Eyona >> Iziyobisi Vs. Umhlobo >> I-Estrace vs.Premarin: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

I-Estrace vs.Premarin: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

Iziyobisi Vs. Umhlobo

Ukuba ufumana iimpawu ze-menopausal, ezifana nokutshisa okutshisa, ukubila ebusuku , iingxaki zokulala, kunye nokomisa kwilungu lobufazi, umboneleli wakho wezempilo unokukhankanya unyango lwehomoni okanye unyango lwe-estrogen. Iimpawu zokuyeka ukuya exesheni zenzeka xa umzimba wenza i-estrogen encinci, ngenxa yoko amayeza athatha indawo ye-estrogen anokunceda ukuphucula ezi mpawu, kwaye ikwanceda ukuthintela i-osteoporosis.

Kwabasetyhini abanesibeleko, Unyango lwehomoni kubandakanya zombini i-estrogen kunye neprogesterone. Kwabasetyhini abanesibeleko, i-estrogen yodwa inyusa umngcipheko womhlaza we-endometrium.

Abasetyhini ngaphandle kwesibeleko (abaye banesibeleko) akufuneki bathathe iprogesterone nge-estrogen. Aba bafazi banokusebenzisa iimveliso ze-estrogen-kuphela ezinje nge-Estrace okanye i-Premarin.

I-Estrace kunye ne-Premarin ngamayeza amabini anegama kraca aboniswe kunyango lweempawu zokuyeka ukuya exesheni. Omabini la machiza avunyiwe yi-United States yokutya kunye noLawulo lweeDrug (FDA). Bakudidi lwamayeza abizwa ngokuba yi-estrogens kwaye ayaziwa ngokuba lonyango olubuyisela iihomoni. Zifumaneka ngeendlela ezahlukeneyo, kubandakanya iikhrimu kunye neepilisi. Nangona zombini i-Estrace kunye ne-Premarin ziqulathe i-estrogen, azifani ncam. Qhubeka nokufunda ukuze ufunde okungakumbi nge-Estrace kunye ne-Premarin.

Nguwuphi umahluko ophambili phakathi kwe-Estrace kunye ne-Premarin?

I-Estrace iyafumaneka ngohlobo lophawu kunye noluqhelekileyo kwaye iqulethe isithako estradiol . I-Estrace iyafumaneka njengekhrimu ye-estrogen yelungu lobufazi, kunye nethebhulethi yomlomo.

I-Premarin ifumaneka njengegama lophawu kuphela. Iqulethe ii-estrogens ezihlanganisiweyo, ezihlanjululwe kumchamo wamitha okhulelweyo (kungoko igama laphambi koPremin- PREgnant MARes urINe). I-premarin ifumaneka njengekhrimu ye-estrogen lobufazi, ithebhulethi yomlomo, okanye inaliti.

Umahluko ophambili phakathi kwe-Estrace kunye ne-Premarin
	Umgca	Ngaphambi
Iklasi yeziyobisi	Estrogens / unyango lwehomoni	Estrogens / unyango lwehomoni
Uhlobo lweBrith / generic	Brand kunye generic	Igama lebrand
Ngubani igama eliqhelekileyo?	I-Estradiol	Ukudibana kwee-estrogens
Zeziphi iifom eza nalo iziyobisi?	Ikhrimu yelungu lobufazi, ithebhulethi yomlomo	Cream lobufazi, tablet yomlomo, isitofu
Ithini idosi esemgangathweni?	I-Cream: 2 ukuya kwi-4 iigrem kusini yonke imihla i-1-2 iiveki, emva koko unciphise kancinci ukuya kumthamo wolondolozo lwe-1 gram 1-3 amaxesha ngeveki Amacwecwe: ziyahluka	I-Cream: i-0.5 yeigrem kusini kabini ngeveki Amacwecwe: ziyahluka
Lude kangakanani unyango oluqhelekileyo?	Iyahluka	Iyahluka
Ngubani oqhelekileyo usebenzisa amayeza?	Abasetyhini basePostmenopausal, ngamanye amaxesha emadodeni ngokubonisa okuthile (jonga ngezantsi)	Abasetyhini basePostmenopausal, ngamanye amaxesha emadodeni ngokubonisa okuthile (jonga ngezantsi)

Iimeko eziphathwe ngu-Estrace kunye no-Premarin

I-Estrace cream kunye ne-premarin cream yonyango oluphakathi ukuya kwiimpawu ezinzima zelungu lobufazi kunye ne-vulvar atrophy (ukuncipha, ukomisa kunye nokudumba) ngenxa yokuyeka ukuya exesheni.

