I-Etodolac vs. ibuprofen: Umahluko, ukufana, kwaye kukuphi okungcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kweinshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
Akukho mntu ufuna ukuhlala ngokungahambi kakuhle okanye iintlungu ixesha elide, okanye kukonke ngalo mbandela. Ngethamsanqa, amayeza amayeza kunye neyeza zokuthomalalisa iintlungu ziyafumaneka kwivenkile ekufuphi kuwe. Ngelixa azomelelanga njengokuthomalalisa iintlungu ze-opioid, ezifuna uvavanyo olunzulu ngakumbi lonyango kunye nonyango, ii-NSAID ezinjenge-etodolac okanye ibuprofen ziyasebenza ekunyangeni iintlungu eziphakathi ukuya kweziphakathi.
Ngaphandle koko yaziwa njengeziyobisi ezichasayo ezingasebenziyo, ii-NSAID zisebenza ngokuthintela ukuveliswa kweprostaglandins. Umzimba wakho unokuphendula kwiimeko ezithile zonyango ngokuvelisa ii-prostaglandins, eziyikhemikhali ezijongene nentlungu, ukudumba kunye nomkhuhlane. Ii-NSAID zivimba ii-enzyme ezivelisa i-prostaglandin-i-COX-1 kunye ne-COX-2 -ukulawula ukuphendula komzimba kunye nokunciphisa iintlungu.
I-Etodolac kunye ne-ibuprofen zihlelwa njengee-NSAID. Nangona kunjalo, banomahluko obalulekileyo.
Nguwuphi umahluko ophambili phakathi kwe-etodolac kunye ne-ibuprofen?
I-Etodolac ngamanye amaxesha yaziwa ngegama layo (ngoku elingasasebenziyo), igama leLodine. Iyafumaneka njengechiza elenza lafana nalawo aveliswe ngumenzi kwaye inokufunyanwa kuphela ngugqirha.
I-Etodolac ine-half-life ye-6 ukuya kwiiyure ezisixhenxe kwaye ifikelela kugqabhuko oluphezulu egazini ukuya kwiiyure ezimbini emva kokuyitya. Ihlala ithathwa amaxesha amabini ukuya kwamathathu yonke imihla ngenxa yeentlungu zesifo samathambo. Kukho ithebhulethi ekhutshwe i-etodolac ene-half-life-longer ye-8 yeeyure kwaye inokuthathwa kanye yonke imihla.
I-Ibuprofen yi-NSAID eqhelekileyo exhaphakileyo efumaneka ngaphezulu kwe-counter (OTC). Amandla aphezulu e-ibuprofen ayafumaneka ngommiselo kagqirha. Amagama aziwayo e-ibuprofen aquka u-Advil, uMotrin noMidol.
I-Ibuprofen ifikelela kumanqanaba aphezulu egazi kwiyure enye ukuya kwezimbini emva kokuyithatha. Nangona kunjalo, ngokungafaniyo ne-etodolac, ibuprofen inexesha elifutshane lobomi lokujikeleza iiyure ezimbini . I-ibuprofen yamandla kagqirha iza kwithebhulethi edla ngokuthathwa kathathu ukuya kwesine amaxesha ngamaxesha. Inguqulelo ye-OTC iza kwiitafile zomlomo, iicapsule, kunye nokumiswa kolwelo.
