I-Lorazepam vs. diazepam: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango iphathwe | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
ILorazepam kunye ne-diazepam ngamachiza enziwe asebenza ukunyanga ukuphazamiseka koxinzelelo, phakathi kwezinye iimeko zempilo yengqondo. Omabini la machiza ahlelwa njenge-benzodiazepines. Basebenza ngokwandisa umsebenzi we-GABA, okanye i-gamma-aminobutyric acid, kwingqondo. I-neurotransmitter GABA yichemical inhibitory ethintela imiqondiso ethile ye-nerve, yokunyusa imood, kunye nokukhuthaza ukuzola.
Zombini i-lorazepam kunye ne-diazepam ngamachiza eShedyuli IV, ngokwe-Drug Enforcing Administration (DEA). Oku kuthetha ukuba la machiza, njengezinye i-benzodiazepines, anomngcipheko wokuxhomekeka kwanokuxhatshazwa. Ke ngoko, kufuneka zisetyenziswe njengonyango lwexesha elifutshane phantsi kweliso lomboneleli wezempilo.
Funda ukuze ufunde ngolwahluko phakathi kwe-lorazepam kunye ne-diazepam.
Nguwuphi umahluko ophambili phakathi kweLorazepam vs diazepam?
Umahluko ophambili phakathi kwe-lorazepam kunye ne-diazepam kukuba i-diazepam ihlala emzimbeni ixesha elide kune-lorazepam. ILorazepam, eligama eliqhelekileyo lika-Ativan, unesiqingatha sobomi ukuya kuthi ga Iiyure eziyi-18 . Kwelinye icala, i-diazepam, eligama eliqhelekileyo le-Valium, linesiqingatha sobomi ukuya kuthi ga Iiyure ezingama-48 . Ke ngoko, i-lorazepam ithathwa njenge-benzodiazepine ephakathi, kwaye i-diazepam ithathwa njenge-benzodiazepine esebenza ixesha elide.
I-Lorazepam kunye ne-diazepam nazo ziyenziwa umzimba, okanye zilungiswe, emzimbeni ngokwahlukileyo. I-Lorazepam idityaniswa esibindini yinkqubo eyaziwa ngokuba yi-glucuronidation . I-Diazepam ifakwe kwisibindi yi-cytochrome enzymes. Ngenxa yoko, i-diazepam inokubanakho ukunxibelelana namanye amachiza kune-lorazepam.
ILorazepam iyafumaneka kwiipilisi zomlomo oqhelekileyo ezinamandla e-0.5 mg, 1 mg, kunye ne-2 mg. Kuza njengesisombululo somlomo kunye nesisombululo senaliti. I-Ativan iyafumaneka kwiipilisi zomlomo oqhelekileyo ezinamandla e-2 mg, 5 mg, kunye no-10 mg. I-Ativan inokuthi ilawulwe njengesisombululo somlomo, isisombululo senaliti, kunye nejeli yecala.
| Umahluko ophambili phakathi kwe-lorazepam vs diazepam | ||
|---|---|---|
| ILorazepam | Diazepam | |
| Iklasi yeziyobisi | Benzodiazepine | Benzodiazepine |
| Uhlobo lweBrith / generic | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo | Ibhranti kunye nohlobo oluqhelekileyo olukhoyo |
| Ngubani igama lophawu? | Ativan | Valium |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo Isisombululo somlomo Isisombululo ngenaliti | Ithebhulethi yomlomo Isisombululo somlomo Isisombululo ngenaliti Ijeli efileyo |
| Ithini idosi esemgangathweni? | Uxinzelelo: Ukuqala kwethamo: 2 ukuya ku-3 mg ngomlomo amaxesha ama-2 ukuya kuma-3 ngosuku Idosi yesondlo: 2 ukuya ku-6 mg amaxesha ama-2 ukuya kuma-3 ngosuku | Uxinzelelo: 2 ukuya kwi-10 mg ngomlomo amaxesha ama-2 ukuya kwezi-4 ngosuku |
| Lude kangakanani unyango oluqhelekileyo? | Akukho ngaphezulu kweenyanga ezi-4 | Akukho ngaphezulu kweenyanga ezi-4 |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala nabantwana abaneminyaka eli-12 ubudala nangaphezulu | Abantu abadala, abantwana, kunye neentsana kwiinyanga ezi-6 nangaphezulu |
Iimeko zonyango lwe-lorazepam vs diazepam
I-Lorazepam kunye ne-diazepam isebenza njenge-anxiolytics ukunciphisa iimpawu zoxinzelelo, ezinje ngoxinzelelo olukhulu kunye nobunzima bokucinga ngokucacileyo. I-Lorazepam kunye ne-diazepam bobabini bavunyelwe yi-FDA ukunyanga uxinzelelo kunye noxinzelelo, njengokuphazamiseka kwesoyiki kunye nohlaselo.
