.

Isebenziselwa ntoni iCelebrex?

ICelebrex isetyenziselwa ukunyanga le miqathango yezempilo:

• Irheumatoid Arthritis
• Osteoarthritis
• I-rheumatoid arthritis yentsha
• I-Ankylosing spondylitis
• Iintlungu zokuya exesheni
• Intlungu ebuhlungu
• I-dysmenorrhea ephambili

Ukongeza ekunyangeni le meko, iCelebrex lunyango olusebenzayo lokuchasana olunokunceda ekunyangeni iintlungu zangasemva, ukuqina, iintlungu ezidibeneyo kunye nentlungu.

Kuya kufuneka iqale ukusebenza ukunciphisa iintlungu kunye nokudumba ngokukhawuleza, kodwa ixesha elithathayo uCelebrex ukuqala ukusebenza liya kwahluka ukusuka komnye umntu ukuya komnye.

Iidosi zeCelebrex

Ifumaneka njengephilisi yomlomo, iCelebrex iza ngamandla ahlukeneyo angama-50 mg, 100 mg, 200 mg, kunye no-400 mg. Thatha iCelebrex njengoko kufuneka ukwenzakala okanye iintlungu zokuya exesheni, kodwa ngamanye amaxesha ifuna ukuthathwa rhoqo. Nantsi imigangatho amathamo yeCelebrex yeemeko ezahlukeneyo zonyango:

Osteoarthritis	Irheumatoid Arthritis	I-rheumatoid arthritis yentsha	I-Ankylosing spondylitis	I-dysmenorrhea ephambili	Intlungu yokwenzakala / yokuya exesheni
I-200 mg ithathwa kanye yonke imihla okanye i-100 mg ithathwa kabini yonke imihla	100-200 mg ithathwa kabini yonke imihla	I-50 mg ithathwa kabini yonke imihla kubantwana ≥10 kg ukuya kwi -25 kg okanye i-100 mg ithathwa kabini yonke imihla kubantwana> 25 kg	I-200 mg ithathwa kanye yonke imihla okanye i-100 mg ithathwa kabini yonke imihla	I-400 mg ekuqaleni, ilandelwa yidosi eyongezelelweyo ye-200 mg ukuba iyafuneka kusuku lokuqala. Ngeentsuku ezilandelayo, i-200 mg kabini yonke imihla njengoko kufuneka	I-200 mg ithathwa kabini imihla ngemihla

I-Celebrex ingathathwa ekuseni okanye ebusuku, kunye okanye ngaphandle kokutya, kodwa ukuyithatha nokutya kunganciphisa ithuba lokufumana isisu esibuhlungu. Ukuba unengxaki yokuginya yonke iicapsule, ungazama ukuvula iphilisi kwaye uyixube ngecephe leapile.

Kungcono ukunqanda ukusela utywala okanye ukutshaya ngelixa uthatha iCelebrex. Ezi zinto zinokunyusa umngcipheko wokufumana isilonda esiswini okanye ukopha esiswini.

Ukuba uphoswa ithamo leCelebrex, kungcono ukuthatha idosi oyiphosileyo kwakamsinya nje emva kokuba ukhumbule. Ukuba uyakhumbula ukuba uphose idosi kwaye kusondele ixesha lokuba uthathe idosi yakho yesibini yosuku, emva koko thatha idosi yakho yesibini. Oku kuya kunceda ukuthintela i-overdose yengozi, enokubangela iziphumo ebezingalindelekanga ezibi.

Uyithatha njani iCelebrex

Nje ukuba iCelebrex ingeniswe, iqala ukusebenza ukukhupha iintlungu kunye nokudumba, rhoqo emva kwethamo lokuqala. Abantu abaninzi baya kuziva bekhululekile kwiimpawu zabo kusuku olunye okanye ezimbini kuba iziphumo zeCelebrex zihlala ukuya kuthi ga kwiiyure ezili-12. Ukuba akukho phuculo kwiimpawu emva kokuthatha iCelebrex ye iiveki ezimbini ukuya kwezintathu , inokuba lixesha lokuthetha nogqirha wakho malunga nokuthatha iyeza elahlukileyo.

