Eyona >> Iziyobisi Vs. Umhlobo >> I-Trulance vs.Linzess: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

I-Trulance vs.Linzess: Umahluko, ukufana, kwaye kukuphi okungcono kuwe

Iziyobisi Vs. Umhlobo

I-Trulance (plecanatide) kunye ne-Linzess (linaclotide) ngamachiza amabini anokusetyenziselwa unyango lwe-syndrome ekhubazayo yamathumbu (IBS). Omabini la machiza akhuthaza ukuhamba kwamathumbu ngokwandisa inani lamanzi emathunjini. Kwinqanaba le-biochemical, i-Trulance kunye ne-Linzess isebenza njenge-agonists ye-guanylate cyclase-C receptors emathunjini. Oku, kwandisa umthwalo wamanzi, kuthambisa ukuthungwa kwesitulo, kwaye kukhawulezise ukuhanjiswa kokutya.

I-Trulance kunye ne-Linzess ikwabonakalisiwe kunyango lokuqhinwa okungapheliyo kwe-idiopathic (CIC). Olu luhlobo lokuqhinwa olungenaso isizathu esaziwayo.

Zombini ezi nyango zisongela ukuqhina zifuna utyelelo logqirha kunye nonyango. I-Trulance kunye neLinzess nazo ziyangqinelana kubantwana abangaphantsi kweminyaka emi-6 ubudala. Azikhuthazwa nakubani na ongaphantsi kweminyaka eli-18 ubudala.

Nguwuphi umahluko ophambili phakathi kweTrulance kunye neLinzess?

Nangona iTrulance kunye neLinzess zisebenza kwi Ii-guanylate cyclase-C ii-receptors , zinamagama ahlukeneyo aqhelekileyo kunye nezinto ezisebenzayo. I-Trulance ligama lophawu lwe-plecanatide ngelixa i-Linzess ligama legama le-linaclotide.

I-Trulance sisiyobisi esitsha kuneLinzess kwaye inokuthathwa kunye okanye ngaphandle kokutya. I-Linzess ihlala ithathwa isisu esingenanto kwimizuzu engama-30 ngaphambi kwesidlo sakusasa. Ngelixa iTrulance ifumaneka njengecwecwe lomlomo elingu-3 mg, iLinzess iyafumaneka njengephilisi yomlomo kumandla ahlukeneyo.

Umahluko ophambili phakathi kweTrulance kunye neLinzess
	Ukutsala	Linzess
Iklasi yeziyobisi	IGuanylate cyclase-C i-agonist	IGuanylate cyclase-C i-agonist
Uhlobo lweBrith / generic	Akukho nguqulo yohlobo oluqhelekileyo ekhoyo	Akukho nguqulo yohlobo oluqhelekileyo ekhoyo
Igama lesiqhelo	IPlecanatide	Linaclotide
Ukufumaneka kweFom yesiqhelo	Ayifumaneki	Ayifumaneki
Zeziphi iifom eza nalo iziyobisi?	3 mg ithebhulethi yomlomo	72, 145, 290 mcg njengezingxobo zomlomo
Ithini idosi esemgangathweni?	Ngokutya okanye ngaphandle kokutya, kanye ngemini.	Kufuneka uthathwe ungatyanga, kanye ngemini.
Lude kangakanani unyango oluqhelekileyo?	Ixesha elide kuxhomekeke kummiselo kagqirha wakho	Ixesha elide kuxhomekeke kummiselo kagqirha wakho
Ngubani oqhelekileyo usebenzisa amayeza?	Abantu abadala abaneminyaka eli-18 nangaphezulu	Abantu abadala abaneminyaka eli-18 nangaphezulu

Ngaba ufuna elona xabiso lilungileyo kwiTrulance?

