Tamiflu vs Xofluza: Umahluko, ukufana, kwaye yeyiphi engcono kuwe
Iziyobisi Vs. UmhloboUkujonga ngokubanzi iziyobisi kunye nolwahluko ophambili | Imiqathango inyangwa | Ukusebenza | Ukuhlawulwa kwe-inshurensi kunye nokuthelekiswa kweendleko | Imiphumela | Ukusebenzisana kweziyobisi | Izilumkiso | FAQ
Xa kufika ixesha lexesha lomkhuhlane, kungcono ukuba uzilungiselele xa usazi ukuba zeziphi iindlela zonyango onokuthi ukhethe kuzo. Ngaphandle kokufumana i- umkhuhlane udutyulwa minyaka le , ekucetyiswa kakhulu, kukho amayeza akhoyo xa unokuhla kunye umkhuhlane . La machiza anokunceda ukunciphisa ubunzima kunye nobude beempawu zomkhuhlane ezinje ngentloko, umkhuhlane, ukudinwa, kunye nentlungu okanye ngokudibeneyo.
Unyango ezimbini zomkhuhlane ezivunyiweyo ze-FDA nguTamiflu (oseltamivir) kunye neXofluza (baloxavir marboxil). Nangona omabini la machiza anokunyanga umkhuhlane, asebenza ngeendlela ezahlukeneyo kwaye aneempembelelo ezahlukeneyo. Funda ukuze ufumane ukuba la machiza athelekiswa njani.
Nguwuphi umahluko ophambili phakathi kweTamiflu vs Xofluza?
Tamiflu ligama lophawu lwe-oseltamivir, elaye lavunywa ngo-1999. Isebenza njenge-neuraminidase inhibitor (NAI) eyeka ukukhutshwa kwentsholongwane yomkhuhlane kwiiseli ezosulelekileyo. Ngokwenza oku, kunciphisa ukusasazeka kwentsholongwane emzimbeni wonke. I-Tamiflu ihlala inikwa kabini imihla ngemihla kangangeentsuku ezintlanuxa unyanga umkhuhlane. Ingasetyenziselwa ukuthintela umkhuhlane (prophylaxis).
Xofluza ligama lophawu lebaloxavir marboxil, elisandula ukwamkelwa ngo-2018. Eli chiza litsha lisebenza njengeI-polymerase acidic (PA)i-endonuclease inhibitor emisa intsholongwane yomkhuhlane ekwenzeni iikopi zayo. Ngale ndlela, iXofluza isebenza ngokwahlukileyo xa ithelekiswa nezinye iziyobisi ezinjenge-Tamiflu (oseltamivir) kunye ne-Relenza (zanamivir). Iyeza kufuneka lithathwe kube kanye njengethamo elinye ukunyanga okanye ukuthintela umbane.
