Isikhokelo seepilisi zokungasebenzi kakuhle, iziyobisi kunye namayeza

Imfundo yezeMpilo

Ngeminyaka engama-70, phantse Iipesenti ezingama-70 zamadoda eUnited States baya kufumana ukungasebenzi kakuhle kwe-erectile, okwabizwa ngokuba kukungabi namandla. Ngamanye amagama, ukungakwazi ukufezekisa okanye ukugcina ulwakhiwo yingxaki eqhelekileyo. Ngethamsanqa, ihlala inyangeka ngokulula kwaye iyanyangeka ngeepilisi zokungasebenzi kakuhle emzimbeni.

Zeziphi ezona pilisi zisebenzayo kwi-erectile dysfunction?

Kuxhomekeka kwisizathu esisisiseko semeko, ezona zinto zixhaphakileyo ezichaziweyo zonyango lokungasebenzi emzimbeni zibandakanya:

• Isildenafil (Viagra, Revatio)
• tadalafil (Adcirca, Cialis)
• vardenafil (ILevitra, iStaxyn)
• avanafil (iStendra)

Nangona nganye yezi pilisi isebenza kusetyenziswa indlela efanayo, nganye inomahluko. Banqanda i-enzyme ebizwa ngokuba luhlobo lwe-phosphodiesterase 5. Ezi phosphodiesterase zohlobo lwe-5 inhibitors (PDE5 inhibitors okanye PDE5i) azibangeli mdla wesondo; baphucula ukuhamba kwegazi ukuya kwilungu lobudoda ekuvumela ukuba ufumane amava aphilileyo.

Ngaba iipilisi ze-erectile dysfunction ziyasebenza?

I-Sildenafil (Viagra), i-vardenafil (i-Levitra), i-avanafil (i-Stendra), kunye ne-tadalafil (i-Cialis) zonke zithathwa njengonyango lokuqala lwe-ED ngenxa yempumelelo kunye neprofayili yokhuseleko.

Ngaphambi kokuba uthathe naliphi na la mayeza e-ED, xelela ugqirha wakho malunga nalo naliphi na iyeza okanye izongezo osele uzithatha, kunye neminye imiba yezempilo, enjengesifo sentliziyo, uxinzelelo lwegazi okanye isifo seswekile. Amachiza athile ayasebenzisana nezi pilisi.Umzekelo, akufuneki usebenzise naziphi na ii-PDE5 inhibitors ukuba uthatha iziyobisi ze-nitrate kwaye ulumkiso luyafuneka ukuba ngaba une-alpha-blockers.Ukungafihli nto nogqirha wakho kuya kukunceda ekuchongeni olona nyango lulungileyo kunye nonyango lokungasebenzi kakuhle emzimbeni.

Ukusetyenziswa gwenxa kweziyobisi

La mayeza alandelayo avunyiweyo yi-FDA aqhele ukumiselwa ukunyanga i-ED.

ISildenafil (Viagra)

Ngokufanelekileyo elona gama lidumileyo le-ED elicetyiswayo ukunyanga ukungasebenzi kakuhle kwe-erectile, iViagra sisixhobo se-PDE5 inhibitor. I-Viagra ifumaneka kwi-25 milligram (mg) ukuya kwi-100 mg yeepilisi. Ithathwe ngomlomo malunga nemizuzu engama-30 ngaphambi kokuvuselelwa ngokwesondo, kwaye iziphumo zayo zinokuhlala iiyure ezine ukuya kwezintlanu.