Inani lexesha umntu ekufuneka ebekwe kwiCelebrex liya kwahluka kwimeko-ngamatyala. Abanye abantu banokufuna ukuthatha iCelebrex ixesha elide kwiimeko ezinje ngesifo samathambo, kwaye abanye abantu banokufuna ukuyithatha iintsuku ezimbalwa kwinto efana neempawu zokuya exesheni.

Andikukhuthazi ukuthatha iCelebrex yonke imihla ngaphezulu kwenyanga, utsho uFarzin Kabaei, MD, ugqirha wamathambo e I-DOCS Spine kunye neOthopedics eLos Angeles. Ukuba isigulana sifuna ukuyithatha kangangeentsuku ezingama-30 okanye nangaphezulu, ndincoma umsebenzi wegazi wonyaka ukujonga ukusebenza kwezintso. Ugqirha Kabaei ucela abaguli bakhe ukuba bangathathi ngaphezulu kwepilisi enye ye-200 mg ngosuku.

Izithintelo

I-Celebrex ayilona iyeza elifanelekileyo kuwo wonke umntu. Okwangoku akukho zifundo zaneleyo nezilawulwayo zeCelebrex kwabasetyhini abakhulelweyo, kwaye oogqirha abaninzi bayakuphepha ukumisela iCelebrex ngexesha lokukhulelwa kuba inokuchaphazela impilo yomntwana. Ezinye iingxelo zibonisa ukuba iCelebrex ingadlula isuka koomama iye kwiintsana ngokuncancisa, kodwa indlela iCelebrex echaphazela ngayo iintsana ayiqondakali ngokupheleleyo.

Ezinxulumene: Ngawaphi amayeza eentlungu akhuselekileyo xa usakhulelwe?

Xa kuziwa ebantwaneni, uCelebrex ukhuselekile ukuba angathathwa ukuba umiselwe ngugqirha. Kwelinye icala, abaguli abakhulileyo ngabona basemngciphekweni wokufumana iziphumo ebezingalindelekanga ezivela kwiCelebrex.

Unxibelelwano

Ukuthatha iCelebrex ngaxeshanye namanye amayeza kunokubangela iziphumo ezibi okanye iziphumo ebezingalindelekanga ezintsha. I-Celebrex akufuneki ithathwe ngaxeshanye nala mayeza ngaphandle kokuba ivunyiwe ngugqirha:

• ICorticosteroids
• I-CYP2D6 substrates
• CYP2C9 inhibitors okanye inducers
• Iphemetrexed
• Ii-NSAID
• IiSalicylates
• ICclosporine
• Imethotrexate
• ILithium
• I-Digoxin
• Womchamo
• I-Aspirin
• I-ACE inhibitors
• Ibhlokhi yeBeta
• I-Angiotensin receptor blockers

Ukuthatha uluhlu olupheleleyo lwawo onke amayeza kunye nezongezo ohamba nazo ugqirha wakho kuya kumnceda ukuba abone ukuba uCelebrex lolona khetho lulungileyo kuwe.

Zithini iziphumo ebezingalindelekanga zeCelebrex?

Njengalo naluphi na unyango, ukuthatha iCelebrex iza neziphumo ebezingalindelekanga. Nazi ezinye zeempembelelo eziqhelekileyo umntu anokuzifumana ekuthatheni iCelebrex:

• Ubuhlungu bomzimba
• Irhasi
• Isicaphucaphu
• Isisu esibuhlungu
• Urhudo
• Ukudumba kwezandla okanye iinyawo
• Ukuba nesiyezi
• Ingxaki yokulala
• Ukuqunjelwa
• Ukutya
• Isitshisa
• Ukozela

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ezibi kakhulu zeCelebrex zibandakanya ukulahleka kweenwele, ukutyeba okungachazwanga, ukusabela kolusu, irhashalala kunye nemilenze. Ukuba uthatha iCelebrex kwaye uqala ukuba nobunzima bokuphefumla, ukudumba kobuso, intamo, umqala, okanye imingxunya, kuya kufuneka ufune unyango kwangoko. Ezi ziimpawu zokungabikho komzimba, ezinokusongela ubomi.