| Umahluko ophambili phakathi kweTamiflu vs Xofluza | ||
|---|---|---|
| Tamiflu | Xofluza | |
| Iklasi yeziyobisi | Intsholongwane I-Neuraminidase inhibitor | Intsholongwane IPolymerase acidic (PA) endonuclease inhibitor |
| Uhlobo lweBrith / generic | Inguqulelo yesiqhelo iyafumaneka | Inguqulelo yesiqhelo ayifumaneki okwangoku |
| Ngubani igama eliqhelekileyo? | Oseltamiviriphosphate | Ibhokisi yebhokisi yebhaloxavir |
| Zeziphi iifom eza nalo iziyobisi? | Ithebhulethi yomlomo Umgubo wokumiswa ngomlomo | Ithebhulethi yomlomo |
| Ithini idosi esemgangathweni? | Unyango lomkhuhlane: Iminyaka eli-13 nangaphezulu: 75 mg kabini yonke imihla kwiintsuku ezi-5 Uneminyaka eli-1 ukuya kweli-12 ubudala: Isikali sixhomekeke kubunzima, kabini imihla ngemihla kwiintsuku ezi-5 Iiveki ezi-2 ukuya ngaphantsi komnyaka omnye: 3 mg / kg kabini yonke imihla kwiintsuku ezi-5 Uthintelo lomkhuhlane: Iminyaka eli-13 nangaphezulu: 75 mg kanye yonke imihla ubuncinci iintsuku ezili-10 Uneminyaka eli-1 ukuya kweli-12 ubudala: Isikali sixhomekeke kubunzima, kube kanye ngeentsuku ezili-10 | Unyango okanye umkhuhlane wokuthintela: Iminyaka eli-12 nangaphezulu inobunzima bomzimba obuyi-90 ukuya kwi-180 lbs (40 ukuya kuma-80 kg): Iipilisi ezimbini ezingama-20 mg zithathiwe zedosi enye engama-40 mg eyi-12 nangaphezulu enobunzima bomzimba obuyi-175 lbs (80 kg): Amacwecwe amabini angama-40 mg athathwe kunye njengedosi enye ye-80 mg |
| Lude kangakanani unyango oluqhelekileyo? | Unyango: Iintsuku ezi-5 Uthintelo: Iintsuku ezili-10 Unyango lothintelo ngexesha lokuqhambuka koluntu lungahlala ukuya kwiiveki ezi-6 | Unyango okanye uthintelo: Usuku olu-1 ngethamo elinye |
| Ngubani oqhelekileyo usebenzisa amayeza? | Unyango: Iiveki ezi-2 ubudala nangaphezulu Uthintelo: 1 unyaka nangaphezulu | Unyango okanye uthintelo: Iminyaka eyi-12 ubudala nangaphezulu |
Iimeko eziphathwe nguTamiflu noXofluza
Zombini i-Tamiflu kunye ne-Xofluza zisetyenziselwa unyango umkhuhlane .Zisebenza ngokukuko xa zinikwa uphawu lokuqala lweempawu nangaphambi kokuba iimpawu zibe namava ngaphezulu kweeyure ezingama-48. Zombini i-Tamiflu kunye ne-Xofluza zinokuthintela umkhuhlane kwabo bathe basondelelana nabantu abosulelekileyo. La machiza anokuba luncedo ngakumbi kubantu abasemngciphekweni omkhulu wokuba nengxaki yomkhuhlane, njengaleyo ihlala kwindawo enesifo sentsholongwane okanye abo banesistim somzimba sokuzikhusela ngenxa yeemeko zonyango.
Sebenzisa le theyibhile ilandelayo ukuthelekisa ukusetyenziswa kwezonyango okuvunyiweyo kunye nokusetyenziswa kwelebheli yeTamiflu kunye neXofluza.
| Tamiflu | Xofluza | |
| Unyango lomkhuhlane A / H1N1 | Ewe | Ewe |
| Unyango lomkhuhlane A / H3N2 | Ewe | Ewe |
| Unyango lwe-Influenza B | Ewe | Ewe |
| Umkhuhlane A / H1N1, umkhuhlane A / H3N2, kunye nomkhuhlane B wokuthintela | Ewe | Ewe |
Ngaba iTamiflu okanye iXofluza isebenza ngakumbi?
Zombini i-Tamiflu kunye ne-Xofluza ziyasebenza ekunciphiseni iimpawu ngokukhawuleza kunokuba ubuza kuthatha i-placebo okanye ungabinanto kwaphela. Ngokwezilingo zeklinikhi, iTamiflu kunye neXofluza zafunyanwa zinciphisa iimpawu ngokukhawuleza xa kuthelekiswa ne-placebo. Kwi uphononongo lwezonyango ,xa kuthelekiswa ne-placebo, iTamiflu yafunyanwa ukunciphisa ixesha lokuphucula iimpawu ngolunye ukuya kwiintsuku ezimbini. Kwilitye le-1 ityala yeXofluza, xa kuthelekiswa ne-placebo, iXofluza yayinexesha elincinci lokufumana isiqabu sempawu (umahluko weeyure ezingama-26.5).