Bhalisela izilumkiso zamaxabiso eTrulance kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Imiqathango ephathwe yiTrulance kunye neLinzess

I-Linzess kunye neTrulance zivunyiwe ukuba zisetyenziswe kwi ukuqhina okungapheliyo kunye nohlobo lokuqaqamba kwesifo esisisifo esibuhlungu (IBS-C). Ngezenzo zabo kwii-receptors zangaphakathi emathunjini, omabini la machiza akhuthaza ukugcinwa kolwelo kunye nokunyuka kokutya okuhamba emathunjini.

Ezi amayeza amiselweyo ayizizo laxatives. Aziboneleli ngoncedo olukhawulezileyo ekuqunjelweni. Iziphumo zihlala zijongwa emva kweveki yonyango kunye neTrulance kunye neLinzess. Ngokuqhelekileyo zikhuselekile ekusebenziseni ixesha elide.

I-Trulance kunye ne-Linzess ngamanye amaxesha inokusetyenziswa ngaphandle kwelebheli kunyango lwe-opioid-indip constipation (OIC) ebangelwa ziziyobisi ezinjenge morphine. Ezinye izikhombisi ezingekho kwilebula zibandakanya i-ulcerative colitis.

Imeko	Ukutsala	Linzess
Isifo esichaphazelayo samathumbu ngokuqhinwa	Ewe	Ewe
Ukuqhina okungapheliyo kwe-idiopathic	Ewe	Ewe
Ukuqunjelwa okubangelwa yiOpioid	Ngaphandle kwelebheli	Ngaphandle kwelebheli
Ulcerative Colitis	Ngaphandle kwelebheli	Ngaphandle kwelebheli

Ngaba iTrulance okanye iLinzess iyasebenza ngakumbi?

I-Trulance sisiyobisi esitsha xa kuthelekiswa neLinzess. Nangona kunjalo, ukusebenza kwawo omabini la mayeza ngaphezulu okanye ngokulinganayo.

Ukuphuculwa kwesantya sokuhamba kwamathumbu kubonwa kwangoko kwiveki e-1 kunye nefuthe elide elizinzileyo. Kunye nokwanda kokuhamba kwamathumbu, la mayeza aphucula umgangatho wesitulo kubandakanya ukuthungwa kwesitulo kunye nokuhambelana.

Ukusebenza kweTrulance kwenye ulingo lwezonyango kwafunyanwa ukuba ibhengezwe ngakumbi kunyango lokuqhinwa okungapheliyo kwe-idiopathic. Xa kuthelekiswa ne-placebo, iTrulance ikwabonakalisiwe iyasebenza ekunyangeni isifo samathumbu esinganyanzelekanga.

Okwangoku, zimbalwa izifundo zokuthelekisa phakathi kweLinzess kunye neTrulance ngokubhekisele ekusebenzeni kwazo kodwa zombini zisebenza ngakumbi kuneziyobisi ze-placebo zokunciphisa ukuqhina. Nye uphononongo olucwangcisiweyo ifumanise ukuba iTrulance kunye neLinzess zinokusebenza ngokuchanekileyo kunye nokhuseleko. Kwakungekho mahluko ubonakalayo kwiziphumo ebezingalindelekanga ezinje ngesifo sorhudo.

Isigqibo malunga neziyobisi ezikhethiweyo sinokumiselwa kuphela ngugqirha. Emva kovavanyo olupheleleyo, ugqirha uya kumisela elona chiza libalaseleyo lilungiselelwe imeko yomntu iyonke.

Ngaba ufuna elona xabiso lilungileyo kwiLinzess?

Bhalisela izilumkiso zamaxabiso eLinzess kwaye ufumane ukuba amaxabiso atshintsha nini!