Ngenxa yokuba iCelebrex yi-NSAID, iza ne isilumkiso sebhokisi emnyama malunga neziganeko ezinzulu ze-cardiovascular thrombotic. Ukuthatha iCelebrex kwandisa umngcipheko wokuhlaselwa sisifo sentliziyo, isifo sentliziyo, imivumbo, amahlwili egazi kunye noxinzelelo lwegazi.

Iziganeko ezibi zesisu njengokuphuma kwegazi, izilonda, kunye nokugcwala kwesisu okanye amathumbu nawo kunokwenzeka. I-Celebrex ayiphazamisi nomsebenzi weeplatelets zegazi kwaye, ngenxa yoko, ayinciphisi ukujiya kwegazi . Izigulana ezisebekhulile kunye nabo banembali yangaphambili yemicimbi ye-cardiovascular and GI zezona zisemngciphekweni wokufumana ezi ziphumo bezingalindelekanga zeCelebrex.

Ukuba uthatha iCelebrex kwaye uqala ukuba nentlungu yesifuba, intetho ekrunekileyo, ukuba ndindisholo ngequbuliso okanye ubuthathaka kwelinye icala lomzimba, ukudumba komlenze, okanye iintlungu zesisu, kuya kufuneka ufune uncedo olukhawulezileyo lonyango. Le yimiqondiso yesifo sentliziyo okanye ukubetha, okunokusongela ubomi. I-Celebrex inokunyusa umngcipheko wokuba nesifo sentliziyo okanye ukubetha nokuba awunazo naziphi na izinto ezinobungozi, ke kuhlala kungumbono olungileyo ukwazi iimpawu zabo zokulumkisa.

Amaqela anobungozi obukhulu kwiziphumo ebezingalindelekanga

Abantu abanezi meko zilandelayo mabathethe nomboneleli wabo wezempilo ngaphambi kokuba bathathe iCelebrex, njengoko inokuba mandundu imeko yezempilo okanye ibangele iziphumo ebezingalindelekanga ezibi:

• Abo bane-hypersensitivity to Celebrex okanye ii-NSAID
• Abantu abaye benza i-coronary artery bypass graft (CABG) yokuhlinzwa
• Abo banesiphendu esiya kwi-sulfonamides (sulfa)
• Abantu abanembali yesifo se-asthma, i-urticaria, okanye abo baye bafumana ukungahambelani ne-NSAID
• Izigulana ezopha esiswini okanye ukopha emathunjini
• Abantu abaneengxaki zezintso okanye zentliziyo

Ukusetyenziswa kwexesha elide kwee-NSAID ezinje ngeCelebrex kunokuza nengozi eyonyukayo yokuhlaselwa sisifo sentliziyo, ukubetha, ukusilela kwentliziyo, ukungachumi, iingxaki zesibindi kunye neengxaki zezintso. Nangona I-FDA wagxininisa isilumkiso sayo sokuba ii-NSAID ezinje ngeCelebrex zonyusa ukuhlaselwa yintliziyo kunye nomngcipheko wokubetha, oku akuthethi ukuba wonke umntu kufuneka aluphephe iyeza. Abanye abantu, izibonelelo zokuthatha iCelebrex ziya kuba ngaphezulu kweziphumo ebezingalindelekanga ezinokubakho. Iingcali zonyango zinokukunceda ubone ukuba ukusetyenziswa kwexesha elide kweCelebrex kukulungele.