Xa uTamiflu noXofluza bethelekiswa kwenye ityala ,
I-Xofluza ibonakala isebenza ngakumbi kuneTamiflu enexesha elifutshane lokuphucula iimpawu: iiyure ezingama-73 kunye neXofluza xa kuthelekiswa neeyure ezingama-81 kunye noTamiflu. I-Xofluza ikwanciphise ixesha lokuphuma kwentsholongwane, okanye ukusasazeka, ukuya kwiiyure ezingama-48 xa kuthelekiswa ukuya kwiiyure ezingama-96 nge-placebo okanye ngeTamiflu. Olu vavanyo lubhalise ngaphezulu kwama-2,000 abathathi-nxaxheba kwaye lubandakanya abaguli abaneminyaka eyi-12 nangaphezulu.
NGAPHAKATHII-hile Xofluza ibonakala isebenza ngakumbi, ukunganyangeki kwintsholongwane kuye kwaba yinkxalabo. Kwi Japhan ,Ezinye iintlobo zomkhuhlane ziye zaxelwa ukuba ziye zaxhathisa iXofluza, isenza ukuba zingasebenzi kakuhle kwezinye iimeko.
Ukufunyanwa kunye nokuthelekiswa kweendleko zeTamiflu vs Xofluza
I-Tamiflu ingathengwa ngugqirha kwaye igutyungelwe yi-inshurensi, i-Medicare, kunye neMedicaid. Iyafumaneka kuzo zombini ii-brand kunye nee-generic versions. Ukubonelelwa ngeentsuku ezili-10 zegama lophawu lweTamiflu njengezingxobo kunokuxabisa phakathi kwe- $ 155 ukuya kwi-170 yeedola ngaphandle kweinshurensi. Unikezelo lweentsuku ezili-10 zee-generic oseltamivir capsules zinokubiza phakathi kwe- $ 20 kunye ne- $ 50. Ungasebenzisa isigqebhezana sesaphulelo se-SingleCare ukugcina kwiTamiflu kwikhemesti ekufutshane nawe.
IXofluza ikwathengwa ngugqirha kwaye igutyungelwe yi-inshurensi, iMedicare, kunye neMedicaid ngokuxhomekeke kwisicwangciso. Itholakala kuphela njengepilisi yegama lomthi. Iindleko zokuphuma epokothweni zeXofluza zinokuba phakathi kwe- $ 150 kunye ne- $ 180. Jonga ukubona ukuba ungasisebenzisa na isaphulelo seSpecialCare sokugcina kwiXofluza kwikhemesti ekufutshane nawe.
| Tamiflu | Xofluza | |
| Ngokuqhelekileyo ihlawulwa yi-inshurensi? | Ewe, kuxhomekeke kwisicwangciso | Ewe, kuxhomekeke kwisicwangciso |
| Ngokuqhelekileyo ihlanganiswe yiCandelo le-Medicare? | Ewe, kuxhomekeke kwisicwangciso | Ewe, kuxhomekeke kwisicwangciso |
| Umthamo osemgangathweni | 75 mg kabini imihla ngemihla ngeentsuku ezi-5 | Amacwecwe amabini angama-20 mg athathwe kunye njengedosi enye ye-40 mg |
| I-Medicare copay eqhelekileyo | $ 10- $ 200 | $ 30- $ 170 |
| Ixabiso elilodwa | $ 30 | $ 160 |
Iziphumo eziqhelekileyo ezichaphazelekayo zeTamiflu vs Xofluza
I-Tamiflu kunye ne-Xofluza babelana ngeziphumo ebezingalindelekanga ezifana nesicanucanu kunye nentloko. Ngokusekwe kuvavanyo lweklinikhi, iTamiflu inokuba nokuvela okuphezulu kwale miphumela. Ezinye iziphumo ebezingalindelekanga eziqhelekileyo zeTamiflu zibandakanya ukugabha kunye nentlungu, ngokwe ileyibheli evela kuLawulo lwezoKutya noLawulo lweziyobisi e-U.S. Ezinye iziphumo ebezingalindelekanga eziqhelekileyo zeXofluza zibandakanya urhudo, ukudumba kwemiphunga yomoya (i-bronchitis), kunye nokudumba kwezono (sinusitis).