| Umahluko ophambili phakathi kwe-etodolac kunye ne-ibuprofen | ||
|---|---|---|
| Etodolac | Ibuprofen | |
| Iklasi yeziyobisi | Izidakamizwa ezichasayo ezichasayo (i-NSAID) | Izidakamizwa ezichasayo ezichasayo (i-NSAID) |
| Uhlobo lweBrith / generic | Uhlobo lwesiqhelo luyafumaneka (uphawu luyekile) | Brand kunye generic ziyafumaneka |
| Ngubani igama lophawu? | Lodine | Iadvil, iMotrin, iMidol |
| Zeziphi iifom eza nalo iziyobisi? | Iifomsile zomlomo Ithebhulethi yomlomo Ithebhulethi yomlomo, ukukhutshwa okwandisiweyo | Iifomsile zomlomo Ithebhulethi yomlomo Ulwelo lomlomo Inaliti (NeoProfen) |
| Ithini idosi esemgangathweni? | Intlungu: 200 ukuya ku-400 mg qho kwiiyure ezi-6 ukuya kwezi-8 xa kufuneka njalo. Musa ukugqitha idosi ephezulu ye-1200 mg ngosuku. Kwi-osteoarthritis okanye i-rheumatoid arthritis: Ukukhululwa kwangoko ngama-300 mg kabini ukuya kathathu ngemini okanye ama-400 ukuya kuma-500 mg kabini yonke imihla. Kukhululwe i-400 ukuya kwi-1000 mg kanye yonke imihla. Musa ukugqitha idosi ephezulu ye-1200 mg ngosuku. | Intlungu: 200 ukuya ku-400 mg qho kwiiyure ezi-4 ukuya kwezi-6 njengoko kufuneka. Musa ukugqitha idosi ephezulu ye-1200 mg ngosuku ngaphandle kokuba uyalelwe ngugqirha. Kwi-osteoarthritis okanye i-rheumatoid arthritis: i-400 ukuya kwi-800 mg kathathu ukuya kwesine amaxesha ngamaxesha. Musa ukugqitha idosi ephezulu ye-3200 mg ngosuku. |
| Lude kangakanani unyango oluqhelekileyo? | Ixesha lonyango lixhomekeke kwimeko yezempilo, ukuba qatha kwentlungu, kunye nezinye izinto. Unyango lunokuba lwexeshana elifutshane okanye ixesha elide. | Ixesha lonyango lixhomekeke kwimeko yezempilo, ukuba qatha kwentlungu, kunye nezinye izinto. Unyango lunokuba lwexeshana elifutshane okanye ixesha elide. |
| Ngubani oqhelekileyo usebenzisa amayeza? | Abantu abadala nabantwana abaneminyaka eyi-6 nangaphezulu | Abantu abadala nabantwana iinyanga ezi-6 nangaphezulu |
Iimeko eziphathwe nge-etodolac kunye ne-ibuprofen
I-Etodolac kunye ne-ibuprofen zinelebheli yokunyanga iintlungu. Zihlala zithathwa ukunyanga iintlungu eziqaqambayo ukuya kweziphakathi kwiinkqubo zamazinyo, migraines , okanye iintlungu zemisipha (myalgia).
I-Etodolac kunye ne-ibuprofen ziluncedo ngakumbi kwaye i-FDA ivunyelwe ukunyanga iintlungu kunye nokudumba kwi-osteoarthritis kunye ne-rheumatoid arthritis. Amandla aphakamileyo ahlala efuneka ukujongana neentlungu ezihlangeneyo okanye iintlungu zethambo ezinxulumene nesifo samathambo. Ngamanye amaxesha, abantwana abangaphezulu komda wobudala obucetyiswayo banokuphathwa ngezi NSAID ulutsha lwe-idiopathic arthritis .
I-ibuprofen engaphezulu kwekhawunta ibhalwe ukunyanga umkhuhlane kunye neempawu zokuya exesheni (idysmenorrhea ephambili). Ifom ejoyiweyo ye-ibuprofen ebizwa ngokuba yi-NeoProfen isetyenziselwa ukunyanga i-patent ductus arteriosus (PDA), uhlobo lwesiphene sentliziyo, kwiintsana ezingaphambi kwexesha.
| Imeko | Etodolac | Ibuprofen |
| Intlungu | Ewe | Ewe |
| Osteoarthritis | Ewe | Ewe |
| Irheumatoid Arthritis | Ewe | Ewe |
| Ulutsha lwe-idiopathic arthritis | Ewe | Ewe |
| Ifiva | Hayi | Ewe |
| I-dysmenorrhea ephambili | Hayi | Ewe |
| Ipatent ductus arteriosus | Hayi | Ewe |
Ngaba i-etodolac okanye ibuprofen isebenza ngakumbi?