Ungaziphepha njani iziphumo ebezingalindelekanga

Ukuthintela iziphumo ebezingalindelekanga ezivela kwiCelebrex, thatha idosi ekucetyiswe ngugqirha wakho. Ukutsiba idosi okanye ukuthatha amathamo ongezelelweyo kuba uneentlungu ezininzi kunokubangela iziphumo ebezingalindelekanga, kwaye ukutyeba ngaphezulu kunokuba semngciphekweni wobomi. Ukuba ucinga unokuba unayo libanda KwiCelebrex, kuya kufuneka ubize iZiko loLawulo lweTyhefu ngo-1-800-222-1222 kwaye ufune unyango ngokukhawuleza ukuba iimpawu zokudlula ngaphezulu zibandakanya isicaphucaphu, iintlungu zesisu esibuhlungu, ukonqena, ukudinwa, kunye nokugabha okujongeka njengendawo yekofu.

I-Celebrex kufuneka igcinwe kubushushu begumbi kude nelanga, ukufuma kunye nobushushu. I-Celebrex egcinwe ngokungalunganga okanye ephelelwe lixesha inokutshintsha ngokwemichiza, ichaphazele indlela elisebenza ngayo iyeza kunye nokubangela iziphumo ebezingalindelekanga xa zifunxiwe. Khusela ngokukhuselekileyo yeCelebrex ukuba iphelelwe lixesha. Jonga isikhokelo sonyango ngolwazi oluthe kratya lweziyobisi.

Ngaba zikhona ezinye iindlela ngaphandle kweCelebrex?

Abanye abantu abanakho ukuthatha i-Celebrex ukuba bayayigulisa, ukuba banemeko yonyango ebathintelayo ukuba bangayithathi, okanye ukuba iphazamisa amayeza abawathathayo. Iindaba ezimnandi zezokuba ezinye iindlela zonyango zinokunciphisa iintlungu kunye nokudumba. Nazi ezinye zeendlela eziqhelekileyo kwiCelebrex:

Ezinye iindlela zeCelebrex
Igama leziyobisi	Sebenzisa	Okuhle nokubi	Ikhuphoni elilodwa	Uthelekiso lwamayeza
Imobic (meloxicam)	Osteoarthritis Irheumatoid Arthritis	I-Meloxicam inokukhethwa ngaphezu kweCelebrex kuba kufuneka ithathwe kube kanye ngosuku. Nangona kunjalo, iCelebrexkungangconoi-ankylosing spondylitis okanye iicamples zokuya exesheni.	Fumana isigqebhezana	Funda nzulu
I-Aleve (naproxen)	Osteoarthritis Irheumatoid Arthritis I-Ankylosing spondylitis Tendonitis Igawuthi Ukuxhuzula exesheni	Iyafumaneka ukuthenga i-OTC ngeedosi ezisezantsi, kodwa ugqirha kufuneka amisele iidosi eziphezulu. Nangona kunjalo, iNaproxen kunokwenzeka ukuba ibangele izilonda zesisu kuneCelebrex.	Fumana isigqebhezana	Funda nzulu
Ibuprofen	Osteoarthritis Irheumatoid Arthritis Intlungu ethambileyo ukuya kumodareyitha I-dysmenorrhea ephambili	I-Ibuprofen iyafumaneka ukuthenga i-OTC, kodwa inengozi enkulu yokubangela izilonda zesisu kunye neengxaki zesisu kuneCelebrex.	Fumana isigqebhezana	Funda nzulu
IVoltaren (diclofenac sodium)	Osteoarthritis Irheumatoid Arthritis I-Ankylosing spondylitis	IVoltaren inokuba nayoukwanda komngciphekoyeziphumo zesisu kunye nesifo sentliziyo xa kuthelekiswa neCelebrex.	Fumana isigqebhezana	Funda nzulu

Ukuba ucinga ukumisa iCelebrex turkey ebandayo, kungcono ukuba uthethe nogqirha wakho kwangaphambili, ngakumbi ukuba uyithatha yonke imihla. Ukuyekisa amayeza ngesiquphe kunokubangela iziphumo ebezingalindelekanga eziya zisiba mbi kwaye kunokudala iziphumo ezibi. Ngumgaqo olungileyo wesithupha osoloko ufuna iingcebiso kwezonyango ngaphambi kokuyeka okanye ukuqala naliphi na iyeza ukuqinisekisa ukuba wenza okona kulungele umzimba wakho.