Nangona ungekho umlutha, kukho umngcipheko weziphumo ezilandelayo xa uthatha i-sildenafil:

• isiyezi
• ukulahlekelwa kukuva okanye ukukhala ezindlebeni
• isisu esibuhlungu kunye isicaphucaphu
• intloko ebuhlungu
• ukufudumala okanye ubomvu ebusweni, entanyeni, okanye esifubeni
• ukuxinana kwempumlo
• urhudo
• umqolo obuhlungu
• iingxaki zememori
• ukungakwazi ukwahlula phakathi kwemibala eluhlaza kunye nohlaza okwesibhakabhaka

ISildenafil ikwafumaneka njenge-Revatio, ipilisi yedosi esezantsi okanye inaliti, kodwa kuphela kunyango lwe-pulmonary arterial hypertension (PAH), hayi ukungasebenzi kakuhle kwe-erectile.

ITadalafil (Adcirca, Cialis)

I-Tadalafil yi-PDE5i, njenge-sildenafil, eyonyusa ukuhamba kwegazi ukuya kwilungu lobudoda ukulungiselela ukwakhiwa. Yonyusa isiphumo semichiza yendalo yemichiza yegazi eveliswa ibizwa ngokuba yi-nitric oxide, enceda izihlunu kwimithambo yelungu lobudoda ukuba ziphumle kwaye zide, zivumele igazi elininzi ukuba lingene. Inesakhiwo semichiza esahlukileyo ngokuthelekiswa neSildenafil kwaye inokuthatha ukuya kuthi ga kwiiyure ezimbini ukufikelela kwisiphumo. Nangona kunjalo, iziphumo zalo zinokuhlala ukuya kuthi ga kwiiyure ezingama-36.

Ukuba i-tadalafil ithathwa njengoko ifunekayo, idosi yi-5 mg ukuya kwi-20 mg ngomlomo ngaphambi komsebenzi wesondo. Nangona kunjalo, amanye amadoda akhetha ukuthatha i-Cialis mihla le. Idosi yokuqala yokusetyenziswa kwemihla ngemihla yi-2.5 mg, ithathwa kanye yonke imihla ngaxeshanye. Ekugqibeleni, isigulana siya kutshintshela kwidosi yesondlo yemihla ngemihla phakathi kwe-2.5 mg kunye ne-5 mg.

Iziphumo eziqhelekileyo ezinokubakho ze-tadalafil zibandakanya:

• impumlo egobileyo okanye egobayo
• ukugungxula
• intloko ebuhlungu
• umqolo obuhlungu
• isisu esimoshakele
• intlungu kumalungu

I-Tadalafil ikwafumaneka njenge-Adcirca, kodwa kuphela kunyango lwe-pulmonary arterial hypertension (PAH), hayi eyokungasebenzi kakuhle kwe-erectile.

IVardenafil (ILevitra, iStaxyn)

Enye i-PDE5 inhibitor, i-vardenafil (i-Levitra, iStaxyn), sisiyobisi somlomo esithathwa njengoko kufuneka kwimizuzu engama-60 ngaphambi kwesondo. Ungalithatha eli chiza lokungasebenzi kakuhle emzimbeni ukuya kuthi ga ngemini njengoko kucetyisiwe ngugqirha wakho.

Uninzi lwezigulana ziqala nge-10 mg yedosi ye-vardenafil, nangona kunjalo iyafumaneka njengeyeza lomlomo kwi-2.5 mg, 5 mg, 10 mg, kunye ne-20 mg doses.

Ineziphumo ebezingalindelekanga ezifanayo njengezinye iziyobisi ze-PDE5i, kubandakanya:

• intloko ebuhlungu
• isiyezi
• isisu esimoshakele

Njengazo zonke ii-PDE5 inhibitors,IVardenafil inokusebenzisana namanye amachiza. Akufanele kumiselwe kwizigulana ezithatha ii-inhibitors ezinamandla ze-CYP3A4 ezifana ne-ketoconazole kunye ne-ritonavir, okanye kwizigulana ezinesifo sentliziyo, ezithatha i-nitrate njenge-nitroglycerin, emiselwe ukuthintela iintlungu zesifuba.