Zombini i-etodolac kunye ne-ibuprofen zii-NSAID ezisebenzayo zokuphelisa iintlungu. Zombini iibhloksi ze-cyclooxygenase (COX) zokulawula ukudumba kunye nokunciphisa iintlungu kwabo bane-arthritis. Nangona kunjalo, iziphumo ze-etodolac zihlala ixesha elide kancinci. Ke ngoko, abanye abantu banokukhetha i-etodolac yedosi yayo yamaza asezantsi.
Kwisifundo esingaboni kabini thelekisa i-etodolac kunye ne-ibuprofen , Izigulana ezili-1,446 ezine-rheumatoid arthritis zinikwe i-150 mg ye-etodolac kabini yonke imihla, i-500 mg ye-etodolac kabini yonke imihla, okanye i-600 mg ye-ibuprofen amaxesha amane yonke imihla. Zombini iidosi ze-etodolac zifunyenwe zifana ngokusebenzayo kumthamo we-ibuprofen. Ngokweziphumo ebezingalindelekanga, abo bathatha i-etodolac bafumana ukungaginyisi mathe, irhashalala kunye nokuphuma kwesisu kunabo bathatha ibuprofen. Nangona kunjalo, oku kunokuba kunxulumene nezixa zezigulana zeziyobisi ezinikiweyo.
Ngelixa ezinye izilingo zeklinikhi zingathelekisi ngokuthe ngqo i-etodolac kunye ne-ibuprofen, izifundo ezahlukeneyo ziye zathelekisa ezinye ii-NSAIDs kunye ne-etodolac okanye ibuprofen. Olunye uhlalutyo lweemeta lufumanise ukuba idosi ephezulu yemihla ngemihla yediclofenac iyasebenza ngakumbi kunedosi ephezulu yemihla ngemihla ye-ibuprofen, naproxen, kunye ne-celecoxib (kodwa eyona idosi isebenzayo ye-NSAID ihlala icetyiswa). Olunye uhlalutyo lweemeta lufumanise ukuba ii-NSAID ezithile ezinje nge-piroxicam kunye ne-azapropazone banomngcipheko omkhulu wokutyhefa Ngelixa idosi ephantsi ibuprofen inomngcipheko ophantsi wetyhefu. Ngokubanzi, kunokuthiwa ukuba ii-NSAID zihlala zihluke ngakumbi kukhuseleko kunokusebenza.
Ngenxa yoluhlu olubanzi lweenketho zentlungu, kubalulekile ukuba uqhagamshelane nomboneleli wezempilo ukuze ufumane olona nyango lulungileyo. Ugqirha okanye umboneleli wezempilo unokubonelela ngengcebiso efanelekileyo yezonyango kwiimeko ezithile zonyango.
Umyinge kunye nokuthelekiswa kweendleko ze-etodolac vs ibuprofen
Iipilisi zeGeneric etodolac zihlala zigutyungelwa yiMedicare kunye nezicwangciso zeinshurensi. Ukuba uneemeko zonyango ezifana nesifo samathambo, izicwangciso zeinshurensi ziya kugubungela i-etodolac yeentlungu. Ixabiso eliphakathi lokuthengisa nge-etodolac lingahluka ngokuxhomekeka kwidosi, kodwa ungahlawula malunga ne- $ 50 ye-etodolac ngokusebenzisa isigqebhezana se-SingleCare kwii-pharmacy ezithatha inxaxheba.
