ILatuda vs. Abilify: Umahluko, ukufana, kwaye yeyiphi engcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango iphathwe | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
ILatuda (i-lurasidone) kunye ne-Abilify (aripiprazole) ngamagama amayeza amayeza asetyenziselwa ukunyanga i-schizophrenia. Ischizophrenia kukuphazamiseka kwengqondo okubonakaliswa ziimpawu ezinjengokukhohlisa, ukubona izinto ezingekhoyo, kunye nokuthetha okungalungelelananga okanye isimilo. Ukongeza kwi-schizophrenia, iLatuda kunye ne-Abilify inokunyanga nezinye iimeko zempilo yengqondo.
Zombini i-Latuda kunye ne-Abilify zihlelwa njenge-atypical antipsychotic, okanye i-antipsychotic yesizukulwane sesibini. Basebenza ngeendlela ezifanayo ukunceda ukunciphisa iimpawu zengqondo. Ngelixa eyona ndlela basebenza ngayo ingaziwa, la mayeza e-antipsychotic asebenzisana ne-dopamine kunye ne-serotonin receptors kwingqondo.
Nguwuphi umahluko ophambili phakathi kweLatuda kunye ne-Abilify?
Umahluko ophambili phakathi kweLatuda kunye ne-Abilify ziqulathe izinto ezahlukeneyo ezisebenzayo. ILatuda iqulethe i-lurasidone kwaye i-Abilify iqulethe i-aripiprazole.
ILatuda yavunywa yi-FDA ngo-2010 ukunyanga i-schizophrenia kunye noxinzelelo lwe-bipolar. Iyafumaneka njengecwecwe lomlomo kumandla angama-20 mg, 40 mg, 60 mg, 80 mg, kunye ne-120 mg. ILatuda ifikelela kumanqanaba aphezulu emzimbeni ngaphakathi kweyure enye ukuya kwezintathu. ILatuda ihlala iqalwa kwi-20 okanye i-40 mg ngosuku kuxhomekeke kwimeko yokunyangwa, kwaye kufuneka ithathwe ngokutya okufunxa ngcono .
I-Abilify yayivunyelwe yi-FDA ngo-2002 ukunyanga i-schizophrenia kunye nezinye iimeko zempilo yengqondo, ezinje nge-bipolar disorder, i-autistic disorder kunye ne-Tourette's disorder. Abilify iyafumaneka njengecwecwe lomlomo kumandla e-2 mg, 5 mg, 10 mg, 15 mg, 20 mg, kunye 30 mg. Kuza njengethebhulethi yokuqhekeka ngomlomo, isisombululo somlomo, kunye nenaliti. Ukuqinisa iipilisi zomlomo kufikelela kumanqanaba aphezulu emzimbeni ngaphakathi kweeyure ezintathu ukuya kwezintlanu emva kolawulo, kwaye zinokuthathwa kunye okanye ngaphandle kokutya.
| Umahluko ophambili phakathi kweLatuda kunye ne-Abilify | ||
|---|---|---|
| ILatuda | Hlaziya | |
| Iklasi yeziyobisi | Intshutshiso yengqondo | Intshutshiso yengqondo |
| Uhlobo lweBrith / generic | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo |
| Ngubani igama eliqhelekileyo? | ILurasidone | Aripiprazole |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo | Ithebhulethi yomlomo Ithebhulethi eyahlulayo ngomlomo Isisombululo somlomo Umgubo wokumiswa kwenaliti yemisipha |
| Ithini idosi esemgangathweni? | I-Schizophrenia kubantu abadala: I-40 ukuya kwi-160 mg ngosuku I-Schizophrenia kulutsha (iminyaka eli-13 ukuya kweli-17 ubudala): 40 ukuya kuma-80 mg ngosuku | I-Schizophrenia kubantu abadala: I-10 ukuya kwi-15 mg ngosuku I-Schizophrenia kulutsha (iminyaka eli-13 ukuya kweli-17 ubudala): 2 ukuya kwi-10 mg ngosuku |
| Lude kangakanani unyango oluqhelekileyo? | Ukungafani: abaguli kufuneka baphinde bavavanywe kwakhona | Ukungafani: abaguli kufuneka baphinde bavavanywe kwakhona |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala, abakwishumi elivisayo, kunye nabantwana abaneminyaka eli-10 nangaphezulu (kuxhomekeke kwimeko yokunyangwa) | Abantu abadala, abakwishumi elivisayo, kunye nabantwana abaneminyaka emi-6 nangaphezulu (kuxhomekeke kwimeko yokunyangwa) |
Imiqathango ephathwe nguLatuda kunye no-Abilify
ILatuda isetyenziselwa ukunyanga i-schizophrenia kubantu abadala kunye nabantwana abaneminyaka eli-13 nangaphezulu. Kukwavunyiwe ukunyanga iziqendu zokudakumba ezinxulunyaniswa ne-bipolar I disorder kubantu abadala kunye nabantwana abaneminyaka eli-10 nangaphezulu.