I-Tamiflu inokubangela iziphumo ebezingalindelekanga ezimandundu ezifana nolusu okanye uvakalelo. Ezi zinto zingahambi kakuhle ziqala njengamaqhakuva kwaye ziba mandundu ngokuhamba kwexesha. Kukwakho neengxelo ze Iziganeko zengqondo ezinje nge-delirium, ukubona izinto ezingekhoyo, kunye nokuziphatha okungaqhelekanga kwabo bathatha iTamiflu.Ezi ziganeko zengqondo zixelwe kakhulu kubantwana abavela eJapan.
I-Xofluza inokubangela ulusu okanye uvakalelo ekuphenduleni. Ezi mpendulo zinokubakho njengokubomvu okanye ukurhawuzelela. Kukho umngcipheko wosulelo lwebacteria xa uthatha iXofluza.
| Tamiflu | Xofluza | |||
| Imiphumela | Iyasebenza? | Rhoqo | Iyasebenza? | Rhoqo |
| Isicaphucaphu | Ewe | 8-10% | Ewe | Mbini% |
| Ukuhlanza | Ewe | 2-8% | Hayi | - |
| Intloko ebuhlungu | Ewe | 2-17% | Ewe | 1% |
| Urhudo | Hayi | - | Ewe | 3% |
| IBronchitis | Hayi | - | Ewe | 3% |
| Isinusitis | Hayi | - | Ewe | Mbini% |
Umthombo: Yonke imihla (Tamiflu) , Yonke imihla (Xofluza) .
Ukudibana kweziyobisi zikaTamiflu kunye neXofluza
Zombini i-Tamiflu kunye ne-Xofluza zinokunxibelelana ne ugonyo lomkhuhlane -Ngokukodwa, isitofu sokugonya somkhuhlane esiphilayo. Ngenxa yokuba la machiza ayizintsholongwane, anokuchaphazela indlela esebenza ngayo iyeza lokugonya umkhuhlane kunye nokunciphisa ukusebenza kwawo. Ke ngoko, iyeza lokuthintela umkhuhlane alifanelanga ukuba linikezwe kwiintsuku ezili-14 ngaphambi okanye kwiintsuku ezimbini emva kolawulo lweTamiflu okanye iXofluza.
I-Xofluza inokusebenzisana namayeza aqukethe ii-polyvalent cations. La mayeza angabandakanya i-laxatives, i-antacids, okanye izongezo eziqukethe i-calcium, isinyithi, i-magnesium, i-zinc, okanye i-selenium. Xa zisetyenziswa kunye neXofluza, la machiza anokunciphisa inqanaba leXofluza emzimbeni kunye nokunciphisa ukusebenza kwawo.
| Tamiflu | Xofluza | |
| Isifo sokugonya somkhuhlane esiphilayo | Ewe | Ewe |
| Amayeza aqukethe i-Polyvalent cation (iimveliso eziqukethe i-calcium, isinyithi, i-magnesium, i-selenium, i-zinc, njl. | Hayi | Ewe |
Izilumkiso zikaTamiflu kunye neXofluza
I-Tamiflu kufuneka ijongwe kwabo baneengxaki zezintso. Kungenxa yokuba ukukhubazeka kwezintso kunokubangela amanqanaba aphezulu eTamiflu emzimbeni, ekhokelela kwiziganeko ezimbi ezinokwenzeka.
Ukufunxwa kukaXofluza akwaziwa ukuba kuchaphazeleka ngumsebenzi wezintso. Ukongeza, ukhuseleko nokusebenza kwayo khange kufundwe kwabo banobunzima obungaphantsi kweekhilogram ezingama-40.