Kuba ibuprofen iyafumaneka kwi-counter, ezinye iifom zinokungagutyungelwa zizicwangciso zeinshurensi. Nangona kunjalo, uninzi lwe-Medicare Icandelo D kunye nezicwangciso ze-inshurensi kufuneka zigubungele amayeza eepilisi ze-ibuprofen ngokuxhomekeke kwirejimeni yonyango. Ngokubanzi, ibuprofen ifikeleleka ngakumbi kune-etodolac. Sebenzisa i-singleCare coupon ye-ibuprofen ukuba uneyeza elivela kumboneleli wakho wezempilo.
| Etodolac | Ibuprofen | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe | Ewe (iipilisi zamandla amiselweyo) |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe | Ewe |
| Umthamo osemgangathweni | Ama-300 mg ama-2 amaxesha ama-3 imihla ngemihla | Ama-400 ukuya kuma-800 mg ama-3 ukuya kuma-4 imihla ngemihla |
| I-Medicare copay eqhelekileyo | $ 0- $ 76 | $ 0- $ 22 |
| Ixabiso elilodwa | $ 40- $ 80 | $ 4- $ 24 |
Iziphumo eziqhelekileyo ezichaphazelekayo ze-etodolac vs ibuprofen
Iziphumo eziqhelekileyo ezichaphazela ii-NSAIDs, kubandakanya i-etodolac kunye ne-ibuprofen, sisicaphucaphu, ukuqunjelwa (dyspepsia), ukuqhina, urhudo, kunye nentlungu esiswini okanye esiswini. Ngaphandle kweziphumo ebezingalindelekanga zesisu, ii-NSAID zinokubangela nesiyezi, ukudumba ezandleni okanye iinyawo (i-edema), intloko ebuhlungu, irhashaza, kunye nokukhala ezindlebeni (i-tinnitus). Uninzi lweziphumo ebezingalindelekanga ze-etodolac kunye ne-ibuprofen zithambile kwaye ziyahamba zodwa.
Iziphumo ezibi kakhulu ze-NSAIDs zinokubandakanya ukusabela okungafunekiyo, njengokukhawuleza okanye i-anaphylaxis, ukusuka kwizithako ezisebenzayo okanye ezingasebenziyo. Ezinye iziphumo ebezingalindelekanga ezinzulu zibandakanya iziphumo ezibi zesisu njengokuphuma kwesisu kunye izilonda Peptic . Qhagamshelana nomboneleli wakho wezempilo xa ufumana igazi kwi-stool, ukulahleka kwesisindo, okanye intlungu yesisu.
| Etodolac | Ibuprofen | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Isicaphucaphu | Ewe | 1% –10% | Ewe | 1% -3% |
| Intlungu zesisu | Ewe | 1% –10% | Ewe | 1% -3% |
| Ukutya | Ewe | 1% –10% | Ewe | 1% -3% |
| Ukuqunjelwa | Ewe | 1% –10% | Ewe | 1% -3% |
| Urhudo | Ewe | 1% –10% | Ewe | 1% -3% |
| Ukuba nesiyezi | Ewe | 1% –10% | Ewe | 1% -3% |
| Edema | Ewe | 1% –10% | Ewe | 1% -3% |
| Intloko ebuhlungu | Ewe | 1% –10% | Ewe | 1% -3% |
| Irhashalala | Ewe | 1% –10% | Ewe | 1% -3% |
| Tinnitus | Ewe | 1% –10% | Ewe | 1% -3% |
Olu alunakuba luluhlu olupheleleyo lweziphumo ezibi ezinokwenzeka. Nceda ujonge ugqirha wakho okanye umboneleli wezempilo ukuze ufunde okungakumbi.
Umthombo: DailyMed ( Etodolac ), Yonke imihla ( Ibuprofen )
Ukudibana kweziyobisi ze-etodolac vs ibuprofen
Ngenxa yokuba bavimba i-COX-1 enzyme, edlala indima kwimveliso yeplatelet kunye namahlwili egazi, ii-NSAID zinokuphazamisa iziphumo zegazi. Ii-NSAID zinokunyusa umngcipheko wokopha kwiiarhente ze-antiplatelet ezinjenge-aspirin kunye nee-anticoagulants ezinjenge-warfarin.