Abilify ikwasetyenziselwa ukunyanga i-schizophrenia kubantu abadala kunye nabantwana abaneminyaka eli-13 nangaphezulu. Nangona kunjalo, ngokungafaniyo neLatuda, kuyamkelwa ukunyanga iziqendu ezixubeneyo okanye ezomntu ezinxulunyaniswa ne-bipolar I disorder kubantu abadala nakubantwana abaneminyaka eli-10 nangaphezulu. Abilify inokunyanga ukuphazamiseka kweTourette, okanye Isifo seTourette , kunye nokucaphuka okunxulunyaniswa nengxaki ye-autistic. Xa unikezelwa ngonyango olongezelelweyo lokunyanga, ukuxilisa kunokunyanga ingxaki enkulu yokudandatheka (MDD). Ukuphelisa inaliti kuvunyelwe i-FDA ukunyanga iimpawu zokuphazamiseka kwi-schizophrenia kunye ne-bipolar mania.
| Imeko | ILatuda | Hlaziya |
| Ischizophrenia | Ewe | Ewe |
| Ukuxhuzula | Ewe | Ewe |
| Uxinzelelo olukhulu lokudakumba | Hayi | Ewe |
| Ukuphazamiseka kwengqondo | Hayi | Ewe |
| Ingxaki kaTourette | Hayi | Ewe |
Ngaba iLatuda okanye ukuCoca kusebenza ngakumbi?
I-Latuda kunye ne-Abilify zombini amayeza asebenzayo kunyango lwe-schizophrenia, esibi isigulo sengqondo . Olona nyango lulungileyo luya kuxhomekeka kwizinto ezinje ngemeko yokuphathwa, iziphumo ebezingalindelekanga ezinokubakho, kunye neendleko.
Olunye uhlalutyo lweemeta luthelekisa ii-antipsychotic ezinjenge-lurasidone, i-olanzapine, i-quetiapine, i-risperidone kunye ne-paliperidone. Abaphandi bafumanise ukuba i-lurasidone ibiyi ngokuthelekiswa nezinye i-antipsychotic Unyango lwe-schizophrenia. Nangona kunjalo, i-lurasidone yafunyanwa inokufumana ubunzima obuncinci kunye nomngcipheko ophantsi wezinye iziphumo ebezingalindelekanga xa kuthelekiswa nezinye i-antipsychotic atypical.
Olunye uhlalutyo lweemeta ezivela kwi- Ijenali yeHlabathi ye-Biological Psychiatry xa kuthelekiswa i-lurasidone nezinye i-antipsychotic zokunyanga uxinzelelo lwe-bipolar. Ngaphezulu kwezilingo ezahlukeneyo zeklinikhi ezingaphezu kwezigulana ezingama-6,000 zavavanywa kuhlalutyo. I-Antipsychotic, ezinje nge-lurasidone, quetiapine, aripiprazole, olanzapine, kunye ne-ziprasidone, zafaniswa ngokubhekisele kukhuseleko kunye nokusebenza. Uphononongo luphethe ukuba i-lurasidone inokusebenza ngakumbi kune-aripiprazole kunye ne-ziprasidone, kwaye inokubangela ukutyeba kancinci kunye nokozela kunezinye i-antipsychotic.
Nxibelelana nomboneleli wezempilo ukuze ufumane olona nyango lulungileyo.
Umgangatho kunye nokuthelekiswa kweendleko zeLatuda vs.
I-FDA ivume ingxelo yohlobo oluqhelekileyo lweLatuda. Nangona kunjalo, uhlobo oluqhelekileyo lunokubakho okanye alunakufumaneka ngoku kwimarike. Njengesiyobisi esinegama lophawu, iLatuda inokubiza kakhulu nange-inshurensi. I-Medicare kunye nezicwangciso zeinshurensi zihlala zigubungela iLatuda, nangona ii-copays zingahluka kwizicwangciso ezahlukeneyo. Ixabiso lemali yeLatuda yi- $ 1,783.52. Ikhuphoni le-SingleCare linokunciphisa iindleko ukuya kuthi ga kwi-1,200 yeedola.