Njengazo ezinye i-benzodiazepines, i-lorazepam kunye ne-diazepam zinokusetyenziselwa ukunyanga ukuphazamiseka, okanye isifo sokuwa. Banokusetyenziswa njengesixhobo sokulungiselela kwangaphambili ngaphambi kotyando ngenjongo yokuthambisa.
I-Diazepam ikwayi-FDA evunyiweyo yokunyanga isifo sokurhoxisa utywala kunye nokudumba kwemisipha. Ukongeza ekunyangeni uxinzelelo, i-lorazepam ikwavunyiwe ukunyanga ukulala okungabangelwa luxinzelelo. Olunye usetyenziso lweelebhile ezingekhoyo lunokufumaneka kule theyibhile ingezantsi.
| Imeko | ILorazepam | Diazepam |
| Ukuxhalaba | Ewe | Ewe |
| Ukuphuthelwa okubangelwa luxinzelelo | Ewe | Ngaphandle kwelebheli |
| Utywala oburhoxisa isifo | Ngaphandle kwelebheli | Ewe |
| Ukudumba kwezihlunu | Ngaphandle kwelebheli | Ewe |
| Iingxaki zokubanjwa | Ewe | Ewe |
| Isimo sokuxhuzula | Ewe | Ewe |
| Ukuhlaliswa okanye ukulungiswa kwangaphambili ngaphambi kotyando | Ewe | Ewe |
Ngaba i-lorazepam vs. diazepam iyasebenza ngakumbi?
Xa kuthelekiswa ne-placebo, okanye akukho mayeza, zombini i-lorazepam kunye ne-diazepam ziyasebenza ekunyangeni uxinzelelo. I-benzodiazepine esebenzayo iya kuxhomekeka kwimeko yokuphathwa, amanye amayeza athathiweyo, kunye naluphi na unyango oluye lwazama ngaphambili.
Uvavanyo lweklinikhi olwenziwe ngokungahleliwe, olulawulwayo lubonakalise ubukhulu becala ukuba i-lorazepam kunye ne-diazepam ziyathelekiswa nokusebenza kwonyango. Imfama ezimbini ulingo lwezonyango ngokuthelekisa i-lorazepam kunye ne-diazepam kwizigulana ezili-134 ezixhalabileyo ngaphezulu kweeveki ezine zifumanise ukuba omabini la machiza ayesebenza ngakumbi kune-placebo. Nangona kunjalo, i-lorazepam yafunyanwa isebenza ngakumbi kwizigulana ezazineempawu ezimbi ekuqaleni. Ukuhlala kuxeliwe njengeyona nto ibalulekileyo kwiqela elithatha i-lorazepam.
Kwi Uhlalutyo lweemeta zenethiwekhi , I-midazolam, i-lorazepam, kunye ne-diazepam zathelekiswa nokunyanga imeko ye-epilepticus, ukuxhuzula ixesha elide, ebantwaneni. Idatha equlunqwe ukusuka kuvavanyo lweeklinikhi ezili-16 ezahlukileyo zafumanisa ukuba i-midazolam kunye ne-lorazepam zazisebenza ngakumbi kune-diazepam.
Olu thelekiso lwenzelwe ulwazi ngokubanzi. Funa ingcebiso yezonyango kugqirha okanye umboneleli wezempilo ngaphambi kokusebenzisa i-benzodiazepine. Umboneleli wakho wezempilo uya kuqhuba uvavanyo olupheleleyo lwezonyango ukumisela ubuzaza bemeko yakho kunye nokulawula ezinye iimeko ezinokubakho zempilo yengqondo.
Umxhesho kunye nokuthelekiswa kweendleko zelorazepam vs diazepam
I-generic lorazepam ngokubanzi igutyungelwa luninzi lwezonyango kunye nezicwangciso zeinshurensi. Ngaphandle kwe-inshurensi, ixabiso lentengo eliphakathi linokuba ngama-25 eedola kwiipilisi ezingama-30, 0.5 mg Ikhuphoni ye-singleCare ye-lorazepam inokuzisa iindleko ukuya kuthi ga kwi-9 yeedola.