I-Etodolac kunye ne-ibuprofen inokubangela ukuba umzimba ugcine ulwelo kwaye uchaphazele umsebenzi wezintso. Ngenxa yoko, ezi NSAID zinokunyusa uxinzelelo lwegazi. Ukuba uthatha amayeza oxinzelelo lwegazi (antihypertensive), njenge-lisinopril okanye i-losartan, uxinzelelo lwegazi lwakho lunokufuna ukubekwa esweni ngelixa uthatha i-NSAID.
I-Etodolac kunye ne-ibuprofen inokuchaphazela indlela ecocwa ngayo i-cyclosporine, digoxin, okanye i-methotrexate emzimbeni. Ukuthatha i-NSAID kunokukhokelela kumngcipheko okhulayo we-cyclosporine, digoxin, okanye i-methotrexate toxicity.
Fumana olunye unxibelelwano olunokubakho apha ngezantsi.
| Iziyobisi | Iklasi yeziyobisi | Etodolac | Ibuprofen |
| I-Aspirin | Antiplatelet | Ewe | Ewe |
| IWarfarin | I-Anticoagulant | Ewe | Ewe |
| Lisinopril ICaptopril IRamipril | I-Angiotensin-eguqula i-enzyme (ACE) inhibitor | Ewe | Ewe |
| ILosartan Valsartan UOlmesartan | I-Angiotensin receptor blocker (i-ARB) | Ewe | Ewe |
| Furosemide IHydrochlorothiazide | Womchamo | Ewe | Ewe |
| ILithium | Imood someleza | Ewe | Ewe |
| Imethotrexate Iphemetrexed | Antimetabolite | Ewe | Ewe |
| ICclosporine | Ugonyo | Ewe | Ewe |
| I-Digoxin | Iglycoside yentliziyo | Ewe | Ewe |
Nxibelelana noochwephesha kwezolunye unxibelelwano olunokubakho ngeziyobisi.
Izilumkiso ze-etodolac kunye ne-ibuprofen
I-Etodolac kunye ne-ibuprofen, njengezinye ii-NSAID, zinokunyusa umngcipheko weziganeko ezinzulu zentliziyo kunye nokuhlaselwa sisifo sentliziyo. Ukusetyenziswa kwe-NSAID kufuneka kuthintelwe okanye kubekwe iliso kubantu abane iingxaki zentliziyo njengokungaphumeleli kwentliziyo, isifo sentliziyo, kunye noxinzelelo lwegazi.
Ukusetyenziswa kwe-etodolac okanye ibuprofen kunokukhokelela kumngcipheko okhulayo wesisu esibi (GI) yeziganeko ezigwenxa, ezinjengokuphuma kwesisu kunye nezilonda ezisemzimbeni. Ngaphandle konyango olululo, ukudumba, kunye nokuphuma kwegazi kwitrakta ye-GI kunokuba yingozi. Abantu abadala banokuba semngciphekweni omkhulu weziganeko ezimbi ze-GI.
Ii-NSAID akufuneki zisetyenziswe ngokufanelekileyo ngaphambi okanye emva kwenkqubo yentliziyo ebizwa Umthambo we-coronary bypass graft (CABG) wotyando .
Abo banesifo sezintso banokuba semngciphekweni okhulayo weengxaki zezintso ngelixa bethatha ii-NSAID.
Qhagamshelana nomboneleli wakho wezempilo malunga nezinye iindlela zokukhusela ngaphambi kokuba uthathe i-NSAID.
Imibuzo ebuzwa rhoqo malunga ne-etodolac vs ibuprofen
Yintoni i-etodolac?