Kwifom yethebhulethi, i-Estrace kunye ne-Premarin ziphatha ezinye iimeko ezahlukeneyo ezidweliswe kwitshathi engezantsi.

Imeko	Umgca	Ngaphambi
Ukumodareyitha ukuya kwiimpawu ezinzima ze-vulvar / atrophy yelungu lobufazi ngenxa yokuyeka ukuya exesheni	Ewe (cream)	Ewe (cream)
Unyango lwe-hypoestrogenism ngenxa ye-hypogonadism, castration, okanye ukusilela kwe-ovari	Ewe (ithebhulethi)	Ewe (ithebhulethi)
Unyango lomhlaza webele (ukunyamezeleka kuphela) kwabasetyhini abathile nakwindoda enesifo se-metastatic	Ewe (ithebhulethi)	Ewe (ithebhulethi)
Unyango lwe-carcinoma exhomekeke kwi-androgen ye-Prostate (yokuthambisa kuphela)	Ewe (ithebhulethi)	Ewe (ithebhulethi)
Ukuthintela i-postmenopausal osteoporosis yabasetyhini abasemngciphekweni omkhulu, xa amayeza angenayo i-estrogen engafanelekanga	Ewe (ithebhulethi)	Ewe (ithebhulethi)
Unyango lwe-atrophic vaginitis kunye ne-kraurosis vulvae	Ngaphandle kwelebheli	Ewe (cream)
Unyango lwe-dyspareunia emodareyitha (ulwalamano olubuhlungu) ngenxa yokuyeka ukuya exesheni	Ngaphandle kwelebheli	Ewe (cream)
Unyango lweempawu ze-vasomotor ezimodareyithayo ngenxa yokuyeka ukuya exesheni	Ewe (ithebhulethi)	Ewe (ithebhulethi)

Ngaba i-Estrace okanye i-Premarin isebenza ngakumbi?

Izifundo zibonisa ukuba xa kuthelekiswa iimveliso ze-estrogen, i-estradiol (isithako e-Estrace) kunye ne-estrogens edibeneyo (isithako se-Premarin) sisebenza ngokulinganayo ekunyangeni iimpawu zokuyeka ukuya exesheni. Iikhrim zangasese ziyasebenza kunye nokunyamezeleka kakuhle.

Umboneleli wakho wezempilo unokumisela ukuba yeyiphi na iyeza ekufaneleyo, ngokujonga iimpawu zakho, iimeko zonyango kunye nembali yezonyango.

Ukufunyanwa kunye nokuthelekiswa kweendleko ze-Estrace vs.Premarin

Izicwangciso ze-inshurensi kunye neMedicare zihlala zigubungela i-Estrace kunye ne-Premarin.

Umyalelo oqhelekileyo we-Estrace yiphubhu yekrimu kunye neendleko ezimalunga ne-36 yeedola ukuba uhlawula epokothweni, kodwa ukusebenzisa isigqebhezana simahla se-SingleCare kunokuzisa ixabiso liye kuthi xhaxhe kwi- $ 6.

Umyalelo oqhelekileyo wombhobho we-Premarin uxabisa malunga ne-250 ngaphandle kwe-pocket. Ikhadi le-SingleCare linokuzisa ixabiso liye ezantsi njenge- $ 198.

Njengoko izicwangciso ziyahluka, nxibelelana nomboneleli wakho weinshurensi ngeenkcukacha zokugubungela.

	Umgca	Ngaphambi
Ngokuqhelekileyo i-inshurensi?	Ewe	Ewe
Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare?	Ewe	Ewe
Ubungakanani	1 ityhubhu	1 ityhubhu
I-Medicare copay eqhelekileyo	$ 1- $ 36	Iidola ezi-2- $ 451
Ixabiso elilodwa	$ 6 +	$ 198 +

Iziphumo eziqhelekileyo ezichaphazelekayo ze-Estrace vs.Premarin

Iziphumo eziqhelekileyo ezichaphazelekayo ze-Estrace kunye ne-Premarin ukhilimu zibandakanya ukuphendulwa kwendawo yesicelo njengokubamba, ukukhupha, ukuphuma kwegazi kunye nokuvuvukala. Ukongeza, iintlungu zentloko kunye neentlungu zangasese zinokwenzeka. Ipesenti yeziphumo ebezingalindelekanga azifakwanga kulwazi olumiselweyo lwe-Estrace.