Ukwenza i-Abilify kufumaneke njengonyango oluqhelekileyo kunye negama lophawu. Uninzi lwezonyango kunye nezicwangciso zeinshurensi ziya kugubungela ukuQinisa. Xa kuthelekiswa neLatuda, Abilify kunokuba lolona khetho lubiza kancinci. Nangona kunjalo, ixabiso lemali lisengabiza malunga ne- $ 1,059.99. Ikhadi lesaphulelo elilodwa le-SingleCare lokuBanakho linakho ukunciphisa iindleko ukuya ngaphantsi kwe- $ 100.
| ILatuda | Hlaziya | |
| Ngokuqhelekileyo i-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Ubungakanani | Iipilisi ezingama-30 (40 mg) | Iipilisi ezingama-30 (5 mg) |
| I-Medicare copay eqhelekileyo | $ 7- $ 46 | $ 3- $ 204 |
| Ixabiso elilodwa | I $ 1,236 + | $ 65 + |
Iziphumo eziqhelekileyo ezichaphazelekayo zeLatuda vs. Abilify
Iziphumo eziqhelekileyo ezichaphazelekayo zeLatuda zibandakanya ukozela, ukungazinzi okanye umnqweno wokuhambahamba (akathisia), isicaphucaphu kunye nokugabha. Ezinye iziphumo ebezingalindelekanga zeLatuda zinokubandakanya ukuqina kwemisipha, ukungcangcazela kunye nokufumana ubunzima.
Iziphumo ebezingalindelekanga zixhaphakileyo ze-Abilify zibandakanya isicaphucaphu, ukugabha, ukuthomalalisa okanye ukozela, isiyezi, ukuqhinwa, intloko ebuhlungu, umbono ongacacanga, i-akathisia kunye nokungalali. Ezinye iziphumo ebezingalindelekanga ze-Abilify zibandakanya ukuqina kwemisipha kunye nokuzuza ubunzima.
Zombini iLatuda kunye ne-Abilify zinokubangela iswekile ephezulu yegazi kunye namanqanaba e-cholesterol egazini. Iziphumo ebezingalindelekanga ezimandundu zeLatuda kunye ne-Abilify zinokubandakanya ukubalwa kweeseli ezimhlophe ezisezantsi, ukubanjwa, ukwehla koxinzelelo lwegazi (i-orthostatic hypotension), kunye nokunyakaza okungalawulekiyo komzimba (i-tardive dyskinesia).
Jonga apha ngezantsi ezinye iziphumo ebezingalindelekanga zeLatuda kunye ne-Abilify.
| ILatuda | Hlaziya | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Ukozela | Ewe | 17% | Ewe | 5% |
| Akathisia | Ewe | 13% | Ewe | 13% |
| Isicaphucaphu | Ewe | 10% | Ewe | Shumi elinantlanu% |
| Ukuhlanza | Ewe | 8% | Ewe | Shumi elinanye% |
| Ukutya | Ewe | 6% | Ewe | 9% |
| Ukuphuthelwa | Ewe | 5% | Ewe | 18% |
| Ixhala | Ewe | 5% | Ewe | 17% |
| Ukuba nesiyezi | Ewe | 5% | Ewe | 3% |
| Ukutyeba kwakho | Ewe | 3% | Ewe | 3% |
| Umqolo obuhlungu | Ewe | 3% | Hayi | - |
| Umbono omfiliba | Ewe | * | Ewe | 3% |
| Umlomo owomileyo | Ewe | * | Ewe | 5% |
| Ukuqunjelwa | Hayi | - | Ewe | Shumi elinanye% |
| Intloko ebuhlungu | Hayi | - | Ewe | 10% |
| Intlungu yezihlunu | Hayi | - | Ewe | Mbini% |
* akuxelwa
Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( ILatuda ), Yonke imihla ( Hlaziya )
Ukudibana kweziyobisi kweLatuda vs. Abilify
I-Latuda kunye ne-Abilify ikakhulu zixutywe esibindini yi-CYP3A4 enzyme. Ukusetyenziswa kwabo kunokufuna ukuthintelwa, ukulungiswa, okanye ukubekwa esweni xa kudityaniswa namayeza asebenza njenge-CYP3A4 inhibitors okanye i-CYP3A4 inducers. Iziyobisi ezisebenza njenge-CYP3A4 inhibitors, ezinje nge-ketoconazole kunye ne-ritonavir, zinokubangela ukunyuka kwamanqanaba eLatuda okanye ukuQinisa nokunyusa umngcipheko weziphumo ebezingalindelekanga. Iziyobisi ezisebenza njenge-CYP3A4 inducers, ezinje nge-rifampin kunye ne-carbamazepine, zinokubangela ukwehla kwamanqanaba eLatuda okanye ukuQinisa nokunciphisa ukusebenza kwe-antipsychotic. Ukudibanisa i-Abilify kunye ne-CYP2D6 inhibitors, ezinje nge-quinidine kunye ne-fluoxetine, kunokukhokelela ekwandiseni amanqanaba e-Abilify kunye neziphumo ebezingalindelekanga.