Fumana izilumkiso zamaxabiso

Ukufunyanwa kunye nokuthelekiswa kweendleko zeTrulance vs.Linzess

I-Trulance yavunywa kwi-2017 njengegama lophawu kuphela. Okwangoku yenziwe yiSynergy Pharmaceuticals. Okwangoku akukho nguqulo yohlobo oluqhelekileyo ekhoyo. I-Medicare kunye nezicwangciso ezininzi ze-inshurensi azinakugubungela iTrulance. Ixabiso eliphakathi lemali yeTrulance linokuba ngaphezulu kwe- $ 500. Sebenzisa ikhadi lesaphulelo se-SingleCare kunokunceda ukuzisa iindleko phantsi kwe- $ 400. Ngelixa iselisiyobisi esinexabiso eliphezulu, ukusebenzisa ikhadi lesaphulelo kungalihlisa ixabiso xa i-inshurensi ingakwazi ukuyigubungela.

I-Linzess yamkelwa ngo-2012 kwaye ifumaneka kuphela njengeyeza elinegama lophawu. Njengazo zonke i-guanylate cyclase-C i-agonists, iLinzess inokubiza kakhulu ngexabiso eliphakathi lokuthengisa ngaphezulu kweedola ezingama-500. Ngethamsanqa, ezinye i-Medicare kunye nezicwangciso zeinshurensi zinokuzigubungela. Nokuba unayo i-inshurensi, unokukwazi ukugcina ngakumbi ngekhadi lesaphulelo elilodwa elinokunciphisa iindleko ukuya kuthi ga kwi-400 yeedola.

	Ukutsala	Linzess
Ngokuqhelekileyo ihlawulwa yi-inshurensi?	Hayi	Hayi
Ngokuqhelekileyo igutyungelwe yiMedicare?	Hayi	Hayi
Umthamo osemgangathweni	Iipilisi ze-3 mg	72, 145, 290 mcg njengezingxobo
I-Medicare copay eqhelekileyo	$ 70- $ 474	$ 19- $ 482
Ixabiso elilodwa	$ 389. +	$ 403.38

Iziphumo eziqhelekileyo ezichaphazelekayo zeTrulance vs.Linzess

Iziphumo ebezingalindelekanga ezixhaphakileyo ezinxulunyaniswa nokusebenzisa iTrulance okanye iLinzess sisifo sorhudo. Ngenxa yobume bomsebenzi wabo, la machiza ikakhulu abangela iziphumo ebezingalindelekanga zesisu. Ngokwelebheli leziyobisi ze-FDA, iTrulance inokuba neziphumo ebezingalindelekanga ezimbalwa ngokuthelekiswa neLinzess. Iziphumo eziphambili zeTrulance sisifo sohudo.

Ngaphandle kwesifo sorhudo, iLinzess inokubangela ezinye iziphumo ebezingalindelekanga eziqhelekileyo njengokuqunjelwa, ukuqumba, kunye nentlungu esiswini.

Kwiimeko ezinqabileyo, iTrulance kunye neLinzess kunokubangela urhudo oluqatha. Kule meko, ugqirha wakho uza kukucebisa ngokupheliswa kwangoko kwesiyobisi. Kubantwana, la mayeza anokubangela ukomisa kakhulu emzimbeni. Ke ngoko, azikhuthazwa kubantwana.

	Ukutsala	Linzess
Imiphumela	Iyasebenza?	Rhoqo	Iyasebenza?	Rhoqo
Urhudo	Ewe	5%	Ewe	Amashumi amabini%
Intlungu zesisu	Ewe	<2%	Ewe	7%
Ukuqhawula	Ewe	<2%	Ewe	Mbini%
Ukuqunjelwa sisisu	Ewe	<2%	Ewe	4%
Intloko ebuhlungu	Hayi	-	Ewe	4%

Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: Yonke imihla Ukutsala ), Yonke imihla ( Linzess )

Ukudibana kweziyobisi kweTrulance vs. Linzess

Kukho unxibelelwano oluncinci lweziyobisi kunye neTrulance. Ngokuqhelekileyo kuthathwa njengokukhuselekileyo ukuthatha kunye nezinye iziyobisi. Nangona kunjalo, iyeza elinye, ngakumbi, linokubanakho ukunxibelelana neTrulance. I-Idelalisib ibonakaliswe kunyango lwee-cancer ezithile zegazi ezinjenge-leukemia engapheliyo.