I-Tamiflu kunye ne-Xofluza azikhuthazwa kuye nawuphina umntu one-aleji eyaziwayo kwizithako zakhe ezisebenzayo. UTamiflu noXofluza khange bafundwe kakhulu xa bekhulelwe. Ukusetyenziswa kwabo ekukhulelweni kufuneka kuvavanywe ngumboneleli wezempilo njengoko izibonelelo zinokudlula ubungozi obunokubakho.
Imibuzo ebuzwa rhoqo malunga neTamiflu vs Xofluza
Yintoni iTamiflu?
I-Tamiflu (oseltamivir) lunyango olusetyenziselwa ukunyanga okanye ukuthintela umkhuhlane. Isebenza njenge-neuraminidase inhibitor ethintela ukusasazeka komkhuhlane u-A kunye no-B emzimbeni. Sebenzisa iTamiflu kunokunciphisa ixesha elithathwayo ukuze kuphuculwe iimpawu zomkhuhlane. Ihlala ithathwa kabini yonke imihla kangangeentsuku ezintlanu.
Yintoni iXofluza?
IXofluza (baloxavir marboxil) lunyango olunokunyanga okanye ukuthintela umkhuhlane. Sisithinteli se-PA endonuclease inhibitor esinqanda intsholongwane yomkhuhlane ekubeni ingazifanisi emzimbeni. NjengoTamiflu, inokunciphisa ixesha lokuphucula iimpawu. IXofluza yaphuhliswa nguSionogi Pharma kwaye imiselwe njengedosi enyekunyango lomkhuhlane okanye kuthintelo.
Ngaba uTamiflu noXofluza bayafana?
I-Tamiflu kunye ne-Xofluza zombini amayeza antiviral. Kodwa azifani. Nangona bobabini bephucula iimpawu zomkhuhlane, basebenza ngokwahlukileyo kwaye baneziphumo ebezingalindelekanga ezahlukeneyo.
Ngaba iTamiflu okanye iXofluza ingcono?
I-Tamiflu kunye ne-Xofluza zombini zisebenza ngokuchasene nentsholongwane yomkhuhlane. IXofluza sisiyobisi esitsha esibonisiweyo ukuphucula iimpawu zomkhuhlane ngokukhawuleza kuneTamiflu. Ikwafuna kuphela ukuba ithathwe njengedosi enye, enokuthi ikhethwe ngabanye abantu. Kubalulekile ukuba uxoxe ngezi ndlela kunye nogqirha ukuze ufumane unyango olungcono kuwe.
Ndingayisebenzisa iTamiflu okanye iXofluza ngelixa ndikhulelwe?
Akukho datha yonyango yaneleyo yokubonisa ukuba iTamiflu kunye neXofluza zikhuselekile kubafazi abakhulelweyo. Nangona ubungqina bokusetyenziswa okukhuselekileyo ngexesha lokukhulelwa bungekho, izibonelelo zabo zinokugqitha umngcipheko wosulelo lomkhuhlane. Nxibelelana nodokotela xa usenza isigqibo sokuba leliphi iyeza oza kulisebenzisa ukuba ukhulelwe.
Ndingayisebenzisa iTamiflu okanye iXofluza ngotywala?
Akukho lwazi kwiileyibhile zamachiza ezichaza iziphumo zeTamiflu okanye iXofluza ngotywala. Nangona kunjalo, ukusela utywala kunokwenza buthathaka amajoni omzimba kwaye kwenze kube nzima ukulwa nomkhuhlane. Ke ngoko, akukhuthazwa ngokubanzi ukuba usele utywala ngelixa ugula.
Ungayithatha iXofluza kunye noTamiflu?
Hayi. Akucetyiswa ukuba uthathe iXofluza kunye neTamiflu kunye. La machiza amiselwe ngokwahlukeneyo, ukhetho lomntu kumkhuhlane. Kuxhomekeka kwimbali yakho yonyango kunye nemeko iyonke, ichiza elinye linokumiselwa ngaphezulu kwelinye.