Njengamanye amayeza e-generic, i-diazepam ihlala igutyungelwe yi-Medicare kunye nezicwangciso zeinshurensi. Ixabiso eliphakathi lemali le-diazepam ejwayelekile limalunga ne-24 yeedola kwiipilisi ezingama-30, 0.5 mg. Xa kuthelekiswa ne-lorazepam, i-diazepam inokuba nexabiso eliphantsi ngokuxhomekeka kwikhemesti yakho. Sebenzisa isigqebhezana se-singleCare se-diazepam kunokunciphisa iindleko ukuya kwi- $ 7 kwii-pharmacy ezithatha inxaxheba.
| ILorazepam | Diazepam | |
| Ngokuqhelekileyo i-inshurensi? | Ewe | Ewe |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Umthamo osemgangathweni | 2 ukuya ku-6 mg amaxesha ama-2 ukuya ku-3 ngosuku | 2 ukuya kwi-10 mg ngomlomo amaxesha ama-2 ukuya kwezi-4 ngosuku |
| I-Medicare copay eqhelekileyo | $ 0- $ 25 | $ 0- $ 12 |
| Ixabiso elilodwa | $ 8 + | $ 6 + |
Iziphumo eziqhelekileyo ebezingalindelekanga zelorazepam vs diazepam
ILorazepam kunye ne-diazepam, njengezinye i-benzodiazepines, ikakhulu zibangela iziphumo ebezingalindelekanga kwinkqubo ye-nervous system (CNS). Eyona ixhaphakileyo Iziphumo ebezingalindelekanga zelorazepam , okanye iAtivan, kukudakasa, isiyezi, ubuthathaka, kunye nokungazinzi, okanye ukulahleka kokudibana. Iziphumo eziqhelekileyo ezichaphazelekayo ze-diazepam, okanye i-Valium, ukozela, ukukhathala, ubuthathaka bemisipha kunye nokulahleka kokulungelelanisa.
Ezinye iziphumo ebezingalindelekanga zinokubandakanya iingxaki zememori. Ukuvela kweziphumo ebezingalindelekanga zihlala zixhomekeke kumthamo weyeza elithathiweyo. Iziphumo ezibi kakhulu zichazwe ngeedosi eziphezulu ze-benzodiazepines. Iziphumo ebezingalindelekanga ezimandundu, kubandakanya nokudakumba, okanye ukuphefumla nzulu, kunokubonisa imeko kaxakeka kwezonyango.
| ILorazepam | Diazepam | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Ukuhlala | Ewe | 16% | Ewe | * |
| Ukozela | Ewe | * | Ewe | * |
| Ukudinwa | Ewe | * | Ewe | * |
| Ukuba nesiyezi | Ewe | 7% | Ewe | * |
| Ubuthathaka | Ewe | 4% | Ewe | * |
| Ulungelelwaniso olungalunganga | Ewe | 3% | Ewe | * |
| Iingxaki zememori | Ewe | * | Ewe | * |
* akuxelwa
Ukuphindaphinda akusekelwanga kwidatha ukusuka kuvavanyo lwentloko ukuya entloko. Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( ILorazepam ), Yonke imihla ( Diazepam )
Ukudibana kweziyobisi ne-lorazepam vs diazepam
ILorazepam kunye ne-diazepam ngokuyintloko bayasebenzisana nezinye iziyobisi ezichaphazela inkqubo ye-nervous system (CNS). Ukuthatha ezi benzodiazepines ngamachiza afana neopioid, barbiturates, antipsychotic, anti-depressants, kunye ne-anticonvulsants kunokukhokelela kwiziphumo zokudakumba ze-CNS, ezinje ngesiyezi, ukudideka kunye nokozela. Amachiza e-antigout probenecid anokuchaphazela imetabolism ye-benzodiazepines kwaye ikhokelele kwiziphumo ebezingalindelekanga.
Ukusetyenziswa kwe-theophylline okanye i-aminophylline inokuphikisa iziphumo zokuthambisa ze-benzodiazepines. Xelela ugqirha wakho ukuba uthatha elinye lala machiza ngaphambi kokuba uqalise i-benzodiazepine.
IDiazepam iqhutywa zii-enzyme ezithile ze-P450 ngelixa i-lorazepam ingekho. Amanye amachiza anokuthintela ezi enzymes, ezichaphazela indlela eqhutywa ngayo i-diazepam emzimbeni. Oku kunokubangela ukwanda kweempembelelo zedayazepam. Iziyobisi ezinje nge-ketoconazole, i-cimetidine, kunye ne-omeprazole zinokusebenzisana ne-diazepam kwaye zikhokelele ekunyukeni kwe-sedation.