Ukusetyenziswa kweLatuda kunye ne-Abilify kunokufuna ukubekwa esweni okanye ukuthintelwe ngelixa kusetyenziswa iziyobisi ezichasayo okanye i-benzodiazepines. Ukuthatha la mayeza antipsychotic kunye neziyobisi ezichasayo kunokunyusa umngcipheko wexinzelelo lwegazi. I-Benzodiazepines inokudibanisa iziphumo ebezingalunganga zeLatuda okanye i-Abilify.
| Iziyobisi | Iklasi yeziyobisi | ILatuda | Hlaziya |
| Ketoconazole IFluconazole Clarithromycin Erythromycin Ritonavir Diltiazem I-Verapamil | CYP3A4 inhibitors | Ewe | Ewe |
| Rifampin IPhenytoin ICarbamazepine Iifayile I-Etravirine Wort eSt | I-CYP3A4 inducers | Ewe | Ewe |
| Iquinidine IFluoxetine Paroxetine | CYP2D6 inhibitors | Hayi | Ewe |
| Amlodipine Lisinopril ILosartan | Izinto ezichaseneyo | Ewe | Ewe |
| IAlprazolam Diazepam ILorazepam | IiBenzodiazepines | Ewe | Ewe |
Nxibelelana noochwephesha kwezonyango malunga nolunye unxibelelwano lweziyobisi
Izilumkiso zaseLatuda kunye nokuFezekisa
Zombini iLatuda kunye ne-Abilify zithwala izilumkiso zebhokisi emnyama. Kukho umngcipheko owandayo wokufa kunye nesifo sengqondo esihambelana nesifo sengqondo esixhalabisayo xa amayeza antipsychotic ethathwa ngabantu abadala. Iingcinga zokuzibulala kunye nokuziphatha kuye kwaxelwa kubantwana nakubantu abadala abancinci besebenzisa iLatuda kunye ne-Abilify. Izigulana ezincinci zingadinga ukubekwa esweni ngenxa yeempawu eziba mandundu okanye utshintsho kwindlela oziphethe ngayo ngelixa uthatha iLatuda okanye i-Abilify.
Kukho umngcipheko okhulayo wokungaziphathi kakuhle kwe-cerebrovascular, ezinje ngokubethwa sisifo kunye nokuhlaselwa yischemic okwethutyana, kwizigulana ezalupheleyo ezinesifo sengqondo esihambelana nokugula ngengqondo. Ukuthatha i-Latuda okanye i-Abilify ikwanomngcipheko woku isifo se-neuroleptic malignant (NMS), ezinokubangela iimpawu ezinje ngomkhuhlane omkhulu, ukuqina kwemisipha, ukudideka, kunye notshintsho kwinqanaba lentliziyo. I-NMS yimeko enzima efuna unyango kwangoko.
I-Latuda kunye ne-Abilify inokubangela utshintsho kwimetabolic, njengamazinga aphezulu eswekile yegazi, ukwanda kwamazinga e-cholesterol kunye nokuzuza ubunzima. La mayeza anokubangela ukubalwa kweeseli ezimhlophe ezisezantsi, ukubanjwa, kunye noxinzelelo lwegazi.
Qhagamshelana nomboneleli wezempilo malunga nezinye izilumkiso kunye nezilumkiso ngaphambi kokusebenzisa iLatuda okanye i-Abilify.
Imibuzo ebuzwa rhoqo malunga neLatuda vs. Abilify
Yintoni iLatuda?
ILatuda lunyango lwe-antipsychotic esetyenziselwa ukunyanga i-schizophrenia kunye neepisodes zokudakumba ezinxulunyaniswa ne-bipolar I disorder. Iyafumaneka njengecwecwe lomlomo. ILatuda ihlala ithathwa kanye ngemini ngokutya.
Yintoni i-Abilify?