IAvanafil (iStendra)

Esona sithintelo sikhawuleze kakhulu se-PDE5 esikhoyo, iAvanafil (iStendra) inokufikelela kwizona ziphumo ziphakamileyo emva kwemizuzu engama-30-45 kuphela. Ithathwe ngomlomo imizuzu engama-30 ngaphambi kokwabelana ngesondo kwaye inokusebenza iiyure ezingama-6 ukuya kwezi-12.

Iziphumo eziqhelekileyo ezichaseneyo ze-avanafil zibandakanya:

• intloko ebuhlungu
• ukugungxula
• Impumlo exineneyo
• umqala obuhkungu

Zihlala ixesha elingakanani iipilisi ze-ED? Thelekisa i-PDE5i

Ngaba iStendra isebenza ngakumbi kuneViagra?

I-Stendra (avanafil) kunye neViagra (sildenafil) zombini ziyasebenza PDE5 inhibitors ezisetyenziselwa ukunyanga ukungasebenzi kakuhle kwe-erectile.Njengazo zonke ii-PDE5 inhibitors, zisebenza ngokuphumla kwezihlunu ezigudileyo kunye nokwandisa ukuhamba kwegazi ukuya kwilungu lobudoda.

Umahluko ophambili phakathi kwamayeza amabini e-erectile dysfunction ayisiyo ukusebenza kwawo, kodwa ukuqala kwawo kunye nexesha.

I-Stendra isebenza ngokukhawuleza kwaye inokuthi isebenze ngokukhawuleza kwimizuzu eli-15 ngaphambi kokuba usebenze ngesondo.Inokuhlala ukuya kuthi ga kwiiyure ezili-12. Ngokuthelekisa, iViagra kufuneka ithathwe kwimizuzu engama-30 ukuya kwengama-60 ngaphambi kwesondo, kwaye ihlala malunga neeyure ezi-5.

Ezinxulumene: I-Stendra vs Viagra: Umahluko ophambili kunye nokufana

Kukuphi okungcono: iViagra okanye iCialis okanye iLevitra?

Umahluko ophambili phakathi kwazo zonke ii-PDE5 inhibitors kukuqala kunye nexesha lexesha leziyobisi.

I-Levitra (vardenafil) kunye neViagra (sildenafil) zezi ngakumbi ezifanayo .

I-Levitra kufuneka ithathwe iyure enye ngaphambi kwemisebenzi yesondo, ngelixa i-sildenafil inefestile enkulu. Ingathathwa naphina ukusuka kwimizuzu engama-30 ukuya kwiiyure ezi-4 ngaphambi kokulalana. Ixesha elithathwayo ukusebenza liyahluka ngokwamntu ngamnye.

Xa uthelekisa Cialis ukuya kwiViagra kunye neLevitra, kukho umahluko ophambili:

1. I-Cialis inokuthathwa nokuba ifuneka, okanye yonke imihla. I-Viagra kunye ne-Levitra zithathwa akukho ngaphezulu kwesinye ngosuku, kuphela njengoko kufuneka.
2. I-Cialis ihlala ixesha elide kune-Viagra okanye i-Levitra, naphi na ukusuka kwi-24 ukuya kwiiyure ze-36 (okanye ngokuqhubekayo ukuba ithathwa yonke imihla) xa kuthelekiswa nee-4 ukuya kwiiyure ze-5.

Olunye unyango lwe-ED

Kuba zininzi izizathu zokungasebenzi kakuhle ngokwesondo, zininzi iindlela ezahlukeneyo zonyango abantu abazisebenzisayo ukuphucula imeko kunye nempilo yabo yesondo. Oku kubandakanya:

• Unyango
• Unyango lokuthetha (iingcebiso)
• Ukutshintsha kokutya kunye nokutya
• Ukucamngca
• Zilolonge
• Ukufakwa kwe-penile kunye neempompo

Okanye, amayeza e-counter-counter kunye neevithamini abanye abantu baxela njengempumelelo kwimpilo yamadoda. Olunye ukhetho oludumileyo lubandakanya:

• L-arginine
• Ginseng
• Yohimbe

Njengokuba kukho umngcipheko wokuba amayeza anokusebenzisana namanye amachiza, kuya kufuneka usoloko ufuna iingcebiso kwezonyango kugqirha wakho ngaphambi kokuba uqalise ngonyango okanye ngendalo.