Iziphumo ebezingalindelekanga eziqhelekileyo ze-Estrace kunye ne-Premarin kwifom yecwecwe zinenkqubo ethe kratya. Ezinye zeziphumo ebezingalindelekanga zibandakanya iintlungu zesisu okanye somqolo, ubuthathaka, ukudumba, intloko ebuhlungu, ukuqhina, irhasi, isicaphucaphu, ukutyeba, ukudakumba, ukoyika, isiyezi, ukuthamba kwebele / iintlungu / utshintsho, kunye nokuphuma kwilungu lobufazi, ukopha, okanye usulelo lwegwele.

Olu aluluhlu olupheleleyo lweziphumo ebezingalindelekanga. Ezinye iziphumo ezibi zinokwenzeka. Nxibelelana nomboneleli wakho wezempilo ukuba axoxe ngeziphi iziphumo ebezingalindelekile, kunye nendlela yokuzilungisa.

	Lungiselela ukhilimu	I-cream yangaphambi kokufakwa
Imiphumela	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Intloko ebuhlungu	Ewe	% ayixelwanga	Ewe	3-5% *
Intlungu yePelvic	Ewe	% ayixelwanga	Ewe	4%
Ukurhawuzelela	Ewe	% ayixelwanga	Ewe	1-2%
Ukukhutshwa kwilungu lobufazi	Hayi	-	Ewe	3-4%
Ukopha kwilungu lobufazi	Ewe	% ayixelwanga	Ewe	1-2%
Ukudumba kwelungu lobufazi	Ewe	% ayixelwanga	Ewe	1-2%
Usulelo lobufazi / usulelo lwegwele	Ewe	% ayixelwanga	Ewe	3-4%

* Kuxhomekeke kubungakanani beedosi
Umthombo: DailyMed ( Lungiselela ukhilimu ), Yonke imihla ( I-cream yangaphambi kokufakwa )

Ukudibana kweziyobisi kwe-Estrace vs.Premarin

I-Estrace okanye i-Premarin inokuchaphazeleka kwizidakamizwa ezithile ezixutywe yi-enzyme ebizwa ngokuba yi-cytochrome-p 450 3A4. Iziyobisi ezithintela i-enzyme zinokucothisa ukwenziwa komzimba kwe-Estrace okanye i-Premarin, okuthetha ukuba i-Estrace okanye i-Premarin inokuhlala emzimbeni ixesha elide, ibangele iziphumo ebezingalindelekanga. Kwakhona, iziyobisi ezenza i-enzyme zinokubangela ukuba umzimba usebenze i-Estrace okanye i-Premarin ngokukhawuleza, uyenze ungasebenzi kakuhle. Qhagamshelana nomboneleli wakho wezempilo malunga nokunxibelelana kweziyobisi okunokwenzeka.

Iziyobisi	Iklasi yeziyobisi	Umgca	Ngaphambi
Clarithromycin Erythromycin Ijusi yamagilebhisi Itraconazole Ketoconazole Ritonavir	I-CYP3A4 enzyme inhibitors	Inokwenzeka	Inokwenzeka
ICarbamazepine IPhenobarbital Rifampin Wort yaseSt	I-CYP3A4 inducers ye-enzyme	Inokwenzeka	Inokwenzeka

Izilumkiso ze-Estrace kunye ne-Premarin

I-Estrace kunye ne-Premarin ine isilumkiso sebhokisi , Esona sisilumkiso esomeleleyo esifunwa yi-FDA. Kuba ukufakwa kwenkqubo kunokwenzeka nge-Estrace okanye i-premarin cream, izilumkiso zisebenza kuzo zonke iifom.