Abilify lunyango lwe-antipsychotic esetyenziselwa ukunyanga i-schizophrenia kunye neziqendu ezixubileyo okanye ze-manic ezinxulunyaniswa ne-bipolar I disorder. Abilify ikwavunyiwe ukunyanga ukungonwabi okukhulu, isifo se-autistic, kunye nesifo sikaTourette. Iyafumaneka njengecwecwe lomlomo, ithebhulethi eyahlayo ngomlomo, isisombululo somlomo, kunye nenaliti. Abilify ihlala ithathwa kanye ngemini kunye okanye ngaphandle kokutya.
Ngaba iLatuda kunye ne-Abilify ziyafana?
Zombini iLatuda kunye ne-Abilify zii-antipsychotic ze-atypical, okanye i-antipsychotic yesizukulwane sesibini, ezivunyiweyo kunyango lwe-schizophrenia. Nangona kunjalo, ziza ngeendlela ezahlukeneyo zedosi kwaye zineempawu ezahlukeneyo ngaphandle kweschizophrenia. ILatuda inyanga iziqendu zoxinzelelo lwe-bipolar I disorder ngelixa u-Abilify treats manic episodes of bipolar I disorder. ILatuda ikwafuneka ukuba ilawulwe ngokutya ngelixa i-Abilize inokwenziwa kunye okanye ngaphandle kokutya.
Ngaba iLatuda okanye iAshilize ingcono?
I-Latuda kunye ne-Abilify zombini amayeza asebenzayo kwi-schizophrenia kunye nezinye iimeko zempilo yengqondo. ILatuda inokuthi isebenze njengokuQinisa kunye namanye amayeza antipsychotic, kwaye inokubangela iziphumo ebezingalindelekanga ezimbalwa ezinje ukutyeba kwakho . Eminye imiba kufuneka iqwalaselwe xa ukhetha iLatuda okanye i-Abilify, njengexabiso. Nxibelelana nomboneleli wezempilo ukuze ufumane olona nyango lulungileyo.
Ngaba ndingamsebenzisa uLatuda okanye ndenze i-Abilify ngelixa ndikhulelwe?
Uphando lilinganiselwe ekusetyenzisweni kweLatuda kunye ne-Abilize ngelixa ukhulelwe. La mayeza e-antipsychotic anokubangela i-extrapyramidal okanye iimpawu zokurhoxa kwi-neonates ngexesha lekota yesithathu. Kufuneka zithathwe kuphela ukuba izibonelelo zingaphezulu komngcipheko. Nxibelelana nomboneleli wakho wezempilo ngengcebiso yezonyango ukumisela ukuba kuya kufuneka usebenzise iLatuda okanye Abilize ngelixa ukhulelwe.
Ngaba ndingasebenzisa iLatuda okanye ndenze Abilize ngotywala?
Omabini la mayeza otywala kunye ne-antipsychotic anenkqubo yoxinzelelo lwe-nervous system (CNS). Ukuthatha ii-antipsychotic ngotywala kunokunyusa umngcipheko weziphumo ebezingalindelekanga ezithile, ezinje ngokozela kunye nesiyezi. Ukusela utywala kufuneka kuthintelwe ngelixa uthatha iLatuda okanye i-Abilify.
Ngaba iLatuda sisimo sokuzinzisa imood okanye i-antipsychotic?
ILatuda ayisiyonto izinzisayo. Endaweni yoko, iLatuda lunyango lwe-antipsychotic olunokumiselwa kunye ne-mood stabilizer efana ne-Lithobid (lithium) okanye i-Depakene (i-valproic acid) yokunyanga uxinzelelo lwe-bipolar. Eminye imizekelo yamayeza antipsychotic afaka i-Invega (paliperidone), iSeroquel (quetiapine), iZyprexa (olanzapine), iGeodon (ziprasidone), Rexulti (brexpiprazole), kunye neVraylar (cariprazine).
Ngaba ikhona igeneric yeLatuda?
Inguqulelo yesiqhelo yeLatuda yamkelwe yi-FDA. Nangona kunjalo, ingxelo yesiqhelo yeLatuda isenokungabikho kwimarike. Abavelisi beLatuda yesiqhelo babandakanya iAccord Healthcare, iPiramal Healthcare UK Limited, kunye neLanga Pharmaceutical Industries Ltd.
Kwenzeka ntoni ukuba awuthathi iLatuda ngokutya?
ILatuda ayinakusebenza ngokufanelekileyo xa ithathwa ngaphandle kokutya. Kuyacetyiswa ukuba uthathe iLatuda ngokutya ubuncinci beekhalori ezingama-350 zokufunxa okufanelekileyo. Ukufakwa kweLatuda kunyuswe kabini xa iyeza lithathwa kunye nokutya.