Ii-Antacids ezinjengecalcium carbonate kunye nemagnesium hayidroksayidi inokunciphisa ukufunxeka kwe-diazepam emzimbeni. Esi siphumo sinokutshintsha indlela esebenza kakuhle ngayo i-diazepam.
| Iziyobisi | Iklasi yeziyobisi | ILorazepam | Diazepam |
| Oxycodone IHydrocodone Ikhowudi Imofini | I-Opioid | Ewe | Ewe |
| IPhenobarbital IPentobarbital Indawo yokuhlala | IBarbiturate | Ewe | Ewe |
| IClozapine ILurasidone Olanzapine | Intshutshiso yengqondo | Ewe | Ewe |
| IFluoxetine IFluvoxamine Amitriptyline Doxepin | Uxinzelelo | Ewe | Ewe |
| IValproate IPhenytoin Clobazam | I-Anticonvulsant | Ewe | Ewe |
| Iiprobene | Igosa lokulwa | Ewe | Ewe |
| Ithiophylline Aminophylline | Imethylxanthine | Ewe | Ewe |
| Ketoconazole | Iarhente yokubola | Hayi | Ewe |
| Cimetidine | Umchasi we-H2-receptor | Hayi | Ewe |
| Omeprazole | Impompo Proton inhibitor | Hayi | Ewe |
| Ikhalsiyam carbonate Magnesium hayidroksayidi | I-Antacid | Hayi | Ewe |
Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi.
Izilumkiso zelorazepam vs diazepam
Ukusetyenziswa kweeopioids ezine-benzodiazepines kufuneka kuthintelwe. Xa zisetyenziswa kunye, i-benzodiazepines kunye ne-opioids zinokunyusa umngcipheko woxinzelelo lokuphefumla, isiqaqa, kunye nokufa. Izigulana kufuneka zijongwe ngokusondeleyo xa ezi klasi zimbini zeziyobisi zithathwa kunye.
I-Lorazepam kunye ne-diazepam Ishedyuli IV iziyobisi . Abo banembali edlulileyo yotywala okanye yokusetyenziswa gwenxa kweziyobisi banokuba semngciphekweni omkhulu wokuxhomekeka kunye nokuxhatshazwa nge-benzodiazepines. Ukuxhomekeka kunye nokusetyenziswa gwenxa kunokunyusa umngcipheko wokudlula kwi-benzodiazepines. Iimpawu kunye neempawu ze-benzodiazepine overdose zibandakanya ukuphulukana nolungelelwaniso, uxinzelelo lwegazi oluyingozi (hypotension), uxinzelelo lokuphefumla, kunye ne-coma.
Kuphela yidosi ephantsi esebenzayo ye-lorazepam okanye i-diazepam ekufuneka isetyenzisiwe. Nxibelelana nogqirha okanye ingcali yezempilo nakwezinye izilumkiso kunye nezilumkiso.
Imibuzo ebuzwa rhoqo malunga nelorazepam vs diazepam
Yintoni ilorazepam?
I-Lorazepam ligama eliqhelekileyo lika-Ativan. Inxalenye yodidi lwamayeza abizwa ngokuba yi-benzodiazepines. ILorazepam ifumaneka njengecwecwe lomlomo kumandla e-0.5 mg, 1 mg, kunye ne-2 mg. Inokulawulwa njengesisombululo somlomo okanye inaliti. ILorazepam yamkelwe ukuba inyange uxinzelelo kunye nokuqaqanjelwa bubuthongo okubangelwa luxinzelelo. Ingasetyenziselwa unyango njengonyango lokuphazamiseka ekubanjweni okanye ukubethelwa ngaphambi kokuhlinzwa.
Yintoni i-diazepam?
I-Diazepam yaziwa ngegama layo, iValium. Yi-benzodiazepine evunyiweyo yi-FDA ukunyanga uxinzelelo, isifo sokurhoxisa utywala, kunye ukudumba kwezihlunu . Ingasetyenziselwa ukuphazamiseka kokuthimba kunye neenjongo zokuthambisa ngaphambi kotyando. I-Diazepam ifumaneka kwi-2 mg, 5 mg, kunye ne-10 mg yeepilisi zomlomo. Kuza njengesisombululo somlomo, inaliti, kunye nejeli engxenyeni.