I-Etodolac sisiyobisi esinganyangekiyo sokudumba (i-NSAID) esisetyenziselwa ukunyanga iintlungu kunye nokudumba. I-FDA ivunyiwe ukunyanga i-osteoarthritis kunye ne-rheumatoid arthritis kubantu abadala. I-generic etodolac inokufunyanwa kuphela ngugqirha.
Yintoni ibuprofen?
Ibuprofen yaziwa ngokubanzi ngamagama egama ezinje ngeAdvil neMotrin. Itholakala kwi-counter-counter ukuphatha intlungu ephantsi ukuya kumodareyitha, umkhuhlane kunye neenkampu zokuya esikhathini. Amandla aphakamileyo ibuprofen anokufumaneka ngonyango lokunyanga iintlungu kunye nokudumba okuvela kwi-osteoarthritis kunye ne-rheumatoid arthritis.
Ngaba i-etodolac kunye ne-ibuprofen ziyafana?
I-Etodolac kunye ne-ibuprofen azifani. Ngelixa zombini ii-NSAID, zinomahluko kwiidosi kunye nendlela ezisetyenziswa ngayo. I-Etodolac sisiyobisi sikagqirha esisetyenziselwa abantu abadala abane-arthritis. I-Ibuprofen ifikeleleka ngakumbi njengechiza elingaphaya kwamayeza ngenxa yeentlungu kunye nomkhuhlane.
Ngaba i-etodolac okanye ibuprofen ibhetele?
I-NSAID engcono ixhomekeke kwidosi oyithathayo kunye nento oyithathayo. Xa kuthelekiswa ne-ibuprofen, i-etodolac ihlala ixesha elide emzimbeni, kwaye ke, inokuthathwa amaxesha ambalwa emini. Nangona kunjalo, kunokuba kubiza kakhulu kune-ibuprofen. Ngokusekwe kwimeko yakho iyonke, ugqirha wakho unokucebisa omnye ngaphezulu komnye.
Ndingayisebenzisa i-etodolac okanye ibuprofen ngelixa ndikhulelwe?
I-Etodolac kunye ne-ibuprofen azikhuthazwa ngokubanzi ngexesha lokukhulelwa. Ukusetyenziswa kwee-NSAID ngexesha lokukhulelwa kunxulunyaniswa nomngcipheko okhulayo wokukhubazeka kokuzalwa okanye ukuphuma kwesisu, ngakumbi ngexesha lokukhulelwa kade. Qhagamshelana nomboneleli wakho wezempilo ukuba ucinga unyango xa ukhulelwe .
Ndingayisebenzisa i-etodolac okanye ibuprofen ngotywala?
Ukusetyenziswa kotywala obuncinci kunokuba kuhle ngamanye amaxesha ngelixa uthatha i-NSAID. Nangona kunjalo, ukusela kakhulu utywala kunokukhokelela kumngcipheko okhulayo weziphumo ezibi zesisu kunye nee-NSAID. Utywala kunye neeNSAID inokucaphukisa isisu kunye namathumbu emathumbu, anokukhokelela kwizilonda okanye ukopha.
Ngaba i-etodolac ngumbulali weentlungu?
U-Etodolac ngumbulali weentlungu osebenzayo. Eyona ndlela isebenzayo ekunyangeni iintlungu kunye nokudumba okubangelwa sisifo samathambo. Kukwaluncedo ekunyangeni iintlungu eziqaqambayo emva kweenkqubo ezithile ezinje ngokuhlinzwa kwamazinyo.
Ngaba i-etodolac yomelele kune naproxen?
Ukusebenza kwee-NSAID kuxhomekeke kwidosi ethathiweyo, phakathi kwezinye izinto. Zonke izinto ziyalingana, i-etodolac kunye ne-naproxen ziyathelekiseka ngokusebenza. Ngokwezifundo ezingaboniyo kabini, i-etodolac kunye ne-naproxen ngokusebenza ngokulinganayo yokunyanga isifo samathambo. Omabini la machiza ayanyamezeleka ngenxa yeziphumo ebezingalindelekanga.