I-Estrogen yodwa:

Ukusebenzisa i-estrogen yodwa (ngaphandle kweprogestin) kumfazi onesibeleko kwandisa umngcipheko womhlaza we-endometrium. Ukongeza iprogestin kunyango lwe-estrogen kunokunciphisa umngcipheko womhlaza we-endometrium (kodwa kunokunyusa umngcipheko womhlaza webele). Abasetyhini be-Postmenopausal abanegazi elingaqhelekanga kufuneka bavavanywe ukukhusela ububi.
Sukusebenzisa i-estrogen yodwa ukuthintela isifo sentliziyo okanye isifo sengqondo esixhalabisayo. Initiative yezeMpilo yaBasetyhini (WHI) ukufunda Ufumene umngcipheko owandileyo wokubethwa yintlungu kunye ne-DVT (inzulu ye-vein thrombosis, okanye i-clot yegazi emlenzeni) kubafazi abasemva kwe-postmenopausal abathathe i-estrogen yodwa (ngaphandle kweprogestin).
Olu phononongo lukwabonakalise ukwanda komngcipheko wesifo sengqondo esixhalabisayo kubantu basetyhini abasele besemini abaye bathabatha i-estrogen yodwa.

I-Estrogen kunye neprogestin:

Sukusebenzisa i-estrogen kunye neprogestin ukukhusela isifo sentliziyo okanye isifo sengqondo esixhalabisayo. Uphononongo lwe-WHI lufumene umngcipheko ophezulu we-DVT, i-PE (pulmonary embolism), ukubetha, kunye ne-MI kwabasetyhini abasemva kwemini abathathe i-estrogen kunye neprogestin. Olu phononongo lukwabonakalise umngcipheko ophezulu wokuba nesifo sengqondo esixhalabisayo kubantu basetyhini abasele besemini abaye bathabatha i-estrogen kunye neprogestins.
Uphononongo lwe-WHI lukwabonisa umngcipheko owandayo wokuhlaselwa ngumhlaza webele kunye ne-estrogen kunye neprogestin.

Ke ngoko, ii-estrogens, nokuba zichazwe kunye okanye zingenayo iprogestins, kufuneka zimiselwe kwelonaqondo lisezantsi kunye nelona xesha lifutshane. Thetha nomboneleli wakho wezempilo malunga nomngcipheko ngokuchasene nezibonelelo zeentlobo ezahlukeneyo zonyango lwehomoni.

Ugqirha wakho uya kukunika iingcebiso zonyango malunga novavanyo. Bonke abantu basetyhini kufuneka bavavanywe ibele minyaka le ngugqirha kwezonyango kwaye bazihlole qho ngenyanga. Bonke abantu basetyhini kufuneka babe ne-mammography esekwe kubudala, izinto ezinobungozi kunye nembali.

Ezinye izilumkiso ze-Estrace kunye ne-Premarin ziyalandela.

Sukusebenzisa i-Estrace okanye i-Premarin ukuba unayo:

Ukopha okungaqhelekanga
Umhlaza webele (owaziwayo, okrokrelwayo, okanye imbali)
I-neoplasia exhomekeke kwi-Estrogen (eyaziwa okanye ekrokrelwayo)
I-DVT okanye i-pulmonary embolism (esebenzayo okanye imbali)
Esebenzayo okanye imbali yesifo se-thromboembolic (stroke, MI)
Ukuphendula kwangaphambili kwe-anaphylactic kwi-estrogen
Isifo sesibindi
Ukuphazamiseka kwethrombophilic
Ukukhulelwa (okwaziwayo okanye okukrokrelwayo)

Ukudityaniswa kwonyango lwehomoni (i-estrogen kunye neprogestin) kunokunyusa umngcipheko womhlaza we-ovari.

Abasetyhini be-Postmenopausal abathatha i-estrogen banokunyuka kwengozi yesifo se-gallbladder esifuna ukuhlinzwa.

Kubantu abathatha ii-estrogens, iingxaki ezibonakalayo zenzekile. Funa unyango lwangoko kwangoko ukuba ulahlekelwe ngumbono (uyinxalenye okanye ugqibelele), umbono ophindwe kabini, ukubetheka kwamehlo, okanye migraine.

Kwiimeko ezinqabileyo, kukho uxabane. Ukuba unemihlathi, ukurhawuzelela, ukuphefumla nzima, ukugabha, okanye ukudumba kobuso, imilebe, ulwimi, izandla, okanye iinyawo, funa unyango olukhawulezileyo kwangoko. Amayeza e-Estrogen anokuzenza mandundu iimpawu ze-angioedema kwabasetyhini abane-angioedema yelifa.

Thetha nomboneleli wakho wezempilo malunga nobungozi ngaphambi kokuthatha i-Estrace okanye i-Premarin, ukubona ukuba ngaba iyeza likhuselekile kuwe.