Ezinxulumene: Unyango lwendalo lokungasebenzi kakuhle kwe-erectile

Ugqirha wakho usenokucebisa ngezi ndlela zilandelayo zonyango lokungasebenzi kakuhle emzimbeni.

IAlprostadil (Caverject, Viridal, MUSE)

IAlprostadil lunyango lwesibini lokungasebenzi kakuhle kwe-erectile. Eli chiza liyafumaneka njengenaliti (Caverject, Viridal) okanye aurethrali-suppository (MUSE). Yi-vasodilator evula imithambo yegazi ukonyusa ukuhamba kwegazi ukuya kwilungu lobudoda kwaye ivumele ulwakhiwo.

Ukutshintshwa kwe testosterone

Ukuba unamanqanaba asezantsi ehomoni yesini eyindoda, i-testosterone, ugqirha wakho unokucebisa ngonyango oluya endaweni lwe-testosterone ukuphucula ukungasebenzi kakuhle ngokwesondo. Oku kunokusetyenziswa kuphela okanye ngokudibeneyo namanye amayeza kunye nonyango.

Amanqanaba akho e testosterone anokujongwa kuvavanyo lwegazi olulula.Ngaphandle kweengxaki zokwakhiwa, iimpawu ze-testosterone ephantsi, ihomoni ebalulekileyo kulungelelwaniso oluqhelekileyo, kubandakanya:

• Ukuncitshiswa kwesondo
• Ukukhula kwebele
• Ukuphulukana neenwele zomzimba
• Ukunyuka kwamafutha omzimba
• Yehla kumandla emisipha kunye nobukhulu

Ukuba uqala unyango lwehomoni, ezi zezinye zeziphumo ebezingalindelekanga ezinokubakho:

• Ukugcina ulwelo
• Amabala
• Ukwandiswa kwamabele kunye neprostate
• Ukuncipha kokuchuma
• Ukwanda kweeseli ezibomvu zegazi
• Iimpawu zokuphefumla zokulala ezixineneyo

Ezinxulumene: Isikhokelo sokugqibela sokungasebenzi kakuhle kwe-Erectile

Ungayikhetha njani inketho efanelekileyo kuwe

Ukungasebenzi kakuhle kwe-Erectile kuyanyangeka kwaye kuhlala kunyangeka. Inokusebenza njengophawu lwesilumkiso, uphawu lokuqala lwe iimeko ezisisiseko ezifana nesifo sentliziyo, uxinzelelo lwegazi oluphezulu, isifo sezintso, icholesterol ephezulu, isifo seswekile, ukutyeba kakhulu, ukusebenzisa kakubi utywala, okanye ukuphazamiseka kwemithambo-luvo. Xa uxelela ugqirha wakho malunga ne-ED, inokukunceda ekufumaneni isifo kwangoko.

Kungcono uthethe ngokuphandle kugqirha wakho okanye ingcali kwi-urology malunga namava akho ukuze ufumanise ukuba yeyiphi iindlela zokonyango iya kusebenza kakuhle kwiimpawu zakho, iimfuno kunye nendlela yokuphila. Ukuba uthatha isigqibo sokuthenga nawaphi na amayeza kagqirha okanye izongezo kwi-Intanethi, soloko uqinisekisa ukuba uyathenga kwiwebhusayithi ethembekileyo nedumileyo. Khangela iziqinisekiso zekhemesti ukunqanda izinto zomgunyathi okanye ezihlanjululwe, kwaye ungaze uzithenge ngaphandle kommiselo.