I-Idelalisib, xa ithathwa ngeTrulance, inokubangela urhudo olubi, nolusongela ubomi. Kubalulekile ukuba unxibelelane nomboneleli wakho wezempilo kwangoko ukuba ufumana iimpawu zokunxibelelana kweziyobisi.

Ngaphandle kwe-idelalisib, azikho ezinye iindlela zokunxibelelana neziyobisi kunye neTrulance. Ayiphazamisi i-cytochrome P450 enzyme complex kwaye ayichaphazeli abanye abathumeli beseli.

I-Linzess, kwelinye icala, inoluhlu olude lonxibelelwano olunokubakho xa kuthelekiswa neTrulance. Eli chiza linakho ukusebenzisana nenani lamayeza afana ne-levothyroxine, i-bisacodyl, i-psyllium, i-magnesium hydroxide, kunye ne-omeprazole.

Iziyobisi	Iklasi yeziyobisi	Ukutsala	Linzess
Idealisib	Iphosphoinositide 3-kinase inhibitor	Ewe	Akuxelwanga
I-Levothyroxine	Idlala lengqula	Akuxelwanga	Ewe
IBisacodyl	I-laxative ekhuthazayo	Akuxelwanga	Ewe
I-Psyllium	Ifayibha laxative	Akuxelwanga	Ewe
Magnesium hayidroksayidi	Isaline laxative	Akuxelwanga	Ewe
Omeprazole	Impompo Proton inhibitor	Akuxelwanga	Ewe

Olu ayilo luhlu lupheleleyo lokunxibelelana kweziyobisi. Nceda uqhagamshelane nogqirha wakho ngaphambi kokuba uthathe la mayeza.

Isilumkiso seTrulance vs. Linzess

Zombini i-Trulance kunye ne-Linzess zinokubangela iziphumo ebezingalindelekanga ezibi, ngakumbi urhudo kunye nokuphelelwa ngamanzi emzimbeni.

Kubantwana abangaphantsi kweminyaka emi-6 ubudala, la mayeza anomngcipheko wokubangela ukomisa kakhulu emzimbeni. Ukhuseleko kunye nokusebenza kwazo akuzange kumiselwe kakuhle kubantwana abangaphantsi kweminyaka eli-18, yiyo loo nto zombini iTrulance kunye neLinzess zichasene nezigulana zabantwana. Ukuphelelwa ngamanzi emzimbeni kunokubakho ngenxa yokunyusa ukonyusa i-guanylate cyclase-C receptors ezonyusa ukuhambisa kwamathumbu kunye nokugcina ulwelo kwinqanaba eliphezulu kuneliqhelekileyo.

Abo banesithintelo esiswini (isithintelo) kufuneka bakuphephe ukuthatha iTrulance okanye iLinzess. Thetha nogqirha ukufumanisa ukuba ngaba unaso isisu ngaphambi kokuthatha amayeza.

Urhudo sesinye isiphumo secala eliqhelekileyo kunye nomngcipheko onokuvela ngokusetyenziswa kweTrulance kunye neLinzess. Urhudo olunamandla alunokubangela kuphela ukomisa komzimba kodwa nokuphazamiseka kwe-electrolyte emzimbeni. Oku kunokufuna olunye unyango ukuba alulungiswanga ngokufanelekileyo.

I-Trulance kunye neLinzess khange kufundwe kwabasetyhini abakhulelweyo okanye abancancisayo. Kuya kufuneka zisetyenziswe kuphela emva kokuvavanya ubungozi obunokubakho beziphene zokuzalwa.

Imibuzo ebuzwa rhoqo malunga neTrulance vs.Linzess

Yintoni iTrulance?