Imibuzo ebuzwa rhoqo malunga ne-Estrace vs Premarin

Yintoni i-Estrace?

I-Estrace sisiyobisi esibuyisela i-hormone esine-estradiol. Isetyenziswa kwizalathiso ezahlukeneyo, amaxesha amaninzi kwiimpawu zokuyeka ukuya exesheni. I-Estrace iyafumaneka njenge-intravaginal cream kunye nethebhulethi yomlomo.

Yintoni i-premarin?

I-Premarin ikwasisiyobisi sehormone. I-premarin iqulethe ii-estrogens ezidibeneyo. Isetyenziselwa izikhombisi ezininzi, amaxesha amaninzi kwiimpawu zokuyeka ukuya exesheni. I-premarin ifumaneka njengecwecwe lomlomo, ukhilimu we-intravaginal, kunye nenaliti.

Ngaba i-Estrace kunye ne-Premarin efanayo?

I-Estrace kunye ne-Premarin ziyafana, kodwa azifani ncam. Olu lwazi lungentla lubonisa umahluko phakathi kwala mayeza mabini.

Ngaba i-Estrace okanye i-Premarin ingcono?

Omabini la mayeza ayasebenza ekunyangeni iimpawu zokuyeka ukuya exesheni, nangona kunjalo, la mayeza eza neziphumo ebezingalindelekanga kunye nomngcipheko. Thetha nomboneleli wakho wezempilo ukuba uqinisekise ukuba i-Estrace okanye i-Premarin ifanelekile kuwe.

Ndingayisebenzisa i-Estrace okanye i-Premarin ngelixa ndikhulelwe?

Hayi. Amayeza akufuneki asetyenziswe xa ukhulelwe.

Ngaba ndingasebenzisa i-Estrace okanye i-Premarin ngotywala?

Ukusela utywala ngokudibeneyo ne-Estrace okanye i-Premarin inako wandise umngcipheko yomhlaza wamabele. Nxibelelana neengcali zakho zonyango malunga nokusebenzisa utywala ngayo nayiphi na imeko yonyango onayo.

Yeyiphi enye indlela ebalaseleyo kwi-Premarin?

I-Estrace yenye indlela efanayo ne-Premarin. Amanye amayeza aqukethe i-estrogen aquka iVivelle Dot Patch, iClimara Patch, okanye i-estrogen yelungu lobufazi ngohlobo lweeVagifem iipilisi zangasese (iipilisi zelungu lobufazi ezisetyenziswe kwisifakeli selungu lobufazi) okanye i-Estring Vaginal Ring. Thetha nomboneleli wakho wezempilo ukuba ubone ukuba elinye lala mayeza lilungele wena.

Ngaba i-estrogen kunye ne-estradiol yinto enye?

I-Estradiol luhlobo lwe-estrogen, ihomoni yabasetyhini. Zonke iimveliso ze-estradiol yi-estrogen. Nangona kunjalo, kukho ezinye iindlela ze-estrogen kune-estradiol nje. Umzekelo, ii-estrogens ezidibeneyo (i-Premarin) lolunye uhlobo lwe-estrogen.

Ngaba i-premarin ibangela isifo sengqondo esixhalabisayo?

I-Premarin (kunye ne-Estrace) inesilumkiso esibhokisiweyo malunga nesifo sengqondo esixhalabisayo. Isifundo seMemori se-WHI esikhankanywe apha ngasentla sifumene umngcipheko okhulayo wokuba nesifo sengqondo esixhalabisayo kubantu basetyhini abasele emva kwexesha baye bathabatha i-estrogen yodwa okanye i-estrogen ene-progestin. Ke ngoko, ulwazi lokumisela lucebisa ukuba i-estrogen, nokuba ithathwe yodwa okanye iprogestin, kufuneka imiselwe kwelonaqondo lisezantsi kunye nelona lifutshane.

Ngaba i-Estrace inyusa amanqanaba e-estrogen?

I-Estrace (kunye ne-Premarin) yonyusa amanqanaba e-estrogen. Kwindlela yelungu lobufazi, kukho ukufunxwa kwenkqubo, kwaye amanqanaba e-estrogen ayonyuka. Umboneleli wakho wezempilo unokumisela ukuba yeyiphi imveliso efanelekileyo kakhulu kuwe.