Ngaba i-lorazepam vs. diazepam iyafana?
I-Lorazepam kunye ne-diazepam zombini zi-benzodiazepines, kodwa azifani. Ziza ngeendlela ezahlukeneyo kwaye zinokusetyenziswa okuvunyiweyo kwe-FDA. Banemida eyahlukeneyo yobudala: I-Lorazepam ayikhuthazwa kubantwana abangaphantsi kweminyaka eyi-12 ngelixa i-diazepam ingacetyiswa kwiintsana ezingaphantsi kweenyanga ezi-6.
Ngaba i-lorazepam okanye i-diazepam ingcono?
I-Lorazepam kunye ne-diazepam zombini ziziyobisi ezisebenzayo. I-Diazepam ihlala emzimbeni ixesha elide kune-lorazepam. Nangona kunjalo, oku akuthethi ukuba sisiyobisi esingcono. Ukusebenza kwe-benzodiazepine kuya kuxhomekeka kwimeko yokuphathwa, phakathi kwezinye izinto. Nxibelelana nomboneleli wezempilo ukumisela olona nyango lukufaneleyo.
Ndingayisebenzisa i-lorazepam okanye i-diazepam ngelixa ndikhulelwe?
Akucetyiswa ukuba uthathe i-lorazepam okanye i-diazepam ngelixa ukhulelwe. Nangona i-diazepam inokukhuseleka kancinci kune-lorazepam ngexesha lokukhulelwa, akukho zifundo zaneleyo zibonise ukuba i-benzodiazepines ikhuselekile ngokupheleleyo ngelixa ukhulelwe. Qhagamshelana nomboneleli wezempilo ngaphambi kokuba uthathe i-benzodiazepine ngexesha lokukhulelwa.
Ndingayisebenzisa i-lorazepam okanye i-diazepam ngotywala?
Ukudibanisa utywala kunye ne-benzodiazepines ayikhuthazwa. Zombini utywala kunye ne-benzodiazepines zinokubangela iziphumo ebezingalindelekanga ze-CNS ezinje ukozela kunye nesiyezi. Ukuthatha ezi zinto kunye kunokunyusa umngcipheko weziphumo ebezingalindelekanga kunye nokudlula.
Ngaba i-3 mg lorazepam ininzi kakhulu?
Umthamo olungileyo we-lorazepam uya kuxhomekeka kwimeko yokuphathwa. Nxibelelana nogqirha ukuze ufumane iingcebiso zonyango kunye nemiyalelo efanelekileyo yokusebenzisa eli yeza. Umthamo oqhelekileyo we-lorazepam unokuba naphina ukusuka kwi-2 kuye kwi-6 mg ngomlomo izihlandlo ezibini ukuya kwezintathu ngemini.
Ngaba i-diazepam ihlala ixesha elide kune-lorazepam?
I-Diazepam ihlala ixesha elide kune-lorazepam. Kuqwalaselwa njenge-benzodiazepine esebenza ixesha elide kunye nesiqingatha sobomi ukuya kwiiyure ezingama-48. I-benzodiazepines esebenza ixesha elide ibandakanya iValium (diazepam), iLibrium (chlordiazepoxide), kunye neDalmane (flurazepam).
Ngaba kubi ukuthatha iAtivan yonke imihla?
Akukhuthazwa ngokubanzi ukuthatha iAtivan (lorazepam) ixesha elide. Akukho zifundo zaneleyo zenziweyo kukhuseleko kunye nokusebenza kweAtivan kwiinyanga ezine ezidlulileyo zokusetyenziswa. Abanye abantu bakhulisa ukuxhomekeka kunye nokunyamezelana neAtivan, enokuthi ichaphazele ukuba isebenza njani ngokuhamba kwexesha. I-Ativan kufuneka isetyenziswe kuphela njengoko kumiselwe ngumboneleli wezempilo.
Ngaba ilorazepam iyasebenza ngokukhawuleza?
ILorazepam yindawo ephakathi esebenza njenge-benzodiazepine. Iziphumo ze-lorazepam zinokuziva ngaphakathi kwe-1 ukuya kwi-1.5 yeeyure emva kokuyithatha. Isiqingatha sobomi be-lorazepam sijikeleze iiyure ezili-10 ukuya kwezi-20. Ezinye i-benzodiazepines eziphakathi zibandakanya i-Xanax (alprazolam), iKlonopin (clonazepam), kunye ne-Restoril (temazepam).