Ukunyanga amayeza amiselweyo avunyiweyo kunyango lokuqunjelwa kwesifo esisisifo esibuhlungu (IBS-C) kunye nokuqunjelwa okungapheliyo kwe-idiopathic (CIC). Yiganylate cyclase-C receptor agonist eyonyusa intshukumo yamathumbu. I-Trulance ikhuselekile ukuba isetyenziswe kwizigulana ezindala kuneminyaka eyi-18. Iza kwifom yecwecwe lomlomo kunye nesiqabu esibonwa ngaphakathi kweveki yokusebenzisa.

Yintoni iLinzess?

I-Linzess sisiyobisi esidala esenza ngendlela efanayo neTrulance. Yi-guanylate cyclase-C receptor agonist eyonyusa ukuhamba emathunjini kwaye ikhuphe ukuqhina. Ngesi sizathu, uLinzess uvunyiwe ngenxa yesifo se-bowel syndrome-C kunye nokuqhinwa okungapheliyo. Sisiyobisi esigqirha ukuba sifumaneka kwifomule yomlomo.

Ngaba iTrulance kunye neLinzess ziyafana?

Hayi. Ngaphandle koluhlobo olufanayo lweziyobisi, la machiza eza ngeendlela ezahlukeneyo zedosi. I-Trulance sisiyobisi esitsha esinokuthathwa kunye okanye ngaphandle kokutya. I-Linzess kufuneka ithathwe isisu esingenanto kwimizuzu engama-30 ngaphambi kwesidlo sakusasa.

Yeyiphi engcono-iTrulance okanye iLinzess?

I-Trulance kunye ne-Linzess zinokusebenza ngokuchanekileyo kunye nokhuseleko. Nangona kunjalo, iLinzess inokudityaniswa neziganeko eziphezulu zorhudo, ukuqunjelwa kunye negesi. Ngesi sizathu, iTrulance inokukhethwa ngaphezu kweLinzess.

Ngaba ndingayisebenzisa iTrulance okanye iLinzess ngelixa ndikhulelwe?

Akukaziwa ukuba i-Trulance okanye i-Linzess ikhuselekile ukuthatha ngexesha lokukhulelwa okanye lokuncancisa. Kuya kufuneka ubonane nogqirha ngaphambi kokuba uthathe la mayeza xa ukhulelwe okanye uncancisa.

Ngaba ndingasebenzisa iTrulance okanye iLinzess ngotywala?

Ukudibana kweziyobisi kweTrulance okanye iLinzess notywala akuqinisekiswanga kakuhle. Kukho ithuba lokusela utywala ngala mayeza kunokunyusa umngcipheko weziganeko ezimbi.

Ngaba i-Amitiza ibhetele kuneLinzess?

Xa kuthelekiswa neLinzess yangemihla ngemihla, Amitiza (i-lubiprostone) kufuneka ithathwe kabini yonke imihla. I-Amitiza inokuba neziphumo ebezingalindelekanga eziqhelekileyo ngokuthelekiswa neLinzess. Ukongeza kwisifo sorhudo, i-Amitiza inokubangela isicaphucaphu, ukungaginyi, kunye nomlomo owomileyo.

Yintoni uhlobo oluqhelekileyo lweLinzess?

Okwangoku akukho luhlobo luqhelekileyo lweLinzess olufumanekayo kwintengiso.

Kukuphi okungcono ekuqunjelweni- Linzess okanye Trulance?

Zombini i-Trulance kunye ne-Linzess zibonisiwe ukuba zinokuthelekiswa nokusebenza kunye nokhuseleko. Elinye iyeza linokukhethwa ngaphezu kwelinye ngokuxhomekeke kwixabiso kunye ne-inshurensi yokugubungela. I-Trulance ikwasisiyobisi esitsha kunye neziphumo ebezingalindelekanga ezimbalwa ezichaziweyo.

Ngaba iLinzess iya kukwenza unciphise umzimba?

Utshintsho lobunzima lunokwenzeka xa uthatha iLinzess. I-Linzess iye yaxelwa ukuba ibangela ukunciphisa umzimba okanye ukuzuza ubunzima.